Professor Craig Murdoch

BSc (Hons), PhD

School of Clinical Dentistry

Professor in Oral Bioscience

c.murdoch@sheffield.ac.uk
+44 114 215 9367

Full contact details

Professor Craig Murdoch
School of Clinical Dentistry
19 Claremont Crescent
Sheffield
S10 2TA
Profile

I obtained my PhD in 1999 at the Institute of Child Health, University of Sheffield, then spent several years working as Post-Doctoral Research Associate in the Departments of Infection and Immunity, and Oncology at the University of Sheffield Medical School. I was appointed Lecturer at the School of Clinical Dentistry in 2006, Senior Lecturer in 2012, Reader in 2015 and then to Personal Chair in 2019.

Research interests

My main interests are centered on the innate immune response in oral diseases, in particular head and neck cancer and host-pathogen interactions. I am particularly interested in how immune cells are recruited to tumour sites, how they interact with other cells in the tumour microenvironment, and how the factors that these cells secrete may affect tumour growth. As part of this research my group has developed novel in vitro 3-dimensional models of oral cancer. My research also includes use of tissue-engineered models of the oral mucosa and zebrafish infection models to study the role of oral microbes in mucosal and systemic disease. I am also involved with projects aimed at developing novel oral patches for oral mucosal drug delivery and non-invasive diagnostics for the detection and management of oral pre-malignant lesions.

  • Role of innate immune cells in head and neck cancer progression.
  • Development of tissue engineered immunocompetent oral mucosal and skin models.
  • Host-pathogen interactions at the mucosal surface.
  • Use of zebrafish to examine the role of oral microbes in systemic disease.
  • Drug delivery and xenobiotic metabolising enzymes in skin and the oral mucosa.

Researchers:

  • Amy Harding (RA): Development and validation of tissue-engineered skin equivalents to detect stinging potential. (Rhoto) with Dr Helen Colley & Dr Simon Danby

Publications

Journal articles

Chapters

Conference proceedings papers

  • Colley HE, Said Z, Santocildes-Romero ME, Baker SR, D'Apice K, Hansen J, Madsen LS, Thornhill MH, Hatton PV & Murdoch C (2018) Novel Bilayer Mucoadhesive Patches for Delivery of Clobetasol-17-Propionate to the Oral Mucosa to Treat Oral Lichen Planus; an in Vitro and in Vivo Evaluation. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 126(4) (pp e204-e204) View this article in WRRO RIS download Bibtex download
  • Amabebe E, Qiao H, Murdoch C & Anumba D (2018) Vaginal epithelial cells co-cultured with Lactobacillus and anaerobes differentially express acetate and CXCL8. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol. 125 (pp 90-90) RIS download Bibtex download
  • Amabebe E, Qiao H, Murdoch C & Anumba D (2018) Cervicovaginal Epithelial Cells Differentially Express Acetate and CXCL8 in Co-Culture with Preterm Birth-Associated Bacteria and Protective Lactobacillus Species.. REPRODUCTIVE SCIENCES, Vol. 25 (pp 187A-187A) RIS download Bibtex download
  • Webb S, Sharma P, Colley HE, Sneddon A, Shipley R, Leedale J, Sarah S & Murdoch C (2018) Defining skin xenobiotic metabolism using a combined in vitro/in silico approach. APPLIED IN VITRO TOXICOLOGY, Vol. 4(1), 23 November 2017 - 24 November 2017. View this article in WRRO RIS download Bibtex download
  • Shipley R, Webb SW, Madden J, Smith SA, Cronin M, Colley HE & Murdoch C (2018) Mathematical modelling predicts the spatial distribution of metabolism in skin. European Cells and Materials, Vol. 32 (pp 96-96) RIS download Bibtex download
  • Hadley L, Santocildes-Romero ME, Thornhill MH, Hansen J, Colley HE, Hatton PV & Murdoch C (2016) Pre-clinical evaluation of novel electrospun patches for intra-oral drug delivery. Oral Diseases((Suppl. 2)) (pp 10-13), 15 September 2016 - 17 September 2016. View this article in WRRO RIS download Bibtex download
  • Santocildes-Romero ME, Hadley L, Clitherow KH, Hansen J, Murdoch C, Colley HE, Thornhill MH & Hatton PV (2016) Novel electrospun bioadhesive oral patches for mucosal drug delivery. Oral Diseases, Vol. 22(S2) (pp 11-11), 15 September 2016 - 17 September 2016. View this article in WRRO RIS download Bibtex download
  • Hadley L, Colley HE & Murdoch C (2016) Development of macrophage-containing in vitro 3D models of oral cancer. Oral Diseases, Vol. 22(S2) (pp 10-11), 15 September 2016 - 17 September 2016. View this article in WRRO RIS download Bibtex download
  • Chasib NH, Murdoch C & Colley HE (2016) Role of scavenger receptors in oral keratinocyte biology. Oral Diseases, Vol. 22 (pp 10-10) View this article in WRRO RIS download Bibtex download
  • Colley HE, D'Apice K, Baker SR, Hatton PV, Santocildes-Romero ME, Thornhill MH, Hansen J & Murdoch C (2016) Adhesion and acceptability of novel oral patches in human volunteers. Oral Diseases, Vol. 22(S2) (pp 19-19), 15 September 2016 - 17 September 2016. View this article in WRRO RIS download Bibtex download
  • Bolt R, Lambert D, Murdoch C, Thomas S, Foran B & Hunter K (2016) Human papillomavirus status and the microenvironment in oropharyngeal carcinoma; determinants of invasion and potential therapeutics. EUROPEAN JOURNAL OF CANCER, Vol. 61 (pp S60-S60) RIS download Bibtex download
  • Grayson A, Hearnden VL, Colley H, Bolt R, Jabreel A & Murdoch C (2016) Isolation and immortalisation of tonsillar keratinocytes for three-dimensional tissue engineered tonsil mucosal models. European Cells and Materials, Vol. 31(Suppl 1) (pp 20-20), 28 June 2016 - 1 July 2016. View this article in WRRO RIS download Bibtex download
  • Boadi J, Byers RA, Fernandes J, Mittar S, Hearnden V, Lu Z, MacNeil S, Thornhill M, Murdoch C, Hunter KD , McKechnie A et al (2016) 1300 nm and 890 nm OCT images of oral cancer tissue engineered models and biopsy samples offer complimentary performance (Conference Presentation). Photonic Therapeutics and Diagnostics XII, 13 February 2016 - 18 February 2016. RIS download Bibtex download
  • Sarb JD, Murdoch C & Anumba D (2016) The Effect of Relaxin-2 and Tissue Inhibitors of Matrix Metalloproteinase-2 (TIMP-2) on the Expression Levels of Matrix Metalloproteinase-2 (MMP-2) by Co-Incubation of Endometrial Stromal and Trophoblast Cell Lines.. REPRODUCTIVE SCIENCES, Vol. 23 (pp 335A-335A) RIS download Bibtex download
  • Gaskell H, Sharma P, Colley H, Murdoch C, Antoine D, Sathish J, Williams D & Webb S (2015) Development and characterisation of a functional 3D liver spheroid model. Toxicology Letters, Vol. 238(2) (pp S176-S176) RIS download Bibtex download
  • Sarb JD, Murdoch C & Anumba DOC (2015) Using 3-D Models To Investigate Trophoblast-Endometrial Interactions In Vitro. REPRODUCTIVE SCIENCES, Vol. 22 (pp 226A-226A) RIS download Bibtex download
  • Alkishi A, Khurram SA, Thornhill M & Murdoch C (2014) Abstract 2091: Metastatic oral cancer cell adhesion to vascular and lymphatic endothelial cells is sialyl Lewis A/X-dependent. Tumor Biology RIS download Bibtex download
  • Hunter K, Hakami F, Darda L, Lambert D, Murdoch C, Morgan R & Woll P (2013) The role of HOX genes in Head and Neck Squamous Cell Carcinoma (HNSCC). VIRCHOWS ARCHIV, Vol. 463(2) (pp 177-177) RIS download Bibtex download
  • Darda L, Lambert D, Morgan R, Murdoch C & Hunter K (2013) The role of miR-196a and HOXB9 in head and neck squamous cell carcinoma. EUROPEAN JOURNAL OF CANCER, Vol. 49 (pp S121-S121) RIS download Bibtex download
  • Alkishi AM, Khurram SA, Thornhill MH & Murdoch C (2013) Sialyl Lewis A and sialyl Lewis X antigens mediate oral cancer cell binding to recombinant E-selectin and TNF-alpha-stimulated endothelial cells. EUROPEAN JOURNAL OF CANCER, Vol. 49 (pp S134-S134) RIS download Bibtex download
  • Floriano PN, Kerr AR, Schmidt BL, Corby P, Khouly Castilla IE, Thornhill MH, D’Apice K, Murdoch C, Speight P, Redding S , McGuff S et al (2013) OP175. Oral Oncology, Vol. 49 (pp S70-S70) RIS download Bibtex download
  • Colley HE, Hearnden V, Wayakanon K, Cecchin D, Armes S, Battaglia G, Murdoch C & Thornhill MH (2012) Tissue engineered models of oral disease for the study of a novel drug delivery system. ORAL DISEASES, Vol. 18 RIS download Bibtex download
  • Murdoch C, Thornhill MH, Fang H-Y, Hearnden V & Colley HE (2012) CXCL12/CXCR4 axis mediates recruitment of monocytes to oral cancer spheroids. ORAL DISEASES, Vol. 18 (pp 8-8) RIS download Bibtex download
  • Kerr AR, Thornhill MH, D'Apice K, Murdoch C, Speight P, Hegarty A, Redding SW, Vigneswaran N, Christodoulides N, Floriano PN & McDevitt JT (2012) Non-invasive lab-on-a-chip characterization of potentially malignant oral disorders. ORAL DISEASES, Vol. 18 (pp 4-4) RIS download Bibtex download
  • Colley HE, Hearnden V, Cecchin D, Armes S, Battaglia G, Murdoch C & Thornhill MH (2012) Polymersomes - a Novel Drug Delivery System for the Delivery of Chemotherapeutic Agents to Oral Cancer Cells. EUROPEAN JOURNAL OF CANCER, Vol. 48 (pp S254-S254) RIS download Bibtex download
  • Hearnden V, Rehman IU, MacNeil S, Murdoch C, Thornhill MH, Hunter K & Colley HE (2012) Investigation of Raman Spectroscopy and Optical Coherence Tomography to Aid in Diagnosis of Oral Cancer. EUROPEAN JOURNAL OF CANCER, Vol. 48 (pp S287-S287) RIS download Bibtex download
  • Evans T, Tazzyman S, Chico T, Thornhill M & Murdoch C (2012) Using zebrafish as an in vivo model to study Candida albicans-mediated systemic candidiasis. MYCOSES, Vol. 55 (pp 11-11) RIS download Bibtex download
  • Venn PW & Murdoch C (2012) Development of a static adhesion assay to identify host proteins exploited by Candida albicans. MYCOSES, Vol. 55 (pp 303-303) RIS download Bibtex download
  • Sorrell I, Webb SD, Shipley RJ, Hearnden VL, Colley HE & Murdoch C (2012) Abstract 4918: Modeling polymersome delivery of anticancer therapeutics. Molecular and Cellular Biology RIS download Bibtex download
  • Muthana M, Giannoudis A, Scott SD, Mistry R, Murdoch C, Coffelt S, Georgeopolous L, Hamdy F, Brown N, Maitland N & Lewis CE (2010) Engineering macrophages to synthesize recombinant adenoviruses in hypoxic areas of human prostate tumours. DRUG DISCOVERY TODAY, Vol. 15(23-24) (pp 1097-1098) RIS download Bibtex download
  • Higham JH, Murdoch CM, Douglas CWI & Thornhill MH (2010) Atherosclerosis and oral health: mechanisms for P.gingivalis survival in endothelial-cells. Oral Diseases, Vol. 16 (pp 516-516) RIS download Bibtex download
  • Hearnden V, Smith L, Colley H, Thornhill M, Murdoch C, Smallwood R, Matcher S & MacNeil S (2010) Using tissue-engineered oral cancer models to evaluate non-invasive diagnostic technologies. ORAL DIS, Vol. 16(6) (pp 518-518) RIS download Bibtex download
  • Colley HE, Hearnden V, Murdoch C, Armes S, Battaglia G & Thornhill MH (2010) Using polymersomes to deliver chemotherapeutic agents to oral cancer cells. ORAL DIS, Vol. 16(6) (pp 527-527) RIS download Bibtex download
  • Yadev N, Bubeck S, Murdoch C, Saville SP, Lopez-Ribot J & Thornhill MH (2010) In vitro modelling of oral and vaginal candidiasis host-pathogen interactions. ORAL DIS, Vol. 16(6) (pp 517-517) RIS download Bibtex download
  • Fang H, Hughes R, Murdoch C, Coffelt S, Biswas SK, Imityaz HZ, Simon MC, Greten F, Rius J & Lewis CE (2010) Hypoxia inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing sustained hypoxia. EJC SUPPLEMENTS, Vol. 8(5) (pp 77-77) RIS download Bibtex download
  • Muthana M, Giannoudis A, Scott SD, Mistry R, Murdoch C, Georgeopolous L, Hamdy F, Brown N, Maitland N & Lewis CE (2010) Engineering Macrophages to Synthesize Recombinant Adenoviruses in Hypoxic Areas of Human Prostate Tumours. HUMAN GENE THERAPY, Vol. 21(4) (pp 488-488) RIS download Bibtex download
  • Wayakanon K, Thornhill M, Douglas I, Battaglia G & Murdoch C (2010) Synthesized polymer vesicles as antibiotic delivery vehicles for treating intracellular porphyromonas gingivalis. Proceedings of the IASTED International Conference on Nanotechnology and Applications, NANA 2010 (pp 559-564) RIS download Bibtex download
  • Colley HE, MacNeil S, Jones AV, Thornhill MH & Murdoch C (2009) The development of in vitro models of squamous cell carcinoma of the oral mucosa - From mild dysplasia to an expanding carcinoma. ORAL ONCOLOGY (pp 160-160) RIS download Bibtex download
  • Hearnden V, Battaglia G, MacNeil S, Murdoch C & Thornhill M (2009) Penetration of polymersome drug and gene delivery nanoparticles into in vitro models of head and neck cancer and tissue engineered oral mucosa. ORAL ONCOLOGY (pp 66-66) RIS download Bibtex download
  • Murdoch C, Colley H, MacNeil S & Thornhill M (2009) Hypoxia-induced secretion of CXCL12 by head and neck tumour spheroids mediates infiltration of monocytes by a CXCR4-dependent mechanism. ORAL ONCOLOGY (pp 68-68) RIS download Bibtex download
  • Hearnden V, Battaglia G, Murdoch C, Thornhill M & MacNeil S (2008) Imaging of polymersome penetration into 3D tissue engineered models of oral mucosa and head and neck cancer. European Cells and Materials, Vol. 16(SUPPL. 3) (pp 58) RIS download Bibtex download
  • Muthana M, Scott S, Farrow N, Murdoch C & Lewis C (2007) Magnetite nanoparticle-loaded macrophages enhance gene delivery to tumours. IMMUNOLOGY, Vol. 120 (pp 82-82) RIS download Bibtex download
  • Hughes R, Murdoch C, Fang HY & Lewis C (2007) Microenvironmental signals regulating the tumour-promoting functions of macrophages: role of hypoxia and necrotic debris. JOURNAL OF LEUKOCYTE BIOLOGY (pp 56-56) RIS download Bibtex download
  • Scott SD, Greco O, Murdoch C & Lewis C (2005) Radiation, hypoxia and chemotherapy-mediated gene therapy and the potential for tumour delivery via macrophages. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol. 63(2) (pp S137-S137) RIS download Bibtex download
  • Murdoch C, Lakshman R, Burkinshaw R, Shaw L & Finn A (2001) Effect of hepatavalent conjugate pneumococcal vaccine in infancy and booster polysaccharide vaccine at 13 months on nasopharyngeal carriage of S-pneumoniae in children aged 2 to 4 years. CLIN INFECT DIS, Vol. 33(7) (pp 1148-1148) RIS download Bibtex download
  • Murdoch C, Monk PN & Finn A (1998) CXC chemokine receptor expression on human endothelial cells. J VASC RES, Vol. 35(5) (pp 388-388) RIS download Bibtex download
  • Murdoch C, Barker MD, Pease JE, Finn A & Monk PN (1996) Leukocyte chemoattractant receptor expression on endothelial and epithelial cells. IMMUNOLOGY, Vol. 89 (pp OM115-OM115) RIS download Bibtex download
  • Murdoch C, Monk PN & Finn A (1996) Analysis of the endothelial panel reactivity against the type II alveolar epithelial cell line, A549.. TISSUE ANTIGENS, Vol. 48(4-II) (pp EC216-EC216) RIS download Bibtex download
Research group

PhD students:

  • Cher Farrugia: Use of in vitro and in vivo zebrafish embryo infection models to investigate the role of oral microorganisms in cardiovascular disease. (co-supervisor: Dr Graham Stafford, University Faculty Studentship)
  • Bethany Ollington: Immune-competent tissue engineered oral mucosal models to investigate xenobiotic metabolism. (co-supervisor: Dr Helen Colley, DiMeN MRC Studentship)
  • Inmaculada Barragan Vazquez: Tissue engineered modelling of atopic dermatitis (co-supervisors: Dr Helen Colley & Dr Simon Danby, Almirall S.A. funded PhD Studentship)
  • Asma El-Howati: Tissue engineered oral inflammatory lesions (lead supervisor: Dr Helen Colley, Funded by Libyan Government Scholarship)
  • Klaudia Slowik: The role of metabolising enzymes in drug delivery for prevention of alveolar osteitis. (lead supervisor: Dr Helen Colley, EPSRC Funded Studentship)
  • Jake Edmans: Peptide delivery using electrospun mucoadhesive patches (lead supervisor: Dr Helen Colley, EPSRC Centre for Doctoral Training in Polymers and Soft Matter)
  • Asmaa Zanki: Fabrication of dentures with anti-fungal properties by additive manufacturing. (lead supervisor: Prof. Paul Hatton - Funded by Kuwait Government Scholarship)
Teaching activities

Undergraduate teaching modules:

Bachelor of Dental Surgery:

  • DEN103 - The Human Body
  • DEN204 - Basic Oral & Dental Care
  • DEN304 - Integrated Human Disease
  • DEN504 - Oral Disease

MbChB Medicine:

  • MEDU01 - Immunology

Post-Graduate Taught Course:

  • DEN616 – Tissue Engineering & Regenerative Dentistry (module lead) taught to both MSc in Dental Materials Science and MMedSci in Diagnostic Oral Pathology
  • OCP604 – MSc(Res) Translational Oncology (Chemokines in Cancer)

PGT research projects regularly supervised for MSc Dental Materials Science, MMedSci in Diagnostic Oral Pathology, MSc Molecular Medicine and MSc(Res) Translational Oncology.

Professional activities
  • British Association for Cancer Research National Executive Committee Member (2017 - present).
  • National Centre for the Replacement Refinement and Reduction of Animals (NC3R) Studentship Grant Review Board Member (2016 - present).
  • PlosOne Academic Editor (2015 - present).
  • Associate Editor Frontiers in Oral Health