Medical Microbiology MBiolSci
School of Biosciences
You are viewing this course for 2021-22 entry.
This course is designed to give you the best start in your pursuit of a career in industrial or academic research. This microbiology course explores the fundamental role these tiny organisms play in the world. You'll study the importance of bacteria, viruses and other microbes in the environment and as pathogens. You’ll gain a broad understanding of microbiology and there is an emphasis on topics of medical relevance. You’ll learn how microbes live, as well as ways to disrupt disease processes.
You’ll also discover how we can manipulate their genetic makeup to put microbes to good use in biotechnology, how we can tackle the threat of antimicrobial-resistant infections, and the role that microbiology continues to play in supporting the global response to pandemics such as Covid-19. The first three years of your course will have the same structure as the BSc, with the fourth year devoted to a major research project working in industry or in an academic lab with our world-leading academics.
From your first year you’ll study modules that span the molecular biosciences covering microbiology, biochemistry, genetics and molecular biology. Alongside these modules you’ll have the freedom to explore complementary topics across the breadth of bioscience, such as biomedicine, ecology, plant science and zoology. This flexibility allows you to study microbiology in greater depth, broaden your interests or even switch to another biosciences degree programme.
No matter what modules you choose to study, you’ll develop the practical laboratory and transferable skills that make our graduates attractive to employers including project management, problem solving, communication skills and data analysis.
We’ll give you plenty of opportunities to apply your new skills and knowledge too. You’ll be in the lab completing in-depth practicals across molecular genetics, DNA manipulation and protein structure analysis. You’ll get the chance to use cutting-edge equipment to run your own in-depth research projects.
Whether you choose to focus solely on microbiology, or study a range of topics across the molecular biosciences and beyond, your personal tutor will support you to tailor your degree to your interests and career goals.
This course has advanced accreditation by the Royal Society of Biology which shows employers that you've developed the practical skills and scientific knowledge that they're looking for.
The modules listed below are examples from the last academic year. There may be some changes before you start your course. For the very latest module information, check with the department directly.
Choose a year to see modules for a level of study:
UCAS code: C523
Years: 2021, 2022
In your first year, you'll spend six hours in the lab each week learning the practical skills and knowledge that every bioscientist needs, including how to establish bacterial cultures, assess bioenergetics and perform gene cloning. Analysis classes will equip you with the skills you'll use outside the lab, from interacting with your data to interpreting your findings. Your lectures will give you a broad understanding of the molecular biosciences, allowing you to explore what you're most interested in.
- Biochemistry 1
This module provides a broad introduction to Biochemistry and examines the molecules that carry out and control all the chemical reactions in biological cells. The basic chemical concepts underlying the structures, functions and mechanisms of action of biomolecules.20 credits
- Microbiology 1
This course is an introduction to the field of microbiology. Students will explore the diversity of microorganisms including Bacteria, Archaea, unicellular Eukaryotes and viruses. They will examine the diversity of the structure and the function of these microorganisms, emphasising the fundamental role that they play in our everyday lives by using examples in medicine and biotechnology.20 credits
- Genetics 1
This course is an introduction to the principles of genetics. Students will explore the genetics of pro- and eukaryotes by studying the mechanisms of gene transmission, genetic exchange, mutations and gene mapping. Additional topics are the genetic basis of diseases, prenatal diagnosis, genetic counselling, gene therapy and genetic basis of antibiotic resistance in bacteria. Students will learn through lectures and videos and independent study.10 credits
- Molecular & Cell Biology
This module considers the fundamental processes at the heart of all life on this planet. Students will learn about the basic molecular processes that enable cells to store and use genetic information to make proteins, as well as the mechanisms that allow cell growth, division, and ultimately cell death. Learning materials will be delivered through a combination of lectures, videos, practical classes and independent study.20 credits
- Skills in Molecular Bioscience
The Skills for Biology module introduces students to the fundamentals of scientific practice: lab practical skills, experimental design, information technology, data visualisation and analysis, writing and presentation skills, skills reflection, professionalism and career development.30 credits
A student will select approved modules from the School of Biosciences to the value of 20 credits.
In your second year, you'll begin learning more advanced scientific techniques, both in the lab and in lectures, with topics including experimental design, genome editing using CRISPR/Cas9 and protein purification. You'll continue to take analysis classes to develop your data handling skills further and you can choose to study modules that allow you to work in teams to come up with pioneering science enterprise ideas to launch a virtual business.
- Practical Molecular Bioscience 2
This module provides detailed knowledge in key areas of practical molecular bioscience, emphasising the integration of the disciplines of biochemistry, microbiology and genetics. An important aim of the module is to provide experience in the preparation of written laboratory reports, and in the correct interpretation and representation of biological data. Laboratory, computer and data analysis sessions build on the skills gained during first year and allow students to develop a high level of technical competence and theoretical understanding. Tutorial-based support is also provided for the enhancement of transferable skills, such as the preparation and delivery of oral and written presentations.30 credits
- Biochemistry 2
This module provides an advanced treatment of the biochemical topics introduced in earlier modules, to provide a deep understanding of the underlying chemical principles and molecular interactions governing life in cells. Topics covered include reaction and ligand binding kinetics, enzyme catalysis and chemical mechanism, protein structure and function, small molecule drug development and methods in which these processes are studied experimentally.20 credits
- Biostructures, Energetics and Synthesis
This module aims to furnish students with a working knowledge of the structures and functions of proteins and nucleic acids, in order that they gain an appreciation of the crucial relationship between structure and function. Both cytosolic globular and membrane proteins will be considered, as well as an introduction to nucleic acid structure. The module also explains the basic principles of how energy is made available (transduced) for essential biological functions, such as ATP synthesis and solute and protein transport. To achieve this understanding, the nature of biological membranes and the energy transducing proteins associated with those membranes are considered, and the principles of chemiosmosis, light absorption and biological redox reactions are discussed. Finally the module provides an understanding of the general principles underlying the biosynthesis of complex biomolecules from simpler precursors, and the control of these processes, with particular relevance to biotechnology.20 credits
- Genes, Genomes and Chromosomes
This module aims to provide the student with a clear understanding of how genomes are organised within cells and how the expression of specific genes can be regulated. One part of the module addresses experimental approaches to address the function of specific genes and how genetic information is expressed in a regulated manner. Both classical and molecular genetics techniques to study gene function will be described. DNA repair and recombination mechanisms will be addressed, along with the use of reporter gene fusions. The regulation of gene expression at the molecular level will be explored through the consideration of (post-) transcriptional control mechanisms and intercellular signalling pathways. The other part of the module discusses the structural features of chromosomes and how they contribute to the maintenance and evolution of the genome; the development of sequencing techniques and their application to genome sequencing projects; the use of scoring systems to determine related DNA sequences and the application of sequencing technologies to measure gene expression, identify protein binding sites within DNA, analyse long range nucleic acid interactions within genomes and study DNA methylation patterns.20 credits
- Microbiology 2
This module builds upon the microbiological topics introduced in earlier modules, including aspects of bacterial growth and gene regulation, microbial biodiversity and cellular differentiation, biotechnology, the mechanisms used by pathogenic bacteria to subvert and fool the host's defences, the use of vaccines and antimicrobial agents in controlling and treating diseases caused by pathogens, the problems associated with newly-emerging pathogens and the role that resistance to antimicrobial agents is playing in the re-emergence of certain diseases.20 credits
In your third year, you'll complete an extended research project alongside your chosen specialist modules. This will reflect an area of molecular bioscience that interests you. Depending on your interests and career goals, you can choose a project from: experimental science, clinical diagnostics, industrial biotechnology, molecular systems and computing, science communication or education and outreach.
This module is a research project in the molecular biosciences that allows students to apply their core subject knowledge to develop key skills in an area related to their career aspirations. Students have the opportunity to design, plan, and undertake an investigation, either within the Department or externally. Projects choices include laboratory-based research; biotechnology; computational biology and bioinformatics; science communication; science teaching in a local school; and clinical diagnostics.30 credits
All projects are undertaken under the supervision of a member of academic staff; most placements are within the Department, but a small proportion of students undertake projects in other locations, such as the Medical School. Students will develop skills in the collation, interpretation, presentation, and communication of data and ideas. Students will submit their work in the form of a formal written report and present their research to the department during a showcase poster event.
- Literature Review
In this module students are required to write a literature review on a topic chosen from a wide range suggested by members of staff. Students will develop a range of transferrable key skills associated with searching for, analysing and critically evaluating information from the literature, together with presentation skills in writing and presenting their review.20 credits
- Bacterial Pathogenicity
Infectious diseases account for the majority of deaths worldwide. This will continue to be the case until we have a greater understanding of the mechanisms of microbial pathogenesis. This course builds on the principles introduced in level 2 microbiology and begins by showing how molecular genetic approaches are being used to unravel the complexities of microbial virulence. Following an introduction to the regulation of virulence genes, the pathogenic mechanisms of selected bacterial pathogens are explored in detail, demonstrating the involvement of multiple virulence determinants and their genetic regulation in the disease process. Mechanisms by which toxins deregulate or kill host cells will be explored. Virulence mechanisms that represent common themes in bacterial pathogenesis will be highlighted. The appearance of antibiotic resistant strains and strategies adopted to tackle this problem will also be considered.10 credits
- Microbial Structure and Dynamics: Genes and Populations
This module aims to give students an overview of the structure and dynamics of bacteria and how they respond to the environment. The module is research led giving current highlights from ongoing work as well as standard lectures. The principles of signal transduction are illustrated with specific examples such as oxygen sensing, cyclic nucleotide signalling and differentiation.10 credits
- Microbiology Data Handling
The module aims to develop problem solving, interpretative and numerical skills by the study of deductive questions drawn from the broad area of microbiology, including gene regulation, microbial physiology and pathogenicity. Students will gain experience in reading scientific papers and in the handling, analysis, interpretation and evaluation of microbiological data of different types. The module also contains an element that develops the skills required by the students to write on a broad topic drawn from across all their areas of study10 credits
- Molecular Immunology
This module explores the mechanisms that higher organisms use to defend themselves against infectious disease. The course considers the relationship between innate immunity (the first line of defence) and adaptive immunity, which can evolve throughout a lifetime to specifically recognise and remember different pathogens. The functions of the various cells and molecules that constitute the immune system are discussed and the genetic mechanisms that contribute to immunological diversity and specificity are examined. Topics include the roles of cytokines, T cell subsets and the structure/function relationship of the different antibody classes. The module also includes an overview of current techniques that exploit or manipulate the immune response for the prevention and treatment of disease e.g. through the development of therapeutic antibodies and the design of new vaccines.10 credits
- Biochemical Basis of Human Disease
The aim of this module is to provide students with an insight into how a fundamental biochemical analysis of the mechanisms of human disease plays a crucial role in understanding the causes of disease and points the way to novel therapeutic interventions. The module aims to show how the combined efforts of biochemists and clinicians are needed to arrive at a complete characterisation of a given disease and to identify possible targets for intervention. During the module we will consider some of the most common major diseases in the population, including inflammation, obesity, amyloid-related diseases, cancer, atherosclerosis and renal scarring, and consider how diseases and their treatments interact.10 credits
- Biochemical Signalling
This module provides students with an understanding of the mechanisms by which eukaryotic cells communicate via signal transduction pathways. We will discuss how mammalian cells transfer, and receive, information via pathways involving hormones and growth factors, cell surface or intracellular receptors, second messengers, G-proteins, reversible phosphorylation mechanisms, and transcriptional controls. We explore how biochemical characteristics define the activity and specificity of signalling components, and the consequences of defective signalling pathways, for example, how oncogene derived proteins lead to cancers. Examples considered in detail may include: the regulation of cell proliferation by epidermal growth factors, and in plants by auxin; stimulation of muscle contraction or relaxation by a range of signals; control of multiple pathways by adrenaline and cyclic AMP signalling during the fight-or-flight response; the role of membrane derived inositol phosphates in triggering in calcium signals and cell survival; and design of anticancer drugs.10 credits
- Cellular Systems Engineering for Biotechnology
This module explores how recent developments in high-throughput methodologies, genomics, bioinformatics and synthetic biology in microbes is transforming biotechnology. Approaches to producing valuable and novel products from microbial cell factories will be examined. Students will learn to appreciate the (1) fast pace at which modern industrial biotechnology is developing, (2) behavioural complexity of biological systems, (3) associated difficulties of predicting biological behaviour in areas such as industrial biotechnology and drug development and (4) emerging approaches to overcome these challenges.10 credits
Students will work both individually and in small groups, to develop presentation skills and the critical skills required for evaluation of primary literature.
- Genomic Science
A top-down approach to biology, simultaneously investigating the structure and function of the entire genome and its products, both contrasts with and complements the traditional gene-by-gene approach, allowing us a birds-eye view. In this module, we cover how genome sequencing can be used to understand the structure of human populations, profile microbial diversity and to trace the origins of disease outbreaks. We then discuss how methods such as RNA-seq, ChIP-seq and 4C can be used to investigate the genome-wide transcriptional profile, the chromatin landscape and the three-dimensional structure of the genome. Finally we describe the use of technologies such as mass spectrometry to investigate the complete proteome of a cell. The module builds on the material from the level 2 module Genes, Genomes and Chromosomes, to illustrate how cutting-edge genomic and proteomic methods can be used address fundamental biological questions.10 credits
- Membrane Protein Structure and Function
The aim of this module is to impart a thorough understanding of the structure and function of membrane proteins. A major theme is the structural basis of energy transduction in membranes. Membrane protein complexes mediate the transfer of excitation energy, electrons and protons upon which all life depends. They also control the entry and exit of proteins, ions, nutrients, drugs and antibiotics from cells and the transfer of signals across membranes. We will examine membrane proteins involved in energy harvesting such as respiration and photosynthesis. The principles underlying the efficiency of energy transduction and redox chemistry taking place in these complexes will be covered. We will look at how harvested energy is coupled to movement of molecules ions and signals across membranes. The role of structure in determining specificity and directionality in vital transport process and signalling will be emphasised.10 credits
- The world of RNA
This module will analyse the vital roles that RNA plays in the life of a cell and how RNA is increasingly used as a tool to understand biology. The module will cover the following 'cutting edge' research topics: RNA interference, CRISPR Genome Editing, non-coding RNAs, together with the latest work on well known RNA based activities. These include transcription, RNA splicing, RNA stability, RNA export and translation and how all these processes are coupled in the cell to ensure efficient, quality-controlled gene expression. The module aims to present the latest innovations and discoveries in the RNA world and their application.10 credits
In your fourth year, the majority of your time will be devoted to a major research project. You can choose between spending a year in industry and completing your project at a company such as AstraZeneca, GSK or Unilever, or undertaking projects in one of our world-leading research labs within the department or the University of Sheffield Medical School.
- Advanced Literature Review
This unit builds upon the skills in literature searching and interpretation developed in the Library Project and Data Handling units at level 3. It is designed to lead to a comprehensive understanding of the literature, approaches and techniques relevant to the Extended Research Project (MBB403) or Project in Industry (MBB404). It will result in the production of a literature review appropriate for inclusion in a postgraduate thesis. The exact nature and scope of the literature review will be determined by discussion between the student and the supervisor, with additional input from the industrial supervisor for those students taking MBB404. Assessment will be on the basis of the literature review.20 credits
- Advanced Research Topics
This module will develop the ability of students to acquire information through the medium of research seminars and published scientific papers. Students will attend Departmental research seminars and monitor the publication of new scientific papers relevant to their research area. They will also attend a journal club, in which they will present a recently published research paper and summarise the presentations of other students. Assessment of the unit will be on the basis of the journal club presentation and a series of short reports on research seminars, journal club presentations and newly published scientific papers.10 credits
- Introduction to Research Methodology
This unit provides an opportunity to revise and update knowledge of technologies used routinely in biological research and introduces some advanced methods, with particular emphasis on raising awareness of the opportunities afforded by complementary technologies. The course engages students with aspects of immunology, molecular biology and genetics, functional genomics, protein expression, statistics and bioinformatics. Diverse teaching formats, including formal lectures, guided small group work, discussion groups and student presentations are used to deliver content.10 credits
- Extended Laboratory Project
This module provides an extended period of laboratory work, with training in experimental techniques, record keeping and writing up. Projects are supervised by a member of staff and related to ongoing research projects within the Department, although a proportion of students undertake projects in other locations such as hospitals and the Medical School. This unit is designed to provide students with experience of undertaking investigations independently on a specific research topic, so that they can develop a research oriented approach, and gain experience of lab work in preparation for a future career in science.80 credits
- Project in Industry
This module provides training in research methods in molecular biology, in an industrial lab, by means of an extended project. Training is also provided in record keeping and writing up. Projects are supervised by industrial research staff, in liaison with a member of MBB staff: this will include a site visit. This unit is designed to provide students with experience of undertaking investigations independently on a specific research topic, in an industrial setting.80 credits
The content of our courses is reviewed annually to make sure it's up-to-date and relevant. Individual modules are occasionally updated or withdrawn. This is in response to discoveries through our world-leading research; funding changes; professional accreditation requirements; student or employer feedback; outcomes of reviews; and variations in staff or student numbers. In the event of any change we'll consult and inform students in good time and take reasonable steps to minimise disruption. We are no longer offering unrestricted module choice. If your course included unrestricted modules, your department will provide a list of modules from their own and other subject areas that you can choose from.
Learning and assessment
To support your learning, you’ll have access to a virtual learning environment with interactive course materials. You'll also have a personal tutor throughout your course, to give you advice and guidance on both academic and pastoral issues.
This tells you the aims and learning outcomes of this course and how these will be achieved and assessed.
With Access Sheffield, you could qualify for additional consideration or an alternative offer - find out if you're eligible
The A Level entry requirements for this course are:
including Biology and a second science
The A Level entry requirements for this course are:
including Biology and a second science
A Levels + additional qualifications | AAB, including Biology and a second science + B in a relevant EPQ; AAB, including Biology and a second science + A in Core Maths AAB, including Biology and a second science + B in a relevant EPQ; AAB, including Biology and a second science + A in Core Maths
International Baccalaureate | 36, 6 in Higher Level Biology and a second science 34 including 6,5 in Higher Level Biology and a second science
BTEC | Interim-Reformed: DD in Applied Science + A Level grade A in a science subject (Biology, Chemistry, Human Biology, Physics, Psychology, Maths and Further Maths) + interview. Reformed: D*DD in Applied Science, including modules in Applications of Inorganic Chemistry, Applications of Organic Chemistry and Practical Chemical Analysis and no more than one of the following: Forensic Evidence Collection and Analysis, Forensic Fire Investigation or Forensic Traffic Collision Investigation + interview BTEC Extended: (RQF) DDD Applied Science; BTEC Dip + A Level: DD Applied Science + B in Science A Level
Scottish Highers + 2 Advanced Highers | AAAAB + AA, including Biology and a second science AAABB + AB, including Biology and a second science
Welsh Baccalaureate + 2 A Levels | A + AA including Biology and a second science B+ AA including Biology and a second science
Access to HE Diploma | 60 credits overall in a relevant subject with Distinctions in 39 Level 3 credits, including Chemistry and Biology units, plus Merits in 6 Level 3 credits. Applicants are also interviewed. 60 credits overall in a relevant subject with Distinctions in 36 Level 3 credits, including Chemistry and Biology units, plus Merits in 9 Level 3 credits. Applicants are also interviewed.
Mature students - explore other routes for mature students
You must demonstrate that your English is good enough for you to successfully complete your course. For this course we require: GCSE English Language at grade 4/C; IELTS grade of 6.5 with a minimum of 6.0 in each component; or an alternative acceptable English language qualification
Acceptable science subjects are Chemistry, Biology/Human Biology, Physics, Psychology Maths and Further Maths
GCSE Maths grade 6 or grade B. See additional GCSE requirements in EAS notes
If you have any questions about entry requirements, please contact the department.
School of Biosciences
Biosciences at Sheffield is home to over 120 lecturers who are actively involved in research at the cutting edge of their field. You'll learn from scientists who are helping to solve some of the biggest global challenges, from global food shortages and antibiotic resistance in MRSA to degenerative illnesses such as Alzheimer's and combating infectious diseases like Covid-19.
We're a close-knit community where every student gets the support and encouragement needed to achieve their best work. Whether it’s joining one of our student-led societies and taking part in nights out, trips abroad and quizzes with lecturers, or volunteering, fundraising and organising your own events, there are lots of opportunities to get involved.
Biosciences students are based across Firth Court, the Alfred Denny, Florey and Addison buildings. We are at the heart of the University campus, adjacent to the Students' Union and just a 15-minute walk from the city centre.
Our students have access to world-class laboratory and computing resources for biological research and are trained in specialist teaching laboratories, supported by teaching assistants and our technician team.
Biosciences at Sheffield is home to state-of-the-art facilities, including super resolution light, cryo-electron and atomic force microscopy, NMR and X-ray facilities, a Biological Mass Spectrometry facility and the NERC Biomolecular Analysis Facility, which provides molecular genetics facilities and training to the UK science community.
We also have controlled environment facilities that can simulate any past, present and future climate, leading equipment for DNA analysis, and facilities for cell culture used in studying immunology, medically important microbes and biotechnology on campus.
Why choose Sheffield?
The University of Sheffield
A Top 100 university 2021
QS World University Rankings
Top 10% of all UK universities
Research Excellence Framework 2014
No 1 Students' Union in the UK
Whatuni Student Choice Awards 2019, 2018, 2017
School of Biosciences
The Times and Sunday Times Good University Guide 2021
National Student Survey 2020
National Student Survey 2020
Research Excellence Framework 2014
High Fliers Research 2020
School of Biosciences
Our courses equip students for a wide range of careers, from scientific roles to graduate schemes with top employers. Whether you want to pursue a career in science, apply your skills in industry, or continue your studies, bioscience graduates are highly sought after due to their specialist laboratory skills, ability to solve problems, handle and analyse data, and effectively communicate complex ideas to a range of audiences.
As well as progressing onto a masters programme or PhD, our students secure roles in biotechnology and pharmaceutical companies like GSK, Pfizer, AstraZeneca and Redx, the NHS Scientist Training Programme (STP) and government bodies like Public Health England.
Transferable skills are embedded and developed throughout our degrees, which means year on year our graduates join high-profile organisations like Microsoft, HSBC, KPMG, United Kingdom Civil Service, Unilever and Wellcome. You can also apply your degree to other varied careers including brewing, bioinformatics, marketing, medical writing, genetic counselling, agrochemicals, teaching and science policy.
Each year undergraduate students can apply to join the Sheffield Undergraduate Research Experience (SURE) scheme. This gives you the chance to spend six weeks working in one of our research groups over the summer. It's a unique opportunity to pursue research in an area that you’re excited about, and can help inform your future career aspirations.
Fees and funding
The annual fee for your course includes a number of items in addition to your tuition. If an item or activity is classed as a compulsory element for your course, it will normally be included in your tuition fee. There are also other costs which you may need to consider.
Funding your study
Depending on your circumstances, you may qualify for a bursary, scholarship or loan to help fund your study and enhance your learning experience.
Use our Student Funding Calculator to work out what you’re eligible for.
University open days
There are four open days every year, usually in June, July, September and October. You can talk to staff and students, tour the campus and see inside the accommodation.
At various times in the year we run online taster sessions to help Year 12 students experience what it is like to study at the University of Sheffield.
If you've received an offer to study with us, we'll invite you to one of our applicant open days, which take place between November and April. These open days give you the chance to really explore student life here, even if you've visited us before.
Campus tours run regularly throughout the year, at 1pm every Monday, Wednesday and Friday.
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The awarding body for this course is the University of Sheffield.
Recognition of professional qualifications: from 1 January 2021, in order to have any UK professional qualifications recognised for work in an EU country across a number of regulated and other professions you need to apply to the host country for recognition. Read information from the UK government and the EU Regulated Professions Database.