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    MSc
    2023 start September 

    Molecular Medicine

    The Medical School, Faculty of Medicine, Dentistry and Health

    This flexible course gives you the chance to choose specialist modules from the pathway that interests you most. You'll carry out a five-month research project, which gives you invaluable laboratory experience. Our graduates go on to PhD study or work in related industries.
    Group of three postgraduate students in the medical scool using medical equipment

    Course description

    Lead academic: Dr Martin Nicklin

    Designed for both animal/human biology and clinical graduates, this flexible course focuses on the molecular and genetic factors of human diseases. Understanding these factors is crucial to the development of therapies.

    The course will

    • provide you with an understanding of both the background and the current technical and scientific advances in biomedical science and therapeutic design.
    • teach you how to use the latest technology to answer research questions
    • emphasise how experiments and experimental programmes are designed and interpreted.
    • provide you with an experience of a hypothesis-driven laboratory research project alongside experts in the field

    All the above will increase your employability in both industry and academia, as well as being an excellent route to a PhD. It will also provide valuable transferable skills that you can use in whatever career path you choose.

    Two-year post-study work visa

    The UK government has announced a two-year post-study work visa for international students.

    Intercalation

    We accept medical students who wish to intercalate their studies. Find out more on the Medical School website.

    Do you have a question? Talk to us

    Book a 15-minute online meeting with our course tutor to find out more information and ask further questions.

    Book an appointment with Martin Nicklin

    Modules

    A selection of modules are available each year - some examples are below. There may be changes before you start your course. From May of the year of entry, formal programme regulations will be available in our Programme Regulations Finder.

    The course begins with six core modules that are appropriate to all specialities. These core modules cover the fundamentals.

    You'll then choose from one of four specialist pathways: Genetic Mechanisms, Microbes and Infection, Cancer and Experimental Medicine, and choose from a selection of projects, associated with these pathways.

    Medical graduates may also be interested in our clinical applications pathway

    Explore core modules and pathways

    The content of our courses is reviewed annually to make sure it's up-to-date and relevant. Individual modules are occasionally updated or withdrawn. This is in response to discoveries through our world-leading research; funding changes; professional accreditation requirements; student or employer feedback; outcomes of reviews; and variations in staff or student numbers.

    In the event of any change, we'll consult and inform students in good time and take reasonable steps to minimise disruption. We are no longer offering unrestricted module choice. If your course included unrestricted modules, your department will provide a list of modules from their own and other subject areas that you can choose from.

    The content of our courses is reviewed annually to make sure it's up-to-date and relevant. Individual modules are occasionally updated or withdrawn. This is in response to discoveries through our world-leading research; funding changes; professional accreditation requirements; student or employer feedback; outcomes of reviews; and variations in staff or student numbers. In the event of any change we'll consult and inform students in good time and take reasonable steps to minimise disruption. We are no longer offering unrestricted module choice. If your course included unrestricted modules, your department will provide a list of modules from their own and other subject areas that you can choose from.

    Open days

    An open day gives you the best opportunity to hear first-hand from our current students and staff about our courses. You'll find out what makes us special.

    Upcoming open days and campus tours

    Duration

    1 year full-time. We are unable to offer a part-time or distance learning study option for this course at present.

    Our expertise

    The University of Sheffield is ranked number one in the UK for the world-leading quality of our biomedical research and in the top ten for combined world-leading and internationally excellent research outputs in clinical medicine.

    The impactful, high-quality research that we undertake influences how we teach across all of our postgraduate courses. In many areas, our research activity spans the spectrum from basic science up to practical clinical applications. We pride ourselves on collaboration between  clinicians and non-clinicians, and many of our courses include teaching from practising clinicians as well as research-active academics.

    Why study molecular medicine with us?

    Learn about the latest developments

    Molecular biology has proved to be a rich source of new therapeutic agents in the last three decades. Recombinant proteins continue to be developed as successful drugs that principally target extracellular proteins such as cytokines and cell-surface receptors. Protein drugs are almost always injected. Bioinformatic data can now be used to identify new intracellular target proteins and investigate the networks of interactions that the target proteins participate in. It is becoming increasingly possible to model the surfaces of target proteins and use this information to model the interaction of low molecular weight, orally available drugs and even design drugs from scratch.

    The completed Human Genome Project revolutionised the ways that we can consider human diseases. Single gene defects that cause rare genetic disorders took man-centuries to discover only 20 years ago. Now, because of next generation sequencing (NGS), single, novel gene defects can sometimes be identified in individual patients with only man-weeks of effort.

    It will soon be economically plausible to sequence all of an individual's genes in the clinic. Common diseases, though, are not caused by single gene defects. Many clearly involve the interaction of many susceptibility genes with the environment.

    An important part of the environment is the microbiome, the collective of microorganisms that inhabit an individual human. These organisms have strong interactions, many beneficial, with the immune system of the host and are fundamental to the understanding of common inflammatory diseases. It is now relatively simply to determine the composition of a microbiome, again by NGS.

    Changes that do not alter DNA sequence, known as epigenetic changes, can modulate the activity of genes too. Genes can be regulated by micro-RNA transcripts. All of these changes can increasingly be analysed by dedicated NGS methods that will be used in clinics of the future to investigate common diseases and to identify the multiple defects that drive individual patients' cancers.

    Our course aims to give you insights into all of these new developments and training in how to be a modern biomedical researcher.

    A recent external examiner report praised the quality of this course:

    This course provides an excellent training in a wide area of biomedical sciences. This explicitly includes soft skills such as critical thinking and processing of information that equips its graduates with the tools for successful careers in both academic and non-academic environments.

    Teaching

    Teaching consists of lectures supported by interactive tutorials, seminars, practical classes and simulations. You will attend departmental seminars and Research in Progress meetings as well as research group meetings once your project has started.

    Our teaching covers practical scientific skills, data analysis skills, and an overview of the current literature. You’ll also develop useful career skills such as presentation, communication, and time management. We use speakers from the pharmaceutical industry to put our teaching into a commercial context. Practising clinical colleagues from the Medical School also contribute to this course.

    Assessment

    Modules are assessed by written assignments, oral presentations, and/or written exams.  The research project is assessed by an oral presentation and written dissertation. You may also have an oral examination of your research project.

    Your career

    A high proportion of students from this course progress to study for a PhD, while others go on to work in the biotechnology or pharmaceutical industries. Our graduates have gone on to work for many prestigious institutions throughout the world, including Cambridge Bioscience, Covance and ADC Biotechnology.

    There are a wide variety of roles you can pursue, including:

    • PhD Studentship in Medical Science
    • Research work in Pharmaceutical/Biotech Industry
    • Laboratory management
    • Clinical trials management
    • Laboratory Research Assistant
    • Medicine
    • Clinical Scientist
    • Teacher of Science
    • Scientific Writer

    Student profiles

    Image of two postgraduate medical students using a microscope

    The medical school where my department is based is one of the best in the UK. This combined with the guest lecturers from the best academics and researchers in their respective fields made University of Sheffield my best choice for pursuing my master’s degree.

    My understanding of the molecular mechanisms of various diseases and disorders combined with the knowledge of emerging technologies in medicine would enable me to improve the understanding of various disease which would help in development of novel therapies in the field of medicine.

    Amanpreet Kaur Bains

    MSc Molecular Medicine

    Entry requirements

    You'll need at least a 2:1 undergraduate honours degree including a substantial element of human or animal biology.

    We also accept medical students who wish to intercalate their studies.

    We also consider a wide range of international qualifications:

    Entry requirements for international students

    Clinical applications pathway:

    Overall IELTS score of 7.0 with a minimum of 6.5 in each component, or equivalent.

    All other pathways:

    Overall IELTS score of 6.5 with a minimum of 6.0 in each component, or equivalent.

    If you have any questions about entry requirements, please contact the department.

    Fees and funding

    For the Clinical pathway use our course fee lookup tool.

    The fees below are applicable to the Genetic Mechanisms, Microbes and infection, Experimental Medicine and Cancer pathways.

    Apply

    You can apply for postgraduate study using our Postgraduate Online Application Form. It's a quick and easy process.

    Apply now

    If you're interested in the clinical applications pathway, please make preliminary contact with the pathway leader Dr Paul Collini.

    More information

    The Medical School

    Interested in the student perspective?

    You can email our current students about their experiences of postgraduate study at Sheffield and our graduates are often available during open days.

    Contact

    Dr J G Shaw
    iicd-pgt-enquiries@sheffield.ac.uk
    +44 114 215 9553

    Any supervisors and research areas listed are indicative and may change before the start of the course.

    Our student protection plan

    Recognition of professional qualifications: from 1 January 2021, in order to have any UK professional qualifications recognised for work in an EU country across a number of regulated and other professions you need to apply to the host country for recognition. Read information from the UK government and the EU Regulated Professions Database.

    MEDT01

    The Medical School

    Interested in the student perspective?

    You can email our current students about their experiences of postgraduate study at Sheffield and our graduates are often available during open days.

    Off

    For the Clinical pathway use our course fee lookup tool.

    The fees below are applicable to the Genetic Mechanisms, Microbes and infection, Experimental Medicine and Cancer pathways.

    On