Dr Matthew Bursnall
Population Health, School of Medicine and Population Health
Medical Statistician, Research Fellow
+44 114 222 0889
Full contact details
Population Health, School of Medicine and Population Health
2028
Regent Court (ScHARR)
30 Regent Street
Sheffield
S1 4DA
- Profile
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I joined the CTRU in 2018, having previously worked as a statistician in the Department for Education and as an econometrician at the National Institute for Economic and Social Research. I mainly work on the statistical design and analysis of Randomised Controlled Trials (RCTs) but am also involved in observational studies and quantitative social research. Most of my experience has been in the areas of mental health and wellbeing of adults and children, Rare diseases, Inflammatory Bowel Disease and Stem Cell therapy.
- Qualifications
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PhD in Statistics, University of Sheffield 2001
MSc in Statistics, University of Sheffield 1995
BSc in Mathematics, University of Sheffield 1994
- Research interests
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I have an interest in the following research:
- Design and analysis methods for trials for rare diseases
- Sample size estimation for studies with clustering in a single arm
- Assumptions for the inter-class correlation coefficient in cluster trials in the absence of previous evidence
- Unbiased estimation of treatment effects in step-up trials where group-based treatment intensity is increased depending on a post-randomisation interim outcome.
- Simulating trials using Causal analysis within a Target Trial Framework
Current projects
I am currently involved in the delivery of the following projects as part of the statistical team
CAPTIVATE Changing Clinical Practice for Rare Diseases Through Innovative Trial DesignsMissionEB A double blinded placebo control study of Mesenchymal Intravenous Stromal cell Infusions in children with recessive dystrophic Epidermolysis Bullosa. This is a collaboration with Great Ormond Street Hospital and the Birmingham Children’s Hospital.
StarMS The trial aims to compare the efficacy and safety profile of Autologous Haematopoietic Stem Cell Transplantation (aHSCT) vs ‘highly effective’ Disease Modifying Therapies (DMTs) – Ocrelizumab, Alemtuzumab, Cladribine and Ofatumumab. This is a collaboration with Sheffield Teaching Hospitals NHS Foundation Trust.
CONTACT-GAD A randomised CONtrolled trial of Tailored Acceptance and Commitment Therapy for older people with treatment resistant Generalised Anxiety Disorder. This is a collaboration with University College London.
ORION RadiO fRequency ablatION for haemorrhoids (ORION). A Pragmatic multicentre patient-/assessor-blind parallel-group individual participant randomised (1:1 allocation) randomised controlled trial. This is a collaboration with Sheffield Teaching Hospitals NHS Foundation Trust.
AWARE-IBD The project is working to re-design services and deliver improved outcomes for people living with Crohn’s and Colitis. This is a collaboration with Crohn’s and Colitis UK.Recent projects
- ESEE Steps - Enhancing Social-Emotional Health and Wellbeing in the Early Years
- ISOCIALISE - Investigating SOcial Competence and Isolation in children with Autism taking part in Lego®-based therapy clubs In School Environments
- PRIEST - Pre-hospital Pandemic Respiratory Infection Emergency System Triage
- VTEAM - Venous Thromboembolism Assessment Model Study
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Accuracy of efficient data methods to determine the incidence of hospital-acquired thrombosis and major bleeding in medical and surgical inpatients: a multicentre observational cohort study in four UK hospitals. BMJ Open, 13(2).
- A randomised controlled trial of acceptance and commitment therapy plus usual care compared to usual care alone for improving psychological health in people with motor neuron disease (COMMEND): study protocol. BMC Neurology, 22(1).
- A randomized controlled trial of a proportionate universal parenting program delivery model (E-SEE Steps) to enhance child social-emotional wellbeing. PLoS ONE, 17(4).
- Clinician and patient experience of internet-mediated eye movement desensitisation and reprocessing therapy. Journal of Psychosocial Rehabilitation and Mental Health. View this article in WRRO
- Prognostic accuracy of emergency department triage tools for adults with suspected COVID-19: the PRIEST observational cohort study. Emergency Medicine Journal, 38(8), 587-593.
- How Dynamic is the Private Sector? Job Creation and Insights from Workplace-Level Data. National Institute Economic Review, 225, F4-F14.
Conference proceedings papers
All publications
Journal articles
- Experiences of acceptance and commitment therapy for people living with motor neuron disease (MND): a qualitative study from the perspective of people living with MND and therapists. The Cognitive Behaviour Therapist, 17.
- Acceptance and Commitment Therapy plus usual care for improving quality of life in people with motor neuron disease (COMMEND): a multicentre, parallel, randomised controlled trial in the UK. The Lancet. View this article in WRRO
- Cost-effectiveness of acceptance and commitment therapy for people living with motor neuron disease, and their health-related quality of life. European Journal of Neurology. View this article in WRRO
- Efficacy and safety of autologous haematopoietic stem cell transplantation versus alemtuzumab, ocrelizumab, ofatumumab or cladribine in relapsing remitting multiple sclerosis (StarMS): protocol for a randomised controlled trial. BMJ Open, 14(2), e083582-e083582.
- Acceptance and commitment therapy for people living with motor neuron disease: an uncontrolled feasibility study. Pilot and Feasibility Studies, 9.
- Su1783 ASSESSING PATIENT EXPERIENCE IN AN INFLAMMATORY BOWEL DISEASE SERVICE. CAN WE MEASURE AN EFFECT FROM SOCIOECONOMIC DEPRIVATION - EXPERIENCE FROM THE AWARE-IBD PROGRAME?. Gastroenterology, 164(6), S-679.
- I-SOCIALISE: Results from a cluster randomised controlled trial investigating the social competence and isolation of children with autism taking part in LEGO® based therapy (‘Play Brick Therapy’) clubs in school environments. Autism.
- Accuracy of efficient data methods to determine the incidence of hospital-acquired thrombosis and major bleeding in medical and surgical inpatients: a multicentre observational cohort study in four UK hospitals. BMJ Open, 13(2).
- P284 Assessing patient experience in an inflammatory bowel disease service. Can we measure an effect from socioeconomic deprivation – experience from the AWARE-IBD programme?. Journal of Crohn's and Colitis, 17(Supplement_1), i431-i432. View this article in WRRO
- A randomised controlled trial of acceptance and commitment therapy plus usual care compared to usual care alone for improving psychological health in people with motor neuron disease (COMMEND): study protocol. BMC Neurology, 22(1).
- Protocol for the ORION trial (RadiO fRequency ablatION for haemorrhoids): a randomised controlled trial. Techniques in Coloproctology. View this article in WRRO
- A randomized controlled trial of a proportionate universal parenting program delivery model (E-SEE Steps) to enhance child social-emotional wellbeing. PLoS ONE, 17(4).
- The effect of embedding formative assessment on pupil attainment. Journal of Research on Educational Effectiveness. View this article in WRRO
- Clinician and patient experience of internet-mediated eye movement desensitisation and reprocessing therapy. Journal of Psychosocial Rehabilitation and Mental Health. View this article in WRRO
- Cost-utility analysis of LEGO based therapy for school children and young people with autism spectrum disorder: results from a randomised controlled trial.. BMJ Open, 12(1). View this article in WRRO
- Enhancing social-emotional outcomes in early years (E-SEE) : randomized pilot study of Incredible Years infant and toddler programs. Journal of Child and Family Studies, 30(8), 1933-1949.
- Prognostic accuracy of emergency department triage tools for adults with suspected COVID-19: the PRIEST observational cohort study. Emergency Medicine Journal, 38(8), 587-593.
- Bridging the age gap in breast cancer: cluster randomized trial of the effects of two decision support interventions for older women with operable breast cancer on quality of life, survival, decision quality, and treatment choices. British Journal of Surgery, 108(5), 499-510. View this article in WRRO
- Comparison of complication and reoperation rates for minimally invasive versus open cheilectomy of the first metatarsophalangeal joint. Foot and Ankle International, 41(1), 31-36.
- How Dynamic is the Private Sector? Job Creation and Insights from Workplace-Level Data. National Institute Economic Review, 225, F4-F14.
- . Statistics and Computing, 9(3), 229-237.
- Evaluation of venous thromboembolism risk assessment models for hospital inpatients: the VTEAM evidence synthesis. Health Technology Assessment, 1-166.
- Implementation successes and lessons learnt from a randomised controlled trial of a complex school-based intervention. Research Methods in Medicine & Health Sciences.
- Play brick therapy to aid the social skills of children and young people with autism spectrum disorder: the I-SOCIALISE cluster RCT. Public Health Research, 1-137.
- A proportionate, universal parenting programme to enhance social-emotional well-being in infants and toddlers in England: the E-SEE Steps RCT. Public Health Research, 10(8), 1-162.
Conference proceedings papers
- P22 Co-design and pilot of a personalised care plan for inflammatory bowel disease; part of a patient-centred quality improvement project (AWARE-IBD). Poster Presentations
- Validation of a newly developed patient-reported experience measure for people with Inflammatory bowel disease. Journal of Crohn's and Colitis, Vol. 18(Supplement 1) (pp I837-I837). Stockholm, Sweden, 21 February 2024 - 21 February 2024. View this article in WRRO
- P332 Experience of care is worse for people with active inflammatory bowel disease than inactive disease. Poster presentations
- Further Results on Optimal and Efficient Designs for Constrained Mixture Experiments (pp 225-239)
Website content
Scholarly editions
Preprints
- Derivation and validation of a clinical severity score for acutely ill adults with suspected COVID-19: The PRIEST observational cohort study, Cold Spring Harbor Laboratory.
- Prognostic accuracy of emergency department triage tools for children with suspected COVID-19: The PRIEST observational cohort study, Cold Spring Harbor Laboratory.
- Professional activities and memberships
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I am the independent statistician on the Data Monitoring Committee or Trial Steering Committees for three trials:
- TBI Sertraline - A multi-centre, placebo-controlled, double-blind, randomised controlled trial of the clinical and cost-effectiveness of sertraline in preventing depression in adults following a traumatic brain injury.
- iACT4CARERS –A randomised controlled trial of the clinical and cost effectiveness of internet-delivered self-help Acceptance and Commitment Therapy for family carers of people with dementia.
- PROSPECT - A multi-centre, two-arm Phase III single-blind randomised controlled trial (RCT) of the clinical cost-effectiveness of targeted psychological therapy for suicidal male prisoners by enhancing access to therapies.