Dr Osman Shabir

BSc (Hons), MSc, PhD

Clinical Medicine, School of Medicine and Population Health

Postdoctoral Research Associate

Alzheimer’s Research UK (ARUK) Yorkshire Network ECR Representative.

Dr Osman Shabir
Dr Osman Shabir
Profile picture of Dr Osman Shabir
+44 114 222 6554

Full contact details

Dr Osman Shabir
Clinical Medicine, School of Medicine and Population Health
Alfred Denny Building
Western Bank
S10 2TN

For enquiries, please contact – iicd-om-operational@sheffield.ac.uk

I graduated with a BSc (Hons) in Biomedical Science in 2015 from the University of Sheffield, specialising in neuroscience in my final year. I then went on to complete an MSc in Translational Neuroscience in SITraN in 2016. In 2020, I was awarded my PhD in Neurovascular Neuroscience, supervised by Dr Jason Berwick & Prof Sheila Francis.

In 2020, Prof Sheila Francis was awarded a BHF project grant titled “Atherosclerosis, the brain and vascular dementia – the role of inflammation in neurovascular function”; based on pilot data from my PhD thesis, on which I am currently the postdoc on.

Research interests

I study neurovascular function in neurodegenerative and cerebrovascular diseases such as Alzheimer’s disease/vascular dementia & cardiovascular disease (atherosclerosis). I use preclinical models of human disease to study neurophysiology, neuropathology & neuroinflammation in these models to gain a better understanding of disease mechanisms and processes.

neurovascular function, heart disease
Neurovascular function; 'healthy' & 'heart disease.

To study neurovascular function, I use neuroimaging techniques including 2D-optical imaging spectroscopy, 2-photon microscopy, GCaMP fluorescence and microelectrode electrophysiology. In addition, I use standard cellular and molecular neuroscience techniques to validate in vivo observations.


Show: Featured publications All publications

Journal articles

All publications

Journal articles

Conference proceedings papers

  • Howarth C, Lee L, Shabir O & Berwick J (2022) Investigating the involvement of nitric oxide in neurovascular coupling. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol. 42(1_SUPPL) (pp 60-60) RIS download Bibtex download


Research group

Prof Sheila Francis is the PI on the BHF grant on which I am the postdoc on. I am a member of the Sheffield Neurovascular Lab where I work directly with Dr Jason Berwick and Dr Clare Howarth (co-PIs on the BHF grant). I also work directly with Dave Drew who is a research technician on the BHF grant. I further collaborate with Prof Stephen Wharton in SITraN.