Professor Li Su
Neuroscience, School of Medicine and Population Health
Professor of Neuroimaging
+44 114 21 59108
Full contact details
Neuroscience, School of Medicine and Population Health
Sheffield Institute for Translational Neuroscience (SITraN)
385a Glossop Road
Professor Su was awarded a PhD in Computational Neuroscience from University of Kent in 2009. After several years of postdoctoral research in Institute of Psychiatry at King’s College London, MRC Cognition and Brain Sciences Unit and University of Cambridge, he was awarded a highly competitive Senior Research Fellowship from Alzheimer’s Research UK in 2017.
He leads the Artificial Intelligence & Computational Neuroscience Group (www.aicn-group.com), which aims to combine innovative and original computational methods with the state-of-the-art brain imaging techniques such as MEG/EEG, 7T MRI and PET in understanding, detecting and developing treatments for neurological and psychiatric conditions.
In 2020, he was appointed Professor of Neuroimaging at the University of Sheffield. He also holds a part-time PI position in Department of Psychiatry at University of Cambridge. He leads the Alzheimer’s Research UK East Network Centre and is an elected Fellow in Clare Hall, University of Cambridge. His research has been recognised through international awards including an International College of Geriatric Psychoneuropharmacology Junior Investigator Award in 2015.
- Research interests
- Conduct multimodal and longitudinal EEG, MRI and PET studies to discover clinically relevant biomarkers for neurodegenerative disorders (including Parkinson’s disease, Alzheimer’s disease), motor neuron disorders, stroke and other related conditions. Apply machine learning and other advanced imaging analysis to the imaging, genetic, blood and other clinical data.
- Develop advanced imaging analysis methods for basic and clinical neuroscience.
- Develop and validate AI models using clinical and neuroimging data. Use the model to predict therapeutic effects of potential drug targets on normalising neural network functions from computer simulations.
- Early detection and prevention of dementia. In particular, apply multimodal imaging and VR to find earliest signals for functional declines and pathological abnormalities. Develop and test pharmaceutical and non-pharmaceutical interventions to slow or reverse disease progression for those with increased risk of developing dementia.
- A promising tool to explore functional impairment in neurodegeneration: A systematic review of near-infrared spectroscopy in dementia.. Ageing Research Reviews, 90, 101992-101992.
- Assessment of Alzheimer-related pathologies of dementia using machine learning feature selection. Alzheimer’s Research & Therapy, 15.
- Illuminating neurodegeneration: a future perspective on near-infrared spectroscopy in dementia research. Neurophotonics, 10(02).
- On the similarities of representations in artificial and brain neural networks for speech recognition. Frontiers in Computational Neuroscience, 16.
- Multifactor mid‐life risk for Alzheimer’s disease associated with alterations in navigation but not episodic memory: the PREVENT‐Dementia study. Alzheimer's & Dementia, 18(S7).
- Modifiable and non-modifiable risk factors of dementia on midlife cerebral small vessel disease in cognitively healthy middle-aged adults: the PREVENT-Dementia study. Alzheimer’s Research & Therapy, 14(1).
- Spatial Distribution and Hierarchical Clustering of β-Amyloid and Glucose Metabolism in Alzheimer’s Disease. Frontiers in Aging Neuroscience, 14, 788567.
- FRACTAL DIMENSION OF THE BRAIN IN NEURODEGENERATIVE DISEASE AND DEMENTIA: A SYSTEMATIC REVIEW.. Ageing Res Rev, 101651.
- Computational psychiatry and computational neurology : seeking for mechanistic modeling in cognitive impairment and dementia. Frontiers in Computational Neuroscience, 16.
- Fluid-attenuated inversion recovery magnetic resonance imaging textural features as sensitive markers of white matter damage in midlife adults. Brain Communications, 4(3).
- Macrostructural brain alterations at midlife are connected to cardiovascular and not inherited risk of future dementia : the PREVENT-Dementia study. Journal of Neurology.
- Difference in amyloid load between single memory domain and multidomain subjective cognitive decline: a study from the SILCODE. Journal of Alzheimer's Disease, 85(4), 1573-1582.
- Differential levels of plasma biomarkers of neurodegeneration in Lewy body dementia, Alzheimer’s disease, frontotemporal dementia and progressive supranuclear palsy. Journal of Neurology, Neurosurgery & Psychiatry.
- Transcutaneous vagus nerve stimulation (tVNS) in stroke: the evidence, challenges and future directions. Autonomic Neuroscience, 237, 102909-102909.
- Neuroinflammation in medial temporal regions predicts cognitive decline in dementia with Lewy bodies. Alzheimer's & Dementia, 17(S4).
- The effects of age and hypertension on cerebral small‐vessel disease differ between men and women at midlife: The PREVENT Dementia study. Alzheimer's & Dementia, 17(S10).
- Resting-state brain connectivity in healthy young and middle-aged adults at risk of progressive Alzheimer’s disease. Neuroscience & Biobehavioral Reviews.
- A Genetic Determinant of the Preference Reversal Phenomenon. The American Journal of Psychology, 134(2), 167-174.
- Proximity to dementia onset and multi-modal neuroimaging changes: The prevent-dementia study. NeuroImage, 229.
- Relationship between tau, neuroinflammation and atrophy in Alzheimer's disease: The NIMROD study. Information Fusion, 67, 116-124.
- Simulating a Community Mental Health Service During the COVID-19 Pandemic: Effects of Clinician–Clinician Encounters, Clinician–Patient–Family Encounters, Symptom-Triggered Protective Behaviour, and Household Clustering. Frontiers in Psychiatry, 12, 620842.
- Resilience to Plasma and Cerebrospinal Fluid Amyloid-β in Cognitively Normal Individuals: Findings From Two Cohort Studies. Frontiers in Aging Neuroscience, 13, 610755.
- Multifaceted pattern of longitudinal imaging changes in cognitively normal midlife adults: The PREVENT‐Dementia study. Alzheimer's & Dementia, 16(S5).
- Progression of cerebral small vessel disease in healthy middle‐aged adults associated with inherited risk of Alzheimer’s disease: The PREVENT‐Dementia study. Alzheimer's & Dementia, 16(S4).
- The prognostic role of microglia and tau PET in Alzheimer’s disease. Alzheimer's & Dementia, 16(S4).
- Impact of mild head injury on diffusion MRI brain characteristics in midlife: Data from the PREVENT Dementia Study. Alzheimer's & Dementia, 16(S5).
- Increased electromagnetic variability in Lewy body dementia: A MILOS study. Alzheimer's & Dementia, 16(S4).
- Multi‐faceted brain changes associated with proximity to dementia onset: The PREVENT‐Dementia study. Alzheimer's & Dementia, 16(S4).
- Hippocampal subfield volumetry in subjects at high risk of dementia: The PREVENT‐Dementia study. Alzheimer's & Dementia, 16(S4).
- Mesoscopic compensations for microscopic impairments in mid‐age individuals with family history of dementia. Alzheimer's & Dementia, 16(S5).
- Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer’s disease. Molecular Neurodegeneration, 15(1).
- Inherited risk of dementia and the progression of cerebral small vessel disease and inflammatory markers in cognitively healthy midlife adults: the PREVENT-Dementia study. Neurobiology of Aging.
- Imaging tau burden in dementia with Lewy bodies using [18F]-AV1451 positron emission tomography. Neurobiology of Aging.
- Semantic and attentional networks in bilingual processing: fMRI connectivity signatures of translation directionality. Brain and Cognition, 143, 105584-105584.
- Volumetric alterations in the hippocampal subfields of subjects at increased risk of dementia. Neurobiology of Aging, 91, 36-44.
- Regional hyperperfusion in cognitively normal APOE ε4 allele carriers in mid-life: analysis of ASL pilot data from the PREVENT-Dementia cohort. Journal of Neurology, Neurosurgery & Psychiatry, 91(8), 861-866.
- Hippocampal Subfield Volumes in Middle-Aged Adults at Risk of Dementia. Journal of Alzheimer's Disease, 75(4), 1211-1218.
- Autosomal dominantly inherited alzheimer disease: Analysis of genetic subgroups by machine learning. Information Fusion, 58, 153-167.
- Microglial activation and tau burden predict cognitive decline in Alzheimer’s disease. Brain, 143(5), 1588-1602.
- Association between midlife dementia risk factors and longitudinal brain atrophy: the PREVENT-Dementia study. Journal of Neurology, Neurosurgery & Psychiatry, 91(2), 158-161.
- The Stroop effect: An activation likelihood estimation meta-analysis in healthy young adults. Neuroscience Letters, 716, 134683-134683.
- Correlation of microglial activation with white matter changes in dementia with Lewy bodies. NeuroImage: Clinical, 25, 102200-102200.
- Asymmetrical atrophy of thalamic subnuclei in Alzheimer's disease and amyloid‐positive mild cognitive impairment is associated with key clinical features. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 11(1), 690-699.
- Predicting the behavioural tendency of loss aversion. Scientific Reports, 9(1).
- Automated Brain MRI Volumetry Differentiates Early Stages of Alzheimer’s Disease From Normal Aging. Journal of Geriatric Psychiatry and Neurology, 32(6), 354-364.
- The role of information sentiment in popularity on social media: a psychoinformatic and electroencephalogram study. Social Influence, 14(3-4), 133-146.
- Neuroinflammation and Functional Connectivity in Alzheimer's Disease: Interactive Influences on Cognitive Performance. The Journal of Neuroscience, 39(36), 7218-7226.
- Sino Longitudinal Study on Cognitive Decline (SILCODE): protocol for a Chinese longitudinal observational study to develop risk prediction models of conversion to mild cognitive impairment in individuals with subjective cognitive decline. BMJ Open, 9(7), e028188-e028188.
- P2-373: ASYMMETRICAL THALAMIC SUBNUCLEI IN ALZHEIMER'S DISEASE ASSOCIATED WITH GREATER DISEASE SEVERITY. Alzheimer's & Dementia, 15, P744-P745.
- The endowment effect in the genes: An exploratory study. Judgment and Decision Making, 14(3), 293-298.
- Normative pathways in the functional connectome. NeuroImage, 184, 317-334.
- P3-362: HYPERFUNCTIONAL CONNECTIVITY ASSOCIATED WITH GENETIC RISKS OF DEMENTIA. Alzheimer's & Dementia, 14(7S_Part_23), P1226-P1226.
- IC-P-169: HYPERFUNCTIONAL CONNECTIVITY ASSOCIATED WITH GENETIC RISKS OF DEMENTIA. Alzheimer's & Dementia, 14(7S_Part_2), P141-P142.
- Longitudinal diffusion tensor imaging changes in early Parkinson’s disease: ICICLE-PD study. Journal of Neurology, 265(7), 1528-1539.
- [11C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy. Neurology, 90(22), e1989-e1996.
- Cerebral small vessel disease in middle age and genetic predisposition to late-onset Alzheimer's disease. Alzheimer's & Dementia, 14(2), 253-258.
- In vivo coupling of tau pathology and cortical thinning in Alzheimer's disease. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 10(1), 678-687.
- Early microglial activation and peripheral inflammation in dementia with Lewy bodies. Brain, 141(12), 3415-3427.
- Allocentric and Egocentric Spatial Processing in Middle-Aged Adults at High Risk of Late-Onset Alzheimer’s Disease: The PREVENT Dementia Study. Journal of Alzheimer's Disease, 65(3), 885-896.
- Hippocampal Stratum Radiatum, Lacunosum, and Moleculare Sparing in Mild Cognitive Impairment. Journal of Alzheimer's Disease, 61(1), 415-424.
- The midlife cognitive profiles of adults at high risk of late-onset Alzheimer's disease: The PREVENT study. Alzheimer's & Dementia, 13(10), 1089-1097.
- INVESTIGATION OF THE RELATIONSHIP BETWEEN TAU AND NEUROINFLAMMATION IN ALZHEIMER’S DISEASE USING PET AND REACTION MODELLING. Alzheimer's & Dementia, 13(7), P921-P922.
- Longitudinal whole-brain atrophy and ventricular enlargement in nondemented Parkinson's disease. Neurobiology of Aging, 55, 78-90.
- Functional neuroimaging findings in healthy middle-aged adults at risk of Alzheimer’s disease. Ageing Research Reviews, 36, 88-104.
- Structural neuroimaging in preclinical dementia: From microstructural deficits and grey matter atrophy to macroscale connectomic changes. Ageing Research Reviews, 35, 250-264.
- Multi-modal MRI investigation of volumetric and microstructural changes in the hippocampus and its subfields in mild cognitive impairment, Alzheimer's disease, and dementia with Lewy bodies. International Psychogeriatrics, 29(4), 545-555.
- Neuroimaging of Inflammation in Memory and Related Other Disorders (NIMROD) study protocol: a deep phenotyping cohort study of the role of brain inflammation in dementia, depression and other neurological illnesses. BMJ Open, 7(1), e013187-e013187.
- Neuroinflammatory and morphological changes in late-life depression: the NIMROD study. British Journal of Psychiatry, 209(6), 525-526.
- Differential mesolimbic and prefrontal alterations during reward anticipation and consummation in positive and negative schizotypy. Psychiatry Research: Neuroimaging, 254, 127-136.
- Whole-brain patterns of 1H-magnetic resonance spectroscopy imaging in Alzheimer's disease and dementia with Lewy bodies. Translational Psychiatry, 6(8), e877-e877.
- Multivariate Neural Representations of Value during Reward Anticipation and Consummation in the Human Orbitofrontal Cortex. Scientific Reports, 6(1).
- Cortical and Subcortical Changes in Alzheimer's Disease: A Longitudinal and Quantitative MRI Study. Current Alzheimer Research, 13(5), 534-544.
- Differential Atrophy of Hippocampal Subfields: A Comparative Study of Dementia with Lewy Bodies and Alzheimer Disease. The American Journal of Geriatric Psychiatry, 24(2), 136-143.
- Temporal Autocorrelation-Based Beamforming With MEG Neuroimaging Data. Journal of the American Statistical Association, 110(512), 1375-1388.
- Baseline and longitudinal grey matter changes in newly diagnosed Parkinson’s disease: ICICLE-PD study. Brain, 138(10), 2974-2986.
- Temporal perception deficits in schizophrenia: integration is the problem, not deployment of attentions. Scientific Reports, 5(1).
- Neuroimaging correlates of cognitive impairment and dementia in Parkinson's disease. Parkinsonism & Related Disorders, 21(8), 862-870.
- P3-003: A longitudinal and quantitative MRI study of Alzheimer's disease. Alzheimer's & Dementia, 11(7S_Part_13), P620-P620.
- P3-151: Comparing trajectories of grey matter changes in Alzheimer's disease and dementia with lewy bodies: A longitudinal study. Alzheimer's & Dementia, 11(7S_Part_15), P685-P685.
- IC-P-075: A longitudinal and quantitative MRI study of Alzheimer's disease. Alzheimer's & Dementia, 11(7S_Part_1), P54-P55.
- Progressive cortical thinning and subcortical atrophy in dementia with Lewy bodies and Alzheimer's disease. Neurobiology of Aging, 36(4), 1743-1750.
- Tissue microstructural changes in dementia with Lewy bodies revealed by quantitative MRI. Journal of Neurology, 262(1), 165-172.
- Longitudinal assessment of global and regional atrophy rates in Alzheimer's disease and dementia with Lewy bodies. NeuroImage: Clinical, 7, 456-462.
- Grammatical analysis as a distributed neurobiological function. Human Brain Mapping, 36(3), 1190-1201.
- Analysing neurobiological models using communicating automata. Formal Aspects of Computing, 26(6), 1169-1204.
- Neuroimaging characteristics of dementia with Lewy bodies. Alzheimer's Research & Therapy, 6(2), 18-18.
- Self-regulation of the anterior insula: Reinforcement learning using real-time fMRI neurofeedback. NeuroImage, 88, 113-124.
- Neurobiological Systems for Lexical Representation and Analysis in English. Journal of Cognitive Neuroscience, 25(10), 1678-1691.
- Behavioral and [F-18] fluorodeoxyglucose micro positron emission tomography imaging study in a rat chronic mild stress model of depression. Neuroscience, 169(1), 171-181.
- Process algebraic modelling of attentional capture and human electrophysiology in interactive systems. Formal Aspects of Computing, 21(6), 513-539.
- Performance of Reactive Interfaces in Stimulus Rich Environments, Applying Formal Methods and Cognitive Frameworks. Electronic Notes in Theoretical Computer Science, 208, 95-111.
- A Tool for the Syntactic Detection of Zeno-timelocks in Timed Automata. Electronic Notes in Theoretical Computer Science, 139(1), 25-47.
- tVNS in Stroke: A Narrative Review on the Current State and the Future. Stroke.
- Genetic risk factors of Alzheimer’s Disease disrupt resting-state functional connectivity in cognitively intact young individuals. Journal of Neurology.
- A double‐blind, randomized, placebo‐controlled trial of ursodeoxycholic acid (UDCA) in Parkinson's disease. Movement Disorders.
- Differential association of cerebral blood flow and anisocytosis in APOE ε4 carriers at midlife. Journal of Cerebral Blood Flow & Metabolism, 0271678X2311735-0271678X2311735.
- Magnetic Resonance Spectroscopy in neurodegenerative dementias, prodromal syndromes and at‐risk states: a systematic review of the literature. NMR in Biomedicine.
- Functional and structural brain network correlates of visual hallucinations in Lewy body dementia. Brain.
- CAIDE dementia risk score relates to severity and progression of cerebral small vessel disease in healthy midlife adults: the PREVENT-Dementia study. Journal of Neurology, Neurosurgery & Psychiatry.
- Higher midlife CAIDE score is associated with increased brain atrophy in a cohort of cognitively healthy middle-aged individuals. Journal of Neurology.
- Evidence of cerebral hemodynamic dysregulation in middle-aged APOE ε4 carriers: The PREVENT-Dementia study. Journal of Cerebral Blood Flow & Metabolism, 0271678X2110208-0271678X2110208.
- The revised Addenbrooke's Cognitive Examination can facilitate differentiation of dementia with Lewy bodies from Alzheimer's disease. International Journal of Geriatric Psychiatry.
- Trauma and depressive symptomatology in middle-aged persons at high risk of dementia: the PREVENT Dementia Study. Journal of Neurology, Neurosurgery & Psychiatry.
- In vivo neuroinflammation and cerebral small vessel disease in mild cognitive impairment and Alzheimer’s disease. Journal of Neurology, Neurosurgery & Psychiatry.
- Midlife alcohol consumption and longitudinal brain atrophy: the PREVENT-Dementia study. Journal of Neurology.
- Can genes modulate anchoring effect?. International Journal of Psychology.
- Can Your DNA Influence Your Bet-Placing? The Impact of Cannabinoid Receptor 1 Gene on Gambling Tasks. Frontiers in Human Neuroscience, 12.
- Predict Disease Progression With Reaction Rate Equation Modeling of Multimodal MRI and PET. Frontiers in Aging Neuroscience, 10.
- Improving motivation through real-time fMRI-based self-regulation of the nucleus accumbens.. Neuropsychology, 32(6), 764-776.
- Relating dynamic brain states to dynamic machine states: Human and machine solutions to the speech recognition problem. PLOS Computational Biology, 13(9), e1005617-e1005617.
- 18F-AV-1451 positron emission tomography in Alzheimer’s disease and progressive supranuclear palsy. Brain, aww340-aww340.
- Classifying Cognitive Profiles Using Machine Learning with Privileged Information in Mild Cognitive Impairment. Frontiers in Computational Neuroscience, 10.
- Neural correlates of prospective memory in individuals with schizotypal personality features.. Neuropsychology, 28(3), 373-381.
- Countering Countermeasures: Detecting Identity Lies by Detecting Conscious Breakthrough. PLoS ONE, 9(3), e90595-e90595.
- Mapping tonotopic organization in human temporal cortex: representational similarity analysis in EMEG source space. Frontiers in Neuroscience, 8.
- A Toolbox for Representational Similarity Analysis. PLoS Computational Biology, 10(4), e1003553-e1003553.
- Subliminal Salience Search Illustrated: EEG Identity and Deception Detection on the Fringe of Awareness. PLoS ONE, 8(1), e54258-e54258.
- Glancing and Then Looking: On the Role of Body, Affect, and Meaning in Cognitive Control. Frontiers in Psychology, 2.
- A Winding Road: Alzheimer’s Disease Increases Circuitous Functional Connectivity Pathways. Frontiers in Computational Neuroscience, 9.
- Dementia, Advances in Magnetic Resonance Technology and Applications (pp. 321-336). Elsevier
- Attentional Deficits in Alzheimer’s Disease: Investigating the Role of Acetylcholine with Computational Modelling, Springer Series in Cognitive and Neural Systems (pp. 113-126). Springer International Publishing
- On the Fringe of Awareness: The Glance-Look Model of Attention-Emotion Interactions, Artificial Neural Networks – ICANN 2010 (pp. 504-509). Springer Berlin Heidelberg
- Salience sensitive control, temporal attention and stimulus-rich reactive interfaces, Human Attention in Digital Environments (pp. 114-144). Cambridge University Press
Conference proceedings papers
- Spatiotemporal Searchlight Representational Similarity Analysis in EMEG Source Space. 2012 Second International Workshop on Pattern Recognition in NeuroImaging, 2 July 2012 - 4 July 2012.
- Vascular risk factors modulate gender-specific aging of brain white matter structural network, Cold Spring Harbor Laboratory.
- Path integration selectively predicts midlife risk of Alzheimer’s disease, Cold Spring Harbor Laboratory.
- Individual Variability in Structural Connectivity Architecture of the Human Brain across the Middle-aged and Old Adult, Cold Spring Harbor Laboratory.
- A systematic review of near-infrared spectroscopy in dementia, Cold Spring Harbor Laboratory.
- Assessment of Alzheimer-related Pathologies of Dementia Using Machine Learning Feature Selection, Research Square.
- Assessment of Alzheimer-related Pathologies of Dementia Using Machine Learning Feature Selection, medRxiv.
- On the similarities of representations in artificial and brain neural networks for speech recognition, Cold Spring Harbor Laboratory.
- Correlation of Microglial Activation with White Matter Changes in Dementia with Lewy Bodies, Cold Spring Harbor Laboratory.
- Neuroinflammation and functional connectivity in Alzheimer’s disease: interactive influences on cognitive performance, Cold Spring Harbor Laboratory.
- Relating dynamic brain states to dynamic machine states: human and machine solutions to the speech recognition problem, Cold Spring Harbor Laboratory.
Principal funding sources:
- Alzheimer’s Research UK
- Alzheimer’s Society
- The Lewy Body Society
- Addenbrooke’s Charitable Trust
- Isaac Newton Trust