Dr Janet Chamberlain


Clinical Medicine, School of Medicine and Population Health

Senior University Teacher

+44 114 215 9566

Full contact details

Dr Janet Chamberlain
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
S10 2RX

For enquiries please contact - ClinMed-Operational@sheffield.ac.uk

After completing an MRC-funded PhD studentship at the University of Manchester, I spent a year working as an immunohistochemist at Zeneca Pharmaceuticals, Alderley Park. I joined the University of Sheffield in 1995, and spent 3 years as a Postdoctoral Research Associate in the Department of Cardiovascular Research (with Professor David Crossman as PI).

Following this, I wrote my own funding applications, although remained as a Postdoctoral Research Associate, then an Experimental Officer; holding several Project Grants as Principal Investigator, working closely with Professors Sheila Francis and Julian Gunn. In 2016, I became a University Teacher and now concentrate mainly on teaching, although still have an interest in research.

Research interests

My research career has focused on the understanding and prevention of restenosis and atherosclerosis, using several different experimental models, including research to develop a miniature stenting device for use in small calibre vessels.

My current areas of research relate to the mechanisms by which IL-1 is released from endothelial and smooth muscle cells, the role of IL-1 in the development of atherosclerosis, and the use of IL-1 antagonists to inhibit disease progression.

In addition, I am currently involved in investigating the role of carbon monoxide as a possible therapeutic for restenosis and myocardial infarction.

Current Projects

  • Release of IL-1 from endothelial and smooth muscle cells (with Professor Francis). 
  • The use of carbon-monoxide releasing molecules in Restenosis/atherosclerosis (BHF, with Francis/Gunn/Mann). 
  • The use of carbon-monoxide releasing molecules in MI (BHF with Gunn/Iqbal/Francis/Mann). 
  • Cholesterol crystal formation in atherosclerosis (with Francis).

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Teaching interests

I teach on several undergraduate and postgraduate taught modules, including MBB334 Biochemical Basis of Human Disease, CDL301 Cardiovascular Pharmacology: Personalising Medicine, several modules within both the MSc in Molecular Medicine, and within the CDLT01 MRes Cardiovascular Medicine: From Molecules to Man.

I am the module co-ordinator for CDL301/6301, module lead CDL601 and CDL602 (Research Skills), deputy module lead for CDL601 (Literature Review) and CDL401 (Vascular Cell Biology), and occasionally deputise for the overall programme of CDLT01 MRes Cardiovacular Medicine:From Molecules to Man. In addition, I also am responsible for the Blackboard site, for CDL302 (Pharmacology of Respiratory Disease).

I am Deputy Director of Learning & Teaching for the Department. I am Chair of the Department’s Undergraduate Teaching Committee, and am a member of the MRes Committee. I have a particular interest in supporting students with an SpLD, and actively engage in delivering CPD to staff with respect to the use of new teaching technologies and ensuring their teaching is inclusive to all students.