STOP-OHSS is a £1.8m grant from the National Institute for Health Research’s (NIHR’s) Health Technology Assessment programme.

The School of Health and Related Research library.

It's led by Mostafa Metwally, a consultant gynaecologist and sub-specialist in reproductive medicine and surgery at Jessop Fertility, Sheffield Teaching Hospitals, in collaboration with colleagues in the Clinical Trials Research Unit and ScHARR.

Ovarian hyperstimulation syndrome (OHSS) affects as many as 33 in 100 women undergoing IVF therapy. In the majority of cases, symptoms are mild. However, in three to eight per cent of sufferers, women can develop serious complications requiring admission to hospital.

The project aims to develop novel early outpatient treatment protocols designed to prevent the worsening of symptoms and reduce admissions to hospital – these will then be tested against usual care in two randomised controlled trials.

STOP-OHSS begins in December 2019 – for more information, please contact David White (

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