Dr Chris Toseland

Department of Oncology and Metabolism

Senior Lecturer

Chris Toseland
c.toseland@sheffield.ac.uk
+44 114 215 9080

Full contact details

Dr Chris Toseland
Department of Oncology and Metabolism
FU34, F Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

For enquiries, please contact - om-operational@sheffield.ac.uk

2019: Senior Lecturer/MRC Career Development Award Fellowship
Dept. of Oncology and Metabolism - University of Sheffield

2015 - 2019: MRC Career Development Award
Schools of Biosciences - University of Kent

April 2015: Leverhulme Early Career Research Fellow
Schools of Biosciences - University of Kent

2013 – 2015: Senior Post-Doc Researcher
Max-Planck Institute for Biochemistry, Munich, Germany

2010 – 2013: EMBO Long Term Fellow
LMU Munich, Munich, Germany

2009 – 2010: Post-Doctoral Research Associate
MRC National Institute for Medical Research, London, UK

2006 – 2009: PhD
MRC National Institute for Medical Research, London, UK

2002 – 2006: BSc Biochemistry
University of Wales - Aberystwyth

Research interests

The lab specialises in application of fluorescence and mechanical measurements from whole cells to single molecules. We are a multidisciplinary lab drawing upon core techniques in Cell Biology, Biochemistry, Biophysics, Mechanobiology, Super Resolution single molecule imaging and Genomics Gene expression, the transfer of the genetic code into cellular proteins is one of the most fundamental processes in living cells. This process is orchestrated by RNA polymerases, which are highly regulated to ensure correct expression.

A breakdown in this regulation leads to development disabilities and most notably cancer formation. Furthermore, changes in expression control embryonic development and stem cell differentiation.

Over the past decade it has become established that myosin motors are present in the nucleus and function in transcription, but what role they play in the organisation and transcription of genetic information is unclear.

For the first time we combine classical biochemical and single molecule assays to provide a quantitative high-resolution description of the activity of these nuclear myosins; providing a mechanistic insight into the activity of these proteins.

Please see External Lab HomePage for more information.

Publications

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Journal articles

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Journal articles

Chapters

Conference proceedings papers

Research group
  • Dr Natalia Fili (Postdoctoral Research Associate)
  • Rosemarie Gough (Postdoctoral Research Associate)
  • Alexander Cook (Postdoctoral Research Associate)
  • Alia dos Santos (PhD Student)
Grants
  • Medical Research Council
  • Cancer Research UK
  • Science and Technology Facilities Council
  • Royal Society
  • Leverhulme Trust