Dr Milena De Felice

BSc, PhD

School of Clinical Dentistry

Lecturer in Oral Neuroscience

m.defelice@sheffield.ac.uk
+44 114 225 9316

Full contact details

Dr Milena De Felice
School of Clinical Dentistry
19 Claremont Crescent
Sheffield
S10 2TA
Profile

I graduated with a degree in Biology followed by a PhD in Pharmacology (2007) from the Sapienza University of Rome.

During my PhD, I had the privilege of visiting the lab of Professor Frank Porreca at the University of Arizona, USA, where I then decided to move after completing my PhD. While in the USA, I worked on investigating mechanisms that drive chronic pain conditions with a particular emphasis on migraine headache pain and I developed two preclinical models to study cephalic pain. 

At the end of 2013, I joined the School of Clinical Dentistry at the University of Sheffield (UK) and I was awarded a prestigious Marie Skłodowska-Curie International Incoming Fellowship funded by the European Union.  Hosted in Prof Fiona Boissonade’s lab, during my fellowship I further developed the translatability of the migraine model using preclinical MRI.

I then joined Professor Arshad Majid’s group at the Sheffield Institute for Translational Neuroscience to expand my knowledge in CNS disorders working on stroke and neuroinflammation.

A move to the private sector in 2021 as the Head of the Pharmacology Department at Labcorp, was followed by a return to the University of Sheffield as a Lecturer in Oral Neuroscience at the School of Clinical Dentistry in 2022.

My main research focuses on the preclinical investigation of chronic orofacial pain and post-stroke pain.

Research interests

I have a long-standing interest in mechanisms that drive chronic pain conditions with a particular emphasis on migraine headaches and post-stroke pain. My research interests are translational and interdisciplinary and lie primarily in novel approaches to better understand the underlying causes of chronic pain conditions, that could lead to discoveries of new targets for drug development with the ultimate goal of improved pain management

By using molecular, neurobiological and neuropharmacological approaches (including MRI imaging, neurochemical and electrophysiological studies) my current research aims at identifying altered neuronal excitability and activity in the central nervous system in preclinical models of post-stroke and migraine pain.

Publications

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Teaching interests

I teach Pharmacology and Oral Neuroscience across the Bachelor of Dental Surgery (BDS) degree.

I am module lead for Head and Oral Cavity in Health and Disease (BSc first year).

Professional activities
  • Member of the International Association for the Study of Pain and the British Pharmacology Society.
  • Member of the Sheffield Neuroscience institute Executive committee as the ED&I lead.
  • Associated editor for Headache Medicine and Facial Pain section in Frontiers in Neurology and for Neurological Drug section in Frontiers in Drug Discovery.
  • Invited peer reviewer for journals (Pain; Cephalalgia; Journal of Pain; British Journal of Pharmacology; etc).
  • Pool reviewer for Versus Arthritis UK and MRC Neurosciences & Mental Health UK funds.
  • External PhD examiner for King’s College London, UK; University of Copenhagen Denmark; Sapienza University of Rome, Italy.