Dr Luke Green

School of Clinical Dentistry

Lecturer in Microbiology

l.r.green@sheffield.ac.uk
+44 114 215 9547

Room LU105, L Floor, 19 Claremont Crescent

Full contact details

Dr Luke Green
School of Clinical Dentistry
Room LU105, L Floor
19 Claremont Crescent
Sheffield
S10 2TA

Profile

2025–present: Lecturer in Microbiology; University of Sheffield, UK
2021–2025: The Humane Research Trust Research Fellow; University of Sheffield, UK
2018–2021: Postdoctoral Associate; Prof. Pete Monk, University of Sheffield, UK
2015–2018: Postdoctoral Researcher; Dr. Chris Bayliss, University of Leicester, UK
2011–2015: Research Associate; Dr. Ingrid Scully Group, Pfizer Inc., USA
2006–2010: PhD; Prof. Rob Read Group, University of Sheffield, UK.

Research interests

Infectious disease is a huge health burden globally and antibiotic resistance is an ever growing problem, currently attributable to ~700,000 deaths per year with projected figures rising to 10 million by the year 2050. For this reason, new therapies to replace antibiotics are crucial. Due to their rapid doubling time, bacteria have the ability to quickly evolve mechanisms to overcome drugs targeted to them, for this reason, I believe the future for anti-infectives is to target infection at the human cell level. Bacteria enter our cells by "hijacking" parts of our own cell machinery (proteins).

Our cells are encased in a membrane consisting of water-repelling fatty acids and proteins. Bacteria have to attach to and breach this membrane in order to get inside our cells. They do this by "hijacking" the proteins within the membrane. Whilst there has been extensive research into how bacteria bind our cells, no universal mechanisms (used by all bacteria) are known. Different bacterial species have been shown to hijack different proteins, which causes problems with therapeutic design. I have discovered that a family of human cell membrane proteins, the tetraspanins, are extremely important in the binding of multiple bacterial species to our cells. Targeting tetraspanins using drugs reduces bacterial binding to multiple types of human cells by greater than 50%. The tetraspanins form part of our cell membranes and act as "organisers", bringing together lots of other proteins to form large protein "islands" in the cell membrane. Bacteria do not directly attach to the tetraspanins but I hypothesise that the tetraspanins organize the proteins required for bacterial binding and it is therefore the loss of this organization which results in reduced bacterial adhesion to our cells when the tetraspanins are blocked.

My lab is interested in investigating the role of these proteins and their interactors in bacterial infection.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Jadi PK, Dave A, Issa R, Tabbasum K, Okurowska K, Samarth A, Urwin L, Green LR, Partridge LJ, MacNeil S , Garg P et al (2024) Tetraspanin CD9-derived peptides inhibit Pseudomonas aeruginosa corneal infection and aid in wound healing of corneal epithelial cells. The Ocular Surface, 32, 211-218.
Green LR, Issa R, Albaldi F, Urwin L, Thompson R, Khalid H, Turner CE, Ciani B, Partridge LJ & Monk PN (2023) CD9 co-operation with syndecan-1 is required for a major staphylococcal adhesion pathway. mBio, e0148223.
Wanford JJ, Holmes JC, Bayliss CD & Green LR (2020) Meningococcal core and accessory phasomes vary by clonal complex. Microbial Genomics, 6(5). View this article in WRRO
Green LR, Al-Rubaiawi AA, Al-Maeni MARM, Harrison OB, Blades M, Oldfield NJ, Turner DPJ, Maiden MCJ & Bayliss CD (2020) Localized Hypermutation is the Major Driver of Meningococcal Genetic Variability during Persistent Asymptomatic Carriage. mBio, 11(2).
Green LR, Dave N, Adewoye AB, Lucidarme J, Clark SA, Oldfield NJ, Turner DPJ, Borrow R & Bayliss CD (2019) Potentiation of Phase Variation in Multiple Outer-Membrane Proteins During Spread of the Hyperinvasive Neisseria meningitidis Serogroup W ST-11 Lineage. The Journal of Infectious Diseases, 220(7), 1109-1117.
Green LR, Lucidarme J, Dave N, Chan H, Clark S, Borrow R & Bayliss CD (2018) Phase Variation of NadA in Invasive Neisseria meningitidis Isolates Impacts on Coverage Estimates for 4C-MenB, a MenB Vaccine. Journal of Clinical Microbiology, 56(9).
Oldfield NJ, Green LR, Parkhill J, Bayliss CD & Turner DPJ (2018) Limited Impact of Adolescent Meningococcal ACWY Vaccination on Neisseria meningitidis Serogroup W Carriage in University Students. The Journal of Infectious Diseases, 217(4), 608-616.
Green LR, Monk PN, Partridge LJ, Morris P, Gorringe AR & Read RC (2011) Cooperative role for tetraspanins in adhesin-mediated attachment of bacterial species to human epithelial cells.. Infect Immun, 79(6), 2241-2249. View this article in WRRO

Preprints

Wolverson PA, Fernandes Parreira I, Collins MO, Shaw JG & Green LR (2024) Dynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics, Cold Spring Harbor Laboratory.

All publications

Journal articles

Jadi PK, Dave A, Issa R, Tabbasum K, Okurowska K, Samarth A, Urwin L, Green LR, Partridge LJ, MacNeil S , Garg P et al (2024) Tetraspanin CD9-derived peptides inhibit Pseudomonas aeruginosa corneal infection and aid in wound healing of corneal epithelial cells. The Ocular Surface, 32, 211-218.
Green LR, Issa R, Albaldi F, Urwin L, Thompson R, Khalid H, Turner CE, Ciani B, Partridge LJ & Monk PN (2023) CD9 co-operation with syndecan-1 is required for a major staphylococcal adhesion pathway. mBio, e0148223.
Cotton S, McHugh MP, Dewar R, Haas JG, Templeton K, Robson SC, Connor TR, Loman NJ, Golubchik T, Martinez Nunez RT , Bonsall D et al (2023) Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes. Journal of Hospital Infection, 135, 28-36.
Dave N, Albiheyri RS, Wanford JJ, Green LR, Oldfield NJ, Turner DPJ, Martinez-Pomares L & Bayliss CD (2023) Variable disruption of epithelial monolayers by Neisseria meningitidis carriage isolates of the hypervirulent MenW cc11 and MenY cc23 lineages. Microbiology, 169(2). View this article in WRRO
Wilkinson SAJ, Richter A, Casey A, Osman H, Mirza JD, Stockton J, Quick J, Ratcliffe L, Sparks N, Cumley N , Poplawski R et al (2022) Recurrent SARS-CoV-2 mutations in immunodeficient patients. Virus Evolution, 8(2). View this article in WRRO
Eales O, Page AJ, de Oliveira Martins L, Wang H, Bodinier B, Haw D, Jonnerby J, Atchison C, Robson SC, Connor TR , Loman NJ et al (2022) SARS-CoV-2 lineage dynamics in England from September to November 2021: high diversity of Delta sub-lineages and increased transmissibility of AY.4.2. BMC Infectious Diseases, 22(1).
Kemp SA, Collier DA, Datir RP, Ferreira IATM, Gayed S, Jahun A, Hosmillo M, Rees-Spear C, Mlcochova P, Lumb IU , Roberts DJ et al (2022) Author Correction: SARS-CoV-2 evolution during treatment of chronic infection. Nature, 608(7922), E23-E23.
Collier DA, De Marco A, Ferreira IATM, Meng B, Datir RP, Walls AC, Kemp SA, Bassi J, Pinto D, Silacci-Fregni C , Bianchi S et al (2022) Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies. Nature, 608(7922), E24-E24.
Smallman-Raynor MR & Cliff AD (2022) Spatial growth rate of emerging SARS-CoV-2 lineages in England, September 2020–December 2021. Epidemiology and Infection, 150.
Parker MD, Stewart H, Shehata OM, Lindsey BB, Shah DR, Hsu S, Keeley AJ, Partridge DG, Leary S, Cope A , State A et al (2022) Altered subgenomic RNA abundance provides unique insight into SARS-CoV-2 B.1.1.7/Alpha variant infections. Communications Biology, 5. View this article in WRRO
Vöhringer HS, Sanderson T, Sinnott M, De Maio N, Nguyen T, Goater R, Schwach F, Harrison I, Hellewell J, Ariani CV , Gonçalves S et al (2022) Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England. Nature, 606(7915), E18-E18.
Ashford F, Best A, Dunn SJ, Ahmed Z, Siddiqui H, Melville J, Wilkinson S, Mirza J, Cumley N, Stockton J , Ferguson J et al (2022) SARS-CoV-2 Testing in the Community: Testing Positive Samples with the TaqMan SARS-CoV-2 Mutation Panel To Find Variants in Real Time. Journal of Clinical Microbiology, 60(4).
Wright DW, Harvey WT, Hughes J, Cox M, Peacock TP, Colquhoun R, Jackson B, Orton R, Nielsen M, Hsu NS , Harrison EM et al (2022) Tracking SARS-CoV-2 mutations and variants through the COG-UK-Mutation Explorer. Virus Evolution, 8(1), 1-14. View this article in WRRO
Aggarwal D, Page AJ, Schaefer U, Savva GM, Myers R, Volz E, Ellaby N, Platt S, Groves N, Gallagher E , Tumelty NM et al (2022) Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission. Nature Communications, 13(1). View this article in WRRO
Green LR, Cole J, Parga EFD & Shaw JG (2022) Neisseria gonorrhoeae physiology and pathogenesis. Advances in microbial physiology, 80, 35-83. View this article in WRRO
Lindsey BB, Villabona-Arenas CJ, Campbell F, Keeley AJ, Parker MD, Shah DR, Parsons H, Zhang P, Kakkar N, Gallis M , Foulkes BH et al (2022) Publisher Correction: Characterising within-hospital SARS-CoV-2 transmission events using epidemiological and viral genomic data across two pandemic waves.. Nat Commun, 13(1), 1013.
Aggarwal D, Warne B, Jahun AS, Hamilton WL, Fieldman T, du Plessis L, Hill V, Blane B, Watkins E, Wright E , Hall G et al (2022) Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission. Nature Communications, 13(1). View this article in WRRO
Lindsey BB, Villabona-Arenas CJ, Campbell F, Keeley AJ, Parker MD, Shah DR, Parsons H, Zhang P, Kakkar N, Gallis M , Foulkes BH et al (2022) Characterising within-hospital SARS-CoV-2 transmission events using epidemiological and viral genomic data across two pandemic waves. Nature Communications, 13(1). View this article in WRRO
Twohig KA, Nyberg T, Zaidi A, Thelwall S, Sinnathamby MA, Aliabadi S, Seaman SR, Harris RJ, Hope R, Lopez-Bernal J , Gallagher E et al (2022) Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study. The Lancet Infectious Diseases, 22(1), 35-42.
Vöhringer HS, Sanderson T, Sinnott M, De Maio N, Nguyen T, Goater R, Schwach F, Harrison I, Hellewell J, Ariani CV , Gonçalves S et al (2021) Genomic reconstruction of the SARS-CoV-2 epidemic in England. Nature, 600(7889), 506-511. View this article in WRRO
de Silva TI, Liu G, Lindsey BB, Dong D, Moore SC, Hsu NS, Shah D, Wellington D, Mentzer AJ, Angyal A , Brown R et al (2021) The impact of viral mutations on recognition by SARS-CoV-2 specific T cells. iScience, 24(11). View this article in WRRO
Jackson B, Boni MF, Bull MJ, Colleran A, Colquhoun RM, Darby AC, Haldenby S, Hill V, Lucaci A, McCrone JT , Nicholls SM et al (2021) Generation and transmission of interlineage recombinants in the SARS-CoV-2 pandemic. Cell, 184(20), 5179-5188.e8.
Meng B, Kemp SA, Papa G, Datir R, Ferreira IATM, Marelli S, Harvey WT, Lytras S, Mohamed A, Gallo G , Thakur N et al (2021) Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7. Cell Reports, 35(13), 109292-109292.
Partridge LJ, Urwin L, Nicklin MJH, James DC, Green LR & Monk PN (2021) ACE2-independent interaction of SARS-CoV-2 spike protein with human epithelial cells is inhibited by unfractionated heparin. Cells, 10(6). View this article in WRRO
Volz E, Mishra S, Chand M, Barrett JC, Johnson R, Geidelberg L, Hinsley WR, Laydon DJ, Dabrera G, O’Toole Á , Amato R et al (2021) Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England. Nature, 593(7858), 266-269. View this article in WRRO
Graham MS, Sudre CH, May A, Antonelli M, Murray B, Varsavsky T, Kläser K, Canas LS, Molteni E, Modat M , Drew DA et al (2021) Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study. The Lancet Public Health, 6(5), e335-e345.
Parker MD, Lindsey BB, Leary S, Gaudieri S, Chopra A, Wyles M, Angyal A, Green LR, Parsons P, Tucker RM , Brown R et al (2021) Subgenomic RNA identification in SARS-CoV-2 genomic sequencing data. Genome Research. View this article in WRRO
Collier DA, De Marco A, Ferreira IATM, Meng B, Datir RP, Walls AC, Kemp SA, Bassi J, Pinto D, Silacci-Fregni C , Bianchi S et al (2021) Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies. Nature, 593(7857), 136-141. View this article in WRRO
Kemp SA, Collier DA, Datir RP, Ferreira IATM, Gayed S, Jahun A, Hosmillo M, Rees-Spear C, Mlcochova P, Lumb IU , Roberts DJ et al (2021) SARS-CoV-2 evolution during treatment of chronic infection. Nature, 592(7853), 277-282. View this article in WRRO
Thomson EC, Rosen LE, Shepherd JG, Spreafico R, da Silva Filipe A, Wojcechowskyj JA, Davis C, Piccoli L, Pascall DJ, Dillen J , Lytras S et al (2021) Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity. Cell, 184(5), 1171-1187.e20.
Remmington A, Haywood S, Edgar J, Green LR, de Silva T & Turner CE (2021) Cryptic prophages within a Streptococcus pyogenes genotype emm4 lineage. Microbial Genomics, 7(1). View this article in WRRO
Volz E, Hill V, McCrone JT, Price A, Jorgensen D, O’Toole Á, Southgate J, Johnson R, Jackson B, Nascimento FF , Rey SM et al (2021) Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity. Cell, 184(1), 64-75.e11.
Urwin L, Okurowska K, Crowther G, Roy S, Garg P, Karunakaran E, MacNeil S, Partridge LJ, Green LR & Monk PN (2020) Corneal infection models : tools to investigate the role of biofilms in bacterial keratitis. Cells, 9(11). View this article in WRRO
Korber B, Fischer WM, Gnanakaran S, Yoon H, Theiler J, Abfalterer W, Hengartner N, Giorgi EE, Bhattacharya T, Foley B , Hastie KM et al (2020) Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus. Cell, 182(4), 812-827.e19. View this article in WRRO
Alm E, Broberg EK, Connor T, Hodcroft EB, Komissarov AB, Maurer-Stroh S, Melidou A, Neher RA, O’Toole Á & Pereyaslov D (2020) Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020. Eurosurveillance, 25(32).
The COVID-19 Genomics UK (COG-UK) consortium , Wang D, Angyal A, Brown RL, Carrilero L, de Silva TI, Green LR, Groves DC, Keeley AJ, Lindsey BB , Parker MD et al (2020) An integrated national scale SARS-CoV-2 genomic surveillance network. The Lancet Microbe, 1(3), e99-e100. View this article in WRRO
Wanford JJ, Holmes JC, Bayliss CD & Green LR (2020) Meningococcal core and accessory phasomes vary by clonal complex. Microbial Genomics, 6(5). View this article in WRRO
Green LR, Al-Rubaiawi AA, Al-Maeni MARM, Harrison OB, Blades M, Oldfield NJ, Turner DPJ, Maiden MCJ & Bayliss CD (2020) Localized Hypermutation is the Major Driver of Meningococcal Genetic Variability during Persistent Asymptomatic Carriage. mBio, 11(2).
Green LR, Dave N, Adewoye AB, Lucidarme J, Clark SA, Oldfield NJ, Turner DPJ, Borrow R & Bayliss CD (2019) Potentiation of Phase Variation in Multiple Outer-Membrane Proteins During Spread of the Hyperinvasive Neisseria meningitidis Serogroup W ST-11 Lineage. The Journal of Infectious Diseases, 220(7), 1109-1117.
Gray K, Green LR, Chaudhuri RR & Shaw JG (2019) Draft Whole-Genome Sequences of 10 Aeromonas Strains from Clinical and Environmental Sources. Microbiology Resource Announcements, 8(30). View this article in WRRO
Dave N, Green L, Lucidarme J, Oldfield N & Bayliss C (2019) Phase variation of Opa proteins in hypervirulent serogroup W meningococcal isolates. Access Microbiology, 1(1A).
Aidley J, Wanford JJ, Green LR, Sheppard SK & Bayliss CD (2018) PhasomeIt: an ‘omics’ approach to cataloguing the potential breadth of phase variation in the genus Campylobacter. Microbial Genomics, 4(11).
Green LR, Lucidarme J, Dave N, Chan H, Clark S, Borrow R & Bayliss CD (2018) Phase Variation of NadA in Invasive Neisseria meningitidis Isolates Impacts on Coverage Estimates for 4C-MenB, a MenB Vaccine. Journal of Clinical Microbiology, 56(9).
Oldfield NJ, Green LR, Parkhill J, Bayliss CD & Turner DPJ (2018) Limited Impact of Adolescent Meningococcal ACWY Vaccination on Neisseria meningitidis Serogroup W Carriage in University Students. The Journal of Infectious Diseases, 217(4), 608-616.
Oldfield NJ, Cayrou C, AlJannat MAK, Al-Rubaiawi AAA, Green LR, Dada S, Steels OD, Stirrup C, Wanford J, Atwah BAY , Bayliss CD et al (2017) Rise in Group W Meningococcal Carriage in University Students, United Kingdom. Emerging Infectious Diseases, 23(6), 1009-1011.
Scully IL, Swanson K, Green L, Jansen KU & Anderson AS (2015) Anti-infective vaccination in the 21st century—new horizons for personal and public health. Current Opinion in Microbiology, 27, 96-102.
Green LR, Monk PN, Partridge LJ, Morris P, Gorringe AR & Read RC (2011) Cooperative role for tetraspanins in adhesin-mediated attachment of bacterial species to human epithelial cells.. Infect Immun, 79(6), 2241-2249. View this article in WRRO
Pascall DJ, Vink E, Blacow R, Bulteel N, Campbell A, Campbell R, Clifford S, Davis C, da Silva Filipe A, El Sakka N , Fjodorova L et al () The SARS-CoV-2 Alpha variant was associated with increased clinical severity of COVID-19 in Scotland: A genomics-based retrospective cohort analysis. PLOS ONE, 18(4), e0284187-e0284187.
Willett BJ, Grove J, MacLean OA, Wilkie C, De Lorenzo G, Furnon W, Cantoni D, Scott S, Logan N, Ashraf S , Manali M et al () Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology, 7(10), 1709-1709.
Nickbakhsh S, Hughes J, Christofidis N, Griffiths E, Shaaban S, Enright J, Smollett K, Nomikou K, Palmalux N, Tong L , Carmichael S et al () Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning. Scientific Reports, 12(1).
Willett BJ, Grove J, MacLean OA, Wilkie C, De Lorenzo G, Furnon W, Cantoni D, Scott S, Logan N, Ashraf S , Manali M et al () SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology, 7(8), 1161-1179.
Kläser K, Molteni E, Graham M, Canas LS, Österdahl MF, Antonelli M, Chen L, Deng J, Murray B, Kerfoot E , Wolf J et al () COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study. Scientific Reports, 12(1).
Holmes JC, Green LR, Oldfield NJ, Turner DPJ & Bayliss CD () Rapid Transmission of a Hyper-Virulent Meningococcal Clone Due to High Effective Contact Numbers and Super Spreaders. Frontiers in Genetics, 11.
Wanford JJ, Green LR, Aidley J & Bayliss CD () Phasome analysis of pathogenic and commensal Neisseria species expands the known repertoire of phase variable genes, and highlights common adaptive strategies. PLOS ONE, 13(5), e0196675-e0196675.
Cayrou C, Akinduko AA, Mirkes EM, Lucidarme J, Clark SA, Green LR, Cooper HJ, Morrissey J, Borrow R & Bayliss CD () Clustered intergenic region sequences as predictors of factor H Binding Protein expression patterns and for assessing Neisseria meningitidis strain coverage by meningococcal vaccines. PLOS ONE, 13(5), e0197186-e0197186.
Parker MD, Lindsey BB, Leary S, Gaudieri S, Chopra A, Wyles M, Angyal A, Green LR, Parsons P, Tucker RM , Brown R et al () periscope: sub-genomic RNA identification in SARS-CoV-2 Genomic Sequencing Data. View this article in WRRO

Chapters

Green LR, Haigh RD & Bayliss CD (2019) Determination of Repeat Number and Expression States of Phase-Variable Loci Through Next Generation Sequencing and Bioinformatic Analysis, Methods in Molecular Biology (pp. 83-92). Springer New York
Green LR, Eiden J, Hao L, Jones T, Perez J, McNeil LK, Jansen KU & Anderson AS (2016) Approach to the Discovery, Development, and Evaluation of a Novel Neisseria meningitidis Serogroup B Vaccine, Vaccine Design (pp. 445-469). Springer New York

Preprints

Wolverson PA, Fernandes Parreira I, Collins MO, Shaw JG & Green LR (2024) Dynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics, Cold Spring Harbor Laboratory.
Green LR, Issa R, Albaldi F, Urwin L, Khalid H, Turner CE, Ciani B, Partridge LJ & Monk PN (2023) CD9 co-operation with syndecan-1 is required for a major staphylococcal adhesion pathway, Cold Spring Harbor Laboratory.
Wilkinson SAJ, Richter A, Casey A, Osman H, Mirza JD, Stockton J, Quick J, Ratcliffe L, Sparks N, Cumley N , Poplawski R et al (2022) Recurrent SARS-CoV-2 Mutations in Immunodeficient Patients, Cold Spring Harbor Laboratory.
Smallman-Raynor MR & Cliff AD (2022) Spatial Growth Rate of Emerging SARS-CoV-2 Lineages in England, September 2020–December 2021, Cold Spring Harbor Laboratory.
Lythgoe K, Golubchik T, Hall M, House T, Cahuantzi R, MacIntyre-Cockett G, Fryer H, Thomson L, Nurtay A, Ghafani M , Buck D et al (2022) Lineage replacement and evolution captured by three years of the United Kingdom Covid Infection Survey, Cold Spring Harbor Laboratory.
Willett BJ, Grove J, MacLean OA, Wilkie C, Logan N, Lorenzo GD, Furnon W, Scott S, Manali M, Szemiel A , Ashraf S et al (2022) The hyper-transmissible SARS-CoV-2 Omicron variant exhibits significant antigenic change, vaccine escape and a switch in cell entry mechanism, Cold Spring Harbor Laboratory.
McCrone JT, Hill V, Bajaj S, Pena RE, Lambert BC, Inward R, Bhatt S, Volz E, Ruis C, Dellicour S , Baele G et al (2021) Context-specific emergence and growth of the SARS-CoV-2 Delta variant, Cold Spring Harbor Laboratory.
O’Toole Á, Hill V, Jackson B, Dewar R, Sahadeo N, Colquhoun R, Rooke S, McCrone JT, McHugh MP, Nicholls S , Poplawski R et al (2021) Genomics-informed outbreak investigations of SARS-CoV-2 using civet, Cold Spring Harbor Laboratory.
Graham MS, Sudre CH, May A, Antonelli M, Murray B, Varsavsky T, Kläser K, Canas LS, Molteni E, Modat M , Drew DA et al (2021) Changes in symptomatology, re-infection and transmissibility associated with SARS-CoV-2 variant B.1.1.7: an ecological study, Cold Spring Harbor Laboratory.
Collier DA, De Marco A, Ferreira IATM, Meng B, Datir R, Walls AC, Kemp S SA, Bassi J, Pinto D, Fregni CS , Bianchi S et al (2021) SARS-CoV-2 B.1.1.7 sensitivity to mRNA vaccine-elicited, convalescent and monoclonal antibodies, Cold Spring Harbor Laboratory.
Golubchik T, Lythgoe KA, Hall M, Ferretti L, Fryer HR, MacIntyre-Cockett G, de Cesare M, Trebes A, Piazza P, Buck D , Todd JA et al (2021) Early analysis of a potential link between viral load and the N501Y mutation in the SARS-COV-2 spike protein, Cold Spring Harbor Laboratory.
Mashe T, Takawira FT, Martins LDO, Gudza-Mugabe M, Chirenda J, Munyanyi M, Chaibva BV, Tarupiwa A, Gumbo H, Juru A , Nyagupe C et al (2021) Genomic epidemiology of the SARS-CoV-2 epidemic in Zimbabwe: Role of international travel and regional migration in spread, Cold Spring Harbor Laboratory.
Volz E, Mishra S, Chand M, Barrett JC, Johnson R, Geidelberg L, Hinsley WR, Laydon DJ, Dabrera G, O’Toole Á , Amato R et al (2021) Transmission of SARS-CoV-2 Lineage B.1.1.7 in England: Insights from linking epidemiological and genetic data, Cold Spring Harbor Laboratory.
Davies NG, Abbott S, Barnard RC, Jarvis CI, Kucharski AJ, Munday JD, Pearson CAB, Russell TW, Tully DC, Washburne AD , Wenseleers T et al (2020) Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England, Cold Spring Harbor Laboratory.
Thomson EC, Rosen LE, Shepherd JG, Spreafico R, da Silva Filipe A, Wojcechowskyj JA, Davis C, Piccoli L, Pascall DJ, Dillen J , Lytras S et al (2020) The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity, Cold Spring Harbor Laboratory.
Nicholls SM, Poplawski R, Bull MJ, Underwood A, Chapman M, Abu-Dahab K, Taylor B, Jackson B, Rey S, Amato R , Livett R et al (2020) MAJORA: Continuous integration supporting decentralised sequencing for SARS-CoV-2 genomic surveillance, Cold Spring Harbor Laboratory.
Parker MD, Lindsey BB, Shah DR, Hsu S, Keeley AJ, Partridge DG, Leary S, Cope A, State A, Johnson K , Ali N et al () Altered Subgenomic RNA Expression in SARS-CoV-2 B.1.1.7 Infections, Cold Spring Harbor Laboratory.
Partridge LJ, Urwin L, Nicklin MJH, James DC, Green LR & Monk PN () ACE2-independent interaction of SARS-CoV-2 spike protein to human epithelial cells can be inhibited by unfractionated heparin.

Research group

We are proud to consist of a global collection of postdoctoral researchers, PhD students and Master's/project students:

PDRA

Dr Isabel Fernandes Parreira - Investigating 3D models of sex-specific N. gonorrhoeae infection

PhD students

Miss Paige Wolverson - 'The effect of novel anti-infectives across the meningococcal infective pathway and in a 3D blood-brain barrier spheroid model'

Miss Anisha Dhanjal - 'Improving diagnostics of antimicrobial resistant N. gonorrhoeae using long-read sequencing'

Miss Luisa Carvalho - 'Determining the importance of LOS phase variation during sex-specific N. gonorrhoeae infection'

Grants

The Humane Research Trust Research Fellowship.
THRT PhD Scholarship.

Opportunities

Postdoctoral funding

Enquiries are welcome from talented postdoctoral researchers interested in schemes such as the Newton Fellowships or Marie Curie Incoming fellowships at all times. Please contact Dr Luke Green for further information.

PhD projects

Enquiries from committed and talented prospective PhD students are welcome in all areas of our research portfolio. For further information contact Dr Luke Green for details. We welcome enquiries from funded overseas and home applicants.

Submit an enquiry