Dr Paul Collini
MBChB PhD BSc MRCP DTM&H FHEA
Clinical Medicine, School of Medicine and Population Health
Senior Clinical Lecturer


+44 114 215 9530
Full contact details
Clinical Medicine, School of Medicine and Population Health
L Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
-
For enquiries, please contact – iicd-om-operational@sheffield.ac.uk
I joined the University of Sheffield in 2006 as a Lecturer and Honorary SpR in Infectious Diseases (based at the Royal Hallamshire Hospital).
I qualified from Edinburgh University Medical School in 1998 and my general medical training was at St George's Hospital London.
I was involved in the roll out programme for ARV in Africa, setting up and running a clinic in Ghana from 2003-2005 while a clinical lecturer at the Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
I am currently an MRC clinical training fellow.
- Research interests
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My research interest is in the innate immune response to pneumococcal infection in HIV, with a specific focus on the role of the macrophage. My MRC clinical training fellowship title is `The modulation of macrophage apoptosis during S. pneumoniae infection by HIV-1 or antiretroviral agents´.
I also have an ongoing interest in the roll out of antiretroviral treatment (ART) for HIV in resource-poor settings. Specifically, I continue to follow a closed cohort of Ghanaian HIV patients on ART in collaboration with researchers from the KNUST in Ghana and the James Cook University Hospital, Middlesbrough and Newcastle University in the UK.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- D614G Spike mutation increases SARS CoV-2 susceptibility to neutralization. Cell Host & Microbe. View this article in WRRO
- Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease is Enhanced by Nrf2 Agonists.. American Journal of Respiratory and Critical Care Medicine, 198(6). View this article in WRRO
- HIV gp120 in the Lungs of Antiretroviral Therapy–treated Individuals Impairs Alveolar Macrophage Responses to Pneumococci. American Journal of Respiratory and Critical Care Medicine, 197(12). View this article in WRRO
- Clostridium difficile infection in patients with HIV/AIDS.. Curr HIV/AIDS Rep, 10(3), 273-282.
- Low concordance with HIV testing guidelines in a retrospective review of intensive care practice.. Thorax, 68(11), 1072-1074.
- Clostridium difficile infection in HIV-seropositive individuals and transplant recipients. Journal of Infection, 64(2), 131-147. View this article in WRRO
- Monocyte and macrophage dysfunction as a cause of HIV-1 induced dysfunction of innate immunity.. Curr Mol Med, 10(8), 727-740. View this article in WRRO
- Inadvertent non-nucleoside reverse transcriptase inhibitor (NNRTI)-based antiretroviral therapy in dual HIV-1/2 and HIV-2 seropositive West Africans: a retrospective study.. J Antimicrob Chemother, 64(3), 667-669.
- Successful use of miltefosine and sodium stibogluconate, in combination, for the treatment of an HIV-positive patient with visceral leishmaniasis: a case report and brief review of the literature.. Ann Trop Med Parasitol, 103(5), 455-459.
- HIV testing: the boundaries. A survey of HIV testing practices and barriers to more widespread testing in a British teaching hospital.. Int J STD AIDS, 20(6), 427-428.
- Sustained immunological responses to highly active antiretroviral therapy at 36 months in a Ghanaian HIV cohort.. Clin Infect Dis, 48(7), 988-991.
- Low prevalence of transmitted antiretroviral drug resistance in a large UK HIV-1 cohort. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 62(3), 464-468.
- Community-acquired pneumonia: doctors do not follow national guidelines.. Postgrad Med J, 83(982), 552-555.
- GB virus C and HIV-1 RNA load in single virus and co-infected West African individuals.. AIDS, 20(3), 379-386.
All publications
Journal articles
- Longitudinal lung function assessment of patients hospitalised with COVID-19 using 1H and 129Xe lung MRI. Chest.
- A randomized phase 3 trial of the immunogenicity and safety of coadministration of a live-attenuated tetravalent dengue vaccine (TAK-003) and an inactivated hepatitis a (HAV) virus vaccine in a dengue non-endemic country. Vaccine.
- SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination. eBioMedicine, 87.
- Outcomes of outpatient parenteral antimicrobial therapy (OPAT) for urinary tract infections – A single center retrospective cohort study. Clinical Infection in Practice, 17.
- A new era of HIV care for age-associated multimorbidity. Current Opinion in Infectious Diseases, 36(1), 9-14.
- Addressing the burden of HIV-associated chronic lung disease in West Africa. AIDS, 36(14), 2075-2076.
- Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial. The Lancet Respiratory Medicine.
- Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis. The Lancet, 400(10349), 359-368.
- Procalcitonin is not a reliable biomarker of bacterial coinfection in people with coronavirus disease 2019 undergoing microbiological investigation at the time of hospital admission. Open Forum Infectious Diseases, 9(5). View this article in WRRO
- Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study. The Lancet Digital Health, 4(4), e220-e234.
- Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 399(10325), 665-676. View this article in WRRO
- Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 399(10320), 143-151. View this article in WRRO
- Assessment of latent tuberculosis infection pre-immunomodulatory therapy; 5 year experience in a UK centre. Clinical Infection in Practice, 13, 100136-100136.
- Risk factors for SARS-CoV-2 seroprevalence following the first pandemic wave in UK healthcare workers in a large NHS Foundation Trust. Wellcome Open Research, 6.
- Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study. The Lancet, 398(10296), 223-237. View this article in WRRO
- Mapping the human genetic architecture of COVID-19. Nature, 600(7889), 472-477. View this article in WRRO
- Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England. BMC Health Services Research, 21. View this article in WRRO
- Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study : a multicentre, prospective cohort study. The Lancet Microbe. View this article in WRRO
- Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial. The Lancet, 397(10289), 2049-2059. View this article in WRRO
- Going viral: misinformation in the time of COVID-19. The Lancet Rheumatology, 3(6), e393-e393.
- Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK. The Lancet Respiratory Medicine, 9(7), 773-785. View this article in WRRO
- Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study. The Lancet Rheumatology, 3(7), e498-e506. View this article in WRRO
- Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 397(10285), 1637-1645. View this article in WRRO
- Lung function declines more rapidly in treated HIV-positive people than in HIV-negative people. The Lancet Healthy Longevity, 2(4), e183-e184.
- Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 : a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK. The Lancet Respiratory Medicine, 9(7), 699-711. View this article in WRRO
- Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 397(10274), 605-612. View this article in WRRO
- Worldwide relative smoking prevalence among people living with and without HIV : a systematic review and meta-analysis. AIDS.
- Consensus-based antimicrobial resistance and stewardship competencies for UK undergraduate medical students. JAC-Antimicrobial Resistance, 2(4). View this article in WRRO
- D614G Spike mutation increases SARS CoV-2 susceptibility to neutralization. Cell Host & Microbe. View this article in WRRO
- Outcome of hospitalization for COVID-19 in patients with interstitial lung disease. An international multicenter study. American Journal of Respiratory and Critical Care Medicine, 202(12), 1656-1665. View this article in WRRO
- Chronic lung disease in patients with perinatally acquired HIV in England: a retrospective case-note review. Pediatric Infectious Disease Journal.
- Anakinra in the treatment of protracted paradoxical inflammatory reactions in HIV-associated tuberculosis in the United Kingdom : a report of two cases. International Journal of STD & AIDS, 31(8), 808-812.
- P24 The successful use of anakinra to control protracted immune reconstitution inflammatory syndrome in HIV associated tuberculosis: a report of two cases. Rheumatology, 59(Supplement_2).
- Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease is Enhanced by Nrf2 Agonists.. American Journal of Respiratory and Critical Care Medicine, 198(6). View this article in WRRO
- HIV gp120 in the Lungs of Antiretroviral Therapy–treated Individuals Impairs Alveolar Macrophage Responses to Pneumococci. American Journal of Respiratory and Critical Care Medicine, 197(12). View this article in WRRO
- Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages.. American Journal of Respiratory and Critical Care Medicine, 196(7), 845-855. View this article in WRRO
- Bilateral Ocular Myositis Associated with Whipple's Disease. Ocular Oncology and Pathology, 3(1), 17-21. View this article in WRRO
- Maintaining lung health with longstanding HIV. Current Opinion in Infectious Diseases, 29(1), 31-38. View this article in WRRO
- Clostridium difficile infection in patients with HIV/AIDS.. Curr HIV/AIDS Rep, 10(3), 273-282.
- Low concordance with HIV testing guidelines in a retrospective review of intensive care practice.. Thorax, 68(11), 1072-1074.
- Clostridium difficile infection in HIV-seropositive individuals and transplant recipients. Journal of Infection, 64(2), 131-147. View this article in WRRO
- A pain in the neck. Journal of Infection, 63(6), e90-e91.
- Cross-talk between monocytes and T–lymphocytes modifies cell death processes following Streptococcus pneumoniae infection. Journal of Infection, 63(6), 490-490.
- Monocyte and macrophage dysfunction as a cause of HIV-1 induced dysfunction of innate immunity.. Curr Mol Med, 10(8), 727-740. View this article in WRRO
- Inadvertent non-nucleoside reverse transcriptase inhibitor (NNRTI)-based antiretroviral therapy in dual HIV-1/2 and HIV-2 seropositive West Africans: a retrospective study.. J Antimicrob Chemother, 64(3), 667-669.
- Successful use of miltefosine and sodium stibogluconate, in combination, for the treatment of an HIV-positive patient with visceral leishmaniasis: a case report and brief review of the literature.. Ann Trop Med Parasitol, 103(5), 455-459.
- HIV testing: the boundaries. A survey of HIV testing practices and barriers to more widespread testing in a British teaching hospital.. Int J STD AIDS, 20(6), 427-428.
- Sustained immunological responses to highly active antiretroviral therapy at 36 months in a Ghanaian HIV cohort.. Clin Infect Dis, 48(7), 988-991.
- Recurrent respiratory infection. HIV needs to be excluded.. BMJ, 339, b5135.
- Low prevalence of transmitted antiretroviral drug resistance in a large UK HIV-1 cohort. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 62(3), 464-468.
- Community acquired pneumonia (CAP): are doctors following the guidelines?. Journal of Infection, 55(3), e84-e84.
- Community-acquired pneumonia: doctors do not follow national guidelines.. Postgrad Med J, 83(982), 552-555.
- GB virus C and HIV-1 RNA load in single virus and co-infected West African individuals.. AIDS, 20(3), 379-386.
- Risk factors for SARS-CoV-2 seroprevalence following the first pandemic wave in UK healthcare workers in a large NHS Foundation Trust. Wellcome Open Research, 6, 220-220.
- Risk factors for SARS-CoV-2 seroprevalence following the first pandemic wave in UK healthcare workers in a large NHS Foundation Trust. Wellcome Open Research, 6, 220-220.
- Obesity, ethnicity and risk of critical care, mechanical ventilation and mortality in patients admitted to hospital with COVID‐19: Analysis of the ISARIC CCP‐UK cohort. Obesity.
Chapters
- Alveolar Macrophages, Mucosal Immunology of Acute Bacterial Pneumonia (pp. 1-48). Springer New York
Conference proceedings papers
- Longitudinal lung function assessment of patients hospitalised with COVID-19 using 1H and 129Xe lung MRI. 14.02 - Imaging
- HIV in postpartum women: Still a turbulent time. Clinical Infection in Practice, Vol. 13(Supplement 1). Virtual, 20 May 2021 - 20 May 2021.
- P34 5-year experience of latent tuberculosis Infection (LTBI) management pre-immunomodulatory therapy at a tertiary hospital infectious diseases unit in the UK. Thorax, Vol. 76(Suppl 2) (pp A84-A84). Online, 24 November 2021 - 26 November 2021.
- P259 A better approach to COPD case finding is required in people with HIV. Thorax, Vol. 74(Suppl 2). London, UK, 4 December 2019 - 6 December 2019. View this article in WRRO
- View this article in WRRO
- P52 Exploring the interaction between hiv-1 gp120, bronchial airway epithelial cells and macrophages. Cellular insights into lung injury repair
- Comparison of 3 He and 129 Xe MRI for evaluation of lung microstructure and ventilation at 1.5 T. European Respiratory Journal, Vol. 48(suppl 60), 3 September 2016 - 7 September 2016. View this article in WRRO
Preprints
- Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial, Cold Spring Harbor Laboratory.
- Longitudinal lung function assessment of patients hospitalised with COVID-19 using 1H and 129Xe lung MRI, Cold Spring Harbor Laboratory.
- Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis, Cold Spring Harbor Laboratory.
- A high content microscopy-based platform for detecting antibodies to the nucleocapsid, spike and membrane proteins of SARS-CoV-2, Cold Spring Harbor Laboratory.
- Risk factors for SARS-CoV-2 seroprevalence following the first pandemic wave in UK healthcare workers in a large NHS Foundation Trust.
- D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization, Cold Spring Harbor Laboratory.
- D614G Spike mutation increases SARS CoV-2 susceptibility to neutralization. Cell Host & Microbe. View this article in WRRO
- Teaching interests
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I am a fellow of the Higher Education Academy and lecture on the MPH and MBChB courses at the University of Sheffield and the DTM&H at the Liverpool School for Tropical Medicine.