Established in 2020 and funded by Mesothelioma UK, the Mesothelioma UK Research Centre - Sheffield conducts a portfolio of robust and rigorous research with a reputation for excellence nationally and internationally.
- Conduct robust and rigorous research with a reputation for excellence nationally and internationally that is of benefit to the care of people diagnosed with mesothelioma and their families,
- Produce research outputs from the outset that demonstrate the success of the Research Centre and facilitate application of findings.
- Ensure the research is disseminated rigorously to enable practice, patients and healthcare professionals remain informed and receive maximum benefit from any evidence generated between Mesothelioma UK and the Mesothelioma UK Research Centre.
- Develop and maintain the infrastructure and systems necessary to ensure the good governance and efficient running of the Research Centre.
- Develop research capacity to inform mesothelioma policy and practice and develop opportunities for future academic and clinical academic workforce related to mesothelioma.
- Generate a clear pathway to impact that improves patient experience.
Details of our current research projects can be found here
MiMES (Military Mesothelioma Experience Study)
This research is part of a larger project run by Mesothelioma UK that aims to improve the service and care provision to people who have served in the armed forces with mesothelioma.
Our 2021 paper from the European Journal of Oncology Nursing on the experiences of male military veterans with mesothelioma can be accessed here.
A full report of the study can be accessed here.
Gendered Experience of Mesothelioma Study (GEMS)
The GEMS study aims to explore the experiences of men and women with mesothelioma, their family carers as well as the various staff they meet. We will seek to understand why any differences that are identified occur. Our goal is to establish with participants how services should best be delivered to be accessible and acceptable to both men and women.
A full report can be accessed here. Our 2021 paper on gender and the experience of mesothelioma, published in the European Journal of Oncology Nursing, can be accessed here.
We have recently published a short animation on gender differences in experiences of mesothelioma to help support professionals
Mesothelioma Asbestos Guidelines Study (MAGS)
The study aimed to explore the experiences of presentation, diagnosis, treatment and care for health care workers with mesothelioma. The study developed a critical account of that experience and developed recommendations for increasing awareness about the dangers of asbestos amongst health care workers.
The full project report was published in September 2020. There is peer reviewed article about the study which was published in Nursing Standard, and also an article published in OH Today.
MesoTRAP was a pilot clinical trial and feasibility study comparing video-assisted thoracoscopic partial pleurectomy/decortication with indwelling pleural catheter in patients with trapped lung due to malignant pleural mesothelioma designed to address recruitment and randomisation uncertainties and sample size requirements for a Phase III trial. The protocol was published in BMJ Open Respiratory Research and can be viewed here.
RADIO Meso (Receiving a diagnosis of mesothelioma)
The project aimed to identify ways to improve the patient and family carer experience of receiving a diagnosis of mesothelioma. Following analysis the researchers identified key themes and developed ‘Ten Top Tips’ for communicating a mesothelioma diagnosis. The study findings were published in 2019 in BMJ Open Respiratory Research.
Zoledronic acid (ZA) in the management of mesothelioma: qualitative nested study (Zol-A Trial)
A double-blind randomised controlled feasibility study was conducted to assess the recruitment and acceptability of ZA/placebo alongside chemotherapy in malignant pleural mesothelioma. A qualitative nested study was included in the study and was undertaken by our team.
MARS 2: The Mesothelioma and Radical Surgery trial 2: Patient experience sub study
The MARS 2 study sought to compare extended pleurectomy decortications (EPD) surgery with no surgery in people receiving standard chemotherapy for malignant pleural mesothelioma. The qualitative sub-study aimed to generate insights into the patient experience of recruitment, consent and randomisation as well as the experience of the MARS 2 interventions. Our findings suggest that patients perceived and derived benefits from taking part in the trial but experienced some negative consequences, such as increased uncertainty amplified by multiple care providers and unclear transition arrangements after the trial.
Gardiner C, Harrison M, Hargreaves S & Taylor B (2022) Palliative care roles and responsibilities of mesothelioma clinical nurse specialists in the UK, Progress in Palliative Care, DOI: 10.1080/09699260.2022.2158286
Hargreaves S, Gardiner G, Couchman E, Caring for mesothelioma patients and their families in primary care: new tools to enable early-stage engagement with palliative care. BJGP Life. 9 December 2022
Couchman E, Fragmented. BJGP Life. 18 November 2022
Taylor B, Allmark P, Tod A (2022) The Experiences of Presentation, Diagnosis, Treatment and Care for School-Based Education Workers with Mesothelioma: A Scoping Review. Int J Nurs Health Care Res 5: 1342. DOI: 10.29011/2688-9501.101342
Hargreaves S, Clayton K, Creech L et al., Impact of Covid-19 on lung cancer and Mesothelioma specialist nurses: A survey of experiences and perceptions. European Journal of Oncology Nursing 2022 DOI:https://doi.org/10.1016/j.ejon.2022.102207
Johnson M, Allmark P, Tod A. Living beyond expectations: a qualitative study into the experience of long-term survivors with pleural mesothelioma and their carers. BMJ Open Respiratory Research 2022;9:e001252. doi: 10.1136/bmjresp-2022-001252
Sherborne S., Tod A. & Taylor B. (2022). The Psychological Effects of Mesothelioma in the UK Military Context From the Carer’s Perspective: A Qualitative Study. Illness, Crisis & Loss 2022
Gardiner C., Harrison M., Hargreaves S. & Taylor B. (2022). Clinical nurse specialist role in providing generalist and specialist palliative care: A qualitative study of mesothelioma clinical nurse specialists. Journal of Advanced Nursing, 00, 1– 10. https://doi.org/10.1111/jan.15277
Couchman E, Gardiner C, Ejegi-Memeh S, Mitchell S. Facilitators of and barriers to continuity with GPs in primary palliative cancer care: A mixed-methods systematic review. Progress in Palliative Care 2022
Ejegi-Memeh S, Taylor B, Gardiner C. Tod A. Patients' and informal carers' experience of living with mesothelioma: A systematic rapid review and synthesis of the literature. European Journal of Oncology Nursing. 2022 DOI: 10.1016/j.ejon.2022.102122
Harrison M, Darlison L, Gardiner C. Understanding the Experiences of end of Life Care for Patients with Mesothelioma from the Perspective of Bereaved Family Caregivers in the UK: A Qualitative Analysis. Journal of Palliative Care. February 2022. doi:10.1177/08258597221079235
Senek M, Robertson S, Darlison L, Creech L & Tod A (2022) Malignant pleural mesothelioma patients' experience by gender : findings from a cross-sectional UK-national questionnaire. BMJ Open Respiratory Research, 9(1).
Gardiner C, Bolton L. Role and support needs of nurses in delivering palliative and end of life care. Nursing Standard. 2021 doi: 10.7748/ns.2021.e11789
Ejegi-Memeh S, Robertson S, Taylor B, Tod A. Gender and the experiences of living with mesothelioma: A thematic analysis. European Journal of Oncology Nursing. Vol 52, June 2021. https://doi.org/10.1016/j.ejon.2021.101966
Harrison M, Gardiner C, Taylor B, Ejegi-Memeh S, Darlison L. Understanding the palliative care needs and experiences of people with mesothelioma and their family carers: An integrative systematic review. Palliative Medicine. April 2021. doi:10.1177/02692163211007379
Taylor B, Tod A, Gardiner C, Darlison L, Creech L. The impact of the covid-19 pandemic on people with mesothelioma and their informal carers in the UK. Cancer Nursing Practice. 2021 doi: 10.7748/cnp.2021.e1773
Ejegi-Memeh S, Darlison L, Moylan A, Tod A, Sherborne V, Warnock C, Taylor B. Living with mesothelioma: A qualitative study of the experiences of male military veterans in the UK. European Journal of Oncology Nursing. Volume 50, February 2021 https://doi.org/10.1016/j.ejon.2020.101889
Allmark A, Tod A, Darlison L (2020) Mesothelioma: are nurses being put at risk in the workplace? Nursing Standard 35(12):14-16 https://rcni.com/nursing-standard/features/mesothelioma-are-nurses-being-put-risk-workplace-168506
Senek M, Robertson S, Tod A et al. Mesothelioma: exploring gender differences in time to diagnosis, seeking legal advice and occupational risk. Cancer Nursing Practice. 2020 doi: 10.7748/cnp.2020.e1745
Sherborne, V, Seymour, J, Taylor, B, Tod, A. What are the psychological effects of mesothelioma on patients and their carers? A scoping review. Psycho‐Oncology. 2020; 29: 1464– 1473. https://doi.org/10.1002/pon.5454
Matthews C, Freeman C, Sharples LD on behalf of the MesoTRAP investigators, et al. MesoTRAP: a feasibility study that includes a pilot clinical trial comparing video-assisted thoracoscopic partial pleurectomy decortication with indwelling pleural catheter in patients with trapped lung due to malignant pleural mesothelioma designed to address recruitment and randomisation uncertainties and sample size requirements for a phase III trial. BMJ Open Respiratory Research 2019;6:e000368. http://dx.doi.org/10.1136/bmjresp-2018-000368
Warnock, C., Lord, K., Taylor, B. et al. Patient experiences of participation in a radical thoracic surgical trial: findings from the Mesothelioma and Radical Surgery Trial 2 (MARS 2). Trials 2019 20, 598. https://doi.org/10.1186/s13063-019-3692-x
Taylor BH, Warnock C, Tod A. Communication of a mesothelioma diagnosis: developing recommendations to improve the patient experience. BMJ Open Respiratory Research 2019;6:e000413. http://dx.doi.org/10.1136/bmjresp-2019-000413