Professor Stephen Matcher
Tel: +44 (0)114 22 25994
Research Centre: Computational Imaging & Simulation Technologies in Biomedicine
I graduated from Imperial College London with a BSc in Physics and subsequently a PhD in optical astronomy, where I used high-speed, low-light-level imaging to overcome atmospheric turbulence and achieve diffraction-limited ground-based imaging. I translated my expertise in low-light-level imaging into medicine at University College London, where I developed near-infrared spectroscopy techniques to study tissue oxygen delivery, especially in newborn infants at risk from birth asphyxia. I joined the staff of the Physics department at the University of Exeter, where I established research programmes in visible light spectroscopy of skin and optical coherence tomography (OCT).
In 2006 I joined the University of Sheffield where I am currently Professor of Biophotonics. My chief research interest lies in the development and application of novel biophotonic imaging tools to aid the characterisation of native and engineered biological tissues. I work extensively with optical coherence tomography (OCT), including novel variants such as polarization-sensitive OCT for the non-invasive assessment of collagen organization and OCT angiography for the measurement of tissue vascularization. I also develop novel microscopy tools based on second harmonic generation (SHG) and novel clinical sensors based on fluorescence.
I am currently collaborating with clinical colleagues to improve the detection of bacterial and fungal eye infections, to provide tools for the early prediction of pre-term birth to develop non-invasive tools, to characterise skin barrier function and assess inflammatory skin disorders such as atopic dermatitis and to determine the biomechanical factors affecting the interaction between skin and man-made objects.