Recipe for the perfect balance of breaks and repairs in our genome could help fight cancer and brain ageing

A new study, led by Bateson member Dr Sherif El-Khamisy at the University of Sheffield’s Department of Molecular Biology and Biotechnology, has revealed an enzyme called UCHL3, which controls DNA repair by removing ubiquitin marks from TDP1 - a DNA repair protein. The findings also have implications in brain ageing which has an affect on memory, cognitive function and learning.

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The full study was published on 12th June 2018 in the journal Cell Reports.