On Thursday 15 of December we will have a joint Development, Regeneration and Neurophysiology cluster/ECM & Insigneo Mechanobiology seminar which will be given in person by Dr Kevin Chalut from Altos Labs.

Title: TBC

Host: Dr Ivana Barbaric

Abstract: 

The role of extracellular matrix (ECM) mechanics in cell fate choice and regeneration has been largely overlooked; however, ECM mechanics plays a significant role in building and maintaining tissue. My lab is investigating the interplay between mechanics and signaling in cell fate transitions in stem cells, and is beginning to apply some of what we have learned to whole tissue. I will show how cell surface mechanics in particular impacts cell signalling that is instructive for cell fate choice, both in stem cells and development. I will also present an outlook suggesting how the interplay between mechanics and signaling has significant impact on regeneration, and what tools and concepts will be important for investigating that interplay.