Dr Dawn Walker
Department of Computer Science
Director of Recruitment and Marketing
Member of the Complex Systems Modelling research group
+44 114 222 1914
Full contact details
Department of Computer Science
Regent Court (DCS)
Dr Dawn Walker is a senior lecturer in the Computational Biology Group in the Department of Computer Science. Her primary research interest is the use of individual-based models to understand the function and structure of biological tissues.
She is also interested in multi-scale and multi-paradigm models in biology and medicine, and the use of bioelectric properties of epithelial tissues in early cancer diagnosis.
- Research interests
- Agent (individual) based Modelling in predicting emergent properties of biological tissues
- Multiscale Modelling in biological and biomedical applications
- Electrical Impedance Spectroscopy (EIS) for the diagnosis of early cancerous changes in epithelial tissues
- Position of the AI for Health Imaging (AI4HI) network on metadata models for imaging biobanks. European Radiology Experimental, 6(1).
- A theoretical analysis of the scale separation in a model to predict solid tumour growth.. J Theor Biol, 547, 111173.
- PRIMAGE project : predictive in silico multiscale analytics to support childhood cancer personalised evaluation empowered by imaging biomarkers. European Radiology Experimental, 4(1). View this article in WRRO
- From cell to multi-crypt: Agent-based models of the human colon suggests novel processes of field cancerisation. Journal of Computational Science. View this article in WRRO
- VPH-HF: A software framework for the execution of complex subject-specific physiology modelling workflows. Journal of Computational Science, 25, 101-114. View this article in WRRO
- A cellular based model of the colon crypt suggests novel effects for Apc phenotype in colorectal carcinogenesis. Journal of Computational Science, 24, 125-131. View this article in WRRO
- An agent-based model of anoikis in the colon crypt displays novel emergent behaviour consistent with biological observations. Royal Society Open Science, 4. View this article in WRRO
- View this article in WRRO Constructive Initialization of a Genetic Algorithm for the Solution of a Highly Constrained Departmental Timetabling Problem. International Journal of Soft Computing and Engineering, 6(4), 18-25.
- Characterization and Classification of Adherent Cells in Monolayer Culture using Automated Tracking and Evolutionary Algorithms.. BioSystems, 146, 110-121. View this article in WRRO
- Sources of variability in cytosolic calcium transients triggered by stimulation of homogeneous uro-epithelial cell monolayers. Journal of The Royal Society Interface, 12(105). View this article in WRRO
- Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. American Journal of Physiology - Renal Physiology, 305(3).
- Measuring three-dimensional strain distribution in tendon. Journal of Microscopy, 249(3), 195-205.
- Cell-type-specific modelling of intracellular calcium signalling: a urothelial cell model.. J R Soc Interface, 10(86), 20130487.
- The modulatory effect of cell–cell contact on the tumourigenic potential of pre-malignant epithelial cells: a computational exploration.. J R Soc Interface, 10(78), 20120703.
- Constructing Complex 3D Biological Environments from Medical Imaging Using High Performance Computing. IEEE/ACM Transactions on Computational Biology and Bioinformatics (ACM), 9(3), 643-654.
- Using computational modeling to investigate sperm navigation and behavior in the female reproductive tract.. Theriogenology, 77(4), 703-716.
- Computational modelling of maternal interactions with spermatozoa: Potentials and prospects. Reproduction, Fertility and Development, 23(8), 976-989.
- Multi-scale interaction of particulate flow and the artery wall. Medical Engineering and Physics, 33(7), 840-848.
- A Complex Automata approach for in-stent restenosis: Two-dimensional multiscale modelling and simulations. Journal of Computational Science.
- Multi-scale interaction of particulate flow and the artery wall.. Med Eng Phys, 33(7), 840-848.
- Differential regulation of growth-promoting signalling pathways by E-cadherin. PLoS ONE, 5(10). View this article in WRRO
- High performance cellular level agent-based simulation with FLAME for the GPU.. Brief Bioinform, 11(3), 334-347.
- Anti-social cells: predicting the influence of E-cadherin loss on the growth of epithelial cell populations.. J Theor Biol, 262(3), 425-440.
- The virtual cell--a candidate co-ordinator for 'middle-out' modelling of biological systems.. Brief Bioinform, 10(4), 450-461.
- Modelling the interaction of haemodynamics and the artery wall: current status and future prospects.. Biomed Pharmacother, 62(8), 530-535.
- The application of multiscale modelling to the process of development and prevention of stenosis in a stented coronary artery.. Philos Trans A Math Phys Eng Sci, 366(1879), 3343-3360.
- MULTISCALE MODELLING: APPLICATION OF THE COMPLEX AUTOMATA SIMULATION TECHNIQUE (COAST). Journal of Biomechanics, 41, S482-S482.
- Epitheliometer: a real time impedance device for the detection of high grade cervical intraepithelial neoplasia. BJOG-INT J OBSTET GY, 115(1), 118-118.
- From pathway to population--a multiscale model of juxtacrine EGFR-MAPK signalling.. BMC Syst Biol, 2, 102. View this article in WRRO
- Impedimetric sensing of cells on polypyrrole-based conducting polymers. J BIOMED MATER RES A, 83A(2), 391-400.
- An integrated agent-mathematical model of the effect of intercellular signalling via the epidermal growth factor receptor on cell proliferation.. J Theor Biol, 242(3), 774-789.
- Modeling the effect of exogenous calcium on keratinocyte and HaCat cell proliferation and differentiation using an agent-based computational paradigm.. Tissue Eng, 12(8), 2301-2309.
- Comparison of human uterine cervical electrical impedance measurements derived using two tetrapolar probes of different sizes.. Biomed Eng Online, 5, 62. View this article in WRRO
- Modelling the electrical properties of bladder tissue--quantifying impedance changes due to inflammation and oedema.. Physiol Meas, 26(3), 251-268.
- Electrical bioimpedance readings increase with higher pressure applied to the measuring probe.. Physiol Meas, 26(2), S39-S47.
- Agent-based computational modeling of wounded epithelial cell monolayers.. IEEE Trans Nanobioscience, 3(3), 153-163. View this article in WRRO
- Development and validation of computational models of cellular interaction.. J Mol Histol, 35(7), 659-665. View this article in WRRO
- The epitheliome: agent-based modelling of the social behaviour of cells.. Biosystems, 76(1-3), 89-100. View this article in WRRO
- Modelling of epithelial tissue impedance measured using three different designs of probe.. Physiol Meas, 24(2), 605-623.
- A study of the morphological parameters of cervical squamous epithelium.. Physiol Meas, 24(1), 121-135.
- Modelled current distribution in cervical squamous tissue.. Physiol Meas, 23(1), 159-168.
- Modelling the electrical impedivity of normal and premalignant cervical tissue. ELECTRON LETT, 36(19), 1603-1604.
- Modeling the Effect of Exogenous Calcium on Keratinocyte and HaCat Cell Proliferation and Differentiation Using an Agent-Based Computational Paradigm. Tissue Engineering, 0(0), 060913044658037-060913044658037.
Conference proceedings papers
- Automated Motion Analysis of Adherent Cells in Monolayer Culture (pp 185-194) View this article in WRRO
- The VPH Hypermodelling framework for cancer multiscale models in the clinical practice. Proceedings of the 2014 6th International Advanced Research Workshop on In Silico Oncology and Cancer Investigation - The CHIC Project Workshop (IARWISOCI), 3 November 2014 - 4 November 2014. View this article in WRRO
- A theoretical model of cytosolic calcium elevation following wounding in urothelial cell monolayers. IC-MSQUARE 2012: INTERNATIONAL CONFERENCE ON MATHEMATICAL MODELLING IN PHYSICAL SCIENCES, Vol. 410
- Modelling sperm behaviour in a 3D environment. Proceedings of the 9th International Conference on Computational Methods in Systems Biology, CMSB'11 (pp 141-149)
- 3D Modelling of Complex Biological Structures: The Oviduct.. TPCG (pp 255-262)
- Using computational systems biology to investigate sperm navigation and transport in the female reproductive tract. Systems Biology in Maternal Communication with Gametes and Embryo. Opatija, Croatia, 9 May 2010 - 13 May 2010.
- Using the GPU and multi-core CPU to generate a 3D oviduct through feature extraction from histology slides. Proceedings of the 9th Int. Workshop on Parallel and Distributed Methods in Verification, PDMC 2010 - Joint with the 2nd Int. Workshop on High Performance Computational Systems Biology, HiBi 2010 (pp 78-87)
- The Virtual Oviduct: An Essential Tool for the Application of Computational Biology Approaches to Investigation of Maternal Interaction with Gametes and Embryo. BIOLOGY OF REPRODUCTION (pp 115-115)
- Towards a complex automata multiscale model of in-stent restenosis. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Vol. 5544 LNCS(PART 1) (pp 705-714)
- COAST: Modelling Restenosis and Stent Based Therapies. INTERNATIONAL CONFERENCE ON ADVANCEMENTS OF MEDICINE AND HEALTH CARE THROUGH TECHNOLOGY, Vol. 26 (pp 319-322)
- Finite element modelling of a cell stressing device. TISSUE ENGINEERING, Vol. 13(7) (pp 1697-1698)
- SBRI Phase 2: Prototype development, Industrial, 01/2020 - 05/2021, £178,944, as Co-PI
- SANO: Centre for New Methods in Computational Diagnostics and Personalised Therapy, EC H2020, 08/2019 - 07/2026, £2,497,386, as Co-PI
- Using mechanistic computational simulation and machine learning to inform instrument design for EIS-guided surgery, Industrial, 10/2019 - 09/2023, £106,804, as PI
- PRIMAGE: PRedictive In-silico Multiscale Analytics to support cancer personalized diaGnosis and prognosis, Empowered by imaging biomarkers, EC H2020, 12/2018 to 11/2022, £549,018, as PI
- CHIC: Computational Horizons in Cancer, EC FP7, 04/2013 to 03/2017, £777,005, as Co-PI
- A combined in vitro and in virtuo multi-scale approach to understanding individual and integrated cell behaviour during homeostasis and wound repair, The Wellcome Trust, 09/2010 to 09/2013, £140,547, as PI
- MeDDiCA: Medical Devices Design in Cardiovascular Applications, University College London, 09/2009 to 08/2013, £340,386, as Co-PI
- The Virtual Tendon - a multi-scale computational model of dnamical tissue remodelling, Arthritis Research Campaign, 09/2009 to 08/2012, £155,321, as PI
- Engineering Virus-like Nanoparticles for Targeting the Central Nervous System, EPSRC, 05/2009 to 08/2012, £2,109,411, as Co-PI
- Professional activities
- Member of the Complex Systems Modelling research group
- Deputy Director of Undergraduate Admissions