Dr Osman Shabir
BSc (Hons), MSc, PhD
Clinical Medicine, School of Medicine and Population Health
Postdoctoral Research Associate
Alzheimer’s Research UK (ARUK) Yorkshire Network ECR Representative.


+44 114 222 6554
Full contact details
Clinical Medicine, School of Medicine and Population Health
B1-223a
Alfred Denny Building
Western Bank
Sheffield
S10 2TN
- Profile
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For enquiries, please contact – iicd-om-operational@sheffield.ac.uk
I graduated with a BSc (Hons) in Biomedical Science in 2015 from the University of Sheffield, specialising in neuroscience in my final year. I then went on to complete an MSc in Translational Neuroscience in SITraN in 2016. In 2020, I was awarded my PhD in Neurovascular Neuroscience, supervised by Dr Jason Berwick & Prof Sheila Francis.
In 2020, Prof Sheila Francis was awarded a BHF project grant titled “Atherosclerosis, the brain and vascular dementia – the role of inflammation in neurovascular function”; based on pilot data from my PhD thesis, on which I am currently the postdoc on.
- Research interests
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I study neurovascular function in neurodegenerative and cerebrovascular diseases such as Alzheimer’s disease/vascular dementia & cardiovascular disease (atherosclerosis). I use preclinical models of human disease to study neurophysiology, neuropathology & neuroinflammation in these models to gain a better understanding of disease mechanisms and processes.
To study neurovascular function, I use neuroimaging techniques including 2D-optical imaging spectroscopy, 2-photon microscopy, GCaMP fluorescence and microelectrode electrophysiology. In addition, I use standard cellular and molecular neuroscience techniques to validate in vivo observations.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Preclinical models of disease and multimorbidity with focus upon cardiovascular disease and dementia. Mechanisms of Ageing and Development, 192, 111361-111361.
- Enhanced cerebral blood volume under normobaric hyperoxia in the J20-hAPP mouse model of Alzheimer’s disease. Scientific Reports, 10(1). View this article in WRRO
- Key Aspects of Neurovascular Control Mediated by Specific Populations of Inhibitory Cortical Interneurons. Cerebral Cortex, 30(4), 2452-2464. View this article in WRRO
- Neurovascular coupling preserved in a chronic mouse model of Alzheimer’s disease: Methodology is critical.. Journal of Cerebral Blood Flow and Metabolism. View this article in WRRO
- Neurovascular Dysfunction in Vascular Dementia, Alzheimer’s and Atherosclerosis. BMC Neuroscience, 19. View this article in WRRO
- Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis. Molecular Neurodegeneration, 13(1). View this article in WRRO
All publications
Journal articles
- Bidirectional alterations in brain temperature profoundly modulate spatiotemporal neurovascular responses in-vivo. Communications Biology, 6.
- Preclinical models of disease and multimorbidity with focus upon cardiovascular disease and dementia. Mechanisms of Ageing and Development, 192, 111361-111361.
- Enhanced cerebral blood volume under normobaric hyperoxia in the J20-hAPP mouse model of Alzheimer’s disease. Scientific Reports, 10(1). View this article in WRRO
- Key Aspects of Neurovascular Control Mediated by Specific Populations of Inhibitory Cortical Interneurons. Cerebral Cortex, 30(4), 2452-2464. View this article in WRRO
- Neurovascular coupling preserved in a chronic mouse model of Alzheimer’s disease: Methodology is critical.. Journal of Cerebral Blood Flow and Metabolism. View this article in WRRO
- Neurovascular Dysfunction in Vascular Dementia, Alzheimer’s and Atherosclerosis. BMC Neuroscience, 19. View this article in WRRO
- Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis. Molecular Neurodegeneration, 13(1). View this article in WRRO
- Mice modelling heart disease have poor brain blood flow regulation: prelude to dementia.. TheScienceBreaker, 8(3).
- Neurovascular Function in a Novel Model of Experimental Atherosclerosis.
- Assessment of neurovascular coupling
and cortical spreading depression in
mixed mouse models of atherosclerosis
and Alzheimer’s disease. eLife. View this article in WRRO
- Assessment of Neurovascular Coupling & Cortical Spreading Depression in Mixed Models of Atherosclerosis & Alzheimer’s Disease.
Conference proceedings papers
Preprints
- Bidirectional alterations in brain temperature profoundly modulate spatiotemporal neurovascular responses in-vivo: Implications for theragnostics, Cold Spring Harbor Laboratory.
- The effects of locomotion on sensory-evoked haemodynamic responses in the cortex of awake mice, Cold Spring Harbor Laboratory.
- Enhanced Cerebral Blood Volume under Normobaric Hyperoxia in the J20-hAPP Mouse Model of Alzheimer’s Disease.
- Preclinical models of disease and multimorbidity with focus upon cardiovascular disease and dementia. Mechanisms of Ageing and Development, 192, 111361-111361.
- Research group
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Prof Sheila Francis is the PI on the BHF grant on which I am the postdoc on. I am a member of the Sheffield Neurovascular Lab where I work directly with Dr Jason Berwick and Dr Clare Howarth (co-PIs on the BHF grant). I also work directly with Dave Drew who is a research technician on the BHF grant. I further collaborate with Prof Stephen Wharton in SITraN.