Dr Ryan West

Neuroscience, School of Medicine and Population Health

Dementia Research Leader Fellow

Dr Ryan West
Profile picture of Dr Ryan West
+44 114 222 2239

Full contact details

Dr Ryan West
Neuroscience, School of Medicine and Population Health
Sheffield Institute for Translational Neuroscience (SITraN)
385a Glossop Road
S10 2HQ

2023 – present: Alzheimer’s Society Dementia Research Leader Fellow (SITraN, University of Sheffield)

2019 – 2023: SITraN Fellow and Alzheimer’s Society Fellow (SITraN, University of Sheffield)

2018 – 2019: Alzheimer’s Society Junior Fellow (University of Manchester)

2015 – 2018: Postdoctoral Research Associate (University of York)

2013-2015: Centre for Chronic Diseases and Disorders Wellcome Trust funded “Discipline hopping” Fellow (University of York)

2010 - 2013: PhD, The University of York

Research interests

My research looks to use Drosophila melanogaster (fruit flies) as a powerful genetic model organism to dissect the molecular mechanisms contributing to neurodegenerative diseases including dementia, motor neurone disease and Parkinson’s disease. My primary research focuses on two overlapping neurodegenerative disorders, Frontotemporal Dementia (FTD) and Motor Neurone Disease (MND). I am particularly interested in how dipeptide-repeats associated with the disease causing hexanucleotide expansion within the C9orf72 gene contribute towards neurodegeneration. In the lab we have a number of Drosophila models of both FTD and MND including C9orf72 related DPRs, C9orf72 pure repeat models and models of CHMP2B, VCP and TDP-43 related disease. I am also interested in how we can use Drosophila as part of a translational pipeline both to understand the molecular mechanisms of disease and as part of a drug-screening strategy.


Journal articles


Research group

PhD Students

  • Duncan Garner
  • Charlotte Gale
  • Ergita Balli
  • Abbie Stretch

Postdoctoral Research Associates

  • Debarati Bhattacharya
  • Kriti Gupta
Professional activities and memberships
  • Member of NC3Rs Studentship Grant Panel, January 2023 - present
Current Funding Sources
  • Alzheimer’s Society
  • ARUK
  • Motor Neurone Disease Association
  • My Name’5 Doddie Foundation