Dr Paul Morris
BMedSci, MBChB, MRCP, PhD, PGCME, FHEA
Clinical Medicine, School of Medicine and Population Health
Senior Clinical Lecturer in Cardiology


+44 114 215 9545
Full contact details
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
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For enquiries, please contact – iicd-om-operational@sheffield.ac.uk
I joined the University of Sheffield in 1998 to study Medicine. I quickly developed an interest in cardiology and research and intercalated a BMedSci degree investigating the role of testosterone in men with heart disease.
I graduated as a medical doctor in 2004, became a member of the Royal College of Physicians in 2007 and then held a number of fellowships and research grants (BHF, NIHR, MRC, WT).
I am currently a Senior Clinical Lecturer at the University of Sheffield and Honorary Cardiology Consultant at Sheffield Teaching Hospitals. I hold a Wellcome Trust Clinical Research Career Development Fellowship.
I am also Director for Clinical Translation at the Insigneo Institute for In Silico Medicine. As an interventional cardiologist, my areas of clinical interest include percutaneous coronary intervention (PCI) and coronary physiological assessment.
- Research interests
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My research interests are in computational modelling of cardiac physiology and heart disease. I am interested in the construction, development and validation of computational workflows which predict cardiac physiology.
My current work is focused on the development of models of intra-coronary physiology including pressure and flow. Our VIRTUheart™ model computes intracoronary physiology and virtual fractional flow reserve (vFFR) a marker of coronary artery disease significance and a guide to treatment.
Current Projects
- British Heart Foundation. BHF Translational Award no TG/19/1/34451. How will virtual (computed) fractional flow reserve (vFFR) impact the management of coronary artery disease? (VIRTU-4). 2019. £295,258.
- National Institute for Health Research, Invention for Innovation (i4i). Gunn JP, Morris PD, Hose DR, Lawford PV. ‘A prototype tool to calculate 'virtual' myocardial fractional flow reserve (vFFR) non-invasively (VIRTU-3)’. R/146986-11-1. £294,746.
- Wellcome Trust Clinical Research Career Development Fellowship. Morris PD. Computational modelling to improve the assessment and management of patients with coronary artery disease. 2019. £570,000.
Image from the VIRTUheart™ workflow. VIRTUheart predicts pressure and flow dynamics within coronary arteries. These data inform decisions about how to treat coronary artery disease with tablets, PCI (stenting) or bypass surgery.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- A novel method for measuring absolute coronary blood flow & microvascular resistance in patients with ischaemic heart disease. Cardiovascular Research. View this article in WRRO
- Virtual Coronary Intervention. A Treatment Planning Tool Based Upon the Angiogram. JACC: Cardiovascular Imaging, 12(5), 865-872. View this article in WRRO
- Personalised Fractional Flow Reserve: Novel Concept to Optimise Myocardial Revascularization.. EuroIntervention. View this article in WRRO
- Simultaneous kissing stents to treat unprotected left main stem coronary artery bifurcation disease; stent expansion, vessel injury, hemodynamics, tissue healing, restenosis, and repeat revascularization.. Catheterization and Cardiovascular Interventions, 92(6), E381-E392. View this article in WRRO
- Microevolution of Neisseria lactamica during nasopharyngeal colonisation induced by controlled human infection. Nature Communications, 9(1). View this article in WRRO
- Non-invasive Stenotic Renal Artery Haemodynamics by in silico Medicine. Frontiers in Physiology, 9. View this article in WRRO
- Predictive Physiological Modeling of Percutaneous Coronary Intervention – Is Virtual Treatment Planning the Future?. Frontiers in Physiology, 9, 1107-1107. View this article in WRRO
- The Impact of Objective Mathematical Analysis During Fractional Flow Reserve Measurement. Eurointervention. View this article in WRRO
- Computing Fractional Flow Reserve From Invasive Coronary Angiography. Circulation: Cardiovascular Interventions, 10(9). View this article in WRRO
- When is rotational angiography superior to conventional single-plane angiography for planning coronary angioplasty?. Catheterization and Cardiovascular Interventions, 87(4), E104-E112. View this article in WRRO
- Computational fluid dynamics modelling in cardiovascular medicine. Heart, 102(1), 18-28. View this article in WRRO
- “Virtual” (Computed) Fractional Flow Reserve. JACC: Cardiovascular Interventions, 8(8), 1009-1017. View this article in WRRO
- Virtual fractional flow reserve from coronary angiography: modeling the significance of coronary lesions: results from the VIRTU-1 (VIRTUal Fractional Flow Reserve From Coronary Angiography) study.. JACC Cardiovasc Interv, 6(2), 149-157.
All publications
Journal articles
- Sex differences in coronary microvascular resistance measured by a computational fluid dynamics model. Frontiers in Cardiovascular Medicine, 10.
- Wearable technology and the cardiovascular system: the future of patient assessment. The Lancet Digital Health, 5(7), e467-e476.
- Quantifying myocardial blood flow and resistance using 4D-flow cardiac magnetic resonance imaging. Cardiology Research and Practice, 2023.
- Validation of a novel numerical model to predict regionalized blood flow in the coronary arteries. European Heart Journal: Digital Health.
- Oral Presentation No. 84 Initial clinical experience with 6-hour enoxaparin regimen in opiate-treated patients undergoing primary percutaneous coronary intervention. Cardiovascular Research, 118(Supplement_2).
- Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents. PLoS ONE, 17(7).
- The complementary value of absolute coronary flow in the assessment of patients with ischaemic heart disease. Nature Cardiovascular Research.
- Coronary physiological assessment in the catheter laboratory: haemodynamics, clinical assessment and future perspectives. Heart.
- Validation of time-resolved, automated peak trans-mitral velocity tracking: Two center four-dimensional flow cardiovascular magnetic resonance study. International Journal of Cardiology.
- The use of digital coronary phantoms for the validation of arterial geometry reconstruction and computation of virtual FFR. Fluids, 7(6).
- Refining our understanding of the flow through coronary artery branches; revisiting Murray’s law in human epicardial coronary arteries. Frontiers in Materials, 13.
- Invasive coronary physiology in patients with angina and non-obstructive coronary artery disease: a consensus document from the coronary microvascular dysfunction workstream of the British Heart Foundation/National Institute for Health Research Partnership. Heart.
- A NOVEL PREDICTIVE MODEL OF CORONARY ARTERIAL INLET, OUTLET AND SIDE-BRANCH BLOOD FLOW. Journal of the American College of Cardiology, 79(9), 2022-2022.
- Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis. European Heart Journal, 43(16), 1582-1593.
- Utilising clinical data to personlaise boundary conditions significantly improves the accuracy of angiography based virtual FFR. European Heart Journal, 42(Supplement_1).
- The importance of three dimensional coronary artery reconstruction accuracy when computing virtual fractional flow reserve from invasive angiography.. Sci Rep, 11(1), 19694.
- Virtual (computed) fractional flow reserve: future role in acute coronary syndromes. Frontiers in Cardiovascular Medicine, 8. View this article in WRRO
- The relationship between coronary stenosis morphology and fractional flow reserve: a computational fluid dynamics modelling study, ztab075-.
- Diagnostic accuracy of handheld cardiac ultrasound device for assessment of left ventricular structure and function: systematic review and meta-analysis. Heart, 107(22), 1826-1834. View this article in WRRO
- Cardiovascular examination using hand-held cardiac ultrasound. Journal of Echocardiography. View this article in WRRO
- Coronary Physiological Assessment in a Patient With Atrial Fibrillation. JACC: Cardiovascular Interventions, 14(15), 1731-1733.
- The impact of virtual fractional flow reserve and virtual coronary intervention upon treatment decisions in the cardiac catheter laboratory. Canadian Journal of Cardiology.
- Feasibility and validation of trans-valvular flow derived by four-dimensional flow cardiovascular magnetic resonance imaging in patients with atrial fibrillation. Wellcome Open Research, 6.
- An encounter with Lattice Boltzmann for biomedical applications: interactive simulation to support clinical and design decisions. Journal of Engineering and Science in Medical Diagnostics and Therapy.
- A further explanation for chest pain without visible coronary artery disease. Clinical Medicine, 21(2), e242.1-e242.
- Operator-dependent variability of angiography-derived fractional flow reserve and the implications for treatment. European Heart Journal - Digital Health.
- The new role of diagnostic angiography in coronary physiological assessment. Heart.
- Sequen-C: A Multilevel Overview of Temporal Event Sequences.. IEEE Trans Vis Comput Graph, PP. View this article in WRRO
- Meta‐analysis of echocardiographic quantification of left ventricular filling pressure. ESC Heart Failure.
- Abstract 16759: In-Hospital Outcomes of Coronary Artery Bypass Grafting Candidates Undergoing Percutaneous Coronary Intervention During the Intensive Care Unit Restricted Covid-19 Pandemic: The Multi-Centre Prospective UK-REVASC Registry. Circulation, 142(Suppl_3).
- Shear stress : the dark energy of atherosclerotic plaques. Cardiovascular Research.
- TCT CONNECT-226 In-Hospital Outcomes of CABG Candidates Undergoing PCI During the ICU Restricted COVID-19 Pandemic: The Multi-Center Prospective UK-REVASC Registry. Journal of the American College of Cardiology, 76(17), B98-B99.
- A novel method for measuring absolute coronary blood flow & microvascular resistance in patients with ischaemic heart disease. Cardiovascular Research. View this article in WRRO
- Endothelial function in cardiovascular precision medicine: A position paper on behalf of the European Society of Cardiology. Cardiovascular Research. View this article in WRRO
- Angiography‐derived fractional flow reserve : more or less physiology?. Journal of the American Heart Association, 9(6). View this article in WRRO
- Effect of side branch flow upon physiological indices in coronary artery disease. Journal of Biomechanics. View this article in WRRO
- How to write a textbook : our experience and advice to budding authors. Heart. View this article in WRRO
- The double-kissing nano-crush for bifurcation lesions : development, bioengineering, fluid dynamics and initial clinical testing. Canadian Journal of Cardiology. View this article in WRRO
- Correction: PCI does not improve outcomes for patients with stable angina. BMJ Evidence-Based Medicine, 24(4), 162-162.
- 60 An atlas of computed FFR in common patterns of coronary artery disease. Heart, 105(Suppl 6), a51-a51. View this article in WRRO
- 17 Computational modelling of fractional flow reserve from coronary angiography : expert training required. Heart, 105(Suppl 6), a15-a15. View this article in WRRO
- 16 Assessing the accuracy of a novel in silico imaging tool for the 3D reconstruction of coronary vasculature in the context of virtual fractional flow reserve. Heart, 105(Suppl 6), a14-a14. View this article in WRRO
- Virtual Coronary Intervention. A Treatment Planning Tool Based Upon the Angiogram. JACC: Cardiovascular Imaging, 12(5), 865-872. View this article in WRRO
- Cardiac auscultation: normal and abnormal. British Journal of Hospital Medicine, 80(2), c28-c31. View this article in WRRO
- Personalised Fractional Flow Reserve: Novel Concept to Optimise Myocardial Revascularization.. EuroIntervention. View this article in WRRO
- Simultaneous kissing stents to treat unprotected left main stem coronary artery bifurcation disease; stent expansion, vessel injury, hemodynamics, tissue healing, restenosis, and repeat revascularization.. Catheterization and Cardiovascular Interventions, 92(6), E381-E392. View this article in WRRO
- Microevolution of Neisseria lactamica during nasopharyngeal colonisation induced by controlled human infection. Nature Communications, 9(1). View this article in WRRO
- Non-invasive Stenotic Renal Artery Haemodynamics by in silico Medicine. Frontiers in Physiology, 9. View this article in WRRO
- Predictive Physiological Modeling of Percutaneous Coronary Intervention – Is Virtual Treatment Planning the Future?. Frontiers in Physiology, 9, 1107-1107. View this article in WRRO
- PCI does not improve outcomes for patients with stable angina. BMJ Evidence-Based Medicine, 23(2), 71-72. View this article in WRRO
- E-learning, collaboration, and group support in medical education. Polish Archives of Internal Medicine, 128(2), 74-76. View this article in WRRO
- The Impact of Objective Mathematical Analysis During Fractional Flow Reserve Measurement. Eurointervention. View this article in WRRO
- Computing Fractional Flow Reserve From Invasive Coronary Angiography. Circulation: Cardiovascular Interventions, 10(9). View this article in WRRO
- Fast Virtual Fractional Flow Reserve Based Upon Steady-State Computational Fluid Dynamics Analysis: Results From the VIRTU-Fast Study. JACC: Basic to Translational Science, 2(4), 434-446. View this article in WRRO
- P842A novel mathematical signal processing application which automates and improves the accuracy of FFR assessment. European Heart Journal, 38(suppl_1).
- Cardiac biomarkers of acute coronary syndrome: from history to high-sensitivity cardiac troponin. Internal and Emergency Medicine, 12(2), 147-155. View this article in WRRO
- A shocking twist. Emergency Medicine Journal, 34(1), 26-26. View this article in WRRO
- Exercise-induced erythema nodosum. British Journal of Hospital Medicine, 77(7), 427-427.
- Revascularization with percutaneous coronary intervention does not affect androgen status in males with chronic stable angina pectoris. Andrology, 4(3), 486-491.
- When is rotational angiography superior to conventional single-plane angiography for planning coronary angioplasty?. Catheterization and Cardiovascular Interventions, 87(4), E104-E112. View this article in WRRO
- Computational fluid dynamics modelling in cardiovascular medicine. Heart, 102(1), 18-28. View this article in WRRO
- REVASCULARISATION WITH PERCUTANEOUS CORONARY INTERVENTION DOES NOT AFFECT ANDROGEN STATUS IN MALES WITH CHRONIC STABLE ANGINA PECTORIS. Canadian Journal of Cardiology, 31(10), S2-S2.
- “Virtual” (Computed) Fractional Flow Reserve. JACC: Cardiovascular Interventions, 8(8), 1009-1017. View this article in WRRO
- Correction. Postgraduate Medical Journal, 90(1068), 575-575.
- Non-vitamin K antagonist oral anticoagulants (NOACs): clinical evidence and therapeutic considerations. Postgraduate Medical Journal, 90(1067), 520-528.
- Pacemaker in the wrong pocket. British Journal of Hospital Medicine, 74(4), 233-233.
- The apex beat.. Br J Hosp Med (Lond), 74(2), C23-C25.
- Heart failure with a preserved ejection fraction.. Br J Hosp Med (Lond), 74(2), C26-C30.
- Virtual fractional flow reserve from coronary angiography: modeling the significance of coronary lesions: results from the VIRTU-1 (VIRTUal Fractional Flow Reserve From Coronary Angiography) study.. JACC Cardiovasc Interv, 6(2), 149-157.
- Focal pulmonary oedema: an unusual presentation of acute mitral regurgitation.. Thorax, 68(5), 498.
- Reversible heart failure: toxins, tachycardiomyopathy and mitochondrial abnormalities.. Postgrad Med J, 88(1046), 706-712.
- Testosterone and cardiovascular disease in men. Asian Journal of Andrology, 14(3), 428-435.
- A 43 year old woman with a 40 year history of exertional chest pain. BMJ (Online), 344(7851).
- Atrial fibrillation with ventricular pre-excitation. Emergency Medicine Journal.
- . BMJ, 344(jun13 2), e3992-e3992.
- Cooperative role for tetraspanins in adhesin-mediated attachment of bacterial species to human epithelial cells.. Infect Immun, 79(6), 2241-2249. View this article in WRRO
- Low serum testosterone and increased mortality in men with coronary heart disease. Heart, 96(22), 1821-1825.
- Junior doctors and the full shift rota--psychological and hormonal changes: a comparative cross-sectional study.. Clin Med (Lond), 6(2), 174-177.
- A mathematical comparison of techniques to predict biologically available testosterone in a cohort of 1072 men. European Journal of Endocrinology, 151(2), 241-249.
- Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life. Heart, 90(8), 871-876.
- Effect of testosterone therapy on QT dispersion in men with heart failure. The American Journal of Cardiology, 92(10), 1241-1243.
- Diabetes and Low Testosterone in Men with Coronary Artery Disease. Clinical Science, 102(s46), 5P-5P.
- Modelling The Hemodynamics of Coronary Ischemia. Fluids, 8(5), 159-159.
- Rapid virtual fractional flow reserve using 3-D computational fluid dynamics. European Heart Journal - Digital Health.
- Incorporating clinical parameters to improve the accuracy of angiography-derived computed fractional flow reserve. European Heart Journal - Digital Health.
- Revascularisation for the proximal left anterior descending artery: special case or part of the package?. Heart.
- Coronary physiology derived from invasive angiography : will it be a game changer?. Interventional Cardiology Review, 15. View this article in WRRO
Chapters
- Cardiac Electrophysiology, Cardiac Pathology (pp. 25-48). Springer International Publishing
- New concepts in coronary physiological assessment, Practical Interventional Cardiology (pp. 109-123). CRC Press
- Cardiac Electrophysiology, Cardiac Pathology (pp. 19-42). Springer London
Conference proceedings papers
- 42 The role of angiography-derived (VIRTUAL) fractional flow reserve in the management of patients with acute coronary syndromes (ACS); the VIRTU4-ACS study. Acute coronary syndromes & Interventional Cardiology
- 33 Absolute coronary blood flow and microvascular resistance modelling in patients with coronary artery disease. Acute coronary syndromes & Interventional cardiology
- Abstract 15636: Effect of COVID-19 Public Health Measures on Activity and Quality of Life in Patients With Pulmonary Arterial Hypertension. Circulation, Vol. 142(Suppl_3) View this article in WRRO
- Virtual (computed) FFR and Virtual Coronary Intervention (VCI) vs angiography for guiding PCI: a virtual study.. Heart, Vol. 105(Suppl 6) (pp a45-a45). Manchester, UK, 3 June 2019 - 5 June 2019. View this article in WRRO
- What will be the Impact of Virtual Coronary Physiology upon the Practice of Coronary Artery Bypass Grafting Surgery for Patients with Coronary Artery Disease?. International Journal of Surgery, Vol. 55 (pp S9-S9)
- Restenosis in simultaneous kissing stents to treat unprotected left main stem coronary artery bifurcation disease: incidence and management. EUROPEAN HEART JOURNAL, Vol. 38 (pp 87-87) View this article in WRRO
- View this article in WRRO
- 209 The Development and Validation of anin silicoModel of Coronary Arterial Physiology for Diagnostic Use. Heart, Vol. 101(Suppl 4) (pp A115.1-A115)
- Reconstruction of Coronary Trees from 3DRA Using a 3D+t Statistical Cardiac Prior. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, Vol. 2 (pp 619-626)
- 021 Computer modelled coronary physiology and “virtual” fractional flow reserve from rotational angiography: Abstract 021 Figure 1. Heart, Vol. 98(Suppl 1) (pp A14.1-A14)
- Metals fit for the twenty-first century: Processing for high performance applications. Ironmaking and Steelmaking, Vol. 39(4) (pp 236-243)
- Alloys for critical applications. Ironmaking and Steelmaking, Vol. 37(4) (pp 242-250)
- Indexed Containers.. LICS (pp 277-285)
- Quality steel - Advances in process control. Ironmaking and Steelmaking, Vol. 32(5) (pp 391-396)
- Advances in the hot rolling of steels. Ironmaking and Steelmaking, Vol. 31(1) (pp 8-13)
- 187 Testosterone replacement therapy improves ischaemic threshold and mood in hypogonadal men with angina. European Heart Journal, Vol. 24(5) (pp 20-20)
- Requirements Engineering and Industrial Uptake.. ICRE (pp 130-137)
- Industrial Workshop on Requirements for R&D in Requirements Engineering.. RE (pp 41-41)
Preprints
- Feasibility and validation of trans-valvular flow derived by four-dimensional flow cardiovascular magnetic resonance imaging in patients with atrial fibrillation.
- The Accuracy of Virtual Fractional Flow Reserve From Invasive Angiography: Importance of the Method of Reconstructing Three-dimensional Coronary Artery Anatomy, Research Square Platform LLC.
- A novel method for measuring absolute coronary blood flow & microvascular resistance in patients with ischaemic heart disease. Cardiovascular Research. View this article in WRRO
- Teaching interests
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I enjoy teaching clinical cardiology to undergraduates and post-graduates. I teach clinical skills to medical students and doctors on the wards and in the clinic.
I have written textbooks and chapters of books focused on clinical and academic aspects of clinical cardiology. I also enjoy teaching about cardiac physiology and fluid dynamics modelling.
I have a Postgraduate Certificate in Medical Education and have recently become a Fellow of the Higher Education Academy.
- Professional activities and memberships
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Other professional activities and interests include public engagement with science and the development of assessments for clinical knowledge and skills.