Dr Osman Shabir

BSc (Hons), MSc, PhD

Clinical Medicine, School of Medicine and Population Health

BHF Immediate Postdoctoral Fellow

Alzheimer’s Research UK (ARUK) Yorkshire Network ECR Representative.

Dr Osman Shabir
Dr Osman Shabir
Profile picture of Dr Osman Shabir
+44 114 215 9524

Full contact details

Dr Osman Shabir
Clinical Medicine, School of Medicine and Population Health
Alfred Denny Building
Western Bank
S10 2TN

For enquiries please contact - ClinMed-Operational@sheffield.ac.uk

  • BSc (Hons) Biomedical Science (2012-15)
  • MSc Translational Neuroscience (2015-16)
  • PhD Neurovascular Neuroscience (2017-20)
  • Postdoctoral Research Associate (2020-23)
  • BHF Research Fellow (2023-present)

I am a member of the Neuroscience Institute and the Healthy Lifespan Institute.

Research interests

I study neuroinflammation, neurovascular function (neurophysiology) in neurodegenerative and cerebrovascular diseases such as Alzheimer’s disease/vascular dementia & cardiovascular disease (atherosclerosis). I use preclinical models of human disease to study neurophysiology, neuropathology & neuroinflammation in these models to gain a better understanding of disease mechanisms and processes.

neurovascular function, heart disease
Neurovascular function; 'healthy' & 'heart disease.

To study neurovascular function, I use neuroimaging techniques including 2D-optical imaging spectroscopy, 2-photon microscopy, GCaMP fluorescence and microelectrode electrophysiology. In addition, I use standard cellular and molecular neuroscience techniques to validate in vivo observations.

In September 2023, I was awarded a 4-year British Heart Foundation (BHF) fellowship (basic science immediate). My fellowship aims to investigate the use of arthritis drugs (IL1 inhibitors) in preclinical models of atherosclerosis (vascular dementia) and Alzheimer’s disease with atherosclerosis.


Show: Featured publications All publications

Journal articles

All publications

Journal articles

Conference proceedings papers

  • Howarth C, Lee L, Shabir O & Berwick J (2022) Investigating the involvement of nitric oxide in neurovascular coupling. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol. 42(1_SUPPL) (pp 60-60) RIS download Bibtex download


Research group

Prof Sheila Francis and Dr Jason Berwick supervise my research. I collaborate with Dr Clare Howarth, Dr Scott Allen, Dr Mark Dunning, Dr Julie Simpson and Prof Stuart Allan at the University of Manchester. I also informally collaborate with Prof Kurt de Vos, Dr Claudia Bauer, Dr Richard Mead and Dr Matt Livesey.

I have supervised several MSc and SSC students:

  • April Carne, MSc Translational Neuroscience (2022-23)
  • Samuel Turner & Thomas Coles, MBChB Phase 2A SSC (2022)
  • Olivia Slanley & Jasmine Waters, MBChB Phase 2A SSC (2021)
  • Paige Wolverson, MSc Translational Neuroscience (2020-21)
  • Ben Pendry, MSc Translational Neuropathology (2018-19)