Dr Kate Ren
BSc (York), MPhil (Cantab), PhD (Sheffield)
Population Health, School of Medicine and Population Health
Senior Research Fellow in Statistics
+44 114 222 0696
Full contact details
Population Health, School of Medicine and Population Health
Regent Court (ScHARR)
30 Regent Street
Sheffield
S1 4DA
- Profile
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I joined SCHARR in 2011 after completing a PhD in Probability and Statistics, specialising in Bayesian methods in clinical trial design at the University of Sheffield. My expertise lies in the development and application of Bayesian methods in Health Technology Assessment. My research interests include evidence synthesis methods (in particular indirect treatment comparisons with single-arm trials), survival extrapolation and structured expert elicitation.
I work as a member of SCHARR-TAG (an external assessment group for NICE technology appraisals). I have extensive experience in critiquing statistical methods used in NICE single technology appraisal submissions. I am also a member of NICE Appraisal Committee C.
I am an NIHR Advanced Fellow, currently working on a project titled “Improving the robustness of health technology funding decisions when evidence is from single-arm trials”.
- Research interests
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- Network meta-analysis
- Indirect treatment comparisons
- Population-adjusted indirect comparisons
- Survival extrapolation
- Structured expert elicitation
- Bayesian statistics in clinical trials and health economics
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Pembrolizumab for Locally Advanced or Metastatic Urothelial Cancer Where Cisplatin is Unsuitable: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. PharmacoEconomics. View this article in WRRO
- Dinutuximab Beta for Treating Neuroblastoma: An Evidence Review Group and Decision Support Unit Perspective of a NICE Single Technology Appraisal. PharmacoEconomics. View this article in WRRO
- Baricitinib for previously treated moderate or severe rheumatoid arthritis: an evidence review group perspective of a NICE single technology appraisal . PharmacoEconomics, 36, 769-778. View this article in WRRO
- Incorporating Genuine Prior Information about Between-Study Heterogeneity in Random Effects Pairwise and Network Meta-analyses. Medical Decision Making, 38(4), 531-542. View this article in WRRO
- A New Approach for Sampling Ordered Parameters in Probabilistic Sensitivity Analysis. PharmacoEconomics. View this article in WRRO
- How to Appropriately Extrapolate Costs and Utilities in Cost-Effectiveness Analysis. PharmacoEconomics. View this article in WRRO
- Extrapolating Survival from Randomized Trials Using External Data: A Review of Methods. Medical Decision Making, 37(4), 377-390. View this article in WRRO
- Assurance calculations for planning clinical trials with time-to-event outcomes. Statistics in Medicine, 33(1), 31-45. View this article in WRRO
- Pre-hospital non-invasive ventilation for acute respiratory failure: a systematic review and cost-effectiveness evaluation. Health Technology Assessment, 19(42), 1-102. View this article in WRRO
All publications
Journal articles
- MCL-509 Indirect Comparison of Efficacy of Zanubrutinib Versus Acalabrutinib in the Treatment of Relapsed/Refractory (R/R) Mantle Cell Lymphoma (MCL). Clinical Lymphoma Myeloma and Leukemia, 24, S516-S517.
- Indirect Comparison of Efficacy of Zanubrutinib Versus Acalabrutinib in the Treatment of Relapsed/Refractory (R/R) Mantle Cell Lymphoma (MCL). Clinical Lymphoma Myeloma and Leukemia, 24, S227-S227.
- Diagnostic accuracy of the aortic dissection detection risk score alone or with D-dimer for acute aortic syndromes: systematic review and meta-analysis. PLOS ONE, 19(6). View this article in WRRO
- Diagnostic Accuracy of D-Dimer for Acute Aortic Syndromes: Systematic Review and Meta-Analysis. Annals of Emergency Medicine.
- SA46 Are We Dealing With Heterogeneity in Network Meta-Analysis Appropriately? A Review of NICE Submissions. Value in Health, 27(6), S403-S404.
- Issues, Challenges and Opportunities for Economic Evaluations of Orphan Drugs in Rare Diseases: An Umbrella Review. PharmacoEconomics, 1-13.
- Advancing unanchored simulated treatment comparisons: A novel implementation and simulation study. Research Synthesis Methods.
- SA80 Priors on Between-Study Heterogeneity in Bayesian Meta-Analysis Models: A Simulation Study Using Hamiltonian Monte Carlo Sampling. Value in Health, 26(12), S557-S557.
- MSR159 A Novel Unanchored Simulated Treatment Comparison Approach for Time-to-Event Data. Value in Health, 26(12), S424-S424.
- Cost-effectiveness of therapeutics for COVID-19 patients: a rapid review and economic analysis. Health Technology Assessment, 27(14). View this article in WRRO
- Rate of complete spectacle independence with a trifocal intraocular lens: a systematic literature review and meta-analysis. Ophthalmology and Therapy, 12(2), 1157-1171.
- An investigation of the constancy of effect in Cochrane systematic reviews in context with the assumptions for noninferiority trials. BMC Medical Research Methodology, 22(1).
- The Cost-Effectiveness of Belimumab and Voclosporin for Patients with Lupus Nephritis in the United States. Clinical Journal of the American Society of Nephrology, 17(3), 385-394.
- Cost-effectiveness of out-of-hospital continuous positive airway pressure for acute respiratory failure: decision analytic modelling using data from a feasibility trial. BMC Emergency Medicine, 21. View this article in WRRO
- Cost effectiveness of nusinersen for patients with infantile-onset spinal muscular atrophy in US. Cost Effectiveness and Resource Allocation, 18. View this article in WRRO
- R and Shiny for cost-effectiveness analyses : why and when? A hypothetical case study. PharmacoEconomics. View this article in WRRO
- How Uncertain is the Survival Extrapolation? A Study of the Impact of Different Parametric Survival Models on Extrapolated Uncertainty About Hazard Functions, Lifetime Mean Survival and Cost Effectiveness. PharmacoEconomics, 38(2), 193-204. View this article in WRRO
- Effectiveness and safety of betrixaban extended prophylaxis for venous thromboembolism compared with standard-duration prophylaxis intervention in acute medically ill patients : a systematic literature review and network meta-analysis. Journal of Medical Economics. View this article in WRRO
- Rheumatoid arthritis treated with 6-months of first-line biologic or biosimilar therapy: an updated systematic review and network meta-analysis.. International Journal of Technology Assessment in Health Care. View this article in WRRO
- Pembrolizumab for Locally Advanced or Metastatic Urothelial Cancer Where Cisplatin is Unsuitable: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. PharmacoEconomics. View this article in WRRO
- Dinutuximab Beta for Treating Neuroblastoma: An Evidence Review Group and Decision Support Unit Perspective of a NICE Single Technology Appraisal. PharmacoEconomics. View this article in WRRO
- Baricitinib for previously treated moderate or severe rheumatoid arthritis: an evidence review group perspective of a NICE single technology appraisal . PharmacoEconomics, 36, 769-778. View this article in WRRO
- Sarilumab for Previously-Treated Moderate or Severe Rheumatoid Arthritis: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. Pharmacoeconomics, 36(12), 1427-1437. View this article in WRRO
- Incorporating Genuine Prior Information about Between-Study Heterogeneity in Random Effects Pairwise and Network Meta-analyses. Medical Decision Making, 38(4), 531-542. View this article in WRRO
- Tofacitinib for Treating Rheumatoid Arthritis After the Failure of Disease-Modifying Anti-rheumatic Drugs: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. PharmacoEconomics, 36(9), 1063-1072. View this article in WRRO
- A New Approach for Sampling Ordered Parameters in Probabilistic Sensitivity Analysis. PharmacoEconomics. View this article in WRRO
- Cost-effectiveness of antibiotic treatment of uncomplicated urinary tract infection in women: a comparison of four antibiotics. BJGP Open, 1(3). View this article in WRRO
- Degarelix for Treating Advanced Hormone-Dependent Prostate Cancer: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. PharmacoEconomics, 35(7), 717-726. View this article in WRRO
- How to Appropriately Extrapolate Costs and Utilities in Cost-Effectiveness Analysis. PharmacoEconomics. View this article in WRRO
- Extrapolating Survival from Randomized Trials Using External Data: A Review of Methods. Medical Decision Making, 37(4), 377-390. View this article in WRRO
- Complementary and Alternative Medicine for Management of Premature Ejaculation: A Systematic Review. Sexual Medicine, 5(1), e1-e18. View this article in WRRO
- Phosphodiesterase Type 5 Inhibitors for Premature Ejaculation: A Systematic Review and Meta-analysis. European Urology Focus, 3(1), 119-129. View this article in WRRO
- Olaparib for Maintenance Treatment of BRCA 1 or 2 Mutated, Relapsed, Platinum-Sensitive Ovarian, Fallopian Tube and Peritoneal Cancer in People Whose Relapsed Disease has Responded to Platinum-Based Chemotherapy: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. PharmacoEconomics, 35(1), 97-109. View this article in WRRO
- A Model-Based Economic Evaluation of Biologic and Non-Biologic Options for the Treatment of Adults with Moderately-to-Severely Active Ulcerative Colitis after the Failure of Conventional Therapy. PharmacoEconomics, 34(10), 1023-1038. View this article in WRRO
- Association between Transfusion Status and Overall Survival in Patients with Myelodysplastic Syndromes: A Systematic Literature Review and Meta-Analysis. Acta Haematologica, 136(1), 23-42. View this article in WRRO
- A systematic review, evidence synthesis and meta-analysis of quantitative and qualitative studies evaluating the clinical effectiveness, the cost-effectiveness, safety and acceptability of interventions to prevent postnatal depression. Health Technology Assessment, 20(37), 1-414. View this article in WRRO
- Infliximab, adalimumab and golimumab for treating moderately to severely active ulcerative colitis after the failure of conventional therapy (including a review of TA140 and TA262): clinical effectiveness systematic review and economic model. Health Technology Assessment, 20(39), 1-326. View this article in WRRO
- Vedolizumab for the Treatment of Adults with Moderate-to-Severe Active Ulcerative Colitis: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. PharmacoEconomics, 34(3), 245-257. View this article in WRRO
- Topical anaesthetics for premature ejaculation: a systematic review and meta-analysis. Sexual Health, 13(2), 114-123. View this article in WRRO
- Prehospital Noninvasive Ventilation for Acute Respiratory Failure: Systematic Review, Network Meta-analysis, and Individual Patient Data Meta-analysis. Academic Emergency Medicine, 21(9), 960-970. View this article in WRRO
- Systematic review, network meta-analysis and exploratory cost-effectiveness model of randomized trials of minimally invasive techniques versus surgery for varicose veins.. Br J Surg, 101(9), 1040-1052. View this article in WRRO
- Clinical and cost-effectiveness of minimally invasive techniques for the treatment of varicosis: Systematic review and economic evaluation. Vasomed, 26(4), 210-211.
- Assurance calculations for planning clinical trials with time-to-event outcomes. Statistics in Medicine, 33(1), 31-45. View this article in WRRO
- What is the clinical effectiveness and cost-effectiveness of cytisine compared with varenicline for smoking cessation? A systematic review and economic evaluation.. Health Technol Assess, 18(33), 1-120.
- Aripiprazole for the treatment and prevention of acute manic and mixed episodes in bipolar I disorder in children and adolescents: a NICE single technology appraisal.. Pharmacoeconomics, 31(11), 981-990.
- Clinical effectiveness and cost-effectiveness of minimally invasive techniques to manage varicose veins: a systematic review and economic evaluation.. Health Technol Assess, 17(48), i-141.
- Assessing the Value of New Antimicrobials: Evaluations of Cefiderocol and Ceftazidime-Avibactam to Inform Delinked Payments by the NHS in England. Applied Health Economics and Health Policy.
- Faecal Immunochemical Tests For Patients With Symptoms Suggestive Of Colorectal Cancer: An Updated Systematic Review And Multiple-Threshold Meta-Analysis of Diagnostic Test Accuracy Studies. Colorectal Disease.
- Ceftazidime with avibactam for treating severe aerobic Gram-negative bacterial infections: technology evaluation to inform a novel subscription-style payment model. Health Technology Assessment, 1-230.
- Cefiderocol for treating severe aerobic Gram-negative bacterial infections: technology evaluation to inform a novel subscription-style payment model. Health Technology Assessment, 1-238.
- Living Health Technology Assessment: Issues, Challenges and Opportunities. PharmacoEconomics.
- Pre-hospital non-invasive ventilation for acute respiratory failure: a systematic review and cost-effectiveness evaluation. Health Technology Assessment, 19(42), 1-102. View this article in WRRO
- Behavioural modification interventions for medically unexplained symptoms in primary care: systematic reviews and economic evaluation. Health Technology Assessment, 24(46), 1-490.
Conference proceedings papers
- 2613 Diagnostic accuracy of the aortic dissection detection risk score alone or with D-dimer for acute aortic syndromes: systematic review and meta-analysis. RCEM Annual Scientific Conference 2024 Abstracts (pp A9.1-A9)
- ARE WE DEALING WITH HETEROGENEITY IN NETWORK META-ANALYSIS APPROPRIATELY? A REVIEW OF NICE SUBMISSIONS. VALUE IN HEALTH, Vol. 27(6) (pp S403-S404)
- Indirect Comparison of Efficacy of Zanubrutinib Versus Acalabrutinib in the Treatment of Relapsed/Refractory (R/R) Mantle Cell Lymphoma (MCL). CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, Vol. 24 (pp S516-S517)
- PRIORS ON BETWEEN- STUDY HETEROGENEITY IN BAYESIAN META-ANALYSIS MODELS: A SIMULATION STUDY USING HAMILTONIAN MONTE CARLO SAMPLING. VALUE IN HEALTH, Vol. 26(12) (pp S557-S557)
- A NOVEL UNANCHORED SIMULATED TREATMENT COMPARISON APPROACH FOR TIME-TO-EVENT DATA. VALUE IN HEALTH, Vol. 26(12) (pp S424-S424)
- REVIEW OF METHODS USED TO ESTIMATE TREATMENT EFFECTS AGAINST RELEVANT COMPARATORS USING EVIDENCE FROM SINGLE-ARM STUDIES IN NICE SINGLE TECHNOLOGY APPRAISALS. VALUE IN HEALTH, Vol. 25(12) (pp S10-S10)
- RATE OF COMPLETE SPECTACLE INDEPENDENCE WITH A TRIFOCAL IOL: A SYSTEMATIC LITERATURE REVIEW AND META-ANALYSIS. VALUE IN HEALTH, Vol. 25(12) (pp S378-S378)
- AN EXTENDED SIMULATED TREATMENT COMPARISON APPROACH ACCOUNTING FOR UNOBSERVED CONFOUNDING IN INDIRECT COMPARISONS FOR SINGLE-ARM TRIALS. VALUE IN HEALTH, Vol. 25(12) (pp S358-S358)
- PRO15 COST-EFFECTIVENESS OF NUSINERSEN AND ONASEMNOGENE ABEPARVOVEC FOR INFANTILE-ONSET SPINAL MUSCULAR ATROPHY (TYPE I SMA) IN THE US. Value in Health, Vol. 22 (pp S337-S338)
- EVIDENCE SYNTHESIS FOR HEALTH TECHNOLOGY ASSESSMENT WITH LIMITED STUDIES. VALUE IN HEALTH, Vol. 20(9) (pp A770-A770)
- Systematic Review and Meta-Analysis of the Association Between Transfusion Independence (TI) and Overall Survival (OS) in Patients (pts) with Myelodysplastic Syndromes (MDS). Blood, Vol. 124(21) (pp 1934-1934)
- The Estimated Survival of Patients with Double Refractory Chronic Lymphocytic Leukaemia; A Reanalysis of NICE TA202 Using Bayesian Methodology to Model Observed Data. Value in Health, Vol. 16(7) (pp A397-A397)
Posters
- MT2 Rate of Complete Spectacle Independence With a Trifocal IOL: A Systematic Literature Review and Meta-Analysis.
- PMS4 - RHEUMATOID ARTHRITIS TREATED WITH SIX-MONTHS OF FIRST-LINE BIOLOGIC OR BIOSIMILAR THERAPY: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS.
- Evidence synthesis with limited studies. HTAi 2018, Vancouver, Canada.
- Evidence synthesis for health technology assessment with limited studies.. . ISPOR Glasgow 2017.
- PRE-HOSPITAL NON-INVASIVE VENTILATION FOR ACUTE RESPIRATORY FAILURE: A SYSTEMATIC REVIEW AND NETWORK META ANALYSIS.
- A systematic review and network meta - analysis of pharmacological therapies used for patients with advanced Parkinson's disease (2014).
- Pre-hospital non-invasive ventilation for acute respiratory failure: a systematic review and network meta-analysis. 999 EMS Research Forum Conference.
Preprints
- Cost-effectiveness of Out-of-Hospital Continuous Positive Airway Pressure for Acute Respiratory Failure: Decision analytic modelling using data from a feasibility trial, Research Square Platform LLC.
- Cost-effectiveness of Out-of-Hospital Continuous Positive Airway Pressure for Acute Respiratory Failure: Decision analytic modelling using data from a feasibility trial, Research Square Platform LLC.
- Cost-effectiveness of Out-of-Hospital Continuous Positive Airway Pressure for Acute Respiratory Failure: Decision analytic modelling using data from a feasibility trial, Research Square Platform LLC.
- An Investigation of the Constancy of Effect in Cochrane Systematic Reviews in Context with the Assumptions for Non-Inferiority trials., Research Square Platform LLC.
- Grants
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- NIHR Evidence Synthesis Group (2023-2028, £4,507,538) Co-investigator.
- NIHR Technology Assessment Reviews (2022-2027, £6,999,908) Co-investigator.
- NIHR Advanced Fellowship (2021-2025, £368,269) Principal investigator.
- NIHR HTA Programme: Effectiveness of interventions for fatigue in long-term conditions (2023-2025, £332,575) Co-investigator.
- NIHR HTA Programme: Diagnostic strategies for suspected acute aortic syndrome (2023-2024, £184,095) Co-investigator.
- NIHR HTA Programme: Medically unexplained symptoms: primary care intervention (2015-2017, £171,405) Co-investigator.
- Teaching interests
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Evidence synthesis, survival analysis