Esther Herbert

MSc, MMath (Hons)

School of Medicine and Population Health

Research Fellow/ Statistician

e.herbert@sheffield.ac.uk
+44 114 21 59428

Barber House

Full contact details

Esther Herbert
School of Medicine and Population Health
Barber House
Sheffield
S10 2HQ

Profile: I joined the CTRU as a medical statistician in October 2018. Prior to this I was an NIHR Research Methods Fellow in ScHARR, looking at futility analysis in the context of publically funded trials with an internal pilot. This work formed part of my dissertation for an MSc in Statistics with Medical Applications. Before moving to Sheffield I graduated from The University of Bath with a MMath (Hons) in 2014.

Research interests

Current projects:

TRICEPS - Transcutaneous Vagus Nerve Stimulation Post-Stroke
MEErKAT - MEsenteric Excision and Kono-S Anastomosis Trial
DENIM - Delivering Effective Non-Invasive ventilation in Motor neuron disease

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Selvakumar D, Hall J, Hawksworth O, Hind D, Walters S, Rombach I, Herbert E, Waterworth W, Sibbald L, Travis M , Brice D et al (2025) Mesenteric excision and Kono‐S anastomosis trial (MEErKAT): A study protocol for a multicentre, 2 × 2 factorial, randomised controlled, open‐label superiority trial. Colorectal Disease, 27(9). View this article in WRRO
Baig SS, Mooney C, McKendrick K, Duffy KEM, Ali AN, Redgrave JN, Herbert E, Waterhouse S, Su L, Drummond A , Dawson J et al (2025) TRanscutaneous lImb reCovEry Post-Stroke (TRICEPS): study protocol for a randomised, controlled, multiarm, multistage adaptive design trial. BMJ Open, 15(3). View this article in WRRO
Fuller GW, Keating S, Goodacre S, Herbert E, Perkins GD, Rosser A, Gunson I, Miller J, Ward M, Bradburn M , Thokala P et al (2021) Prehospital continuous positive airway pressure for acute respiratory failure: the ACUTE feasibility RCT. Health Technology Assessment, 25(7). View this article in WRRO
Herbert E, Julious SA & Goodacre S (2019) Progression criteria in trials with an internal pilot : an audit of publicly funded randomised controlled trials. Trials, 20(1). View this article in WRRO

All publications

Journal articles

Girling C, Ryan G, Bradburn M, Caprioli T, Dawson S, Fisher E, Haynes N, Herbert E, Hill H, Hind D , May C et al (2026) Delivering effective non-invasive ventilation in amyotrophic lateral sclerosis using intensive remote support (DENIM): protocol for an embedded process evaluation in a hybrid type 3 implementation-effectiveness trial. Implementation Science Communications, 7. View this article in WRRO
Morgan JL, Hubbard T, Herbert E, Hartup S, Cheng V, Barry PA, Copson E, Cutress RI, Dave R, Elsberger B , Fairbrother P et al (2026) National United Kingdom study of the management of breast cancer locoregional recurrence (MARECA) study: Analysis of disease presentation and patient management. European Journal of Surgical Oncology, 111881-111881.
Fuller G, Baird J, Herbert E, Keating S, Miller J, Pilbery R, Turner J, Lecky F, Edwards A, Rosser A , Callaghan T et al (2026) Accuracy of major trauma triage using the MATTS tool: a cohort study. Emergency Medicine Journal. View this article in WRRO
Fuller GW, Baird J, Keating S, Miller J, Pilbery R, Scotney N, McKnee K, Turner J, Lecky F, Edwards A , Rosser A et al (2026) Major Trauma Triage Study (MATTS): Diagnostic accuracy of major trauma triage tools in English regional trauma networks – A case-cohort study. PLoS ONE, 21(3). View this article in WRRO
Young TA, Hyslop ME, Papaioannou DE, Deery C, Bolt R, Wilson MJ, Vernazza C, Herbert E, Totton N, Flight L , Clarkson J et al (2025) A cost-effectiveness analysis of melatonin in comparison with midazolam for anxiety prior to general anaesthesia in children: the MAGIC randomised controlled trial (melatonin for anxiety prior to general anaesthesia in children). BMC Anesthesiology, 26. View this article in WRRO
Brown SR, Hall J, Hancock L & Herbert E (2025) Response to MESOCOLIC Trial Interim Analysis. GASTROENTEROLOGY, 169(5).
Selvakumar D, Hall J, Hawksworth O, Hind D, Walters S, Rombach I, Herbert E, Waterworth W, Sibbald L, Travis M , Brice D et al (2025) Mesenteric excision and Kono‐S anastomosis trial (MEErKAT): A study protocol for a multicentre, 2 × 2 factorial, randomised controlled, open‐label superiority trial. Colorectal Disease, 27(9). View this article in WRRO
Theodoulou E, Martin C, Morgan J, Turner O, Hartup S, Achuthan R, Azmy I, Henderson J, Reed M, Holen I , Brown J et al (2025) Variation in bone health management in older women with breast cancer: a secondary analysis of the age gap study. Journal of Geriatric Oncology, 16(7). View this article in WRRO
Deery C, Bolt R, Papaioannou D, Wilson M, Hyslop M, Herbert E, Totton N, Marshman Z, Young T, Kettle J , Albadri S et al (2025) Melatonin versus midazolam in the premedication of anxious children attending for elective surgery under general anaesthesia: the MAGIC non-inferiority RCT. Health Technology Assessment, 29(29). View this article in WRRO
Brown SR, Hall J, Hancock L & Herbert E (2025) Response to MESOCOLIC Trial Interim Analysis. Gastroenterology, 169(5), 1089-1090.
Baig SS, Mooney C, McKendrick K, Duffy KEM, Ali AN, Redgrave JN, Herbert E, Waterhouse S, Su L, Drummond A , Dawson J et al (2025) TRanscutaneous lImb reCovEry Post-Stroke (TRICEPS): study protocol for a randomised, controlled, multiarm, multistage adaptive design trial. BMJ Open, 15(3). View this article in WRRO
Pilbery R, Sampson FC, Herbert E, Goodacre S, Bell F, Spaight R, Rosser A, Webster P, Millins M, Pountney A , Coster J et al (2025) What factors predict ambulance prealerts to the emergency department? Retrospective observational study from three UK ambulance services. BMJ Open, 15(3). View this article in WRRO
Hyslop MC, Papaioannou DE, Bolt R, Wilson MJ, Bradburn M, Clarkson J, Herbert E, Ireland N, Kettle J, Loban A , Norrington AC et al (2025) Barriers and enablers to recruiting participants within paediatric perioperative and anaesthetic settings: lessons learned from a trial of melatonin versus midazolam in the premedication of anxious children (the MAGIC trial). BJA Open, 13. View this article in WRRO
Fuller G, Baird J, Keating S, Miller J, Pilbery R, Kean N, McKnee K, Turner J, Lecky F, Edwards A , Rosser A et al (2024) The accuracy of prehospital triage decisions in English trauma networks – a case-cohort study. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 32. View this article in WRRO
Petrie J, Loban A, Turton E, Derebecka J, North S, Herbert E & Hind D (2024) “Reality is frequently inaccurate” A case study examining the whens and whys of post-live database changes in a UK clinical trials unit *Douglas Adams. Contemporary Clinical Trials, 142. View this article in WRRO
Herbert E, Papaioannou D, Loban A, Totton N, Hyslop M, Bolt R & Deery C (2024) Personalised versus standard text message prompts for increasing trial participant response to telephone follow-up: an embedded randomised controlled retention trial. Trials, 25(1). View this article in WRRO
Bolt R, Hyslop MC, Herbert E, Papaioannou DE, Totton N, Wilson MJ, Clarkson J, Evans C, Ireland N, Kettle J , Marshman Z et al (2024) The MAGIC trial: a pragmatic, multicentre, parallel, noninferiority, randomised trial of melatonin versus midazolam in the premedication of anxious children attending for elective surgery under general anaesthesia. British Journal of Anaesthesia, 132(1), 76-85. View this article in WRRO
Wyld L, Reed MWR, Collins K, Ward S, Holmes G, Morgan J, Bradburn M, Walters S, Burton M, Lifford K , Edwards A et al (2022) Improving outcomes for women aged 70 years or above with early breast cancer: research programme including a cluster RCT. Programme Grants for Applied Research, 10(6), 1-114. View this article in WRRO
Battisti NML, Hatton MQ, Reed MWR, Herbert E, Morgan JL, Bradburn M, Simcock R, Walters SJ, Collins KA, Ward SE , Holmes GR et al (2021) Observational cohort study in older women with early breast cancer : use of radiation therapy and impact on health-related quality of life and mortality. Radiotherapy and Oncology, 161, 166-176. View this article in WRRO
Burton M, Lifford KJ, Wyld L, Armitage F, Ring A, Nettleship A, Collins K, Morgan J, Reed MWR, Holmes GR , Bradburn M et al (2021) Process evaluation of the Bridging the Age Gap in Breast Cancer decision support intervention cluster randomised trial. Trials, 22(1). View this article in WRRO
Sims-Williams HP, Rajapaksa K, Yianni J, Walton L, Sinha S, Radatz M, Herbert E, Bradburn M & Newell-Price J (2021) Long-term safety of gamma knife radiosurgery (SRS) for acromegaly. Pituitary, 24(5), 724-736. View this article in WRRO
Ring A, Battisti NML, Reed MWR, Herbert E, Morgan JL, Bradburn M, Walters SJ, Collins KA, Ward SE, Holmes GR , Burton M et al (2021) Bridging The Age Gap: observational cohort study of effects of chemotherapy and trastuzumab on recurrence, survival and quality of life in older women with early breast cancer.. British Journal of Cancer, 125(2), 209-219. View this article in WRRO
Morgan JL, Shrestha A, Reed MWR, Herbert E, Bradburn M, Walters SJ, Martin C, Collins K, Ward S, Holmes G , Burton M et al (2021) Bridging the age gap in breast cancer : impact of omission of breast cancer surgery in older women with oestrogen receptor-positive early breast cancer on quality-of-life outcomes. British Journal of Surgery, 108(3), 315-325. View this article in WRRO
Fuller GW, Keating S, Goodacre S, Herbert E, Perkins GD, Rosser A, Gunson I, Miller J, Ward M, Bradburn M , Thokala P et al (2021) Prehospital continuous positive airway pressure for acute respiratory failure: the ACUTE feasibility RCT. Health Technology Assessment, 25(7). View this article in WRRO
Battisti NML, Reed MWR, Herbert E, Morgan JL, Collins KA, Ward SE, Holmes GR, Bradburn M, Walters SJ, Burton M , Lifford K et al (2021) Bridging the age gap in breast cancer: impact of chemotherapy on quality of life in older women with early breast cancer. European Journal of Cancer, 144, 269-280. View this article in WRRO
Thokala P, Fuller GW, Goodacre S, Keating S, Herbert E, Perkins GD, Rosser A, Gunson I, Miller J, Ward M , Bradburn M et al (2021) Cost-effectiveness of out-of-hospital continuous positive airway pressure for acute respiratory failure: decision analytic modelling using data from a feasibility trial. BMC Emergency Medicine, 21. View this article in WRRO
Wyld L, Reed MWR, Morgan J, Collins K, Ward S, Holmes GR, Bradburn M, Walters S, Burton M, Herbert E , Lifford K et al (2021) Bridging the age gap in breast cancer. Impacts of omission of breast cancer surgery in older women with oestrogen receptor positive early breast cancer. A risk stratified analysis of survival outcomes and quality of life. European Journal of Cancer, 142, 48-62. View this article in WRRO
Martin C, Shrestha A, Morgan J, Bradburn M, Herbert E, Burton M, Todd A, Walters S, Ward S, Holmes G , Reed M et al (2021) Treatment choices for older women with primary operable breast cancer and cognitive impairment: Results from a prospective, multicentre cohort study. Journal of Geriatric Oncology, 12(5), 705-713. View this article in WRRO
Todd A, Martin C, Morgan J, Herbert E, Bradburn M, Burton M, Reed MWR, Chater T, Pemberton K, Walters S , Cheung KL et al (2021) Age specific recruitment and retention to a large multicentre observational breast cancer trial in older women : the Age Gap trial. Journal of Geriatric Oncology, 12(5), 714-723. View this article in WRRO
Fuller GW, Goodacre S, Keating S, Herbert E, Perkins G, Ward M, Rosser A, Gunson I, Miller J, Bradburn M , Harris T et al (2020) The diagnostic accuracy of pre-hospital assessment of acute respiratory failure. British Paramedic Journal, 5(3), 15-22. View this article in WRRO
Fuller G, Keating S, Goodacre S, Herbert E, Perkins G, Rosser A, Gunson I, Miller J, Ward M, Bradburn M , Thokala P et al (2020) Is a definitive trial of prehospital continuous positive airway pressure versus standard oxygen therapy for acute respiratory failure indicated? The ACUTE pilot randomised controlled trial. BMJ Open, 10(7). View this article in WRRO
Palmer R, Dimairo M, Latimer N, Cross E, Brady M, Enderby P, Bowen A, Julious S, Harrison M, Alshreef A , Bradley E et al (2020) Computerised speech and language therapy or attention control added to usual care for people with long-term post-stroke aphasia : the Big CACTUS three-arm RCT. Health Technology Assessment, 24(19), 1-176. View this article in WRRO
Herbert E, Julious SA & Goodacre S (2019) Progression criteria in trials with an internal pilot : an audit of publicly funded randomised controlled trials. Trials, 20(1). View this article in WRRO
Heller S, Scott E, Elliott J, Herbert E, Rombach I, Cooper C, Brennan A, Pollard D, Lawton J, Rankin D , Lorencatto F et al () A lifelong approach to promote effective self-management in adults with type 1 diabetes: the DAFNEplus research programme including a cluster RCT. Programme Grants for Applied Research, 1-70. View this article in WRRO
Fuller GW, Baird J, Miller J, Pilbery R, Herbert E, Keating S, Callaghan T, Pollard D, Pandor A, Essat M , Charles D et al () Developing a national triage tool for use in NHS regional trauma networks: the MATTS mixed methods study. Health Technology Assessment, 1-222.
Sampson FC, Long J, Coster J, O’Hara R, Pilbery R, Bell F, Goodacre S, Boyd A, Webster P, Herbert E , Foster A et al () Exploring the use of pre-hospital pre-alerts and their impact on patients, Ambulance Service and Emergency Department staff: a mixed-methods study. Health and Social Care Delivery Research, 1-46.

Conference proceedings

Sampson F, Pilbery R, Herbert E, Long J, Coster J, O’Hara R, Bell F, Goodacre S, Rosser A, Spaight R & Millins M (2023) 2245 Mixed methods study exploring factors influencing ambulance clinician decisions to pre-alert emergency departments (EDs) of a patient’s arrival. RCEM Annual Scientific Conference Glasgow 2023 Meeting Abstracts (pp 875-875)
Sampson F, Pilbery R, Herbert E, Bell F, Rosser A, Spaight R, Goodacre S, Pountney A & Millins M (2023) PP33 Which patients receive a prealert? Analysis of linked data in three ambulance services. 999 EMS Research Forum 2023 meeting abstracts (pp A14.1-A14)
Pilbery R, Sampson F, Herbert E, Bell F, Rosser A, Spaight R, Pountney A, Millins M & Goodacre S (2023) PP32 What factors affect pre-hospital pre-alerts? Analysis of routine ambulance data. 999 EMS Research Forum 2023 meeting abstracts (pp A13.2-A13)
Holt C, Fuller G, Keating S, Turner J, Irving A & Herbert E (2020) 01 Major trauma triage tools study (MATTS) triage tools summary. Emergency Medicine Journal, Vol. 37(10) (pp e2.1-e2). Brighton, UK, 3 March 2020 - 3 March 2020. View this article in WRRO
Battisti NML, Herbert E, Bradburn M, Morgan J, Wyld L & Ring A (2020) 190P Impact of chemotherapy for early stage breast cancer on quality of life in older adults: Results from 2811 women enrolled in the Bridging the Age Gap study. Annals of Oncology, Vol. 31 (pp S318-S319)
Fuller GW, Keating S, Goodacre S, Herbert E, Perkins G, Rosser A, Gunson I, Ward M, Miller J, Bradburn M , Thokala P et al (2019) Pre-hospital CPAP for acute respiratory failure : the ACUTE feasibility and pilot randomised controlled trial. British Paramedic Journal, Vol. 4(3) (pp 53-54). Cardiff, Wales, 24 September 2019 - 24 September 2019. View this article in WRRO
Gunson IM, Herbert E & Fuller G (2019) PP26 Incidence of acute respiratory failure cases in west midlands ambulance service (WMAS) – sub-study of ACUTE (ambulance CPAP: use, treatment effect and economics) trial. Emergency Medicine Journal, Vol. 36(10) (pp e11.3-e12)

Other

Deery C, Bolt R, Papaioannou D, Totton N, Herbert E, Hyslop M, Marshman Z, Wilson M, Eissa A, Young T , Loban A et al () The MAGIC trial (Melatonin for Anxiety prior to General anaesthesia In Children): A Multicentre, Parallel Randomised Controlled Trial of Melatonin Versus Midazolam in the Premedication of Anxious Children Attending for Elective Surgery Under General Anaesthesia.
Herbert E, Totton N, Deery C, Bolt R, Hyslop M, Bradburn M, Dimairo M, Schilder A, Papaioannou D, Wilson M & Biggs C () MAGIC trial - Statistical Analysis Plan.

Preprints

Sampson FC, Pilbery R, Herbert E, Goodacre SW, Bell FB, Spaight R, Rosser A, Webster P, Millins M, Pountney A , Coster JE et al (2024) What factors predict ambulance pre-alerts to the emergency department? Analysis of routine data from three UK ambulance services., Springer Science and Business Media LLC.
Sampson F, Pilbery R, Herbert E, Goodacre S, Bell F, Spaight R, Rosser A, Webster P, Millins M, Pountney A , Coster J et al (2023) What factors predict ambulance pre-alerts to the emergency department? Analysis of routine data from 3 UK ambulance services, Cold Spring Harbor Laboratory.
Wilson E, Smith C, Herbert E & Julious S () Investigating the Impact of a Menstrual Hygiene Program on School Absenteeism of Rural Ugandan Girls: A Delayed Cluster Randomised Control Trial.