Dr Andrew Streets


Clinical Medicine, School of Medicine and Population Health

Research Fellow in Nephrology

+44 114 215 9555

Full contact details

Dr Andrew Streets
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
S10 2RX

For enquiries please contact - ClinMed-Operational@sheffield.ac.uk

I obtained a BSc (Hons) from the University of Durham in 1993, an MSc from UCL in 1996 and completed my PhD at the University of Leeds in 2000. I joined the University of Sheffield in 1999 working in the Kidney Genetics Group headed by Professor Albert Ong.

After completing a Kidney Research UK Career Development Fellowship I was awarded an RCUK Academic Fellowship in 2006 with support from the Sheffield Kidney Research Foundation. I currently hold the title of Senior Research Fellow in Nephrology.

Research interests

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic disease affecting the kidney (incidence 1 in 1000) and is caused by mutations in two genes, PKD1 (85-90%) or PKD2 (10-15%) which encode the polycystin-1 and 2 proteins respectively.

Around 10% of patients on renal replacement therapy have ADPKD and it is estimated that this treatment costs £40 million per annum to the NHS alone. There are currently no effective drugs for slowing progression in the 50% of ADPKD patients who are destined to develop end-stage renal failure.

The aim of my current research is to test the hypothesis that the biology of the polycystin-1 and 2 complex is regulated by reversible protein phosphorylation under the control of tightly regulated protein kinases and phosphatases. Reversible phosphorylation regulates protein trafficking, protein-protein interactions and protein functions such as cell-cell adhesion, channel activity and cell signalling. Polycystin-1 and 2 can act either as part of a complex, or as individual proteins to carry out these functions.

Understanding this dynamic process will provide important new information which could lead to new treatments to retard cyst formation in ADPKD. My recent work has shown that phosphorylation plays a key role in regulating polycystin-2 function both in vitro and in vivo and that polycystin-1 regulates cell adhesion, both of which are critically important for the maintenance of normal tubular and glomerular morphology.

I also have a keen interest in the role of microRNAs in ADPKD. We and others have shown that alterations in miRNA may contribute to the pathogenesis of ADPKD as well as acting as novel biomarkers. We have carried out microarrays as well as Next Generation Sequencing to identify changes in miRNAs in ADPKD. My work aims to understand the function of these dysregulated miRNAs in ADPKD.

Current projects

My research has been funded by the RCUK, KRUK, SKRF, ERA-EDTA and the Northern General Hospital trustees as well as the Medical School.

My current projects include:

  1. The role of phosphorylation in the regulation of polycystin-2 function.
  2. The role of polycystin 1 and 2 in the regulation of cell adhesion.
  3. The role of microRNAs in the pathogenesis of ADPKD.
  4. Trafficking of the polycystin proteins.

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Research group

PhD Students

  • Fatima Abdeli-Ali
  • Debo Adekewola
  • Tajdida Mayer
  • Paolo Prosseda
  • Siavash Rostami Ravi
  • Devon Smith
  • Laura Vergoz
Teaching activities

I teach on the following courses:

  • Molecular Biology and Biochemistry undergraduate module MBB334
  • MSc Molecular Medicine modules MED6002, 6003 and 6005