Dr Paul Morris

BMedSci, MBChB, MRCP, PhD, PGCME, FHEA

Clinical Medicine, School of Medicine and Population Health

Senior Clinical Lecturer in Cardiology, Wellcome Trust Clinical Research Career Development Fellow

Honorary Consultant Interventional Cardiologist, Sheffield Teaching Hospital NHS Foundation Trust

paul.morris@sheffield.ac.uk
+44 114 215 9545

The Medical School

Full contact details

Dr Paul Morris
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX

Profile

For enquiries please contact - ClinMed-Operational@sheffield.ac.uk

I joined the University of Sheffield in 1998 to study Medicine. I quickly developed an interest in clinical cardiology and academic research, and I intercalated a BMedSci degree investigating the role of testosterone in men with heart disease; work that was awarded the inaugural Royal Society of Medicine Research prize. I graduated as a medical doctor in 2004, top of my year and was awarded with the Dr Mark Gregory Baker, Ashby-de-la-Zouch prize. I became a member of the Royal College of Physicians in 2007. Since then, I have held an NIHR Clinical Academic Fellowship (NIHR), a Clinical Research Training Fellowship (British Heart Foundation), a Clinical Lectureship (NIHR), the British Cardiovascular Interventions Society Interventional Fellowship (Vancouver Island, British Columbia, Canada) and I am currently a Wellcome Trust Clinical Research Career Development Fellow, working as a clinical academic at the University of Sheffield and Sheffield Teaching Hospitals NHS Trust.

Clinical work. I work as an NHS consultant cardiologist at Sheffield Teaching Hospitals NHS Trust. As an interventional cardiologist, I specialise in percutaneous coronary intervention (PCI, ‘stenting’). I have sub-specialty interest and expertise in complex PCI, CTO (chronic total occlusion) PCI and invasive coronary physiological assessment. The latter helps in the care of patients with epicardial and microvascular coronary disease (also known as ANOCA – angina with no obstructive coronary artery disease).

Research interests

My research is focused on computational, physics-based mathematical modelling of cardiovascular physiology and heart disease. I lead the continued development of the VIRTUheart suite of cardiovascular physiological simulation methods which is an image-based model that computes fractional flow reserve (FFR), flow and resistance in the coronary arterial circulation. Current work focusses on the integration of x-ray angiography with optical coherence tomography (OCT) to develop detailed and comprehensive 3D models of coronary disease that bring anatomy and physiology together into comprehensive clinical assessment tools. Other projects are focused on the in vivo validation of the virtuQ tool for computing absolute coronary physiology.

I have done significant work on coronary morphometric scaling; i.e. the relationships between arterial size and blood flow, with particular focus on bifurcation physiology. A meta-analysis on various morphometric scaling laws including Murray’s law, can be found here. I am also interested in use of non-invasive imaging (cardiac MRI) can be used to derive metrics of coronary physiology. Published early pilot work on this project can be found here. I am also leading the development of zero-dimensional models of cardiovascular physiology, with the aim of understanding the link between ischaemia and cardiac function.

I am also leading a collaboration between the University of Sheffield and the UK Civil Aviation Authority (CAA), where we are seeking to use Zero-dimensional models to predict the response of the ageing and diseased cardiovascular system to the acceleration forces involved in commercial spaceflight. A more detailed description of this work published in Nature Reviews Cardiology, co-authored with NASA, Virgin Galactic, UK CAA and the RAF, can be found here.

Image from the VIRTUheart™ workflow. VIRTUheart predicts pressure and flow dynamics within coronary arteries. These data inform decisions about how to treat coronary artery disease with tablets, PCI (stenting) or bypass surgery.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Taylor DJ, Aubiniere-Robb L, Gosling R, Newman T, Hose DR, Halliday I, Lawford PV, Narracott AJ, Gunn JP & Morris PD (2023) Sex differences in coronary microvascular resistance measured by a computational fluid dynamics model. Frontiers in Cardiovascular Medicine, 10. View this article in WRRO
Morris PD, Gosling R, Zwierzak I, Evans H, Aubiniere-Robb L, Czechowicz K, Evans PC, Hose DR, Lawford PV, Narracott A & Gunn JP (2020) A novel method for measuring absolute coronary blood flow & microvascular resistance in patients with ischaemic heart disease. Cardiovascular Research. View this article in WRRO
Gosling RC, Morris PD, Silva Soto DA, Lawford PV, Hose DR & Gunn JP (2019) Virtual Coronary Intervention. A Treatment Planning Tool Based Upon the Angiogram. JACC: Cardiovascular Imaging, 12(5), 865-872. View this article in WRRO
Gosling RD, Morris PD, Lawford PV, Hose DR & Gunn JP (2018) Personalised Fractional Flow Reserve: Novel Concept to Optimise Myocardial Revascularization.. EuroIntervention. View this article in WRRO
Morris PD, Iqbal J, Chiastra C, Wu W, Migliavacca F & Gunn JP (2018) Simultaneous kissing stents to treat unprotected left main stem coronary artery bifurcation disease; stent expansion, vessel injury, hemodynamics, tissue healing, restenosis, and repeat revascularization.. Catheterization and Cardiovascular Interventions, 92(6), E381-E392. View this article in WRRO
Pandey A, Cleary DW, Laver JR, Gorringe A, Deasy AM, Dale AP, Morris PD, Didelot X, Maiden MCJ & Read RC (2018) Microevolution of Neisseria lactamica during nasopharyngeal colonisation induced by controlled human infection. Nature Communications, 9(1). View this article in WRRO
Mandaltsi A, Grytsan A, Odudu A, Kadziela J, Morris PD, Witkowski A, Ellam T, Kalra P & Marzo A (2018) Non-invasive Stenotic Renal Artery Haemodynamics by in silico Medicine. Frontiers in Physiology, 9. View this article in WRRO
Gosling R, Morris P, Lawford P, Hose D & Gunn J (2018) Predictive Physiological Modeling of Percutaneous Coronary Intervention – Is Virtual Treatment Planning the Future?. Frontiers in Physiology, 9, 1107-1107. View this article in WRRO
Sciola MI, Morris PD, Gosling R, Lawford PV, Hose DR & Gunn JP (2018) The Impact of Objective Mathematical Analysis During Fractional Flow Reserve Measurement. Eurointervention. View this article in WRRO
Morris PD & Gunn JP (2017) Computing Fractional Flow Reserve From Invasive Coronary Angiography. Circulation: Cardiovascular Interventions, 10(9). View this article in WRRO
Morris PD, Taylor J, Boutong S, Brett S, Louis A, Heppenstall J, Morton AC & Gunn JP (2016) When is rotational angiography superior to conventional single-plane angiography for planning coronary angioplasty?. Catheterization and Cardiovascular Interventions, 87(4), E104-E112. View this article in WRRO
Morris PD, Narracott A, Von Tengg-Kobligk H, Soto DAS, Hsiao S, Lungu A, Evans P, Bressloff NW, Lawford PV, Rodney Hose D & Gunn JP (2016) Computational fluid dynamics modelling in cardiovascular medicine. Heart, 102(1), 18-28. View this article in WRRO
Morris PD, van de Vosse FN, Lawford PV, Hose DR & Gunn JP (2015) “Virtual” (Computed) Fractional Flow Reserve. JACC: Cardiovascular Interventions, 8(8), 1009-1017. View this article in WRRO
Morris PD, Ryan D, Morton AC, Lycett R, Lawford PV, Hose DR & Gunn JP (2013) Virtual fractional flow reserve from coronary angiography: modeling the significance of coronary lesions: results from the VIRTU-1 (VIRTUal Fractional Flow Reserve From Coronary Angiography) study.. JACC Cardiovasc Interv, 6(2), 149-157.

All publications

Journal articles

Taylor DJ & Morris PD (2024) Letter to the editor. Medical Engineering and Physics, 130.
Taylor DJ, Saxton H, Halliday I, Newman T, Feher J, Gosling R, Narracott AJ, van Kemenade D, van’t Veer M, Tonino PAL , Rochette M et al (2024) Evaluation of models of sequestration flow in coronary arteries—Physiology versus anatomy?. Computers in Biology and Medicine, 173, 108299-108299.
Taylor DJ & Morris PD (2024) Letter to the editor. Medical Engineering & Physics, 130, 104204-104204.
Taylor DJ, Aubiniere-Robb L, Gosling R, Newman T, Hose DR, Halliday I, Lawford PV, Narracott AJ, Gunn JP & Morris PD (2023) Sex differences in coronary microvascular resistance measured by a computational fluid dynamics model. Frontiers in Cardiovascular Medicine, 10. View this article in WRRO
Williams GJ, Al-Baraikan A, Rademakers FE, Ciravegna F, van de Vosse FN, Lawrie A, Rothman A, Ashley EA, Wilkins MR, Lawford PV , Omholt SW et al (2023) Wearable technology and the cardiovascular system: the future of patient assessment. The Lancet Digital Health, 5(7), e467-e476.
Gosling RC, Williams G, Al Baraikan A, Alabed S, Levelt E, Chowdhary A, Swoboda PP, Halliday I, Hose DR, Gunn JP , Greenwood JP et al (2023) Quantifying myocardial blood flow and resistance using 4D-flow cardiac magnetic resonance imaging. Cardiology Research and Practice, 2023.
Taylor DJ, Feher J, Czechowicz K, Halliday I, Hose DR, Gosling R, Aubiniere-Robb L, van’t Veer M, Keulards DCJ, Tonino P , Rochette M et al (2023) Validation of a novel numerical model to predict regionalized blood flow in the coronary arteries. European Heart Journal: Digital Health.
Elamin N, Ow KW, Parker WAE, Nelson TA, Middle J, Hanson J, Moyle B, Krishnamurthy A, Barmby D, Morgan K , Adam Z et al (2022) Oral Presentation No. 84 Initial clinical experience with 6-hour enoxaparin regimen in opiate-treated patients undergoing primary percutaneous coronary intervention. Cardiovascular Research, 118(Supplement_2).
Boldock L, Inzoli A, Bonardelli S, Hsiao S, Marzo A, Narracott A, Gunn J, Dubini G, Chiastra C, Halliday I , Morris PD et al (2022) Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents. PLoS ONE, 17(7).
Aubiniere-Robb L, Gosling R, Taylor DJ, Newman T, Hose DR, Halliday I, Lawford PV, Narracott AJ, Gunn JP & Morris PD (2022) The complementary value of absolute coronary flow in the assessment of patients with ischaemic heart disease. Nature Cardiovascular Research.
Morris PD, Al-Lamee RK & Berry C (2022) Coronary physiological assessment in the catheter laboratory: haemodynamics, clinical assessment and future perspectives. Heart.
Njoku P, Grafton-Clarke C, Assadi H, Gosling R, Archer G, Swift AJ, Morris PD, Albaraikan A, Williams G, Westenberg J , Aben J-P et al (2022) Validation of time-resolved, automated peak trans-mitral velocity tracking: Two center four-dimensional flow cardiovascular magnetic resonance study. International Journal of Cardiology.
Pederzani G, Czechowicz K, Ghorab N, Morris PD, Gunn JP, Narracott AJ, Hose DR & Halliday I (2022) The use of digital coronary phantoms for the validation of arterial geometry reconstruction and computation of virtual FFR. Fluids, 7(6).
Taylor DJ, Feher J, Halliday I, Hose DR, Gosling R, Aubiniere-Robb L, van ‘t Veer M, Keulards D, Tonino PAL, Rochette M , Gunn J et al (2022) Refining our understanding of the flow through coronary artery branches; revisiting Murray’s law in human epicardial coronary arteries. Frontiers in Materials, 13.
Perera D, Berry C, Hoole SP, Sinha A, Rahman H, Morris PD, Kharbanda RK, Petraco R & Channon K (2022) Invasive coronary physiology in patients with angina and non-obstructive coronary artery disease: a consensus document from the coronary microvascular dysfunction workstream of the British Heart Foundation/National Institute for Health Research Partnership. Heart.
Taylor D, Morris PD, Gunn J, Gosling R, Halliday I, Hose DR, Rammohan V, van‘t Veer M, Tonino PA, Keulards D , Feher J et al (2022) A NOVEL PREDICTIVE MODEL OF CORONARY ARTERIAL INLET, OUTLET AND SIDE-BRANCH BLOOD FLOW. Journal of the American College of Cardiology, 79(9), 2022-2022.
Kelshiker MA, Seligman H, Howard JP, Rahman H, Foley M, Nowbar AN, Rajkumar CA, Shun-Shin MJ, Ahmad Y, Sen S , Al-Lamee R et al (2022) Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis. European Heart Journal, 43(16), 1582-1593.
Solanki R, Gosling R, Rammohan V, Pederzani G, Garg P, Heppenstall J, Hose DR, Lawford PV, Narracott AJ, Fenner J , Gunn JP et al (2021) The importance of three dimensional coronary artery reconstruction accuracy when computing virtual fractional flow reserve from invasive angiography.. Sci Rep, 11(1), 19694.
Haley HA, Ghobrial M, Morris PD, Gosling R, Williams G, Mills MT, Newman T, Rammohan V, Pederzani G, Lawford PV , Hose R et al (2021) Virtual (computed) fractional flow reserve: future role in acute coronary syndromes. Frontiers in Cardiovascular Medicine, 8. View this article in WRRO
Newcombe RTF, Gosling RC, Rammohan V, Lawford PV, Hose DR, Gunn JP & Morris PD (2021) The relationship between coronary stenosis morphology and fractional flow reserve: a computational fluid dynamics modelling study, ztab075-.
Jenkins S, Alabed S, Swift A, Marques G, Ryding A, Sawh C, Wardley J, Shah BN, Swoboda P, Senior R , Nijveldt R et al (2021) Diagnostic accuracy of handheld cardiac ultrasound device for assessment of left ventricular structure and function: systematic review and meta-analysis. Heart, 107(22), 1826-1834. View this article in WRRO
Jenkins S, Shiha MG, Yones E, Wardley J, Ryding A, Sawh C, Flather M, Morris P, Swift AJ, Vassiliou VS & Garg P (2021) Cardiovascular examination using hand-held cardiac ultrasound. Journal of Echocardiography. View this article in WRRO
Mills MT, Kyriacou AL, Morris PD & Gunn JP (2021) Coronary Physiological Assessment in a Patient With Atrial Fibrillation. JACC: Cardiovascular Interventions, 14(15), 1731-1733.
Gosling DRC, Adam Z, Barmby DS, Iqbal J, Morgan KP, Richardson JD, Rothman AMK, Lawford PV, Hose DR, Gunn JP & Morris PD (2021) The impact of virtual fractional flow reserve and virtual coronary intervention upon treatment decisions in the cardiac catheter laboratory. Canadian Journal of Cardiology.
Mills MT, Grafton-Clarke C, Williams G, Gosling RC, Baraikan AA, Kyriacou AL, Morris PD, Gunn JP, Swoboda PP, Levelt E , Tsampasian V et al (2021) Feasibility and validation of trans-valvular flow derived by four-dimensional flow cardiovascular magnetic resonance imaging in patients with atrial fibrillation. Wellcome Open Research, 6.
Ferrari S, Ambrogio S, Narracott AJ, Walker A, Morris PD & Fenner JW (2021) An encounter with Lattice Boltzmann for biomedical applications: interactive simulation to support clinical and design decisions. Journal of Engineering and Science in Medical Diagnostics and Therapy.
Newman T, Morris P & Gunn J (2021) A further explanation for chest pain without visible coronary artery disease. Clinical Medicine, 21(2), e242.1-e242.
Lal K, Gosling R, Ghobrial M, Williams GJ, Rammohan V, Rod Hose D, Lawford PV, Narracott A, Fenner J, Gunn JP & Morris PD (2021) Operator-dependent variability of angiography-derived fractional flow reserve and the implications for treatment. European Heart Journal - Digital Health.
Ghobrial M, Haley HA, Gosling R, Rammohan V, Lawford PV, Hose DR, Gunn JP & Morris PD (2021) The new role of diagnostic angiography in coronary physiological assessment. Heart.
Magallanes J, Stone T, Morris PD, Mason S, Wood S & Villa-Uriol M-C (2021) Sequen-C: A Multilevel Overview of Temporal Event Sequences.. IEEE Trans Vis Comput Graph, PP. View this article in WRRO
Jones R, Varian F, Alabed S, Morris P, Rothman A, Swift AJ, Lewis N, Kyriacou A, Wild JM, Al‐Mohammad A , Zhong L et al (2020) Meta‐analysis of echocardiographic quantification of left ventricular filling pressure. ESC Heart Failure.
Kite TA, Owens C, Chase A, Mozid A, Routledge H, Hoole SP, Palmer N, Egred M, Perera D, Kyriacos M , Sinha M et al (2020) Abstract 16759: In-Hospital Outcomes of Coronary Artery Bypass Grafting Candidates Undergoing Percutaneous Coronary Intervention During the Intensive Care Unit Restricted Covid-19 Pandemic: The Multi-Centre Prospective UK-REVASC Registry. Circulation, 142(Suppl_3).
Evans PC, Fragiadaki M, Morris PD & Serbanovic-Canic J (2020) Shear stress : the dark energy of atherosclerotic plaques. Cardiovascular Research.
Kite T, Ladwiniec A, Routledge H, Hoole S, Palmer N, Egred M, Perera D, Mouyis K, Sinha M, Candilio L , Anantharam B et al (2020) TCT CONNECT-226 In-Hospital Outcomes of CABG Candidates Undergoing PCI During the ICU Restricted COVID-19 Pandemic: The Multi-Center Prospective UK-REVASC Registry. Journal of the American College of Cardiology, 76(17), B98-B99.
Morris PD, Gosling R, Zwierzak I, Evans H, Aubiniere-Robb L, Czechowicz K, Evans PC, Hose DR, Lawford PV, Narracott A & Gunn JP (2020) A novel method for measuring absolute coronary blood flow & microvascular resistance in patients with ischaemic heart disease. Cardiovascular Research. View this article in WRRO
Alexander Y, Osto E, Schmidt-Trucksäss A, Shechter M, Trifunovic D, Duncker DJ, Aboyans V, Bäck M, Badimon L, Cosentino F , De Carlo M et al (2020) Endothelial function in cardiovascular precision medicine: A position paper on behalf of the European Society of Cardiology. Cardiovascular Research. View this article in WRRO
Morris PD, Curzen N & Gunn JP (2020) Angiography‐derived fractional flow reserve : more or less physiology?. Journal of the American Heart Association, 9(6). View this article in WRRO
Gosling RC, Sturdy J, Morris PD, Fossan FE, Hellevik LR, Lawford P, Hose DR & Gunn J (2020) Effect of side branch flow upon physiological indices in coronary artery disease. Journal of Biomechanics. View this article in WRRO
Warriner D & Morris P (2019) How to write a textbook : our experience and advice to budding authors. Heart. View this article in WRRO
Morris PD, Gosling R, Rothman A, Iqbal J, Chiastra C, Colombo M, Migliavacca F, Banning A & Gunn JP (2019) The double-kissing nano-crush for bifurcation lesions : development, bioengineering, fluid dynamics and initial clinical testing. Canadian Journal of Cardiology. View this article in WRRO
(2019) Correction: PCI does not improve outcomes for patients with stable angina. BMJ Evidence-Based Medicine, 24(4), 162-162.
Newcombe R, Gosling R, Gunn J, Narracott A, Hose R, Morris P & Lawford P (2019) 60 An atlas of computed FFR in common patterns of coronary artery disease. Heart, 105(Suppl 6), a51-a51. View this article in WRRO
Lal K, Gunn J, Morris P, Gosling R, Lawford P, Hose R, Priest J, Stephenson T, Lee T, Robinson N , O’Connor T et al (2019) 17 Computational modelling of fractional flow reserve from coronary angiography : expert training required. Heart, 105(Suppl 6), a15-a15. View this article in WRRO
Solanki R, Gosling R, Rammohan V, Hose R, Lawford P, Gunn J, Morris P & Ahmed Y (2019) 16 Assessing the accuracy of a novel in silico imaging tool for the 3D reconstruction of coronary vasculature in the context of virtual fractional flow reserve. Heart, 105(Suppl 6), a14-a14. View this article in WRRO
Gosling RC, Morris PD, Silva Soto DA, Lawford PV, Hose DR & Gunn JP (2019) Virtual Coronary Intervention. A Treatment Planning Tool Based Upon the Angiogram. JACC: Cardiovascular Imaging, 12(5), 865-872. View this article in WRRO
Warriner D, Michaels J & Morris PD (2019) Cardiac auscultation: normal and abnormal. British Journal of Hospital Medicine, 80(2), c28-c31. View this article in WRRO
Gosling RD, Morris PD, Lawford PV, Hose DR & Gunn JP (2018) Personalised Fractional Flow Reserve: Novel Concept to Optimise Myocardial Revascularization.. EuroIntervention. View this article in WRRO
Morris PD, Iqbal J, Chiastra C, Wu W, Migliavacca F & Gunn JP (2018) Simultaneous kissing stents to treat unprotected left main stem coronary artery bifurcation disease; stent expansion, vessel injury, hemodynamics, tissue healing, restenosis, and repeat revascularization.. Catheterization and Cardiovascular Interventions, 92(6), E381-E392. View this article in WRRO
Pandey A, Cleary DW, Laver JR, Gorringe A, Deasy AM, Dale AP, Morris PD, Didelot X, Maiden MCJ & Read RC (2018) Microevolution of Neisseria lactamica during nasopharyngeal colonisation induced by controlled human infection. Nature Communications, 9(1). View this article in WRRO
Mandaltsi A, Grytsan A, Odudu A, Kadziela J, Morris PD, Witkowski A, Ellam T, Kalra P & Marzo A (2018) Non-invasive Stenotic Renal Artery Haemodynamics by in silico Medicine. Frontiers in Physiology, 9. View this article in WRRO
Gosling R, Morris P, Lawford P, Hose D & Gunn J (2018) Predictive Physiological Modeling of Percutaneous Coronary Intervention – Is Virtual Treatment Planning the Future?. Frontiers in Physiology, 9, 1107-1107. View this article in WRRO
Morris PD & Warriner DR (2018) PCI does not improve outcomes for patients with stable angina. BMJ Evidence-Based Medicine, 23(2), 71-72. View this article in WRRO
Warriner DR & Morris PD (2018) E-learning, collaboration, and group support in medical education. Polish Archives of Internal Medicine, 128(2), 74-76. View this article in WRRO
Sciola MI, Morris PD, Gosling R, Lawford PV, Hose DR & Gunn JP (2018) The Impact of Objective Mathematical Analysis During Fractional Flow Reserve Measurement. Eurointervention. View this article in WRRO
Morris PD & Gunn JP (2017) Computing Fractional Flow Reserve From Invasive Coronary Angiography. Circulation: Cardiovascular Interventions, 10(9). View this article in WRRO
Morris PD, Silva Soto DA, Feher JFA, Rafiroiu D, Lungu A, Varma S, Lawford PV, Hose DR & Gunn JP (2017) Fast Virtual Fractional Flow Reserve Based Upon Steady-State Computational Fluid Dynamics Analysis: Results From the VIRTU-Fast Study. JACC: Basic to Translational Science, 2(4), 434-446. View this article in WRRO
Sciola MI, Morris PD, Lawford PV, Hose DR & Gunn JP (2017) P842A novel mathematical signal processing application which automates and improves the accuracy of FFR assessment. European Heart Journal, 38(suppl_1).
Garg P, Morris P, Fazlanie AL, Vijayan S, Dancso B, Dastidar AG, Plein S, Mueller C & Haaf P (2017) Cardiac biomarkers of acute coronary syndrome: from history to high-sensitivity cardiac troponin. Internal and Emergency Medicine, 12(2), 147-155. View this article in WRRO
Morris PD, Yones E & Warriner DR (2017) A shocking twist. Emergency Medicine Journal, 34(1), 26-26. View this article in WRRO
Saman R, Withycombe E, Morris PD & Warriner DR (2016) Exercise-induced erythema nodosum. British Journal of Hospital Medicine, 77(7), 427-427.
Gosai JN, Charalampidis P, Nikolaidou T, Parviz Y, Morris PD, Channer KS, Jones TH & Grech ED (2016) Revascularization with percutaneous coronary intervention does not affect androgen status in males with chronic stable angina pectoris. Andrology, 4(3), 486-491.
Morris PD, Taylor J, Boutong S, Brett S, Louis A, Heppenstall J, Morton AC & Gunn JP (2016) When is rotational angiography superior to conventional single-plane angiography for planning coronary angioplasty?. Catheterization and Cardiovascular Interventions, 87(4), E104-E112. View this article in WRRO
Morris PD, Narracott A, Von Tengg-Kobligk H, Soto DAS, Hsiao S, Lungu A, Evans P, Bressloff NW, Lawford PV, Rodney Hose D & Gunn JP (2016) Computational fluid dynamics modelling in cardiovascular medicine. Heart, 102(1), 18-28. View this article in WRRO
Gosai J, Parviz Y, Chlarampidis P, Nikolaidou T, Morris P & Grech E (2015) REVASCULARISATION WITH PERCUTANEOUS CORONARY INTERVENTION DOES NOT AFFECT ANDROGEN STATUS IN MALES WITH CHRONIC STABLE ANGINA PECTORIS. Canadian Journal of Cardiology, 31(10), S2-S2.
Morris PD, van de Vosse FN, Lawford PV, Hose DR & Gunn JP (2015) “Virtual” (Computed) Fractional Flow Reserve. JACC: Cardiovascular Interventions, 8(8), 1009-1017. View this article in WRRO
(2014) Correction. Postgraduate Medical Journal, 90(1068), 575-575.
Saraf K, Morris P, Garg P, Sheridan P & Storey R (2014) Non-vitamin K antagonist oral anticoagulants (NOACs): clinical evidence and therapeutic considerations. Postgraduate Medical Journal, 90(1067), 520-528.
Morris PD, Lee DZJ, Warriner DR & Sheridan PJ (2013) Pacemaker in the wrong pocket. British Journal of Hospital Medicine, 74(4), 233-233.
Morris PD, Warriner DR, Saraf K & Morton AC (2013) The apex beat.. Br J Hosp Med (Lond), 74(2), C23-C25.
Warriner DR, Morris PD, Saraf K & Al-Mohammad A (2013) Heart failure with a preserved ejection fraction.. Br J Hosp Med (Lond), 74(2), C26-C30.
Morris PD, Ryan D, Morton AC, Lycett R, Lawford PV, Hose DR & Gunn JP (2013) Virtual fractional flow reserve from coronary angiography: modeling the significance of coronary lesions: results from the VIRTU-1 (VIRTUal Fractional Flow Reserve From Coronary Angiography) study.. JACC Cardiovasc Interv, 6(2), 149-157.
Morris PD, Warriner DR & Channer KS (2013) Focal pulmonary oedema: an unusual presentation of acute mitral regurgitation.. Thorax, 68(5), 498.
Morris PD, Robinson T & Channer KS (2012) Reversible heart failure: toxins, tachycardiomyopathy and mitochondrial abnormalities.. Postgrad Med J, 88(1046), 706-712.
Morris PD & Channer KS (2012) Testosterone and cardiovascular disease in men. Asian Journal of Andrology, 14(3), 428-435.
Morris PD, Trevest KJ, Butt AY & Grech ED (2012) A 43 year old woman with a 40 year history of exertional chest pain. BMJ (Online), 344(7851).
Morris PD, Sahu J, Sheridan P & Saraf K (2012) Atrial fibrillation with ventricular pre-excitation. Emergency Medicine Journal.
Warriner DR, Morris PD, Kanaan MZ, Collins MC & Hopper AD (2012) . BMJ, 344(jun13 2), e3992-e3992.
Green LR, Monk PN, Partridge LJ, Morris P, Gorringe AR & Read RC (2011) Cooperative role for tetraspanins in adhesin-mediated attachment of bacterial species to human epithelial cells.. Infect Immun, 79(6), 2241-2249. View this article in WRRO
Warriner DR, Morris P, Ramjiani V, Morton A & Sheridan P (2011) Smells like a heart attack, but is it?. BMJ Case Reports.
Malkin CJ, Pugh PJ, Morris PD, Asif S, Jones TH & Channer KS (2010) Low serum testosterone and increased mortality in men with coronary heart disease. Heart, 96(22), 1821-1825.
Smith AM, Morris P, Rowell KO, Clarke S, Jones TH & Channer KS (2006) Junior doctors and the full shift rota--psychological and hormonal changes: a comparative cross-sectional study.. Clin Med (Lond), 6(2), 174-177.
Morris PD, Malkin CJ, Channer KS & Jones TH (2004) A mathematical comparison of techniques to predict biologically available testosterone in a cohort of 1072 men. European Journal of Endocrinology, 151(2), 241-249.
Malkin CJ, Pugh PJ, Morris PD, Kerry KE, Jones RD, Jones TH & Channer KS (2004) Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life. Heart, 90(8), 871-876.
Malkin CJ, Morris PD, Pugh PJ, English KM & Channer KS (2003) Effect of testosterone therapy on QT dispersion in men with heart failure. The American Journal of Cardiology, 92(10), 1241-1243.
Morris PD, Pugh PJ, Jones TH & Channer KS (2002) Diabetes and Low Testosterone in Men with Coronary Artery Disease. Clinical Science, 102(s46), 5P-5P.
Morris PD, Anderton RA, Marshall-Goebel K, Britton JK, Lee SMC, Smith NP, van de Vosse FN, Ong KM, Newman TA, Taylor DJ , Chico T et al () Computational modelling of cardiovascular pathophysiology to risk stratify commercial spaceflight. Nature Reviews Cardiology.
Sammut MA, Conway D, Iqbal J, Krishnamurthy A, Morgan KP, Morris PD, Richardson JD, Rothman AMK, Gunn JP & Storey RF () Duration of triple antithrombotic therapy and clinical outcomes after percutaneous coronary intervention in atrial fibrillation. Expert Review of Cardiovascular Therapy, 1-7.
Taylor DJ, Saxton H, Halliday I, Newman T, Hose DR, Kassab GS, Gunn JP & Morris PD () A systematic review and meta-analysis of Murray's Law in the Coronary Arterial Circulation. American Journal of Physiology-Heart and Circulatory Physiology.
Ghobrial M, Haley H, Gosling R, Taylor DJ, Richardson J, Morgan K, Barmby D, Iqbal J, Krishnamurthy A, Singh R , Conway D et al () Modelled impact of virtual fractional flow reserve in patients undergoing coronary angiography (VIRTU-4). Heart.
Kite T, Chase A, Owens C, Shaukat A, Mozid A, O'Kane P, Routledge H, Perera D, Jain A, Palmer N , Hoole S et al () Complex Percutaneous Coronary Intervention in Patients Unable to Undergo Coronary Artery Bypass Grafting During the COVID-19 Pandemic: Insights From the UK-ReVasc Registry. Journal of Invasive Cardiology.
Baraikan AA, Czechowicz K, Morris PD, Halliday I, Gosling RC, Gunn JP, Narracott AJ, Williams G, Garg P, Malawski M , Vosse FVD et al () Modelling The Hemodynamics of Coronary Ischemia. Fluids, 8(5), 159-159.
Newman T, Borker R, Aubiniere-Robb L, Hendrickson J, Choudhury D, Halliday I, Fenner J, Narracott A, Hose DR, Gosling R , Gunn JP et al () Rapid virtual fractional flow reserve using 3-D computational fluid dynamics. European Heart Journal - Digital Health.
Gosling RC, Gunn E, Wei H-L, Gu Y, Rammohan V, Hughes T, Hose DR, Lawford PV, Gunn JP & Morris PD () Incorporating clinical parameters to improve the accuracy of angiography-derived computed fractional flow reserve. European Heart Journal - Digital Health.
Gunn J & Morris PD () Revascularisation for the proximal left anterior descending artery: special case or part of the package?. Heart.
Gabara L, Hinton J, Gunn J, Morris PD & Curzen N () Coronary physiology derived from invasive angiography : will it be a game changer?. Interventional Cardiology Review, 15. View this article in WRRO

Chapters

Morris PD & Sahu J (2019) Cardiac Electrophysiology, Cardiac Pathology (pp. 25-48). Springer International Publishing
Morris PD & Gunn J (2017) New concepts in coronary physiological assessment, Practical Interventional Cardiology (pp. 109-123). CRC Press
Morris PD & Sahu J (2013) Cardiac Electrophysiology, Cardiac Pathology (pp. 19-42). Springer London

Conference proceedings papers

Taylor D, Saxton H, Halliday I, Newman T, Kassab G, Gunn J & Morris P (2024) BS54 A systematic review and meta-analysis of murray’s law in the coronary arterial circulation. Basic science
Taylor D, Gunn J, Halliday I, Narracott A, Gosling R, Morris P, Newman T & Saxton H (2024) 220 Sensitivity of computed coronary physiology to murray’s law of vascular scaling. Stable IHD/Prevention/Hypertension/Lipids
Haley H, Ghobrial M, Lawford P, Morris P, Hose DR, Gunn J & Gosling R (2023) 42 The role of angiography-derived (VIRTUAL) fractional flow reserve in the management of patients with acute coronary syndromes (ACS); the VIRTU4-ACS study. Acute coronary syndromes & Interventional Cardiology
Albaraikan A, Williams G, Morris P & Gunn J (2023) 52 Does physical activity change in patients undergoing PCI for chronic coronary syndrome?. Acute coronary syndromes & Interventional Cardiology
Elamin N, Nelson TA, Richardson JD, Adam Z, Krishnamurthy A, Iqbal J, Morgan KP, Hall IR, Rothman A, Parker WAE , Storey RF et al (2023) 71 Initial clinical experience with 6-hour enoxaparin regimen in opiate-treated patients undergoing primary percutaneous coronary intervention. Acute coronary syndromes & Interventional Cardiology
Albaraikan A, Williams G, Gosling R, Morris P & Gunn J (2023) 39 Does FFR-guided PCI result in improved absolute coronary blood flow?. Acute coronary syndromes & Interventional Cardiology
Kelshiker M, Seligman H, Howard JP, Rahman H, Foley M, Nowbar AN, Rajkumar CA, Shun-Shin M, Ahmad Y, Sen S , Al-Lamee R et al (2022) CORONARY FLOW RESERVE AND CARDIOVASCULAR OUTCOMES: A SYSTEMATIC REVIEW AND META-ANALYSIS. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 79(9) (pp 989-989)
Gosling R, Gunn E, Wei HL, Gu Y, Rammohan V, Hughes T, Hose DR, Lawford PV, Gunn JP & Morris PD (2021) Utilising clinical data to personlaise boundary conditions significantly improves the accuracy of angiography based virtual FFR. European Heart Journal, Vol. 42(Suppl 1) (pp 1074-1074). Digital Congress, 27 August 2021 - 27 August 2021. View this article in WRRO
Aubiniere-Robb L, Morris P, Gunn J, Gosling R, Hose R, Rammohan V & Lawford P (2021) 33 Absolute coronary blood flow and microvascular resistance modelling in patients with coronary artery disease. Acute coronary syndromes & Interventional cardiology
Middleton JT, Konganige S, Dahaghin P, Zafar H, Reddy A, Martin C, Thompson AAR, Swift AJ, Morris P, Condliffe R , Morrell NW et al (2020) Abstract 15636: Effect of COVID-19 Public Health Measures on Activity and Quality of Life in Patients With Pulmonary Arterial Hypertension. Circulation, Vol. 142(Suppl_3) View this article in WRRO
Kite T, Ladwiniec A, Routledge H, Hoole S, Palmer N, Egred M, Perera D, Mouyis K, Sinha M, Candilio L , Anantharam B et al (2020) In-Hospital Outcomes of CABG Candidates Undergoing PCI During the ICU Restricted COVID-19 Pandemic: The Multi-Center Prospective UK-REVASC Registry. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 76(17) (pp B98-B99)
Gosling R, Morris P, Lawford P, Hose R & Gunn J (2019) Virtual (computed) FFR and Virtual Coronary Intervention (VCI) vs angiography for guiding PCI: a virtual study.. Heart, Vol. 105(Suppl 6) (pp a45-a45). Manchester, UK, 3 June 2019 - 5 June 2019. View this article in WRRO
Son S, Gosling R, Morris P & Gunn J (2018) What will be the Impact of Virtual Coronary Physiology upon the Practice of Coronary Artery Bypass Grafting Surgery for Patients with Coronary Artery Disease?. International Journal of Surgery, Vol. 55 (pp S9-S9)
Morris P, Iqbal J & Gunn JP (2017) Restenosis in simultaneous kissing stents to treat unprotected left main stem coronary artery bifurcation disease: incidence and management. EUROPEAN HEART JOURNAL, Vol. 38 (pp 87-87) View this article in WRRO
Sciola MI, Morris PD, Lawford PV, Hose DR & Gunn JP (2017) A novel mathematical signal processing application which automates and improves the accuracy of FFR assessment. EUROPEAN HEART JOURNAL, Vol. 38 (pp 183-184) View this article in WRRO
Morris P, Zwierzak I, Lawford P, Sir D, Hose R & Gunn J (2015) 209 The Development and Validation of anin silicoModel of Coronary Arterial Physiology for Diagnostic Use. Heart, Vol. 101(Suppl 4) (pp A115.1-A115)
Cimen S, Hoogendoorn C, Morris PD, Gunn J & Frangi A (2014) Reconstruction of Coronary Trees from 3DRA Using a 3D+t Statistical Cardiac Prior. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, Vol. 2 (pp 619-626)
Çimen S, Hoogendoorn C, Morris PD, Gunn J & Frangi AF (2014) Reconstruction of coronary trees from 3DRA using a 3D+t statistical cardiac prior. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, Vol. 17 (pp 619-626)
Morris PD, Ryan DR, Lycett R, Morton AC, Lawford PV, Hose DR & Gunn J (2012) 021 Computer modelled coronary physiology and “virtual” fractional flow reserve from rotational angiography: Abstract 021 Figure 1. Heart, Vol. 98(Suppl 1) (pp A14.1-A14)
Morris PF, Morgan P & Ridal KA (2012) Metals fit for the twenty-first century: Processing for high performance applications. Ironmaking and Steelmaking, Vol. 39(4) (pp 236-243)
Morris PD, Ryan DM, Lycett R, Morton AC, Lawford PV, Hose DR & Gunn JP (2011) Virtual Coronary Physiology and Anatomy Derived From Rotational Angiography: The First Step. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 58(20) (pp B189-B189)
Altenkirch T, Morris P, Forsberg FN & Setzer A (2011) A Categorical Semantics for Inductive-Inductive Definitions.. CALCO, Vol. 6859 (pp 70-84)
Morris P & Dowdall S (2011) Computer-aided Self-assessment and Independent Learning in Higher Education.. CSEDU (2) (pp 139-142)
Chapman J, Dagand P-É, McBride C & Morris P (2010) The gentle art of levitation.. ICFP (pp 3-14)
Thackray R, Morris PF & Ridal K (2010) Alloys for critical applications. Ironmaking and Steelmaking, Vol. 37(4) (pp 242-250)
Altenkirch T & Morris P (2009) Indexed Containers.. LICS (pp 277-285)
Lichtenberg J, Morris P, Ecker K & Welch LR (2008) Discovery of Regulatory Elements in Oomycete Orthologs.. BIOCOMP (pp 34-38)
Morris P, Altenkirch T & Ghani N (2007) Constructing Strictly Positive Families.. CATS, Vol. 65 (pp 111-121)
Morris P (2006) A Structural Characterization of Temporal Dynamic Controllability.. CP, Vol. 4204 (pp 375-389)
Morris P, Silk N & Ridal K (2005) Quality steel - Advances in process control. Ironmaking and Steelmaking, Vol. 32(5) (pp 391-396)
Morris P, Altenkirch T & McBride C (2004) Exploring the Regular Tree Types.. TYPES, Vol. 3839 (pp 252-267)
Morris P, Beynon J & Ridal K (2004) Advances in the hot rolling of steels. Ironmaking and Steelmaking, Vol. 31(1) (pp 8-13)
Pugh PJ, Malkin CJ, Morris PD, Asif S, Jones RD, Jones TH & Channer KS (2003) Prevalence of hypogonadism in men with coronary artery disease. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 41(6) (pp 344A-344A)
Pugh PJ, Malkin CJ, Morris PD, Nettleship J, Jones RD, Jones TH & Channer KS (2003) Relation of testosterone with inflammatory cytokines in men with coronary artery disease. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 41(6) (pp 344A-344A)
MALKIN C (2003) 187 Testosterone replacement therapy improves ischaemic threshold and mood in hypogonadal men with angina. European Heart Journal, Vol. 24(5) (pp 20-20)
Morris P (2003) Keynote: Metrics Based Project Governance.. IEEE METRICS
Morris P, Norlin E, Glogoff S & Forger G (2001) The Academic Library's Role in Transmitting Cultural Heritage Using 21st Centuri Technology: The University of Arizona Libraries and the Cultural Community Collaboration Model.. ICHIM (1) (pp 375-383)
Masera M & Morris P (1998) Dependable Embedded Systems: The Challenges for Requirements Engineering.. REFSQ (pp 187-192)
Morris P, Masera M & Wilikens M (1998) Requirements Engineering and Industrial Uptake.. ICRE (pp 130-137)
Morris P, Masera M & Wilikens M (1997) Industrial Workshop on Requirements for R&D in Requirements Engineering.. RE (pp 41-41)
Duffy DA, MacNish C, McDermid JA & Morris P (1995) A Framework for Requirements Analysis Using Automated Reasoning. CAiSE, Vol. 932 (pp 68-81)
Morris P (1993) The Breakout Method for Escaping from Local Minima.. AAAI (pp 40-45)
Morris P & McDermid JA (1992) Formalizing and Validating Complex Security Requirements.. DBSec, Vol. A-21 (pp 113-124)
Morris P (1992) On the Density of Solutions in Equilibrium Points for the Queens Problem.. AAAI (pp 428-433)
Morris P & McDermid JA (1991) The Structure of Permissions: A Normative Framework for Access Rights.. DBSec, Vol. A-6 (pp 77-97)
Feldman R & Morris P (1990) Admissible Criteria for Loop Control in Planning.. AAAI (pp 151-157)
Morris P (1988) Stable Closures, Defeasible Logic and Contradiction Tolerant Reasoning.. AAAI (pp 506-511)
Morris P (1987) Curing Anomalous Extensions.. AAAI (pp 437-442)
Morris P & Nado R (1986) Representing Actions with an Assumption-Based Truth Maintenance System.. AAAI (pp 13-20)
Kibler DF & Morris P (1981) Don't Be Stupid.. IJCAI (pp 345-347)
Morris P & Sagalowicz D (1977) Managing Network Access to a Distributed Database.. Berkeley Workshop (pp 58-67)

Preprints

Middleton JT, Binmahfooz S, Zafar H, Patel J, Ashraf C, Taylor J, Neelam-Naganathan D, Battersby C, Pearson C, Roddis C , Roman S et al (2023) Remote evaluation of risk and physiological response to therapeutic escalation and clinical worsening in patients with pulmonary hypertension, Cold Spring Harbor Laboratory.
Magallanes J, Stone T, Morris PD, Mason S, Wood S & Villa-Uriol M-C (2021) Sequen-C: A Multilevel Overview of Temporal Event Sequences, arXiv.
Mills MT, Grafton-Clarke C, Williams G, Gosling RC, Al Baraikan A, Kyriacou AL, Morris PD, Gunn JP, Swoboda PP, Levelt E , Tsampasian V et al (2021) Feasibility and validation of trans-valvular flow derived by four-dimensional flow cardiovascular magnetic resonance imaging in patients with atrial fibrillation.
Solanki R, Gosling R, Rammohan V, Pederzani G, Garg P, Heppenstall J, Hose D, Lawford P, Narracott A, Fenner J , Gunn J et al () The Accuracy of Virtual Fractional Flow Reserve From Invasive Angiography: Importance of the Method of Reconstructing Three-dimensional Coronary Artery Anatomy, Research Square Platform LLC.

Grants

UK-CAA Spaceflight. Computational modelling to risk stratify commercial spaceflight. £200,000. 2023-2024.
British Heart Foundation. Translational Award no TG/19/1/34451. How will virtual (computed) fractional flow reserve (vFFR) impact the management of coronary artery disease? (VIRTU-4). 2019. £370,679.
National Institute for Health Research, Invention for Innovation (i4i). A prototype tool to calculate 'virtual' myocardial fractional flow reserve (vFFR) non-invasively (VIRTU-3). II-LB-0216-20006. £282,186.
Wellcome Trust. Clinical Research Career Development Fellowship. Morris PD. Computational modelling to improve the assessment and management of patients with coronary artery disease. 2019. £570,000.

Teaching interests

I enjoy teaching clinical cardiology to undergraduates and post-graduates. I teach clinical skills to medical students and doctors on the wards and in the clinic.

I have written textbooks and chapters of books focused on clinical and academic aspects of clinical cardiology. I also enjoy teaching about cardiac physiology and fluid dynamics modelling.

I have a Postgraduate Certificate in Medical Education and have recently become a Fellow of the Higher Education Academy.

Professional activities and memberships: I am Director for Clinical Translation at the Insigneo Institute. I sit on the NIHR-BHF Coronary Microvascular Dysfunction Workstream Steering Committee. I am phase lead for Cardiology Teaching on the Sheffield Medical (MBChB) and Physician Associate (MMedSci) courses. I am also a member of the British Cardiovascular Society, the British Cardiovascular Interventions Society, the Royal College of Physicians and the European Society of Cardiology.

Invention and innovation: My research has led to several innovations. In 2012, I led the development of angiography-derived ‘virtual’ fractional flow reserve (vFFR), an approach that has translated into routine clinical practice to assess the physiological significance of coronary disease in the cardiac catheter laboratory. Similar image-based CFD modelling methods were used to develop the patented virtuQ method of computing absolute coronary flow, microvascular resistance and flow reserve. I also co-led to the development of the patented GuideGlide^TM catheter that is designed to improve comfort and safety of radial access procedures during radial coronary intervention.

School of Medicine and Population Health

School of Medicine and Population Health

Dr Paul Morris

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