Dr Karen Sisley

BSc, PhD

Clinical Medicine, School of Medicine and Population Health

Senior Lecturer in Rare Cancers

k.sisley@sheffield.ac.uk
+44 114 215 9061

Office: EU21, The Medical School

Full contact details

Dr Karen Sisley
Clinical Medicine, School of Medicine and Population Health
Office: EU21
The Medical School
Beech Hill Road
Sheffield
S10 2RX

Profile

For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk

Having obtained my PhD from the University of Sheffield in 1992, I continued my active research into rare cancers and as Senior Lecturer I am the lead of the Rare Cancer Research Group (RCRG) with a main focus on ocular tumours and sarcoma, but also with an interest in thyroid and other rare cancers.

Cancer Cell Line Expertise

I have a specialist interest and expertise in the generation of cell lines from rare and common cancers. To date over 20 cell lines have been generated, with additional variants of some original cell lines. My group has expertise in working with both commercial and other partners to generate cell lines and/or deliver specific R&D work. Please get in contact for information on our currently available and emerging cell lines, or to discuss potential projects.

The TUoS licensing website, detailing available cell-lines, can be viewed here:
https://licensing.sheffield.ac.uk/products/biological-materials

Research interests

My research interests are the genetic and biological behaviour of uveal melanoma. Sheffield is one of three national centres for the treatment of uveal melanoma, and I work closely with Professor Ian Rennie and the Sheffield Ocular Oncology Service to establish an active research group investigating how the genetic basis of uveal melanoma underpins its behaviour.

As a group we were instrumental in the introduction of genetic biomarker testing for uveal melanoma and actively continue our investigations in this area. I am also interested in the DNA damage response of uveal melanomas and how we can facilitate new and novel therapeutics.

My research continues to investigate the genetic basis of uveal melanomas but has broadened in recent years to consider how the interaction with the environment affects the way these melanomas develop. I also collaborate and work on another rare tumour, sarcoma and have become actively involved in investigating the genetic characterization of sarcoma and developing a molecular pathological classification suitable for all subtypes.

As a group, we also have an interest in cancer stem cells and the heterogeneity of tumours.

Current projects

Understanding the aggressive behaviour of uveal melanoma, and the potential role that stem cells may have.
Determining the key genetic events in the development of uveal melanoma.
Investigating how the environment may influence the behaviour and development of uveal melanoma.
The molecular pathological classification of sarcomas.
Investigating how genetic defects influence sarcoma behaviour.

Within each project area are a number of smaller focussed research projects suitable for development as student projects, although funding is not currently available for these projects. Interested students are welcome to contact me to discuss the possibilities of undertaking research with the RTRG.

Publications

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Journal articles

Cole LM, Handley J, Claude E, Duckett CJ, Mudhar HS, Sisley K & Clench MR (2021) Multi-modal mass spectrometric imaging of uveal melanoma. Metabolites, 11(8).
Doherty RE, Bryant HE, Valluru MK, Rennie IG & Sisley K (2019) Increased non-homologous end joining makes DNA-PK a promising target for therapeutic intervention in uveal melanoma. Cancers, 11(9). View this article in WRRO
Kopsidas K, Mudhar H, Sisley K, Hammond DW, Worthington L, Suvarna K, Foran B & Salvi S (2019) Aggressive Ciliary Body Adenocarcinoma with Bilateral Lung Metastases: Histological, Molecular, Genetic and Clinical Aspects. Ocular Oncology and Pathology, 5(2), 79-84.
Mudhar HS, Doherty RE, Salvi SM, Currie ZI, Tan JH & Sisley K (2018) Genetic profiling of primary orbital melanoma-an analysis of 6 cases with clinico-pathological correlation. Ophthalmology. View this article in WRRO
van Poppelen NM, Vaarwater J, Mudhar HS, Sisley K, van den Bosch QCC, de Klein A, Kiliç E & Verdijk RM (2018) Reply. Ophthalmology, 125(11), e79-e80.
van Poppelen NM, Vaarwater J, Mudhar HS, Sisley K, Rennie IG, Rundle P, Brands T, van den Bosch QCC, Mensink HW, de Klein A , Kiliç E et al (2018) Genetic Background of Iris Melanomas and Iris Melanocytic Tumors of Uncertain Malignant Potential. Ophthalmology, 125(6), 904-912. View this article in WRRO
Salawu A, Wright K, Al-Kathiri A, Wyld L, Reed M & Sisley K (2018) Sister Chromatid Exchange and Genomic Instability in Soft Tissue Sarcomas: Potential Implications for Response to DNA-Damaging Treatments. Sarcoma, 2018. View this article in WRRO
Doherty RE, Sisley K, Hammond DW, Rennie IG & Cross NA (2017) Phenotypic Plasticity in Uveal Melanoma Is Not Restricted to a Tumor Subpopulation and Is Unrelated to Cancer Stem Cell Characteristics.. Invest Ophthalmol Vis Sci, 58(12), 5387-5395. View this article in WRRO
Salawu A, Fernando M, Hughes D, Reed M, Woll P & Sisley K (2017) One tumour, two clones: An in vitro model of intra-tumour heterogeneity. Annals of Oncology, 28, v14-v14.
Fabian ID, Thaung C, AlHarby L, Sisley K, Mudhar HS, Doherty RE, Stacey AW, Arora AK, Cohen VML & Sagoo MS (2017) Late Solitary Extraocular Recurrence from Previously Resected Iris Melanoma. American Journal of Ophthalmology, 181, 97-105. View this article in WRRO
Kheder S, Sisley K, Hadad S & Balasubramanian SP (2017) Effects of prolonged exposure to low dose metformin in thyroid cancer cell lines. Journal of Cancer, 8(6), 1053-1061. View this article in WRRO
Salawu A, Fernando M, Hughes D, Reed MWR, Woll P, Greaves C, Day C, Alhajimohammed M & Sisley K (2016) Establishment and molecular characterisation of seven novel soft-tissue sarcoma cell lines. British Journal of Cancer, 115, 1058-1068. View this article in WRRO
Hammond DW, Al-Shammari NSD, Danson S, Jacques R, Rennie IG & Sisley K (2015) High-Resolution Array CGH Analysis Identifies Regional Deletions and Amplifications of Chromosome 8 in Uveal Melanoma. Investigative Opthalmology & Visual Science, 56(6), 3460-3466.
Kheder S, Hadad S, Sisley K & Balasubramanian S (2014) Reprint of: Investigation of the role of Metformin in thyroid cancer. European Journal of Surgical Oncology (EJSO), 40(12), 1799-1800.
Kheder S, Hadad S, Sisley K & Balasubramanian S (2014) Investigation of the role of Metformin in thyroid cancer. European Journal of Surgical Oncology (EJSO), 40, S3-S4.
Mudhar HS, Doherty R, Salawu A, Sisley K & Rennie I (2013) Immunohistochemical and molecular pathology of ocular uveal melanocytoma: Evidence for somatic GNAQ mutations. British journal of Ophthalmology, 97(7), 924-928.
Gravells P, Hoh L, Solovieva S, Patil A, Dudziec E, Rennie IG, Sisley K & Bryant HE (2013) Reduced FANCD2 influences spontaneous SCE and RAD51 foci formation in uveal melanoma and Fanconi anaemia.. Oncogene, 32(46), 5338-5346. View this article in WRRO
Mudhar HS, Scott I, Ul-Hassan A, Burton D, Doherty R, Cross N, Rennie IG & Sisley K (2012) Bilateral diffuse uveal melanocytic hyperplasia: molecular characterization and novel association with bilateral renal papillary carcinoma.. Histopathology, 61(4), 751-754.
Salawu A, Ul-Hassan A, Hammond D, Fernando M, Reed M & Sisley K (2012) High quality genomic copy number data from archival formalin-fixed paraffin-embedded leiomyosarcoma: optimisation of universal linkage system labelling.. PLoS One, 7(11), e50415. View this article in WRRO
Gravells P, Hoh L, Sisley K & Bryant HE (2012) FANCD2: lessons in recombination from uveal melanoma.. MUTAGENESIS, 27(1), 107-107.
Doherty RE, Haywood-Small SL, Sisley K & Cross NA (2011) Aldehyde dehydrogenase activity selects for the holoclone phenotype in prostate cancer cells.. Biochem Biophys Res Commun, 414(4), 801-807.
Gravells P, Hoh L, Canovas D, Rennie IG, Sisley K & Bryant HE (2011) Resistance of uveal melanoma to the interstrand cross-linking agent mitomycin C is associated with reduced expression of CYP450R.. Br J Cancer, 104(7), 1098-1105. View this article in WRRO
Sisley K, Doherty R & Cross NA (2011) What hope for the future? GNAQ and uveal melanoma.. Br J Ophthalmol, 95(5), 620-623.
Hoh L, Gravells P, Canovas D, Ul-Hassan A, Rennie IG, Bryant H & Sisley K (2011) Atypically low spontaneous sister chromatid exchange formation in uveal melanoma.. Genes Chromosomes Cancer, 50(1), 34-42.
Ul-Hassan A, Sisley K, Hughes D, Hammond DW, Robinson MH & Reed MWR (2009) Common genetic changes in leiomyosarcoma and gastrointestinal stromal tumour: implication for ataxia telangiectasia mutated involvement.. Int J Exp Pathol, 90(5), 549-557.
Raoof N, Rennie IG, Salvi SM, Sisley K, Caine A & Mudhar HS (2009) What is the significance of vortex vein invasion in uveal melanoma?. Eye (Lond), 23(8), 1661-1667.
Mudhar HS, Saunders E, Rundle P, Rennie IG & Sisley K (2009) The in vivo modulatory effects of an anterior-chamber microenvironment on uveal melanoma.. Br J Ophthalmol, 93(4), 535-540.
Sisley K (2008) USING GENETIC MARKERS TO DETERMINE PROGNOSIS OF UVEAL MELANOMA. ANTICANCER RES, 28(5C), 3489-3489.
Canovas D, Rennie IG, Nichols CE & Sisley K (2008) Local environmental influences on uveal melanoma: vitreous humor promotes uveal melanoma invasion, whereas the aqueous can be inhibitory.. Cancer, 112(8), 1787-1794.
Singh AD, Sisley K, Xu Y, Li J, Faber P, Plummer SJ, Mudhar HS, Rennie IG, Kessler PM, Casey G & Williams BG (2007) Reduced expression of autotaxin predicts survival in uveal melanoma.. Br J Ophthalmol, 91(10), 1385-1392.
Sisley K, Tattersall N, Dyson M, Smith K, Mudhar HS & Rennie IG (2006) Multiplex fluorescence in situ hybridization identifies novel rearrangements of chromosomes 6, 15, and 18 in primary uveal melanoma.. Exp Eye Res, 83(3), 554-559.
Cross NA, Ganesh A, Parpia M, Murray AK, Rennie IG & Sisley K (2006) Multiple locations on chromosome 3 are the targets of specific deletions in uveal melanoma.. Eye (Lond), 20(4), 476-481.
Ul-Hassan A, Hammond DW, Feeley K, Sisley K, Robinson M & Reed MW (2005) Genetic characterisation of leiomyosarcoma. EJC SUPPL, 3(2), 352-352.
Woodward JKL, Rennie IG, Burn JL & Sisley K (2005) A potential role for TGFbeta in the regulation of uveal melanoma adhesive interactions with the hepatic endothelium.. Invest Ophthalmol Vis Sci, 46(10), 3473-3477.
Woodward JKL, Rennie IG, Elshaw SR, Burn JL & Sisley K (2005) Invasive and noninvasive uveal melanomas have different adhesive properties.. Eye (Lond), 19(3), 342-348.
Cross NA, Rennie IG, Murray AK & Sisley K (2005) The identification of chromosome abnormalities associated with the invasive phenotype of uveal melanoma in vitro.. Clin Exp Metastasis, 22(2), 107-113.
Woodward JKL, Rennie IG, Burn JL, Evans GS & Sisley K (2004) PC43 ENDOTHELIAL VCAM-1 AND MELANOMA α4 EXPRESSION INCREASE FOLLOWING INTERACTION OF INVASIVE UVEAL MELANOMAS WITH THE HEPATIC ENDOTHELIUM. Microcirculation, 11(6), 553-553.
Mudhar HS, Parsons MA, Sisley K, Rundle P, Singh A & Rennie IG (2004) A critical appraisal of the prognostic and predictive factors for uveal malignant melanoma.. Histopathology, 45(1), 1-12.
Woodward J, Sisley K, Reeves G, Nichols C, Parsons MA, Mudhar H & Rennie I (2004) Evidence of macrophage and lymphocyte, but not dendritic cell, infiltration in posterior uveal melanomas, whilst cultured uveal melanomas demonstrate pluripotency by expressing CD68 and CD163.. Int J Exp Pathol, 85(1), 35-43.
Parker CJ, Shawcross SG, Li H, Wang Q-Y, Herrington CS, Kumar S, MacKie RM, Prime W, Rennie IG, Sisley K & Kumar P (2004) Expression of PAX 3 alternatively spliced transcripts and identification of two new isoforms in human tumors of neural crest origin.. Int J Cancer, 108(2), 314-320.
Brown M, Bicknell R, Mortimer P, Levick J, Bates D, Wang W, Lu Y, Levick J, Joory K, Levick J , Mortimer P et al (2004) Abstracts of the 41st Meeting of the British Microcirculation Society. Microcirculation, 11(6), 527-558.
Cross NA, Murray AK, Rennie IG, Ganesh A & Sisley K (2003) Instability of microsatellites is an infrequent event in uveal melanoma.. Melanoma Res, 13(5), 435-440.
Cantón I, Eves PC, Szabo M, Vidal-Vanaclocha F, Sisley K, Rennie IG, Haycock JW & MacNeil S (2003) Tumor necrosis factor alpha increases and alpha-melanocyte-stimulating hormone reduces uveal melanoma invasion through fibronectin.. J Invest Dermatol, 121(3), 557-563.
Carlring J, Shaif-Muthana M, Sisley K, Rennie IG & Murray AK (2003) Apoptotic cell death in conjunction with CD80 costimulation confers uveal melanoma cells with the ability to induce immune responses.. Immunology, 109(1), 41-48.
Woodward JKL, Elshaw SR, Murray AK, Nichols CE, Cross N, Laws D, Rennie IG & Sisley K (2002) Stimulation and inhibition of uveal melanoma invasion by HGF, GRO, IL-1alpha and TGF-beta.. Invest Ophthalmol Vis Sci, 43(10), 3144-3152.
Woodward JKL, Nichols CE, Rennie IG, Parsons MA, Murray AK & Sisley K (2002) An in vitro assay to assess uveal melanoma invasion across endothelial and basement membrane barriers.. Invest Ophthalmol Vis Sci, 43(6), 1708-1714.
Mulcahy KA, Alexander S, Platts KE, Wardle C, Sisley K, Rennie IG & Murray AK (2002) CD80-mediated induction of immunostimulation in two ocular melanoma cell lines is augmented by interferon-gamma.. Melanoma Res, 12(2), 129-138.
Patel KA, Edmondson ND, Talbot F, Parsons MA, Rennie IG & Sisley K (2001) Prediction of prognosis in patients with uveal melanoma using fluorescence in situ hybridisation.. Br J Ophthalmol, 85(12), 1440-1444.
Prasad S, Puri P, Sisley K, Parsons A & Rennie IG (2001) Cytogenetic analysis in ocular lymphoma.. Br J Ophthalmol, 85(11), 1388-1389.
Parker C, Shawcross SG, Hart I, Kumar S, MacKie R, Sisley K & Kumar P (2001) Expression of PAX-3 alternatively spliced transcripts in human tumours of neural crest origin. BRIT J CANCER, 85, 107-107.
Baker JK, Elshaw SR, Mathewman GE, Nichols CE, Murray AK, Parsons MA, Rennie IG & Sisley K (2001) Expression of integrins, degradative enzymes and their inhibitors in uveal melanoma: differences between in vitro and in vivo expression.. Melanoma Res, 11(3), 265-273.
Cresswell AC, Sisley K, Laws D, Parsons MA, Rennie IG & Murray AK (2001) Reduced expression of TAP-1 and TAP-2 in posterior uveal melanoma is associated with progression to metastatic disease.. Melanoma Res, 11(3), 275-281.
Elshaw SR, Sisley K, Cross N, Murray AK, MacNeil SM, Wagner M, Nichols CE & Rennie IG (2001) A comparison of ocular melanocyte and uveal melanoma cell invasion and the implication of alpha1beta1, alpha4beta1 and alpha6beta1 integrins.. Br J Ophthalmol, 85(6), 732-738.
Baker JK, Rennie IG, Murray AK & Sisley K (2001) An in vitro model of metastasis for uveal melanoma. INVEST OPHTH VIS SCI, 42(4), S219-S219.
Shaif-Muthana M, McIntyre C, Sisley K, Rennie I & Murray A (2000) Dead or alive: immunogenicity of human melanoma cells when presented by dendritic cells.. Cancer Res, 60(22), 6441-6447.
Hedley SJ, Murray A, Sisley K, Ghanem G, Morandini R, Gawkrodger DJ & Mac Neil S (2000) Alpha-melanocyte stimulating hormone can reduce T-cell interaction with melanoma cells in vitro.. Melanoma Res, 10(4), 323-330.
Parker C, Wang W, Hart I, Sisley K, Kumar S & Kumar P (2000) Expression of genes Pax-3 and Pax-7 in neural crest lineage tumours. BRIT J CANCER, 83, 36-36.
Sisley K, Parsons MA, Garnham J, Potter AM, Curtis D, Rees RC & Rennie IG (2000) Association of specific chromosome alterations with tumour phenotype in posterior uveal melanoma.. Br J Cancer, 82(2), 330-338. View this article in WRRO
Rennie IG, Elshaw SR, Sisley K & Murray AK (1999) Expression of proteolytic enzymes and integrins in uveal melanoma and association to in vitro invasion. INVEST OPHTH VIS SCI, 40(4), S246-S246.
Sisley K, Brand C, Parsons MA, Maltby E, Rees RC & Rennie IG (1998) Cytogenetics of iris melanomas: disparity with other uveal tract melanomas.. Cancer Genet Cytogenet, 101(2), 128-133.
Sisley K, Nichols C, Parsons MA, Farr R, Rees RC & Rennie IG (1998) Clinical applications of chromosome analysis, from fine needle aspiration biopsies, of posterior uveal melanomas.. Eye (Lond), 12 ( Pt 2), 203-207.
Sisley K, Nichols C, Parsons MA & Rennie IG (1997) Chromosomal analysis of fine needle aspiration biopsies of uveal melanomas. Melanoma Research, 7(Supplement 1), S136-S136.
Sisley K, Rennie IG, Parsons MA, Jacques R, Hammond DW, Bell SM, Potter AM & Rees RC (1997) Abnormalities of chromosomes 3 and 8 in posterior uveal melanoma correlate with prognosis.. Genes Chromosomes Cancer, 19(1), 22-28.
Sisley K, Nichols C, Parsons MA, Rees RC & Rennie IG (1997) Cytogenetic analysis of fine needle aspiration biopsies; Potential use in the prognosis of small posterior uveal melanoma.. INVEST OPHTH VIS SCI, 38(4), 3764-3764.
Andalib AR, Lawry J, Ali SA, Murray AK, Sisley K, Silcocks P, Herlyn M & Rees RC (1997) Cytokine modulation of antigen expression in human melanoma cell lines derived from primary and metastatic tumour tissues.. Melanoma Res, 7(1), 32-42.
Sisley K, Rennie IG, Parsons MA, Jacques RM & Rees RC (1996) Secondary chromosome alterations in ocular melanomas and relationship to prognosis. Cancer Genetics and Cytogenetics, 91(2), 180-180.
Brand C, Sisley K, Rennie IG, Parsons MA & Rees RC (1996) Chromosome changes iris melanomas.. INVEST OPHTH VIS SCI, 37(3), 959-959.
Tappin MJ, Parsons MA, Sisley K, Rees RC & Rennie IG (1996) Two cases of double melanoma of the uvea.. Eye (Lond), 10 ( Pt 5), 600-602.
SISLEY K, RENNIE IG, PARSONS MA & REES RC (1995) CYTOGENETIC ALTERATIONS ASSOCIATED WITH ADVANCED UVEAL MELANOMAS. INVEST OPHTH VIS SCI, 36(4), S415-S415.
Sisley K, Rennie IG & Rees RC (1994) Loss of heterozygosity of chromosome 3 in subsets of uveal melanomas. Cancer Genetics and Cytogenetics, 77(2), 183-183.
SISLEY K, RENNIE IG & REES RC (1994) COMPARISON OF THE LOSS OF HETEROZYGOSITY OF CHROMOSOME-3 MARKERS BETWEEN SUBSETS OF UVEAL MELANOMAS. INVEST OPHTH VIS SCI, 35(4), 1928-1928.
Sisley K, Curtis D, Rennie IG & Rees RC (1993) Loss of heterozygosity of the thyroid hormone receptor B in posterior uveal melanoma.. Melanoma Res, 3(6), 457-461.
SISLEY K, RENNIE IG, COTTAM DW, CURTIS D, PARSONS MA & REES RC (1993) INVESTIGATION OF A POTENTIAL MARKER FOR METASTATIC SPREAD IN POSTERIOR UVEAL MELANOMA. INVEST OPHTH VIS SCI, 34(4), 965-965.
Sisley K, Rogers K, Goepel J, Potter AM & Rees RC (1992) Cytogenetic study of primary and metastatic lesions of breast cancer. Cancer Genetics and Cytogenetics, 63(2), 159-159.
Sisley K, Rennie IG, Cottam DW, Potter AM & Rees RC (1992) Abnormalities of chromosomes 3, 6 and 8 in posterior uveal melanoma. Cancer Genetics and Cytogenetics, 63(2), 182-182.
Sisley K, Cottam DW, Rennie IG, Parsons MA, Potter AM, Potter CW & Rees RC (1992) Non-random abnormalities of chromosomes 3, 6, and 8 associated with posterior uveal melanoma.. Genes Chromosomes Cancer, 5(3), 197-200.
SISLEY K, COTTAM D, RENNIE IG, POTTER AM, POTTER CW & REES RC (1992) CYTOGENETICS OF UVEAL MELANOMA. INVEST OPHTH VIS SCI, 33(4), 1243-1243.
Sisley K, Rennie IG, Cottom D, Potter AM, Potter CW & Rees RC (1991) Cytogenetic findings on six posterior uveal melanomas. Involvement of chromosomes. 3, 6 and 8.. Cancer Genetics and Cytogenetics, 52(2), 215-215.
Sisley K, Rennie IG, Cottam DW, Potter AM, Potter CW & Rees RC (1990) Cytogenetic findings in six posterior uveal melanomas: involvement of chromosomes 3, 6, and 8.. Genes Chromosomes Cancer, 2(3), 205-209.
DIXON DR, MCFADZEN IRB & SISLEY K (1986) HETEROCHROMATIC MARKER REGIONS (NUCLEOLAR ORGANIZERS) IN THE CHROMOSOMES OF THE COMMON MUSSEL, MYTILUS-EDULIS (MOLLUSCA, PELECYPODA). J EXP MAR BIOL ECOL, 97(2), 205-212.
Pankova V, Krasny L, Kerrison W, Tam YB, Chadha M, Burns J, Wilding CP, Chen L, Chowdhury A, Perkins E , Lee ATJ et al () Clinical implications and molecular features of extracellular matrix networks in soft tissue sarcomas. Clinical Cancer Research.
Sisley K () Head and neck: Posterior uveal melanoma. Atlas of Genetics and Cytogenetics in Oncology and Haematology(3).
Mudhar HS, Doherty R, Salawu A, Sisley K & Rennie I () Immunohistochemical and molecular pathology of ocular uveal melanocytoma: Evidence for somatic GNAQ mutations.. British Journal of Ophthalmology.

Chapters

Sisley K (2009) Tumours of the eye In Heim S (Ed.), Cancer Cytogenetics John Wiley Press
Singh AD, Sisley K & Wackernagel W (2008) Genetics of Uveal Melanoma, Albert &amp Jakobiec's Principles &amp Practice of Ophthalmology (pp. 4925-4934). Elsevier
Abad J-C, Abelson MB, Abramson DH, Acquadro MA, Adamis AP, Adams WH, Afshari NA, Ai E, Aiello LM, Aiello LP , Akduman L et al (2008) List of Contributors, Albert &amp Jakobiec's Principles &amp Practice of Ophthalmology (pp. xxiii-xliv). Elsevier
Sisley K & Wackernagel W (2007) Genetics of uveal melanoma In Albert & Jakobiec (Ed.), Principles and Practise of Ophthalmology Philadelphia: Lippincott,.
Sisley K & Naus N (2004) The relevance of Chromosome Abnormalities in posterior uveal melanoma. In: Uveal Melanoma In Jager MJ & Neiderkorn JY (Ed.), Uveal Melanoma: A Model for Exploring Fundamental Cancer Biology CRC Press
Sisley K & Rennie I (2003) Genetics of Uveal Melanoma, Ocular Oncology (pp. 63-79). CRC Press
Sisley K & Rennie I (2003) Genetics of Uveal Melanoma, Ocular Oncology Informa Healthcare
Sisley K & Rennie IG (2003) Genetics of uveal melanoma: chromosomal rearrangements and the identification of genes involved in tumourigenesis. In Albert DM & Polans A (Ed.), Ocular Oncology (pp. 66-83). Informa Healthcare
Sisley K () Tumors of the eye, Cancer Cytogenetics (pp. 538-554). John Wiley & Sons, Ltd
Sisley K & Rennie IG () Genetics of Uveal Melanoma: Chromosomal Rearrangements and the Identification of Genes Involved in Tumorigenesis, Ocular Oncology (pp. 77-94). Taylor & Francis

Conference proceedings papers

Salawu A, Fernando M, Hughes D, Reed M, Woll P & Sisley K (2017) One tumour, two clones: An in vitro model of intra-tumour heterogeneity. ANNALS OF ONCOLOGY, Vol. 28
Cole LM, Mudhar HS, Sisley K, Peck A, Batey M, Claude E & Clench M (2016) Abstract 4231: Analysis of FFPE treated clinical tissue sections obtained from human intraocular malignancy, uveal melanoma by mass spectrometry imaging (MSI). Tumor Biology
Doherty RE, Hoh L, Rennie I, Sisley K & Cross NA (2012) Isolation and Characterisation of Cancer Stem Cells in Solid Tumours. JOURNAL OF PATHOLOGY, Vol. 228 (pp S34-S34)
Doherty R, Hoh L, Rennie I, Sisley K & Cross N (2012) Isolation and Characterisation of Cancer Stem Cells in Solid Tumours. EUROPEAN JOURNAL OF CANCER, Vol. 48 (pp S65-S66)
Salawu A, Ul-Hassan A, Woll P, Wyld L, Fernando M, Reed MWR & Sisley K (2012) Identification of soft tissue sarcoma subtypes using microarray-based comparative genomic hybridization. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, Vol. 30 (pp S61-S61)
Doherty R, Hoh L, Rennie I, Cross N & Sisley K (2012) Isolation and characterisation of cancer stem cells in uveal melanoma. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, Vol. 30 (pp S61-S61)
Sisley K (2007) Genetic advances in uveal melanoma. JOURNAL OF MEDICAL GENETICS, Vol. 44 (pp S42-S42)
Rennie IG, Woodward JKL & Sisley K (2005) TGF beta plays both a stimulatory and inhibitory role in the regulation of uveal melanoma invasion in vitro. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol. 46
Rennie IG, Woodward JKL, Nichols CE, Reeves G, Parsons MA & Sisley K (2003) Investigations of macrophage and dendritic cell markers in uveal melanoma. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol. 44 (pp U362-U362)
Woodward JK, Rennie IG, Burn L, Evans GS & Sisley K (2003) Hepatic endothelial cells may assist uveal melanomas to target the liver through alpha-4 integrin and VCAM-1 interactions. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol. 44 (pp U367-U367)
Inglis AC, Sisley K, Singh AD, Currie ZI & Rennie IG (2003) Prognostic factors in uveal melanoma: Correlation of vascular loop patterns with genetic imbalance as determined using fluorescence in situ hybridization (FISH). INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol. 44 (pp U255-U255)
Rennie IG, Baker JKL, Elshaw SR, Murray AK, Nichols CE & Sisley K (2002) HGF, GRO and MIP-1 beta stimulate uveal melanoma migration whilst IL-1 alpha and TGF-beta inhibit migration. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol. 43 (pp U246-U246)

Teaching activities

I am the course lead for Pathology on the undergraduate BMedSci Orthoptics course. The course spans two academic years and covers the basis of Ophthalmic disease, its presentation and consequences.

In addition I offer a supportive role annually to up to 5 students in the second year of the MBChB degree course, who select to undertake their research attachment with the research group.

Following on from these attachments a number of students have subsequently chosen to continue their research under my supervision by undertaking a BMedSci.

I am also a regular supervisor of both MSc students from University of Sheffield and Hallam University and a pesonal tutor for MSc, PhD and medical students.

Professional activities and memberships

Regular reviewer for both Cancer and Ophthalmology journals.
Reviewer for national and international grants.