Dr Adrian Higgingbottom

Neuroscience, School of Medicine and Population Health

Senior Scientific Officer

+44 114 222 2253

Full contact details

Dr Adrian Higgingbottom
Neuroscience, School of Medicine and Population Health
Sheffield Institute for Translational Neuroscience (SITraN)
385a Glossop Road
S10 2HQ

Journal articles

Conference proceedings papers

  • Alves-Cruzeiro JM, Karyka E, Bauer C, Coldicott I, Simon S, Hautbergue GM, Webster C, Myszczynska M, Higginbottom A, Ferraiuolo L & Azzouz M (2019) Gene editing as a potential therapeutic approach for ALS/FTD-associated with expanded C9ORF72. HUMAN GENE THERAPY, Vol. 30(8) (pp A22-A22) RIS download Bibtex download
  • Allen SP, Hall B, Castelli L, Francis L, Woof R, Higginbottom A, Myszczynska M, Allen CF, Stopford MJ, Webster CP , De Vos K et al (2018) Inosine reverses motor neuron toxicity observed in amyotrophic lateral sclerosis patient astrocytes with an adenosine deaminase deficiency. Biochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1859 (pp e23-e23) RIS download Bibtex download
  • Hewamadduma C, Grierson A, Higginbottom A & Shaw P (2015) Fibroblasts from patients with amyotrophic lateral sclerosis (ALS) associated with mutations in tardbp gene as model of TDP-43 proteinopathy. Journal of the Neurological Sciences, Vol. 357 (pp e49-e49) RIS download Bibtex download
  • Beer A, Cooper-Knock J, Higginbottom A, Robin Highley J, Wharton SP, Milano A, Jones A, Al-Chalabi A, Kirby J & Shaw PJ (2014) AMYOTROPHIC LATERAL SCLEROSIS ASSOCIATED WITH AN INTERMEDIATE LENGTH GGGGCC REPEAT EXPANSION HAS DISTINCT NEUROPATHOLOGY COMPARED TO PATIENTS WITH LARGER EXPANSIONS. Journal of Neurology, Neurosurgery & Psychiatry, Vol. 85(10) (pp e4.130-e4) RIS download Bibtex download
  • Simpson JE, Ince PG, Matthews F, Shaw PJ, Heath PR, Brayne C, Garwood C, Abdalla H, Higginbottom A & Wharton SB (2014) A neuronal DNA damage response is detected at low Braak stages and correlates with cognitive impairment in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 40 (pp 31-32) RIS download Bibtex download
  • Ferraiuolo L, Higginbottom A, Heath PR, Barber S, Greenald D, Kirby J & Shaw PJ (2012) 159 Dysregulation of the cross-talk with astrocytes as a contributory factor to motor neuron injury in motor neuron disease. Journal of Neurology, Neurosurgery & Psychiatry, Vol. 83(3) (pp e1.115-e1) RIS download Bibtex download
  • Ning K, Drepper C, Ismail A, Valori CF, Wyles M, Higginbottom A, Herrmann T, Shaw P, Sharrack B, Sendtner M & Azzouz M (2010) PTEN Depletion Rescues the beta-Actin Deficit in Axonal Growth Cones in Motoneurons from a Mouse Model of Spinal Muscular Atrophy. NEUROLOGY, Vol. 74(9) (pp A489-A489) RIS download Bibtex download
  • Nanou A, Higginbottom A, Valori C, Wyles M, Ning K, Shaw P & Azzouz M (2010) Oxidative Stress as Target for Neuroprotection in Experimental Models of Amyotrophic Lateral Sclerosis (ALS). NEUROLOGY, Vol. 74(9) (pp A436-A436) RIS download Bibtex download
  • Madala PK, Stoermer M, Tyndall JDA, Monk PN, Higginbottom A & Fairlie DP (2008) COMP 264-Unraveling the mechanism of antagonism for human C5a receptor: Comparison of three structurally different antagonists. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 236 RIS download Bibtex download
  • Scola A-M, Higginbottom A, Partridge LJ & Monk PN (2007) Different ligand-binding mechanisms used by the two C5a receptors, C5L2 and C5aR. Molecular Immunology, Vol. 44(1-3) (pp 237-237) RIS download Bibtex download
  • Monk PN, Higginbottom A, Madala PK, Tyndall JDA, Stoermer M & Fairlie DP (2006) Defining the ligand binding site on the human C5a receptor. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 231 RIS download Bibtex download
  • Wong CH, Higginbottom A, Monk P, Partridge LJ & Moore HD (2001) Inhibition of sperm-oolemma interactions by the extracellular domains of CD9 and CD81. ANDROLOGY IN THE 21ST CENTURY, SHORT COMMUNICATIONS (pp 565-572) RIS download Bibtex download
  • Higginbottom A, Partridge LJ & Monk PN (1996) Identification of potential ligands for CD63 from random peptide libraries. IMMUNOLOGY, Vol. 89 (pp OM117-OM117) RIS download Bibtex download