Dr Matthew Livesey


Neuroscience, School of Medicine and Population Health

Research Fellow

Matt Livesey
Profile picture of Matt Livesey
+44 114 222 2233

Full contact details

Dr Matthew Livesey
Neuroscience, School of Medicine and Population Health
Sheffield Institute for Translational Neuroscience (SITraN)
385a Glossop Road
S10 2HQ

I studied Pharmacology (B.Sc. Hons) at the University of Edinburgh between 2001 – 2005. In 2005, I joined the Department of Neuroscience, University of Dundee, to undertake a BBSRC-Case PhD studentship. Here, using patch-clamp electrophysiology techniques, I examined the structure-function of pentameric ligand-gated ion channels. My time in Dundee included a short post-doctoral position (JBC, 2008 and JBC, 2011).

I joined the University of Edinburgh at the start of 2011 and undertook a postdoctoral position to examine the functional capabilities and developmental properties of pluripotent stem cell-derived cortical neurons (J.Neurosci, 2014; J.Physiol, 2014 and PLoS One, 2014). In this time I became interested in using this technology in order to model disease, specifically amyotrophic lateral sclerosis and frontotemporal dementia, and was awarded a Royal Society of Edinburgh Fellowship (2015) in order to investigate synaptic impairments in ALS-FTD (Nature Neuroscience, 2016; Nature Communications, 2018; J.Pathology, 2020; Molecular Neurodegeneration, 2021). Furthermore, noting the increasing appreciation of the roles of non-neuronal cell types in healthy neuronal health and disease, I have also explored the functional properties of oligodendrocytes-derived from ALS patients (Stem Cells, 2016) and also began to examine the heavily underexplored area of oligodendrocyte physiology (Glia, 2019; Journal of Neuroscience, 2021).  

In March 2020, I arrived at SITraN as a principle investigator to lead work on neurophysiological perturbations and their mechanistic bases in ALS-FTD.

Research interests

In neurodegenerative disease, neuronal dysfunction precedes neuronal death. My research interests centre around understanding these functional disturbances in neurons. Furthermore, it is increasingly regarded that such diseases are not ‘purely’ neuronal and often include a role for their supporting cells called glia. Our research also therefore investigates the properties of glia; both their functional properties and their role on neuronal function.

To do this we combine multiple research specialisations; electrophysiology, human in vitro cell models and rodent models.

Current Projects

  •  Glutamatergic dysfunction in ALS patient-derived neurons and glia.
  •  Synaptic pathophysiology in cortical neurons derived from ALS patients.
  •  The physiological role of C9ORF72.
  •  The role of ion channels on oligodendrocyte-lineage cell function.

Journal articles



Research group
  • Ms Iris Pasniceanu (PhD student)
  • Mr Manpreet Atwal (PhD student)
  • Ms Marilina Douloudi (PhD Student)
  • Research Lab Alumni (including current position where known)
  • Ms Niamh Conway (MSc student)
  • Ms Zahra Shather (MSc student, Research assistant at Samsara Therapeutics)
  • Ms Ergita Bali (Technician, PhD student at University of Sheffield)
  • Ms Amelia Potter (MSc student)

The lab is currently funded by the following sources;

  • Motor Neurone Disease Association
  • MRC
  • Industrial collaboration with MSD

Previous funders

  • ARUK
  • Royal Society
  • Rosetrees Trust
Professional activities and memberships


  • Post-graduate research tutor
  • MSc teaching


  • Peer reviewer for journals including Nature Communications, Cell Reports, Journal of Neuroscience and Journal of Physiology.
  • Peer reviewer for grant funding bodies including MRC, BBSRC, NC3Rs, MNDA and ARUK.