Dead cells disrupt how immune cells respond to wounds and patrol for infection
Immune cells prioritise the clearance of dead cells overriding their normal migration to sites of injury.
University of Sheffield research paves the way for new therapies to manipulate how white blood cells get to and are kept at sites of injuries during healing.
Dead cells disrupt immune responses and undermine defence against infection, new research has found.
The study, led by scientists at the University of Sheffield, revealed that cells which are programmed to die, a process known as apoptosis, can disrupt the normal function of immune cells, called macrophages. This can impact on how well they respond to wounds and patrol the body to seek out infection.