Professor Arshad Majid
Department of Neuroscience
Professor of Cerebrovascular Neurology
Consultant Neurologist, Royal Hallamshire Hospital
Director, Comprehensive Cerebrovascular Research Unit
Stroke Theme Lead, Yorkshire and Humber LCRN
+44 114 222 2290
Full contact details
Department of Neuroscience
385a Glossop Road
Professor Arshad Majid’s professional mission is to develop new therapies for patients afflicted with neurological diseases, especially cerebrovascular diseases.
Professor Majid’s training and background is unique in that as well as being a leading translational neuroscientist, he is also an accomplished Vascular and Interventional Neurologist. He graduated in Medicine from the University of Glasgow, Scotland.
After obtaining Membership of the Royal College of Physicians (MRCP) he moved to the USA where he did further training in Neurology at the University of Pennsylvania and Fellowship training in Stroke Research at Washington University in St. Louis.
He did additional Fellowship training in Endovascular Surgical Neuroradiology at the Medical College of Wisconsin. Professor Majid has published extensively in high impact international peer-reviewed journals, and presented at national and international meetings.
After finishing his training, Professor Majid served as the founding Director of the Division of Cerebrovascular Diseases at Michigan State University and was the founding Medical Director of the William and Claire Dart Stroke Center at Sparrow Health System.
Professor Majid is a diplomate of the American Board of Psychiatry and Neurology and is a Fellow of the Royal College of Physicians and Surgeons of Glasgow and also serves as their Regional Advisor.
He joined the University of Sheffield and Royal Hallamshire Hospital in August 2013 as Professor of Cerebrovascular Neurology and Consultant Neurologist.
Professor Majid also serves as a Governor of Rotherham NHS Foundation Trust.
- Research interests
Key research areas:
- Neuroprotection and Neuroregeneration
- Stroke Clinical Trials,
- Animal and Cellular Models of Stroke and Neuroinflammation
- Novel Drug Delivery (nanotechnology and exosomes)
- Remote Conditioning, Vagus Nerve Stimulation.
Professor Majid is the Director of the Comprehensive Cerebrovascular Research Unit (CCRU). Professor Majid's focus is translational neuroscience research with special focus on cerebrovascular disease and neuroinflammation.
Stroke models: The models that are used in his research include both in vitro models (cell culture) and in vivo models (focal ischaemia and global ischaemia).
He is interested in understanding the pathogenesis of cerebrovascular diseases with the overall aim of developing new treatment and brain repair strategies. To this end, his lab has been successful in developing two novel treatments which are undergoing further preclinical testing before they are taken to the clinic.
He has a particular interest in ischaemic preconditioning, a fascinating phenomenon whereby animals exposed to sub-lethal or mild insults develop protection against subsequent severe insults. His lab has developed a mouse model of ischaemic preconditioning which is used extensively in their research efforts.
Other interests and areas of collaboration include: large animal (ovine) models of stroke, clinical outcomes research, clinical trials, stroke epidemiology and translational bioengineering.
- Neuroinflammation: In collaboration with Professor Basil Sharrack, Professor Majid’s lab are working on neuroprotection in Multiple Sclerosis (MS) and are developing in vitro and in vivo models of MS such as the Experimental Allergic Encephalomyelitis (EAE). This work involves study of novel carnosine analogues and the use of exosomes to modulate neuroinflammation.
- Vagal nerve stimulation: In collaboration with Dr. Jessica Redgrave and Harvey Leung (PhD student), Professor Majid has been evaluating the mechanisms of action and the feasibility and safety of invasive and non-invasive vagal nerve stimulation in limb and speech recovery after stroke.
- Exercise and stroke: In collaboration with Dr. Ali Ali, Sheffield Teaching Hospitals, the safety and efficacy of post stroke and TIA exercise programmes are being evaluated.
- Stroke vaccine: Professor Majid’s lab has developed a therapeutic vaccine which is in the final stages of preclinical testing. This project is being led by Dr. Saurabh Jain (post-doctoral fellow).
His research has been funded by the NIH, the American Heart Association, MRC (UK), NIHR (UK) and industry.
- Electroceuticals: Advances in Electrostimulation Therapies. Cham: Springer.
- LRP-1 functionalized polymersomes enhance the efficacy of carnosine in experimental stroke. Scientific Reports, 10(1). View this article in WRRO
- Comparative cerebroprotective potential of d- and l-carnosine following ischemic stroke in mice. International Journal of Molecular Sciences, 21(9). View this article in WRRO
- Intracerebral implantation of human neural stem cells and motor recovery after stroke: multicentre prospective single-arm study (PISCES-2). Journal of Neurology, Neurosurgery & Psychiatry, 91(4), 396-401. View this article in WRRO
- Autophagy-mediated occludin degradation contributes to blood–brain barrier disruption during ischemia in bEnd.3 brain endothelial cells and rat ischemic stroke models. Fluids and Barriers of the CNS, 17(1).
- Neuroprotective effects of carnosine-loaded elastic liposomes in cerebral ischemia rat model. Journal of Pharmaceutical Investigation, 50(4), 373-381.
- Transcutaneous auricular vagus nerve stimulation with upper limb repetitive task practice may improve sensory recovery in chronic stroke. Journal of Stroke and Cerebrovascular Diseases, 28(12). View this article in WRRO
- Cerebral Venous Thrombosis at High Altitude: Analysis of 28 Cases. Cerebrovascular Diseases, 48(3-6), 184-192.
- Improving the safety of atrial fibrillation monitoring systems through human verification. Safety Science, 118, 881-886.
- Improving Lung Function in Severe Heterogenous Emphysema with the Spiration Valve System (EMPROVE). A Multicenter, Open-Label Randomized Controlled Clinical Trial. American Journal of Respiratory and Critical Care Medicine, 200(11), 1354-1362.
- BS22 Double positive (CD86+ MRC1+) inflammatory macrophages in the pathogenesis of carotid atherosclerosis. Basic Science.
- Animal models of multiple sclerosis: From rodents to zebrafish.. Multiple Sclerosis Journal, 25(3), 306-324. View this article in WRRO
- Hypoxia mimetic agents for ischemic stroke. Frontiers in Cell and Developmental Biology, 6. View this article in WRRO
- Aerobic exercise interventions reduce blood pressure in patients after stroke or transient ischaemic attack: a systematic review and meta-analysis. British Journal of Sports Medicine, 53(24), 1515-1525.
- Very Delayed Remote Ischemic Post-conditioning Induces Sustained Neurological Recovery by Mechanisms Involving Enhanced Angioneurogenesis and Peripheral Immunosuppression Reversal. Frontiers in Cellular Neuroscience, 12. View this article in WRRO
- Safety and tolerability of Transcutaneous Vagus Nerve stimulation in humans; a systematic review. Brain Stimulation, 11(6), 1225-1238.
- Transcutaneous Auricular Vagus Nerve Stimulation with Concurrent Upper Limb Repetitive Task Practice for Poststroke Motor Recovery: A Pilot Study. Journal of Stroke & Cerebrovascular Diseases, 27(7), 1998-2005. View this article in WRRO
- Role of Autophagy in Endothelial Damage and Blood–Brain Barrier Disruption in Ischemic Stroke. Stroke, 49(6), 1571-1579.
- Methylglyoxal induced advanced glycation end products (AGE)/receptor for AGE (RAGE)-mediated angiogenic impairment in bone marrow-derived endothelial progenitor cells. Journal of Toxicology and Environmental Health, Part A, 81(9), 266-277.
- Central and peripheral processes in headache. Current Opinion in Supportive and Palliative Care, 12(2), 142-147.
- The economic cost of stroke-associated pneumonia in a UK setting. Topics in Stroke Rehabilitation, 25(3), 214-223.
- Enhanced anti-rheumatic activity of methotrexate-entrapped ultradeformable liposomal gel in adjuvant-induced arthritis rat model. International Journal of Pharmaceutics, 525(1), 92-100. View this article in WRRO
- Ischemic Post-Conditioning Induces Post-Stroke Neuroprotection via Hsp70-Mediated Proteasome Inhibition and Facilitates Neural Progenitor Cell Transplantation.. Mol Neurobiol. View this article in WRRO
- Systematic review and stratified meta-analysis of the efficacy of carnosine in animal models of ischemic stroke. Journal of Cerebral Blood Flow and Metabolism, 36(10), 1686-1694. View this article in WRRO
- Enhanced acute anti-inflammatory effects of CORM-2-loaded nanoparticles via sustained carbon monoxide delivery.. Eur J Pharm Biopharm, 108, 187-195. View this article in WRRO
- Selective inhibition of JAK2/STAT1 signaling and iNOS expression mediates the anti-inflammatory effects of coniferyl aldehyde. Chemico-Biological Interactions, 256, 102-110. View this article in WRRO
- Cerebral Ischemic Preconditioning: the Road So Far…. Molecular Neurobiology, 53(4), 2579-2593.
- The role of relatives in help-seeking for patients with stroke/TIA: Results from Stroke and TIA Awareness and Response to Symptoms (STARS) study. INTERNATIONAL JOURNAL OF STROKE, 10, 121-121.
- Ethnic minority recruitment into stroke research trials at a university teaching hospital in the UK.. CEREBROVASCULAR DISEASES, 39, 287-287.
- Post stroke cognitive and mood screening: The Sheffield experience. INTERNATIONAL JOURNAL OF STROKE, 9, 42-42.
- The Influence of Bolus to Infusion Delays on Plasma Tissue Plasminogen Activator Levels. International Journal of Stroke, 9(7), 939-942.
- Neuroprotective Effect of Asiatic Acid in Rat Model of Focal Embolic Stroke. Biological and Pharmaceutical Bulletin, 37(8), 1397-1401.
- Modulation of Mitochondrial Function and Autophagy Mediates Carnosine Neuroprotection Against Ischemic Brain Damage. Stroke, 45(8), 2438-2443. View this article in WRRO
- Detection of Atrial Fibrillation After Ischemic Stroke or Transient Ischemic Attack. Stroke, 45(2), 520-526.
- Neuroprotection in stroke: past, present, and future.. ISRN Neurology, 2014(2014). View this article in WRRO
- A methodical study of the role of trust at various development stages of virtual organisations. International Journal of Networking and Virtual Organisations, 14(4), 377-377.
- The impact of stent strut porosity on reducing flow in cerebral aneurysms.. J Neuroimaging, 23(4), 495-501.
- Role of histidine/histamine in carnosine-induced neuroprotection during ischemic brain damage.. Brain Res, 1527, 246-254.
- Sex differences of high-risk carotid atherosclerotic plaque with less than 50% stenosis in asymptomatic patients: an in vivo 3T MRI study.. AJNR Am J Neuroradiol, 34(5), 1049-S1.
- Safety and efficacy evaluation of carnosine, an endogenous neuroprotective agent for ischemic stroke.. Stroke, 44(1), 205-212.
- Systematic review and meta-analysis of newly detected atrial fibrillation after ischaemic stroke/TIA using non-invasive and invasive cardiac monitoring. INTERNATIONAL JOURNAL OF STROKE, 7, 17-17.
- Stroke symptoms and risk factor awareness in high school children in Pakistan. International Journal of Stroke, 7(8).
- Anesthesia for endovascular treatment of acute ischemic stroke. Neurology, 79(13 SUPPL. 1).
- Asiatic acid attenuates infarct volume, mitochondrial dysfunction, and matrix metalloproteinase-9 induction after focal cerebral ischemia.. Stroke, 43(6), 1632-1638.
- Lymphocyte cell kinase activation mediates neuroprotection during ischemic preconditioning.. J Neurosci, 32(21), 7278-7286.
- ABCD2 Score and Large-Artery Atherosclerosis. The Neurohospitalist, 2(1), 12-17.
- Symptomatic and asymptomatic carotid artery plaque.. Expert Rev Cardiovasc Ther, 9(10), 1315-1330.
- Neuroprotective effect of cyanidin-3-O-glucoside anthocyanin in mice with focal cerebral ischemia.. Neurosci Lett, 500(3), 157-161.
- Predictors of occult paroxysmal atrial fibrillation in cryptogenic strokes detected by long-term noninvasive cardiac monitoring.. Stroke Res Treat, 2011, 172074.
- Clinical significance of serum zinc levels in cerebral ischemia.. Stroke Res Treat, 2010, 245715.
- Endovascular treatment of symptomatic intracranial atherosclerotic disease.. Front Neurol, 1, 160.
- MR carotid plaque imaging and contrast-enhanced MR angiography identifies lesions associated with recent ipsilateral thromboembolic symptoms: an in vivo study at 3T.. AJNR Am J Neuroradiol, 31(8), 1395-1402.
- Sex differences in patients with asymptomatic carotid atherosclerotic plaque: in vivo 3.0-T magnetic resonance study.. Stroke, 41(8), 1630-1635.
- Peripheral neuropathy: differential diagnosis and management.. Am Fam Physician, 81(7), 887-892.
- Elevated levels of pre-procedural high-sensitivity C-reactive protein is associated with midterm restenosis after extra- and intracranial stenting.. J Neuroimaging, 20(1), 74-77.
- Response to letter by tsuda. Stroke, 40(12).
- Blood pressure changes after intravenous fosphenytoin and levetiracetam in patients with acute cerebral symptoms.. Epilepsy Res, 87(2-3), 268-271.
- The epidemiology of stroke in Pakistan: past, present, and future.. Int J Stroke, 4(5), 381-389.
- Asiatic acid, a pentacyclic triterpene from Centella asiatica, is neuroprotective in a mouse model of focal cerebral ischemia.. J Neurosci Res, 87(11), 2541-2550.
- Stroke Therapy Academic Industry Roundtable (STAIR) Recommendations for Extended Window Acute Stroke Therapy Trials. Stroke, 40(7), 2594-2600.
- Cardiac dysfunction after left permanent cerebral focal ischemia: the brain and heart connection.. Stroke, 40(7), 2560-2563.
- Distribution of carnosine-like peptides in the nervous system of developing and adult zebrafish (Danio rerio) and embryonic effects of chronic carnosine exposure.. Cell Tissue Res, 337(1), 45-61.
- Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations. Stroke, 40(6), 2244-2250.
- Hereditary neuropathy with liability to pressure palsies and amyotrophic lateral sclerosis.. Neurol Sci, 30(3), 241-245.
- Hypothermia Decreases The Fibrinolytic Activity Of Tissue Plasminogen Activator. STROKE, 40(4), E243-E243.
- Levetiracetam for managing neurologic and psychiatric disorders.. Am J Health Syst Pharm, 66(6), 541-561.
- Chemotherapy-related posterior reversible leukoencephalopathy syndrome.. Nat Clin Pract Neurol, 5(3), 163-169.
- The role of optical coherence tomography in vascular medicine. VASCULAR MEDICINE, 14(1), 63-71.
- Chronic total symptomatic carotid artery occlusion treated successfully with stenting and angioplasty.. J Neuroimaging, 19(1), 68-71.
- Extent of intra-arterial calcification on head CT is predictive of the degree of intracranial atherosclerosis on digital subtraction angiography.. Cerebrovasc Dis, 28(1), 45-48.
- Erratum: Treatment of a basilar artery occlusion with intra-arterial thrombolysis in a 3-year-old girl (Neurocrit Care) DOI: 10.1007/s12028-008-9086- 7). Neurocritical Care, 9(3), 412.
- Response to letter by Tsuda. Stroke, 39(11).
- Role of sildenafil in neurological disorders.. Clin Neuropharmacol, 31(6), 353-362.
- Lower pretreatment cerebral blood volume affects hemorrhagic risks after intra-arterial revascularization in acute stroke.. Neurosurgery, 63(5), 874-878.
- The WHO STEPwise Approach to Stroke Surveillance. JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN, 18(10), 665-665.
- Differential neuroprotective effects of carnosine, anserine, and N-acetyl carnosine against permanent focal ischemia.. J Neurosci Res, 86(13), 2984-2991.
- Intravascular ultrasound to assess extracranial vertebral artery restenosis: case report.. J Neuroimaging, 18(3), 336-339.
- Effect of pretreatment with statins on ischemic stroke outcomes.. Stroke, 39(6), 1779-1785.
- In-hospital stroke in a statewide stroke registry.. Cerebrovasc Dis, 25(1-2), 12-20.
- The effect of anticonvulsant drugs on the fibrinolytic activity of tissue plasminogen activator.. Cerebrovasc Dis, 25(1-2), 107-110.
- Treatment of a basilar artery occlusion with intra-arterial thrombolysis in a 3-year-old girl.. Neurocrit Care, 9(3), 357-360.
- Periodic lateralized epileptiform discharges: an initial electrographic pattern in reversible posterior leukoencephalopathy syndrome.. Neurol Neurochir Pol, 42(1), 55-59.
- Carnosine is neuroprotective against permanent focal cerebral ischemia in mice.. Stroke, 38(11), 3023-3031.
- Implementation of an emergency department-based transient ischemic attack clinical pathway: A pilot study in knowledge translation. ACADEMIC EMERGENCY MEDICINE, 14(11), 1114-1119.
- The mTOR pathway as a potential target for the development of therapies against neurological disease.. Drug News Perspect, 20(8), 495-499.
- Transcranial Doppler measurements in migraine and nitroglycerin headache.. J Headache Pain, 8(5), 289-293.
- US multicenter experience with the Wingspan stent system for the treatment of intracranial atheromatous disease: Periprocedural results . Stroke, 38(9).
- Role of intravenous levetiracetam in status migrainosus . Journal of Headache and Pain, 8(2), 143-144. View this article in WRRO
- IV levetiracetam in the management of non-convulsive status epilepticus.. Neurocrit Care, 7(1), 36-39.
- Transcranial Doppler: an introduction for primary care physicians.. J Am Board Fam Med, 20(1), 65-71.
- Delayed ischemia after subarachnoid hemorrhage: result of vasospasm alone or a broader vasculopathy?. VASCULAR MEDICINE, 12(3), 243-249.
- The therapeutic potential of statins in neurological disorders. CURRENT MEDICINAL CHEMISTRY, 14(1), 103-112.
- IV tissue plasminogen activator use in acute stroke: experience from a statewide registry.. Neurology, 66(3), 306-312.
- Inhibition of brain GTP cyclohydrolase I and tetrahydrobiopterin attenuates cerebral infarction via reducing inducible NO synthase and peroxynitrite in ischemic stroke. STROKE, 36(12), 2705-2711.
- Inhibition of brain GTP cyclohydrolase I and tetrahydrobiopterin attenuates cerebral infarction via reducing inducible NO synthase and peroxynitrite in ischemic stroke.. Stroke, 36(12), 2705-2711.
- Carnosine is neuroprotective in a mouse model of stroke. Journal of Cerebral Blood Flow & Metabolism, 25(1_suppl), S313-S313.
- Minocycline has no effect on the fibrinolytic activity of alteplase. ANNALS OF PHARMACOTHERAPY, 39(2), 387-388.
- Ischemia and ischemic tolerance in the brain: an overview.. Neurotoxicology, 25(6), 895-904.
- The potential of minocycline for neuroprotection in human neurologic disease.. Clin Neuropharmacol, 27(6), 293-298.
- Images in vascular medicine. An unusual presentation of cerebral sinus thrombosis.. Vasc Med, 9(3), 225-226.
- Epstein–Barr virus myeloradiculitis and encephalomyeloradiculitis. Brain, 125(1), 159-165.
- Differences in Vulnerability to Permanent Focal Cerebral Ischemia Among 3 Common Mouse Strains. Stroke, 31(11), 2707-2714.
- The order of draw of blood specimens into additive containing tubes not affect potassium and calcium measurements.. Journal of Clinical Pathology, 49(12), 1019-1020.
- Effects of tiagabine and vigabatrin on GABA uptake into primary cultures of rat cortical astrocytes. Seizure, 5(3), 229-234.
- Involvement of alpha 1-adrenoceptors in the depolarizing but not the hyperpolarizing responses of motorneurones in the neonate rat to noradrenaline. Neuropharmacology, 1399-404.
- The Potential of Carnosine in Brain-Related Disorders: A Comprehensive Review of Current Evidence. Nutrients, 11(6), 1196-1196.
- The Potential of Adaptive Design in Animal Studies. International Journal of Molecular Sciences, 16(10), 24048-24058. View this article in WRRO
- Electroceutical Approaches for the Treatment of Traumatic Brain Injury, Electroceuticals (pp. 55-73). Springer International Publishing
- Carnosine-induced neuroprotection, Food and Nutritional Components in Focus (pp. 412-431).
- Chapter 6. The Molecular Neuroprotective Strategies in Cerebral Ischemia: An Insight into Emerging Treatments for Oxidative Stress, Acute Brain Impairment (pp. 82-104). Royal Society of Chemistry
- CHAPTER 22. Carnosine-Induced Neuroprotection, Food and Nutritional Components in Focus (pp. 412-431). Royal Society of Chemistry
Conference proceedings papers
- Stroke and TIA awareness and response to symptoms study (STARSS): assessing the relationship between stroke knowledge and help-seeking behaviour. INTERNATIONAL JOURNAL OF STROKE, Vol. 13 (pp 21-21)
- P16 HUMAN MACROPHAGE SUBSETS IN THE PATHOGENESIS OF CAROTID ATHEROSCLEROSIS. Cardiovascular Research, Vol. 114(suppl_2) (pp S5-S6)
- 116 Semi-quantitative imaging of macrophages in human carotid atherosclerotic plaques. Basic Science
- Microglial activation in recent ischemic stroke: comparison of two TSPO tracers. JOURNAL OF NUCLEAR MEDICINE, Vol. 58
- Difference in Acute Ischemic Post Thrombolytic Stroke Outcomes in Pre Comprehensive and Post Comprehensive Status: Single Center Experience. STROKE, Vol. 47
- Inter-rater Reliability of Transient Ischemic Attack Diagnosis in the Emergency Department. STROKE, Vol. 41(4) (pp E203-E203)
- Stroke Symptoms and Risk Factor Awareness Amongst High School Children in Pakistan. STROKE, Vol. 41(4) (pp E291-E291)
- Concordance Between Patient Bedside Dysphagia Assessment Results Obtained From Neurological Nurses and Speech Pathologists. STROKE, Vol. 41(4) (pp E230-E230)
- Predictors of discharge disposition for TIA cases presenting to community-based emergency departments. STROKE, Vol. 39(2) (pp 704-704)
- Ability of the ABCD2 clinical prediction rule to identify low-risk TIA cases in community-based emergency departments. STROKE, Vol. 39(2) (pp 558-558)
- BLOOD PRESSURE CHANGES AFTER INTRAVENOUS LOADING WITH FOSPHENYTOIN AND LEVETIRACETAM IN PATIENTS WITH ACUTE CEREBRAL INSULTS. EPILEPSIA, Vol. 49 (pp 430-431)
- Implementation of a transient ischemic attack clinical pathway: A pilot study in knowledge translation. ANNALS OF EMERGENCY MEDICINE, Vol. 50(3) (pp S102-S102)
- Effect of pre-existing statin use on in-hospital mortality and functional status at discharge in stroke patients: A propensity-based analysis. CIRCULATION, Vol. 115(21) (pp E581-E582)
- The effect of hypoxic preconditioning on the mTOR pathway. STROKE, Vol. 37(2) (pp 682-682)
- Inhibition of brain GTP cyclohydrolase I and tetrahydrobiopterin attenuates cerebral infarction via reducing iNOS and peroxynitrite in ischemic stroke. JOURNAL OF THE NEUROLOGICAL SCIENCES, Vol. 238 (pp S388-S389)
- Factors associated with IV tPA use in eligible acute stroke patients in Michigan. STROKE, Vol. 35(1) (pp 335-335)
- Research group
Professor Majid welcomes enquiries from students interested in pursuing a doctorate in translational and clinical research. Several projects, preclinical (translational) and clinical are available. These include development of vaccines for neurological diseases, remote conditioning, development of exosome technologies for therapeutics and development of novel neurotherapeutics.
Post-Doctoral Scientists (short and long-term):
Several preclinical and clinical projects are available.
- Teaching activities
Professor Majid is the Phase 3a Neurology Lead for Sheffield Medical school.