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TiLLI: Thromboprophylaxis in Lower Limb Immobilisation

People who have their leg immobilised in a plaster cast or brace are at risk of developing a blood clot in the leg that can travel to their lungs and make them seriously ill. Drugs to thin the blood (anticoagulants) can reduce the risk of this happening but carry a small risk of serious bleeding complications. Previous research has shown that anticoagulant drugs reduce the risk of finding clots in people with an immobilised leg if we look for them with an ultrasound scan of the leg, but we don't know whether this translates into a meaningful reduction in serious clots that make people unwell or whether the reduction in blood clots justifies the risk of bleeding complications

We plan to draw upon existing research (involving systematic review, meta-analysis and elicitation of expert consensus methods to draw up strategies that could be used to select people with leg immobilisation for anticoagulant treatment based on their risk of developing a blood clot) and use health economic modelling to simulate different approaches to treating the risk of blood clots in people with leg immobilisation.
This study is currently in ongoing.