Professor Endre Kiss-Toth

Clinical Medicine, School of Medicine and Population Health

School Director of Innovation

Professor of Cell Signalling
+44 114 215 9534

Full contact details

Professor Endre Kiss-Toth
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
S10 2RX

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I joined the University of Sheffield in 1988 as a postdoctoral researcher and was working on the development and implementation of a novel genetic screening approach.

This is based on detecting the bioactivity of proteins, which are transiently over expressed in mammalian cells. We used this approach to identify novel components of signalling pathways key in innate immunity. I have kept interest and association with this screening platform ever since and have recently been leading research identifying novel inflammatory regulators of macrophages.

In 2000, I was awarded a Career Development Fellowship by the Arthritis Research Campaign (now AR-UK) to characterise the mode of action of a novel family of proteins, tribbles.

In 2002, I joined the Cardiovascular Research Group as a Lecturer and developed my interest in tribbles further, by investigating their biological importance in vascular cells.

I became a Reader in 2013 and a Professor in 2017 with the same overall focus around regulation of innate immune signalling.

Research interests

My group is interested in identifying novel regulators of inflammatory signal transduction, characterising their basic mechanism of action, as well as validating some of these novel genes as potential drug targets for therapeutic intervention in chronic inflammatory diseases.

Much of our recent work has been focussing on studying the biological importance of the tribbles family of pseudokinases in cell types that are relevant to the development of cardiovascular disease.

We have established a global network of collaborators to pursue joint projects that aim to understand the importance of tribbles in cell biology, both in health and disease.

Current projects

  • Discovery of novel regulators of inflammatory signalling.
  • Defining the molecular mechanism of action for TMEM203, a novel inflammatory signalling regulator.
  • Characterisation the biological importance of tribbles proteins in the development of lipid homeostasis, inflammation and metabolic syndromes
  • Regulation of tribbles expression in vascular cells: development of novel anti-atherosclerotic drug targeting strategies.

Show: Featured publications All publications

Journal articles

All publications

Journal articles


  • (2018) T, Encyclopedia of Signaling Molecules (pp. 5299-5299). Springer International Publishing RIS download Bibtex download

Conference proceedings papers


Research group
  • Kajus Baidzajevas
  • Eva Hadadi
  • Zabran Ilyas
  • Jessica Johnston
  • Li Yang
Teaching interests

I lecture on technologies and approaches designed to identify novel genes with a particular function. My other main area of teaching involves bioinformatics for molecular biology and functional genomics applications.