Professor Martin Thornhill

MBBS, BDS, PhD, MSc, FDSRCS(Edin), FDSRCSI, FDSRCS(Eng)

School of Clinical Dentistry

Professor of Translational Medical Research in Dentistry

Although I am no longer an NHS Oral Medicine consultant I am still active in my specialty in other capacities.

m.thornhill@sheffield.ac.uk
+44 114 215 9397

+44 7515552925

19 Claremont Crescent

Full contact details

Professor Martin Thornhill
School of Clinical Dentistry
19 Claremont Crescent
Sheffield
S10 2TA

Profile

I qualified in medicine and dentistry before completing an MSc, PhD and Oral Medicine specialist training. I am a Fellow of the Royal Colleges of Surgeons of Edinburgh, England and Ireland and have held Oral Medicine Chair positions in London, Manchester, Texas-USA and Sheffield. Currently, I am Professor of Translational Research in Dentistry at the University of Sheffield and Adjunct Professor of Oral Medicine at The Carolinas Medical Center, Charlotte, N. Carolina, USA.

I have been a clinical academic for 40 years combining clinical practice in oral medicine with undergraduate and postgraduate teaching, and basic and translational research. Understanding the clinical nature of disease, and the needs of patients, is fundamental to good research. While top quality collaborative, multidisciplinary research involving basic scientists and clinicians is essential for improving disease outcomes. I am now lucky to be able to focus on the research that I enjoy so much

Research interests

My research spans basic, translational and clinical. Recent research has focussed on the development of mucosal and transmucosal drug delivery systems, new diagnostic technologies for diagnosis of potentially malignant oral lesions and the role of invasive dental procedures and poor oral hygiene in the development of systemic diseases such as infective endocarditis.

My recent research on infective endocarditis, it’s relationship to invasive dental procedures and the risks and benefits of antibiotic prophylaxis has had a particular impact on guideline committees and the clinical practice of dentists and cardiologists around the world. Earlier research focussed on the immunological basis of oral mucosal diseases.

My grant income exceeds £8m, I have more than 200 peer reviewed publications, including papers in the New England Journal of Medicine and Lancet and an h-index of 45.

My research team now includes a network of senior clinicians, scientists, statisticians and data specialists around the world who work together in mutual respect and collaboration to produce high-quality research on important issues at the interface of medicine and dentistry.

Publications

Journal articles

Quintero Martinez JA, Hindy J-R, Villarraga HR, Lahr B, Dayer MJ, Thornhill M, OHoro J, Michelena HI, Anavekar NS, Sendi P , Desimone DC et al (2023) Abstract 12875: Echocardiographic Findings Associated With Subsequent Risk of Native Valve Endocarditis. Circulation, 148(Suppl_1).
Sperotto F, France K, Gobbo M, Bindakhil M, Pimolbutr K, Holmes H, Monteiro L, Graham L, Hong C, Sollecito T , Lodi G et al () Antibiotic prophylaxis and the incidence of infective endocarditis following invasive dental procedures: A systematic review and meta-analysis. JAMA Cardiology.
Thornhill M, Prendergast B, Dayer M, Frisby A & Baddour L () Endocarditis prevention: time for a review of NICE guidance. The Lancet Regional Health - Europe.
Thornhill M, Prendergast B, Dayer M, Frisby A, Lockhart P & Baddour L () New evidence calls into question NICE’s endocarditis prevention guidance. British Dental Journal.
Thornhill M, Prendergast B, Dayer M, Frisby A, Lockhart P & Baddour L () Prevention of infective endocarditis in at risk patients: how should dentists proceed in 2024?. British Dental Journal.
Quintero-Martinez J, Hindy J-R, Villarraga H, Lahr B, Dayer M, Thornhill M, O'Horo J, Michelena H, Anavekar N, Sendi P , DeSimone D et al () Echocardiographic Findings and Subsequent Risk of Native Valve Endocarditis. Preprints.
Dayer M, Quintero-Martinez J, Thornhill M, Chambers J, Pettersson G & Baddour L () Recent advances in native valve endocarditis. Journal of the American College of Cardiology.
Miller CS & Thornhill MH () Re: Estimating the cost of inappropriate antibiotic prophylaxis prior to dental procedures. Infection Control & Hospital Epidemiology, 1-2.

Preprints

Quintero-Martinez JA, Hindy J-R, Villarraga HR, Lahr BD, Dayer MJ, Thornhill MH, O'Horo JC, Michelena HI, Anavekar NS, Sendi P , DeSimone DC et al (2024) Echocardiographic Findings and Subsequent Risk of Native Valve Endocarditis, MDPI AG.

Grants: I have received over £8 million in grant funding. Current grants include funding from the National Institutes for Health (NIH) and National Institute for Dental and Craniofacial Research (NIDCR) in the USA, British Heart Foundation and Delta Dental (USA).

Teaching activities: As I am now a research-only member of staff, I am no longer involved in undergraduate education. However, I still lecture on clinical and research matters to clinicians and post-graduate scientists on an ad-hoc basis.

Professional activities and memberships

Awarded the International Association for Dental Research (IADR) Distinguished Scientist Award for Pharmacology, Therapeutics and Toxicology Research (2021)
Awarded the International Association for Dental Research (IADR) Distinguished Scientist Award for Oral Medicine & Pathology Research (2015)
Awarded the prestigious American Academy for Oral Medicine (AAOM) Samuel Charles Miller Award (2014)
Made an Honorary Fellow of the British Society for Oral Medicine
Member of the Research Committee of the American Academy for Oral Medicine