Dr Munya Dimairo
BSc (Hons) (Statistics), MSc (Medical Statistics), PhD (Medical Statistics)
Population Health, School of Medicine and Population Health
Senior Research Fellow/ Statistician
+44 114 222 5204
Full contact details
Population Health, School of Medicine and Population Health
Room 2029
Regent Court (ScHARR)
30 Regent Street
Sheffield
S1 4DA
- Profile
-
Munya leads statistical support in the design, conduct, monitoring, analysis, and reporting of studies (mostly clinical trials) within the University of Sheffield Clinical Trials Research Unit (CTRU). This includes overseeing multiple projects that are at various stages to ensure high-quality delivery. He also supports research proposal development of research for funding. In addition, Munya leads and collaborates on methodological research aimed at improving efficiency in the conduct of trials as well as the implementation of innovative and efficient designs within the unit, such as adaptive trial designs. His vast research interests are around innovative clinical trials statistical methodology and their translation into routine practice. He serves as an independent statistician on trial steering and data monitoring committees of several publicly funded clinical trials.
Munya holds a BSc (Hons) in Statistics from the University of Zimbabwe, an MSc in Medical Statistics from the London School of Hygiene and Tropical Medicine (funded by Wellcome Trust), and a PhD in Medical Statistics from the University of Sheffield (funded by the NIHR, DRF-2012-05-182). His PhD investigated the utility of adaptive designs in publicly funded confirmatory trials.
Munya is based in the Design, Trials and Statistics (DTS) section within ScHARR.
- Qualifications
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BSc (Hons) (Statistics), MSc (Medical Statistics), PhD (Medical Statistics)
- Research interests
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- Clinical trials methodology
- Adaptive designs, especially group sequential methods and treatment selection in multi-arm and platform trials
- Transparency and reporting of adaptive trials
- Statistical issues around the application of a stepped wedge trial design
- Bayesian inference and borrowing of information in clinical trials
- Early phase clinical trials
- Diagnostic accuracy studies
- Hierarchical or Multilevel modelling
- Multiple imputation techniques in dealing with missing data
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Reporting and communication of sample size calculations in adaptive clinical trials: a review of trial protocols and grant applications. BMC Medical Research Methodology, 24(1). View this article in WRRO
- Outpatient paracentesis for the management of ovarian hyperstimulation syndrome: study protocol for the STOP-OHSS randomised controlled trial. BMJ Open, 14(1), e076434-e076434.
- Enhancing reporting quality and impact of early phase dose-finding clinical trials: CONSORT Dose-finding Extension (CONSORT-DEFINE) guidance.. BMJ, 383, e076387.
- Enhancing quality and impact of early phase dose-finding clinical trial protocols: SPIRIT Dose-finding Extension (SPIRIT-DEFINE) guidance.. BMJ, 383, e076386.
- Development of consensus-driven SPIRIT and CONSORT extensions for early phase dose-finding trials: the DEFINE study. BMC Medicine, 21(1), 246.
- Point estimation for adaptive trial designs II: practical considerations and guidance.. Statistics in Medicine.
- SPIRIT and CONSORT extensions for early phase dose-finding clinical trials: the DEFINE (DosE-FIndiNg Extensions) study protocol. BMJ Open, 13.
- Point estimation for adaptive trial designs I: a methodological review. Statistics in Medicine.
- Practical guidance for planning resources required to support publicly-funded adaptive clinical trials. BMC Medicine, 20(1). View this article in WRRO
- Endometrial scratch to increase live birth rates in women undergoing first-time in vitro fertilisation : RCT and systematic review. Health Technology Assessment, 26(10), 1-211. View this article in WRRO
- The need for reporting guidelines for early phase dose-finding trials: Dose-Finding CONSORT Extension. Nature Medicine, 28(1), 6-7.
- Costs and staffing resource requirements for adaptive clinical trials: quantitative and qualitative results from the Costing Adaptive Trials project. BMC Medicine, 19(1). View this article in WRRO
- A randomised controlled trial to assess the clinical effectiveness and safety of the endometrial scratch procedure prior to first-time IVF, with or without ICSI. Human Reproduction, 36(7), 1841-1853. View this article in WRRO
- Self-managed, computerised word finding therapy as an add-on to usual care for chronic aphasia post-stroke : an economic evaluation. Clinical Rehabilitation. View this article in WRRO
- The adaptive designs CONSORT extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design. Trials, 21(1). View this article in WRRO
- The Adaptive designs CONSORT Extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design. BMJ, 369. View this article in WRRO
- Computerised speech and language therapy or attention control added to usual care for people with long-term post-stroke aphasia : the Big CACTUS three-arm RCT. Health Technology Assessment, 24(19), 1-176. View this article in WRRO
- Self-managed, computerised speech and language therapy for patients with chronic aphasia post-stroke compared with usual care or attention control (Big CACTUS) : a multicentre, single-blinded, randomised controlled trial. The Lancet Neurology, 18(9), 821-833. View this article in WRRO
- A review of perspectives on the use of randomization in phase II oncology trials. JNCI: Journal of the National Cancer Institute. View this article in WRRO
- Delphi consensus reached to produce a decision tool for SelecTing Approaches forRapid Reviews (STARR). Journal of Clinical Epidemiology. View this article in WRRO
- Development process of a consensus-driven CONSORT extension for randomised trials using an adaptive design. BMC Medicine, 16. View this article in WRRO
- Appropriate statistical methods for analysing partially nested randomised controlled trials with continuous outcomes: a simulation study.. BMC Medical Research Methodology, 18(1), 105-105. View this article in WRRO
- Adaptive designs in clinical trials: why use them, and how to run and report them. BMC Medicine, 16. View this article in WRRO
- A cluster randomised trial, cost-effectiveness analysis and psychosocial evaluation of insulin pump therapy compared with multiple injections during flexible intensive insulin therapy for type 1 diabetes: the REPOSE Trial. Health Technology Assessment, 21(20), 1-278. View this article in WRRO
- Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE). BMJ, 356. View this article in WRRO
- Informing efficient randomised controlled trials: Exploration of challenges in developing progression criteria for internal pilot studies. BMJ Open, 7(e013537). View this article in WRRO
- Recommendations for the analysis of individually randomised controlled trials with clustering in one arm – a case of continuous outcomes. BMC Medical Research Methodology, 16. View this article in WRRO
- Adaptive designs undertaken in clinical research: a review of registered clinical trials. Trials, 17(1). View this article in WRRO
- Missing steps in a staircase: a qualitative study of the perspectives of key stakeholders on the use of adaptive designs in confirmatory trials. Trials, 16(1). View this article in WRRO
- Cross-sector surveys assessing perceptions of key stakeholders towards barriers, concerns and facilitators to the appropriate use of adaptive designs in confirmatory trials. Trials, 16(1). View this article in WRRO
- Sample size requirements to estimate key design parameters from external pilot randomised controlled trials: a simulation study. Trials, 15(1), 264-264. View this article in WRRO
- A randomised controlled trial and cost-effectiveness evaluation of 'booster' interventions to sustain increases in physical activity in middle-aged adults in deprived urban neighbourhoods.. Health Technol Assess, 18(13), 1-210.
- Risk factors for mortality in smear-negative tuberculosis suspects: A cohort study in Harare, Zimbabwe. International Journal of Tuberculosis and Lung Disease, 15(10), 1390-1396.
- Skin disease among human immunodeficiency virus-infected adolescents in Zimbabwe: a strong indicator of underlying HIV infection.. Pediatr Infect Dis J, 29(4), 346-351.
- The risk and timing of tuberculosis diagnosed in smear-negative TB suspects: A 12 month cohort study in Harare, Zimbabwe. PLoS ONE, 5(7). View this article in WRRO
- Diagnostic accuracy of commercial urinary lipoarabinomannan detection in African tuberculosis suspects and patients.. Int J Tuberc Lung Dis, 13(10), 1253-1259.
- tVNS in Stroke: A Narrative Review on the Current State and the Future. Stroke.
- An Investigation of the Shortcomings of the CONSORT 2010 Statement for the Reporting of Group Sequential Randomised Controlled Trials: A Methodological Systematic Review. PLOS ONE, 10(11), e0141104-e0141104. View this article in WRRO
Conference proceedings papers
- Journeying through the development of an adaptive designs reporting guidance: findings from Delphi process. CEN ISBS Vienna 2017 (pp 94-94), 28 August 2017 - 1 September 2017.
- Journeying through the development of an adaptive designs reporting guidance: preliminary findings. Evidence Live 2017 (pp 42-43), 21 June 2017 - 22 June 2017.
- Meandering journey towards routine trial adaptation: survey results on barriers to use of adaptive designs in confirmatory trials. Trials, Vol. 16(S2) View this article in WRRO
- Investigation of the shortcomings of the consort 2010 statement for the reporting of group sequential randomised controlled trials. Trials, Vol. 16(S2) View this article in WRRO
- Differential reporting of group sequential RCTs: shortcomings ofthe CONSORT 2010 statement. CPS 11: Group Sequential Methods and Interim Analysis. ARLINGTON, VIRGINIA, USA, 17 May 2015 - 20 May 2015.
- Sample size determination through power simulation; practical lessons from a stepped wedge cluster randomised trial (SW CRT).. Trials, Vol. 12 Suppl 1 (pp A26)
- The Fate of Sputum Smear-negative TB Suspects Managed by Routine Clinical Services in Harare, Zimbabwe. 16th Conference on Retroviruses and Opportunistic Infections, Vol. 17(2). Montreal; Canada
- Risk Factors and Timing of Mortality in HIV+ Smear-negative TB Suspects: 12-Month Cohort Study in Harare, Zimbabwe. 18th Conference on Retroviruses and Opportunistic Infections, Montreal. Boston, USA, 27 February 2011 - 2 March 2011.
Website content
Posters
- View this article in WRRO Journeying through the development of a consensus-driven adaptive designs reporting guidance. Global Forum on Bioethics in Research.
- Methods to analyse partially nested randomised controlled trials.
Theses / Dissertations
All publications
Journal articles
- Reporting and communication of sample size calculations in adaptive clinical trials: a review of trial protocols and grant applications. BMC Medical Research Methodology, 24(1). View this article in WRRO
- Exploring the barriers to, and importance of, participant diversity in early-phase clinical trials: an interview-based qualitative study of professionals and patient and public representatives. BMJ Open, 14(3). View this article in WRRO
- Outpatient paracentesis for the management of ovarian hyperstimulation syndrome: study protocol for the STOP-OHSS randomised controlled trial. BMJ Open, 14(1), e076434-e076434.
- The MAGIC trial: a pragmatic, multicentre, parallel, noninferiority, randomised trial of melatonin versus midazolam in the premedication of anxious children attending for elective surgery under general anaesthesia. British Journal of Anaesthesia.
- Enhancing reporting quality and impact of early phase dose-finding clinical trials: CONSORT Dose-finding Extension (CONSORT-DEFINE) guidance.. BMJ, 383, e076387.
- Enhancing quality and impact of early phase dose-finding clinical trial protocols: SPIRIT Dose-finding Extension (SPIRIT-DEFINE) guidance.. BMJ, 383, e076386.
- O08 Mesenchymal stromal cells infusions in children with recessive dystrophic epidermolysis bullosa (MissionEB): a randomized controlled trial. British Journal of Dermatology, 189(3), e42-e43.
- Development of consensus-driven SPIRIT and CONSORT extensions for early phase dose-finding trials: the DEFINE study. BMC Medicine, 21(1), 246.
- Point estimation for adaptive trial designs II: practical considerations and guidance.. Statistics in Medicine.
- SPIRIT and CONSORT extensions for early phase dose-finding clinical trials: the DEFINE (DosE-FIndiNg Extensions) study protocol. BMJ Open, 13.
- Point estimation for adaptive trial designs I: a methodological review. Statistics in Medicine.
- Practical guidance for planning resources required to support publicly-funded adaptive clinical trials. BMC Medicine, 20(1). View this article in WRRO
- Endometrial scratch to increase live birth rates in women undergoing first-time in vitro fertilisation : RCT and systematic review. Health Technology Assessment, 26(10), 1-211. View this article in WRRO
- The need for reporting guidelines for early phase dose-finding trials: Dose-Finding CONSORT Extension. Nature Medicine, 28(1), 6-7.
- Costs and staffing resource requirements for adaptive clinical trials: quantitative and qualitative results from the Costing Adaptive Trials project. BMC Medicine, 19(1). View this article in WRRO
- A randomised controlled trial to assess the clinical effectiveness and safety of the endometrial scratch procedure prior to first-time IVF, with or without ICSI. Human Reproduction, 36(7), 1841-1853. View this article in WRRO
- Self-managed, computerised word finding therapy as an add-on to usual care for chronic aphasia post-stroke : an economic evaluation. Clinical Rehabilitation. View this article in WRRO
- Non-randomised studies should be considered for assessing surgical techniques in rectal prolapse : prospective cohort study. Colorectal Disease. View this article in WRRO
- The adaptive designs CONSORT extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design. Trials, 21(1). View this article in WRRO
- The Adaptive designs CONSORT Extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design. BMJ, 369. View this article in WRRO
- Computerised speech and language therapy or attention control added to usual care for people with long-term post-stroke aphasia : the Big CACTUS three-arm RCT. Health Technology Assessment, 24(19), 1-176. View this article in WRRO
- Self-managed, computerised speech and language therapy for patients with chronic aphasia post-stroke compared with usual care or attention control (Big CACTUS) : a multicentre, single-blinded, randomised controlled trial. The Lancet Neurology, 18(9), 821-833. View this article in WRRO
- A review of perspectives on the use of randomization in phase II oncology trials. JNCI: Journal of the National Cancer Institute. View this article in WRRO
- Delphi consensus reached to produce a decision tool for SelecTing Approaches forRapid Reviews (STARR). Journal of Clinical Epidemiology. View this article in WRRO
- Development process of a consensus-driven CONSORT extension for randomised trials using an adaptive design. BMC Medicine, 16. View this article in WRRO
- Appropriate statistical methods for analysing partially nested randomised controlled trials with continuous outcomes: a simulation study.. BMC Medical Research Methodology, 18(1), 105-105. View this article in WRRO
- Cost-effectiveness of insulin pumps compared with multiple daily injections both provided with structured education for adults with type 1 diabetes: a health economic analysis of the Relative Effectiveness of Pumps over Structured Education (REPOSE) randomised controlled trial. BMJ Open, 8(4). View this article in WRRO
- Adaptive designs in clinical trials: why use them, and how to run and report them. BMC Medicine, 16. View this article in WRRO
- Physiotherapy for Patients with Sciatica Awaiting Lumbar Micro-discectomy Surgery: A Nested, Qualitative Study of Patients' Views and Experiences. European Spine Journal, 22(3). View this article in WRRO
- A cluster randomised trial, cost-effectiveness analysis and psychosocial evaluation of insulin pump therapy compared with multiple injections during flexible intensive insulin therapy for type 1 diabetes: the REPOSE Trial. Health Technology Assessment, 21(20), 1-278. View this article in WRRO
- Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE). BMJ, 356. View this article in WRRO
- Informing efficient randomised controlled trials: Exploration of challenges in developing progression criteria for internal pilot studies. BMJ Open, 7(e013537). View this article in WRRO
- Recommendations for the analysis of individually randomised controlled trials with clustering in one arm – a case of continuous outcomes. BMC Medical Research Methodology, 16. View this article in WRRO
- Adaptive designs undertaken in clinical research: a review of registered clinical trials. Trials, 17(1). View this article in WRRO
- Who gains clinical benefit from using insulin pump therapy? A qualitative study of the perceptions and views of health professionals involved in the Relative Effectiveness of Pumps over MDI and Structured Education (REPOSE) trial. Diabetic Medicine, 33(2), 243-251.
- Missing steps in a staircase: a qualitative study of the perspectives of key stakeholders on the use of adaptive designs in confirmatory trials. Trials, 16(1). View this article in WRRO
- Cross-sector surveys assessing perceptions of key stakeholders towards barriers, concerns and facilitators to the appropriate use of adaptive designs in confirmatory trials. Trials, 16(1). View this article in WRRO
- Sample size requirements to estimate key design parameters from external pilot randomised controlled trials: a simulation study. Trials, 15(1), 264-264. View this article in WRRO
- A randomised controlled trial and cost-effectiveness evaluation of 'booster' interventions to sustain increases in physical activity in middle-aged adults in deprived urban neighbourhoods.. Health Technol Assess, 18(13), 1-210.
- Sample size requirements for pilot randomised controlled trials with continuous outcomes: a simulation study. Trials, 14(Suppl 1), 46.
- Discussion on the paper by Hampson and Jennison. JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 75(1), 40-54.
- Exploring the relationship between baseline physical activity levels and mortality reduction associated with increases in physical activity: a modelling study.. BMJ Open, 3(10), e003509. View this article in WRRO
- Sample size requirements for pilot randomised controlled trials with binary outcomes: a simulation study. Trials, 14(Suppl 1), O21.
- Computer therapy compared with usual care for people with long-standing aphasia poststroke: a pilot randomized controlled trial.. Stroke, 43(7), 1904-1911.
- Computerised cognitive behavioural therapy for the treatment of depression in people with multiple sclerosis: external pilot trial.. Trials, 12, 259. View this article in WRRO
- "Booster" interventions to sustain increases in physical activity in middle-aged adults in deprived urban neighbourhoods: internal pilot and feasibility study.. BMC Public Health, 11, 129. View this article in WRRO
- Risk factors for mortality in smear-negative tuberculosis suspects: A cohort study in Harare, Zimbabwe. International Journal of Tuberculosis and Lung Disease, 15(10), 1390-1396.
- Skin disease among human immunodeficiency virus-infected adolescents in Zimbabwe: a strong indicator of underlying HIV infection.. Pediatr Infect Dis J, 29(4), 346-351.
- The risk and timing of tuberculosis diagnosed in smear-negative TB suspects: A 12 month cohort study in Harare, Zimbabwe. PLoS ONE, 5(7). View this article in WRRO
- Diagnostic accuracy of commercial urinary lipoarabinomannan detection in African tuberculosis suspects and patients.. Int J Tuberc Lung Dis, 13(10), 1253-1259.
- tVNS in Stroke: A Narrative Review on the Current State and the Future. Stroke.
- An Investigation of the Shortcomings of the CONSORT 2010 Statement for the Reporting of Group Sequential Randomised Controlled Trials: A Methodological Systematic Review. PLOS ONE, 10(11), e0141104-e0141104. View this article in WRRO
Conference proceedings papers
- Endometrial scratching in women undergoing their first In Vitro Fertilisation (IVF) cycle: results from the UK Multicentre Endometrial Scratch Randomised Controlled Trial. HUMAN REPRODUCTION, Vol. 35 (pp 140-141)
- Introducing the adaptive designs CONSORT extension (ACE) statement to improve reporting of randomised trials that use an adaptive design. Trials, Vol. 20(Supplement 1) (pp 2-3). Brighton, UK, 6 October 2019 - 9 October 2019. View this article in WRRO
- Journeying through the development of an adaptive designs reporting guidance: findings from Delphi process. CEN ISBS Vienna 2017 (pp 94-94), 28 August 2017 - 1 September 2017.
- Journeying through the development of an adaptive designs reporting guidance: preliminary findings. Evidence Live 2017 (pp 42-43), 21 June 2017 - 22 June 2017.
- Erratum to: Researching Complex Interventions in Health: The State of the Art. BMC Health Services Research, Vol. 16(1) View this article in WRRO
- Meandering journey towards routine trial adaptation: survey results on barriers to use of adaptive designs in confirmatory trials. Trials, Vol. 16(S2) View this article in WRRO
- Investigation of the shortcomings of the consort 2010 statement for the reporting of group sequential randomised controlled trials. Trials, Vol. 16(S2) View this article in WRRO
- Differential reporting of group sequential RCTs: shortcomings ofthe CONSORT 2010 statement. CPS 11: Group Sequential Methods and Interim Analysis. ARLINGTON, VIRGINIA, USA, 17 May 2015 - 20 May 2015.
- Sample size determination through power simulation; practical lessons from a stepped wedge cluster randomised trial (SW CRT).. Trials, Vol. 12 Suppl 1 (pp A26)
- A phase II, randomized, open-label, pilot study to evaluate the safety and the effects on bone resorption of saracatinib (AZD0530) in patients with prostate cancer or breast cancer with metastatic bone disease. BONE, Vol. 48(1) (pp S17-S17)
- The Fate of Sputum Smear-negative TB Suspects Managed by Routine Clinical Services in Harare, Zimbabwe. 16th Conference on Retroviruses and Opportunistic Infections, Vol. 17(2). Montreal; Canada
- Risk Factors and Timing of Mortality in HIV+ Smear-negative TB Suspects: 12-Month Cohort Study in Harare, Zimbabwe. 18th Conference on Retroviruses and Opportunistic Infections, Montreal. Boston, USA, 27 February 2011 - 2 March 2011.
- Evaluation of a Commercial Urine Lipoarabinomannan ELISA Kit for Diagnosis of TB in a High HIV Prevalence Setting. 16th Conference on Retroviruses and Opportunistic Infections. Montreal, Canada, 8 February 2009 - 11 February 2011.
Website content
- Big CACTUS Statistical Analysis Plan v1.2 mar2018.
- Adaptive designs CONSORT Extension: draft checklist for round 1 Delphi survey.
- Adaptive designs CONSORT Extension: Consensus meeting report.
- Adaptive designs CONSORT Extension: draft checklist for round 2 Delphi survey.
- Adaptive designs CONSORT Extension: Reports and summary of the open-ended feedback from Delphi survey rounds.
- Development of a CONSORT Extension for adaptive clinical trials.
Posters
- View this article in WRRO Journeying through the development of a consensus-driven adaptive designs reporting guidance. Global Forum on Bioethics in Research.
- Methods to analyse partially nested randomised controlled trials.
Theses / Dissertations
Datasets
Preprints
- Confidence intervals for adaptive trial designs II: Case study and practical guidance, arXiv.
- Confidence intervals for adaptive trial designs I: A methodological review, arXiv.
- Development process of consensus-driven SPIRIT and CONSORT extensions for early phase dose-finding trials: the DEFINE (DosE FIndiNg Extensions) study, Center for Open Science.
- Point estimation for adaptive trial designs II: practical considerations and guidance, arXiv.
- Ten Simple Rules for Post-Pandemic Preprinting, ScienceOpen.
- Point estimation for adaptive trial designs.
- Point estimation for adaptive trial designs, arXiv.
- The Adaptive designs CONSORT Extension (ACE) Statement: A checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design, Research Square.
- Ten Simple Rules for Post-Pandemic Preprinting, Center for Open Science.
- Grants
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- Accelerating the development of a perinatal platform trial to efficiently evaluate the effectiveness of multiple interventions in maternity and neonatal care. NIHR (NIHR156043). Co-applicant. £199,592
- NIHR Pre-Doctoral Fellowship Award for Isabelle Wilson. NIHRC (NIHR302738). Co-applicant and Lead Supervisor. £66,757
- Diversity and inclusion in early phase trials. Research England. Co-applicant. £22.910
- Efficacy and mechanism evaluation of transcutaneous vagal nerve stimulation for upper limb recovery post-stroke – a randomised, controlled, multi-arm, multi-stage, adaptive design trial. NIHR (NIHR133169). Co-applicant. £1,704,864.
- Double-blinded placebo control study of Mesenchymal Intravenous Stromal cell Infusions in children with recessive dystrophic Epidermolysis Bullosa (MissionEB). NIHR (NIHR127963). Co-applicant. £2,451,255.
- MICA: Early Phase Dose-finding Trials: Development of reporting guidance to improve knowledge transfer. MRC (MR/T044934/1). Co-applicant. £306,579.
- STOP-OHSS (Shaping and Trialling Outpatient Protocols for Ovarian Hyper-Stimulation Syndrome): A feasibility study and randomised controlled trial, with internal pilot, to assess the clinical and cost-effectiveness of earlier active management of OHSS. NIHR HTA (NIHR128137). Co-applicant. £1,782,753.
- A Practical Adaptive & Novel Design and Analysis (PANDA) toolkit. NIHR CTU Support Funding (NIHR129761). Lead Investigator. £98,886.
- Costing Adaptive Trials (CAT): developing best practice costing guidance for CTUs supporting adaptive trials. NIHR CTU Support Funding (NIHR130351). Co-applicant. £55,629.
- Development of CONSORT guidance for adaptive clinical trials. NIHR CTU Support Funding (NIHR129671) and MRC HTMR (MR/L004933/1-R/N/P/B1). Lead Investigator in collaboration with the MRC HTMR Adaptive Designs Working Group, CONSORT Group and international researchers. £63,000.
- Utility of adaptive designs in publicly funded trials. NIHR Doctoral Research Fellowship (DRF-2012-05-182). Lead investigator. £206,221.
- NHS England Specialised Commissioning – NIHR 2018 Funding Call for CTUs. Co-applicant. £13 961.
- Outcome Measures for Emergency Care after a Seizure (OMECS): NIHR CTU Support Funding. (NIHR129743). Co-applicant. £9,852.
- Can Physiotherapy effectively treat patients with Lumbar Radicular Syndrome secondary to MRI demonstrable disc prolapse? A preliminary randomised trial of patients awaiting lumbar micro-discectomy. NIHR RfPB (PB-PG-0110-21158). Co-applicant. £197,129.
- Nutritional Rehabilitation in Stable Chronic Obstructive Pulmonary Disease (COPD) – A randomised controlled pilot trial. CLAHRC South Yorkshire. Co-applicant. £28,170.
- Masters Fellowship in Public Health and Tropical Medicine at LSHTM. Wellcome Trust (085840/Z/08/Z). Lead Investigator. £75,919.
- Teaching interests
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Supervision of postgraduate research students in areas around trials and statistical methods.
- Professional activities and memberships
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- Trials Associate Editor
- Member of the BMC Medicine Editorial Board
- Member of the Research Square Advisory Board
- Member of the ICTMC Scientific Committee
- Member of the MRC/NIHR TMRP ADWG
- Advisory board member of The Bill & Melinda Gates Foundation on adaptive trials in low- and middle-income countries
- Reviewer of grant proposals for publicly funding bodies such as NIHR and MRC
- Independent Trial Statistician on trial steering and data monitoring committees
- Independent statistical reviewer for several journals including the BMJ, The Lancet, and The Lancet Infectious Diseases
- Member of the NIHR HTA CET Funding Committee