Professor Alison Gartland

BSc (Hons), PhD

Clinical Medicine, School of Medicine and Population Health

Professor of Bone and Cancer Biology

a.gartland@sheffield.ac.uk
+44 114 215 9046

Full contact details

Professor Alison Gartland
Clinical Medicine, School of Medicine and Population Health
DU34
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

For enquiries, please contact – ClinMed-Operational@sheffield.ac.uk

I studied Biomedical Technology at Sheffield Hallam University and - following a period in industry - studied for my PhD at The University of Liverpool in Prof Jim Gallagher´s lab on the "Expression and functional significance of the P2X7 receptor in skeletal tissue".

I then moved to Montpellier, France where I was a Post-Doctoral Researcher at IGMM, CNRS in Bob Hipskind´s lab. Following this, I was a Senior Post-Doctoral Researcher in the Department of Cell Biology at the University of Massachusetts Medical School USA, in the late Prof Sandy Marks Jnr´s lab.

I joined the University of Sheffield in 2006 as a Lecturer in Bone Biology.

Research interests

My research interests are in P2 receptor signalling in musculoskeletal disease and cancer. The role of P2 purinoreceptor ligands (ATP and other nucleotides) as extracellular messengers is well established and there is now conclusive evidence, from my previous work and that of others, that extracellular nucleotides have a highly influential role in the bone microenvironment. In addition to their roles in bone, nucleotides and P2 receptor signalling have been shown to play a role in cancer.

Publications

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All publications

Journal articles

Chapters

  • Tattersall L, Davison Z & Gartland A (2020) Osteosarcoma, Encyclopedia of Bone Biology (pp. 362-378). Elsevier RIS download Bibtex download
  • Buckley KA, Gartland A & Gallagher JA (2006) The role of purinergic signaling in the interactions between skeletal cells, Nucleotides and Regulation of Bone Cell Function (pp. 61-74). RIS download Bibtex download
  • Gartland A, Buckley KA, Dillon JP, Curran JM, Hunt JA & Gallagher JA (2005) Isolation and culture of human osteoblasts. (pp. 29-54). RIS download Bibtex download

Conference proceedings papers

  • Sprules AR, Latif NB, Brown JE, Gartland A & Wang N (2021) Abstract 2904: Mechanical loading induced osteogenic response does not interfere with the colonization of breast cancer in bone. Cancer Research, Vol. 81(13_Supplement) (pp 2904-2904) RIS download Bibtex download
  • Gartland A (2021) Primordial signalling in prehistoric cancer. JOURNAL OF ANATOMY, Vol. 238(1) (pp 191-191) RIS download Bibtex download
  • Sprules AR, Latif NB, Brown JE, Gartland A & Wang N (2021) Mechanical loading induced osteogenic response does not interfere with the colonization of breast cancer in bone.. CANCER RESEARCH, Vol. 81(13) RIS download Bibtex download
  • Roberts B, Carrera HA, Pour SZ, Boudiffa M, Gartland A, Wang N & Dall'Ara E (2019) Longitudinal Effects of Combined Bone Anabolic Interventions on Ovariectomised Mice. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 34 (pp 258-259) RIS download Bibtex download
  • Tattersall L, De Marchi E, Williamson A, Di VF, Lawson MA, Adinolfi E & Gartland A (2018) P2X7R in primary bone cancer. PURINERGIC SIGNALLING, Vol. 14 (pp S13-S14) RIS download Bibtex download
  • Syberg S, Agrawal A, Petersen S, Jensen J-EB, Schwarz P, Gartland A, Boes M & Jorgensen N (2014) The P2X7 Antagonist AFC-5261 rescues Ovariectomy-induced Bone Loss in Mice.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 29 (pp S402-S403) RIS download Bibtex download
  • Dillon J, Wilson P, Gartland A, Hipskind R & Gallagher J (2013) A Novel Factor Derived From Resorbing Bone In Vitro Potently Stimulates C-Fos Expression In Breast Cancer Cells. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 28 RIS download Bibtex download
  • Wang QG, Adinolfi E & Gartland A (2013) P2X7 Receptor Polymorphisms Modulate Osteoblast Cell Functions. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 28 RIS download Bibtex download
  • Wang QG, Mohanty S, Bellantuono I & Gartland A (2012) TIBIAL PLATEAU BONE SURFACE ROUGHNESS - A POTENTIAL NEW EARLY MARKER TO DETECT ARTHRITIS?. OSTEOPOROSIS INTERNATIONAL, Vol. 23 (pp S574-S574) RIS download Bibtex download
  • Shah K, Quinn P, Wilkinson M & Gartland A (2012) SPECIATION AND DISTRIBUTION OF COBALT AND CHROMIUM IN OSTEOBLASTS AND OSTEOCLASTS USING MICROFOCUS X-RAY FLUORESCENCE AND X-RAY ABSORPTION NEAR-EDGE STRUCTURE. OSTEOPOROSIS INTERNATIONAL, Vol. 23 (pp S592-S592) RIS download Bibtex download
  • Syberg S, Agca C, Wang N, Petersen S, Gartland A, Schwarz P, Jorgensen NR & Agca Y (2012) P2Y2 receptor overexpression results in decreased bone formation. BONE, Vol. 50 (pp S85-S86) RIS download Bibtex download
  • Syberg S, Agca C, Wang N, Petersen S, Gartland A, Schwarz P, Jorgensen NR & Agca Y (2012) P2Y2 receptor overexpression results in decreased bone formation. BONE, Vol. 50 (pp S67-S67) RIS download Bibtex download
  • Greeves J, Fraser W, Friedman E, Wilson P, Dillon J, Gartland A & Gallagher J (2012) Association of polymorphisms in the P2X7 receptor gene with stress fracture risk in military recruits. BONE, Vol. 50 (pp S108-S108) RIS download Bibtex download
  • Agrawal A & Gartland A (2011) Expression of NFATc1 is inducible by P2X7 receptor activation in human osteoclasts. BONE, Vol. 48 (pp S126-S126) RIS download Bibtex download
  • Wang N, Robaye B, Agrawal A, Reilly G, Boeynaems JM & Gartland A (2011) Deletion of the P2Y13 receptor leads to reduced bone turnover and protection from ovariectomy-induced bone loss. BONE, Vol. 48 (pp S227-S227) RIS download Bibtex download
  • Evans HR, Ab Latif N, Cox TR, Bird D, Lang G, Erler JT & Gartland A (2011) Tumour-secreted lox mediates osteolytic bone metastases prior to metastatic tumour cell colonisation. BONE, Vol. 48(1) (pp S21-S21) RIS download Bibtex download
  • Syberg S, Schwarz P, Petersen S, Jensen JEB, Steinberg TH, Gartland A, Chessell I & Jorgensen NR (2010) Bone status of P2X7 knockout mice in two different strains. PURINERG SIGNAL, Vol. 6 (pp 158-158) RIS download Bibtex download
  • Shah K, Patel V, Wang N & Gartland A (2010) The Effect of ATP on cancer cell proliferation in vitro -involvement of multiple P2X Receptors. PURINERG SIGNAL, Vol. 6(1) (pp 140-140) RIS download Bibtex download
  • Wang N, Rumney RMH, Agrawal A, Robaye B, Boeynaems JM & Gartland A (2010) Bone Phenotype of P2Y13 Receptor Knock-Out Mice. PURINERG SIGNAL, Vol. 6(1) (pp 144-144) RIS download Bibtex download
  • Rumney RMH, Wang N & Gartland A (2010) The role of P2X(7) receptors in ATP release from osteoblasts. PURINERG SIGNAL, Vol. 6(1) (pp 129-129) RIS download Bibtex download
  • Andrews R, Wilkinson J & Gartland A (2010) The effect of cobalt and chromium ions at clinically relevant concentrations on human osteoblast and osteoclast physiology in vitro: implications for skeletal health. BONE, Vol. 46 (pp S71-S71) RIS download Bibtex download
  • Orriss IR, Burnstock G, Gartland A & Arnett TR (2009) Regulation of osteoblast function and mineralisation by extracellular nucleotides: The role of P2Y and P2X receptors. BONE, Vol. 44 (pp S154-S154) RIS download Bibtex download
  • Gartland A, Skarratt KK, Hocking LJ, Stokes L, Clifton-Bligh R, Parsons C, Fraser WD, Reid DM, Wiley JS & Gallagher JA (2008) Loss of Function Polymorphisms in The P2X(7) Receptor Gene Are Associated with Accelerated Lumbar Spine Bone Loss in Postmenopausal Women.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 23 (pp S296-S296) RIS download Bibtex download
  • Gartland A, Buckley KA, Bowers K, Gaw A, Furber M & Gallagher JA (2008) A Novel Selective P2X(7) Receptor Antagonist Inhibits Human Osteoclast Formation in vitro.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 23 (pp S403-S403) RIS download Bibtex download
  • Orriss IR, Evans HR, Gartland A & Arnett TR (2008) Microct analysis of P2Y1 and P2Y2 receptor knockout mice demonstrates significant changes in bone phenotype. CALCIFIED TISSUE INT, Vol. 83(1) (pp 2-3) RIS download Bibtex download
  • Rumney RMH, Sittichokechaiwut A, Reilly G & Gartland A (2008) ATP release from osteoblasts is increased in response to mechanical loading by different amounts when grown in standard monolayer and novel 3D scaffolds. CALCIFIED TISSUE INT, Vol. 83(1) (pp 16-16) RIS download Bibtex download
  • Patel V, Rumney R, Wang N, Hipskind RH, Gallagher JA & Gartland A (2008) The effect of ATP, alone and in combination with EGF, on breast cancer cell survival. PURINERG SIGNAL, Vol. 4 (pp S205-S206) RIS download Bibtex download
  • Gartland A, Skarratt K, Hocking L, Clifton-Bligh R, Parsons C, Fraser W, Reid D, Wiley J & Gallagher J (2008) A polymorphism in the P2X7 receptor gene is associated with loss of lumbar spine bone mineral density in postmenopausal women. PURINERG SIGNAL, Vol. 4 (pp S172-S173) RIS download Bibtex download
  • Orriss I, Evans H, Arnett T & Gartland A (2008) MicroCT analysis of P2Y1 and P2Y2 receptor knockout mice demonstrates significant changes in bone phenotype. PURINERG SIGNAL, Vol. 4 (pp S176-S176) RIS download Bibtex download
  • Gallagher JA, Dillon JP, Kimani BM, Hayton MJ & Gartland A (2008) Regulation and mechanisms of ATP release from osteoblasts. PURINERG SIGNAL, Vol. 4 (pp S161-S161) RIS download Bibtex download
  • Rumney R, Wang N, Sittichokechaiwut A, Reilly G & Gartland A (2008) Different types of mechanical loading induce differentitial ATP release from osteoblasts grown on 3-dimensional scaffolds. PURINERG SIGNAL, Vol. 4 (pp S164-S165) RIS download Bibtex download
  • Rumney RMH, Sittichokechaiwut A, Reilly GC & Gartland A (2008) Cyclical compressive loading induces changes in cellular behaviour and ATP release from osteoblasts grown on 3-dimensional scaffolds. CALCIFIED TISSUE INT, Vol. 82 (pp S115-S116) RIS download Bibtex download
  • Gartland A, Skarrat KK, Hocking LJ, Clifton-Bligh R, Parsons C, Fraser WD, Reid DM, Gallagher JA & Wiley JS (2008) Novel association between a polymorphism in the P2X7 receptor gene and loss of lumbar spine bone mineral density in postmenopausal women. CALCIFIED TISSUE INT, Vol. 82 (pp S43-S43) RIS download Bibtex download
  • Gallaigher JA, Dillon JP, Wilson PM, Burrell HE, Hayton MJ, Fraser WD & Gartland A (2007) ATP is released from human osteoblasts by multiple mechanisms.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 22 (pp S146-S146) RIS download Bibtex download
  • Mwaura BK, Hayton MJ, Dillon JP, Burrell HE, Gallagher JA & Gartland A (2006) Release of ATP from human osteoblastic cell lines and primary osteoblasts occurs via exocytosis. BONE, Vol. 38(3) (pp S11-S11) RIS download Bibtex download
  • Gartland A, Hipskind RA, Fraser WD & Gallagher JA (2006) The synergistic effect of extracellular nucleotides and EGF on c-fos expression in two breast cancer cell lines. BONE, Vol. 38(3) (pp S35-S35) RIS download Bibtex download
  • Buckley KA, Dillon JP, Chan BYY, Gartland A, Fraser WD & Gallagher JA (2006) Low dose PTH, insufficient to induce cyclic AMP or C-fos, stimulates an anabolic gene response in human osteoblasts in vitro. BONE, Vol. 38(3) (pp S10-S11) RIS download Bibtex download
  • (2006) Regulation of ATP release from human osteoblasts: A calcium dependant, exocytotic vesicular mechanism. CALCIFIED TISSUE INTERNATIONAL, Vol. 78 (pp S49-S49) RIS download Bibtex download
  • Chan BY, Buckley KA, Wilson PJ, Wherly N, Cheng Y, Dillon JP, Gartland A, Fraser WD & Gallagher JA (2005) Differential effect of PPAR agonists on human recombinant RANKL generated osteoclast culture in vitro. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 20(7) (pp 1303-1303) RIS download Bibtex download
  • Gartland A, Buckley KA, Dillon JP, Curran JM, Chan BYY, Fraser WD & Gallagher JA (2005) A biphasic pattern of osteoblast gene expression by differing concentrations of PTH 1-34. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 20(7) (pp 1308-1308) RIS download Bibtex download
  • Gartland A, Wilson PJ, Dillon JP, Chan BY, Buckley KA, Fraser WD & Gallagher JA (2005) ATP release and P2 receptor expression by human chondrocytes.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 20(7) (pp 1301-1301) RIS download Bibtex download
  • Chan BYY, Buckley KA, Wilson PJ, Wherly N, Cheng JY, Dillon JP, Gartland A, Fraser WD & Gallagher JA (2005) Effect of PPAR agonists, on human osteoclast formation and activity in vitro. BONE, Vol. 36 (pp S300-S301) RIS download Bibtex download
  • Mailhot G, Gartland A, Mason-Savas A, Mackay CA & Odgren PR (2005) Cellular and molecular characterization of primary rat chondrocytes differentiated in culture. BONE, Vol. 36 (pp S173-S173) RIS download Bibtex download
  • Gartland A, Fraser WD, Gallagher JA & Hipskind RA (2005) The effects of extracellular nucleotides on EGF-induced c-fos gene expression. BONE, Vol. 36 (pp S256-S256) RIS download Bibtex download
  • Chan BY, Buckley KA, Gartland A, Fraser WD & Gallagher JA (2005) Differential effect of PPAR agonists on generation of human osteoclasts in vitro. CLINICA CHIMICA ACTA, Vol. 355 (pp S32-S32) RIS download Bibtex download
  • Chan BY, Buckley KA, Gartland A, Fraser WD & Gallagher JA (2005) Differential effect of PPAR agonists on generation of human osteoclasts in vitro. CLINICA CHIMICA ACTA, Vol. 355 (pp S255-S255) RIS download Bibtex download
  • Gartland A, Mason-Savas A, MacKay C, Lee ER, Mort J, Odgren PR & Marks SC (2004) Abnormal septoclasts at the chondroosseous junction in the TL rat are normalised following CSF-1 treatment. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19(6) (pp 1049-1049) RIS download Bibtex download
  • Odgren PR, Gartland A, Gartland A, Devraj K, Bonassar LJ, MacKay C & Mason-Savas A (2004) Osteopetrotic chondrodysplasia in the toothless (CSF-1null) rat: A paradigm for the role of osteoclastogenic factors as integrators of endochondral ossification. BONE, Vol. 34 (pp S38-S38) RIS download Bibtex download
  • Gartland A, Mason-Savas A, MacKay C, Lee ER, Mort J, Odgren PR & Marks SC (2003) CSF-1 treatment corrects septoclast abnormalities at the chondroosseous junction in the Toothless rat.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 18 (pp S111-S111) RIS download Bibtex download
  • Gartland A, Mason-Savas A, MacKay CA, Marks SC & Odgren PR (2003) Chondrocytes from the osteopetrotic mutation toothless (TL)/Csf-1 null rat differentiate in vitro. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 18(7) (pp 1370-1370) RIS download Bibtex download
  • Gartland A, Mason-Savas A, MacKay CA, Marks SC & Odgren PR (2002) Chondrocytes, growth plates, and RANKL-induced signalling: Observations and implications of osteopetrotic mutations. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 17(7) (pp 1339-1339) RIS download Bibtex download
  • Gartland A, Buckley KA, Hipskind RA, Perry MJ, Tobias JH, Buell G, Chessel I, Bowler WB & Gallagher JA (2002) P2X(7) receptor-deficient mice maintain the ability to form multinucleated) osteoclasts in vivo and in vitro. J BONE MINER RES, Vol. 17(7) (pp 1338-1338) RIS download Bibtex download
  • Gartland A, Gallagher JA & Bowler WB (2001) Blockade of P2X(7) receptors inhibits osteoclast fusion in vitro. BONE, Vol. 28(5) (pp S166-S167) RIS download Bibtex download
  • Bowler WB, Gartland A, Buckley KA, Golding SL & Gallagher JA (2000) ATP released into the extracellular environment by osteoblasts regulates differentiation and apoptosis of bone cells.. J BONE MINER RES, Vol. 15 (pp S476-S476) RIS download Bibtex download
  • Gartland A, Gallagher JA & Bowler WB (2000) Expression of the pore forming P2X(7) receptor by human rank ligand-generated osteoclasts and human osteoclastic cells in situ.. J BONE MINER RES, Vol. 15(6) (pp 1227-1227) RIS download Bibtex download
  • Shah KM () The Effect of ATP on cancer cell proliferation in vitro -involvement of multiple P2X Receptors. Purinergic Signalling, Vol. 6(1) (pp 140). Sheffield RIS download Bibtex download

Preprints

Research group

Current Collaborators

  • Professor Mark Wilkinson
  • Dr Dawn Teare
  • Dr Gaynor Miller
  • Dr Shelly Lawson

Postgraduate Students

  • Mr Luke Tattersall
Teaching interests

I am Chair of the Medical School Graduate Research Committee, I lecture on the undergraduate Medical Course as well as being the academic lead for the research Attachment SSC, I also run the Doctoral Development Programme module "Effective Presentation and Seminar Participation" MED605.

Professional activities and memberships

I am the Founder and President of the UK Purine Club, and member of the Bone Research Society, European Calcified Tissue Society, the International Bone and Mineral Society and the American Society for Bone and Mineral Research.