Professor Ian Peake

Department of Infection, Immunity and Cardiovascular Disease

Emeritus Professor of Molecular Medicine

i.r.peake@sheffield.ac.uk
+44 7785 247 928

Full contact details

Professor Ian Peake
Department of Infection, Immunity and Cardiovascular Disease
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

I joined the University in 1990 as the Sir Edward Mellanby Professor of Molecular Medicine and also hold an Honorary Consultant position with the Sheffield Teaching Hospitals NHS Foundation Trust. I have been Deputy Director of the Division of Genomic Medicine and Director of Research for Medicine.

I am currently focused on my research into inherited bleeding disorders in particular von Willebrands disease.

Research interests

My research interests are inherited disorders of Haemostasis and Thrombosis.

My current research interests focus on von Willebrands Disease. I was a co-applicant on an NIH funded PPG (the Zimmerman Project) with collaborators in Canada and USA. I also co-chaired the EU von Willebrands disease collaborative group which has projects continuing from the EU funded MCMDM-1VWD project which I directed.

Since 2011 I have been a coordinator of an International EU/Iran study of severe Von Willebrands Disease (3WINTERS IPS) sponsored by the a Medical research Charity in Milan Italy.

Publications

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Journal articles

Conference proceedings papers

All publications

Journal articles

Chapters

Conference proceedings papers

  • Baronciani L, Budde U, Stufano F, Peyvandi F, Goodeve A, Schneppenheim R, Badiee Z, Baghaipour MR, Battle J, Berntorp E , Bodo I et al (2019) EVALUATION OF THE VON WILLEBRAND FACTOR (VWF) INHIBITOR IN A LARGE COHORT OF EUROPEAN AND IRANIAN PATIENTS PREVIOUSLY DIAGNOSED WITH TYPE 3 VON WILLEBRAND DISEASE (VWD3) ENROLLED INTO THE 3WINTER-IPS PROJECT. HAEMATOLOGICA, Vol. 104 (pp 24-24) RIS download Bibtex download
  • Federici AB, Badiee Z, Baghaipour M-R, Castaman G, Eshghi P, Goudemand J, Hay CRM, Hoorfar H, Karimi M, Keikhaei B , Lassila R et al (2018) Prospective Observation on the Use of Von Willebrand Factor (VWF) Concentrates in a Large Cohort of Type 3 Von Willebrand Disease (VWD): Interim (18-months) Analyses on 149 Cases Enrolled into the 3Winters-Ips Project. Blood, Vol. 132(Supplement 1) (pp 2464-2464) RIS download Bibtex download
  • Tosetto A, Christopherson PA, Eikenboom JCJ, Grabell J, James PD, Montgomery RR, Peake I, Silva M & Investigators ZP (2018) Bleeding Patterns in Type I VWD in Effect of VWF Levels: An Individual Participant Data Meta-Analysis of Three Cohorts. Blood, Vol. 132(Supplement 1) (pp 1180-1180) RIS download Bibtex download
  • Tosetto A, Badiee Z, Baghaipour M-R, Baronciani L, Battle J, Berntorp E, Bodó I, Budde U, Castaman G, Eikenboom JCJ , Eshghi P et al (2018) Clustering of Bleeding Symptoms in Patients Previously Diagnosed As Type 3 Von Willebrand Disease: Results from a Large Cohort of Type 3 Von Willebrand Disease (the 3Winters-Ips Project). Blood, Vol. 132(Supplement 1) (pp 2465-2465) RIS download Bibtex download
  • Baronciani L, Peyvandi F, Goodeve A, Schneppenheim R, Badiee Z, Baghaipour M-R, Battle J, Berntorp E, Bodó I, Budde U , Cairo A et al (2018) Profile of Mutations Identified in the 3WINTERS-IPS Project on European & Iranian Patients with Previously Diagnosed Type 3 Von Willebrand Disease.. Blood, Vol. 132(Supplement 1) (pp 1184-1184) RIS download Bibtex download
  • Webster SJ, Cartwright A, Hampshire DJ, Peake IR, Goodeve AC & EU-VWD and ZPMCB-VWD study groups (2015) High resolution microscopic characterisation of VWF biosynthesis, storage and secretion in type 1 VWD patients with large in-frame VWF deletions. Journal of Thrombosis and Haemostasis, Vol. 13(Suppl. 2) (pp 23-23), 20 June 2015 - 25 June 2015. RIS download Bibtex download
  • Mufti A, Goodeve A, Peake I, Hampshire D & EU-VWD and ZPMCB-VWD study groups (2015) Single nucleotide variants c.2365A>G and c.2385T>C are associated with increased VWF plasma levels through an effect on mRNA half-life. Journal of Thrombosis and Haemostasis, Vol. 13(Suppl. 2) (pp 251-251), 20 June 2015 - 25 June 2015. RIS download Bibtex download
  • Dsouza MM, Webster SJ, McMaster J, Cartwright A, Budde U, Peake IR, Goodeve AC, Hampshire DJ & EU-VWD and ZPMCB-VWD study groups (2015) Missense mutations located in the von Willebrand factor (VWF) D1 domain cause quantitative VWF deficiency through impairment of VWF packaging into storage organelles. Journal of Thrombosis and Haemostasis, Vol. 13(Suppl. 2) (pp 508-508), 20 June 2015 - 25 June 2015. RIS download Bibtex download
  • Cartwright A, Webster SJ, Jacobi PM, Hickson N, Budde U, Peake IR, Goodeve AC, Haberichter SL, Hampshire DJ & EU-VWD and ZPMCB-VWD study groups (2015) Functional characterisation of a novel splice mutation, c.7887+2T>A, associated with type 1 von Willebrand disease. Journal of Thrombosis and Haemostasis, Vol. 13(Suppl. 2) (pp 505-505), 20 June 2015 - 25 June 2015. RIS download Bibtex download
  • Webster SJ, Hampshire DJ, Schneppenheim R, Bellissimo D, James P, Theophilus B, Peake IR, Goodeve AC & EU-VWD and ZPMCB-VWD study groups (2015) Detection of large exonic and intergenic deletions in the VWF locus of VWD patients using array comparative genomic hybridisation (ACGH). Journal of Thrombosis and Haemostasis, Vol. 13(Suppl. 2) (pp 126-126), 20 June 2015 - 25 June 2015. RIS download Bibtex download
  • Cartwright A, Christopherson PA, Perry CL, Haberichter SL, Hampshire D, Peake IR, Goodeve A, Montgomery RR, Bellissimo DB & Zimmerman Program Investigators (2014) Characterization and expression of an in-frame exon 33-34 deletion causing type 1 VWD. Blood, Vol. 124 RIS download Bibtex download
  • Goodeve AC, Hampshire D, Batlle J, Budde U, Castaman G, Eikenboom HCJ, Federici AB, Schneppenheim R & Peake IR (2013) Re-evaluation of sequence variation in type 1 von Willebrand disease in the MCMDM-1VWD cohort. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol. 11 (pp 413-414) RIS download Bibtex download
  • Mufti A, Lillicrap D, Peake IR, Goodeve AC & Hampshire D (2013) Investigation of the effect of CLEC4M on plasma von Willebrand factor level in the general population. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol. 11 (pp 552-553) RIS download Bibtex download
  • Cartwright A, Hampshire DJ, Bloomer L, Al-Buhairan AM, Vijzelaar NCP, Budde U, Eikenboom HCJ, Schneppenheim R, Peake IR & Goodeve AC (2013) Characterisation of large in-frame deletions contributing to type 1 VWD pathogenesis in the MCMDM-1VWD study. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol. 11 (pp 117-118) RIS download Bibtex download
  • Alyami NH, Hampshire D, Goudemand J, Castaman G, Federici AB, Cartwright A, Peake IR & Goodeve AC (2013) Previously missed mutations in the MCMDM-1VWD type 1 von Willebrand disease study. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol. 11 (pp 415-415) RIS download Bibtex download
  • Hampshire DJ, Abuzenadah AM, Al-Shammari NS, Eckert M, Coyle RE, Al-Buhairan AM, Messenger SL, Gursel T, Ingerslev J, Peake IR & Goodeve AC (2011) Characterisation of von Willebrand disease mutational spectrum in a Turkish patient cohort. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol. 9 (pp 914-914) RIS download Bibtex download
  • Alyami NH, Hampshire DJ, Goudemand J, Castaman G, Federici AB, Peake IR, Goodeve AC, Grp EU-VWDS & Grp ZPMCB-VWDS (2011) Missing mutation in type 1 von Willebrand disease in the MCMDM-1 VWD study. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol. 9 (pp 914-914) RIS download Bibtex download
  • Hampshire DJ, Cartwright A, Bloomer LD, Al-Buhairan AM, Vijzelaar RNCP, Habart D, Hill FGH, Rodeghiero F, Budde U, Eikenboom JCJ , Peake IR et al (2011) Copy number variation is a significant contributor to type 1 VWD pathogenesis in the EU MCMDM-1VWD cohort. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol. 9 (pp 55-56) RIS download Bibtex download
  • Hampshire DJ, Bloomer LD, Al-Buhairan AM, Coyle RE, Vijzelaar RNCP, Lillicrap D, James PD, Eikenboom JCJ, Schneppenheim R, Rodeghiero F , Montgomery RR et al (2010) Investigation of the Role of Copy Number Variation In the Pathogenesis of Type 1 Von Willebrand Disease.. BLOOD, Vol. 116(21) (pp 913-913) RIS download Bibtex download
  • Flood VH, Kautza BC, Miller CA, Branchford BR, Gill JC, Haberichter SL, Morateck PA, Christopherson PA, Perry CL, Friedman KD , Bellissimo DB et al (2007) Common VWF Haplotypes in Normal African-Americans and Caucasians Recruited into the ZPMCB-VWD and Their Impact on VWF Laboratory Testing.. Blood, Vol. 110(11) (pp 714-714) RIS download Bibtex download
  • Chuansumrit A, Sasanakul W, Williams I, Goodeve A, Kadegasem P & Peake I (2004) Comparison of Phenotypic Assessment and Mutation Detection in the Diagnosis of Carrier State in Hemophilia: Identification of 10 Novel Mutations.. Blood, Vol. 104(11) (pp 4020-4020) RIS download Bibtex download
  • Eikenboom JCJ, van Marion V, Putter H, Garcia EBG, Peake I, Goodeve A, Rodeghiero F, Castaman G, Federici AB, Batlle J , Meyer D et al (2003) Analysis of cosegregation of type 1 Von Willebrands disease phenotype and von Willebrand factor gene haplotypes in the European Multicenter MCMDM-1VWD study.. BLOOD, Vol. 102(11) (pp 90A-90A) RIS download Bibtex download
  • Goodeve A, Walker M, Peake I, Rodeghiero F, Castaman G, Federici A, Batlle J, Meyer D, Eikenboom J, Schneppenheim R , Ingerslev J et al (2003) Contribution of ABO blood group to type 1 von Willebrand disease in patients entered in the multicentre MCMDM-1VWD study.. BLOOD, Vol. 102(11) (pp 91A-91A) RIS download Bibtex download
  • Lester WA, Bowen DJ, Cumming A, Collins PW, Watson P, Keeney S, Enayat MS, Keeling D, Pasi KJ, Bolton-Maggs P , Liesner R et al (2003) Variable phenotypic penetrance of von Willebrand factor gene Y1584C heterozygosity in type 1 von Willebrand disease families and its association with enhanced in vitro susceptibility to ADAMTS 13 mediated proteolysis.. BLOOD, Vol. 102(11) (pp 311A-311A) RIS download Bibtex download
  • Hashemi MB, Inbal A, Peake IR, Mikris M, Hampton E & Goodeve AC (2002) Mutational analysis in five families with type 1 von Willebrand disease. BLOOD, Vol. 100(11) (pp 69B-69B) RIS download Bibtex download
  • Care RS, Goodeve AC, Abu-Duhier FM, Geertsma-Kleinekoort W, Valk PJM, Lowenberg B, Wilson GA, Gari MA, Peake IR & Reilly JT (2002) Incidence and prognosis of c-kit and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias.. BLOOD, Vol. 100(11) (pp 746A-746A) RIS download Bibtex download
  • Sadler JE, Berntorp E, Bochkov N, Boulyjenkov V, Ginsburg D, Meyer D, Peake I, Rodeghiero F, Srivastava A & Mannucci PM (2000) Impact, Diagnosis and Treatment of von Willebrand Disease. Thrombosis and Haemostasis, Vol. 84(08) (pp 160-174) RIS download Bibtex download
  • Hop C, Guilliatt A, Daly M, de Leeuw HP, Brinkman H-JM, Peake IR, van Mourik JA & Pannekoek H (2000) Assembly of Multimeric von Willebrand Factor Directs Sorting of P-Selectin. Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 20(7) (pp 1763-1768) RIS download Bibtex download
  • Frost L, Wilson G, Goodeve A, Gerrard M, Snowden J, Peake I & Vora A (1999) Relapsing precursor B-ALL presenting as CD-10 positive isolated extramedullary lymphoma.. BLOOD, Vol. 94(10) (pp 219B-219B) RIS download Bibtex download
  • Coughlan TC, Goodeve AC, Hampton KK, Makris M & Peake IR (1998) Null alleles are not a common cause of type 1 vonWillebrand's disease. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 102(1) (pp 15-15) RIS download Bibtex download
  • Nesbitt IM, Goodeve AC, Hampton KK, Preston FE & Peake IR (1998) Two unrelated families with different type 2N VWD mutations share a common splice site mutation.. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 101 (pp 87-87) RIS download Bibtex download
  • Abuzenadah AM, Goodeve AC, Gursel T, Daly ME, Ingerslev J & Peake IR (1998) Mutations in the pro-peptide of VWF causing type 1 and type 3 VWD.. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 101 (pp 67-67) RIS download Bibtex download
  • Williams IJ, Peake IR, Goodeve AC & Grp RPUPS (1998) Recombinate PUP mutation study: Relationship between factor VIII mutation and inhibitor development. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 101 (pp 84-84) RIS download Bibtex download
  • Abuzenadah AM, Goodeve AC, Ingerslev J, Gursel T & Peake IR (1997) Mutations within the vWF gene resulting in type 1 and type 3 vWD in consanguineous families. THROMBOSIS AND HAEMOSTASIS (pp P2667-P2667) RIS download Bibtex download
  • Ollier W, Hay CRM, Pepper L, Cumming A, Keeney S, Goodeve AC, Preston FE, Colvin BT, Hill FGH & Peake IR (1997) HLA class II profile: A determinant of inhibitor development in severe haemophilia A. THROMBOSIS AND HAEMOSTASIS (pp P2657-P2657) RIS download Bibtex download
  • Nesbitt IM, Goodeve AC, Daly ME, Hampton KK, Makris M, Preston FE & Peake IR (1997) Mutation at Arg611 in the von Willebrand factor gene results in unclassifiable type 2 von Willebrand disease. THROMBOSIS AND HAEMOSTASIS (pp P2665-P2665) RIS download Bibtex download
  • Naylor JA, Nicholson P, Goodeve A, Hassock S, Peake I & Giannelli F (1996) A novel DNA inversion causing severe hemophilia A. Blood, Vol. 87(8) (pp 3255-3261) RIS download Bibtex download
  • GOODEVE AC, PRESTON FE & PEAKE IR (1995) A RAPID AND COST-EFFECTIVE METHOD FOR ANALYSIS OF DINUCLEOTIDE REPEAT POLYMORPHISMS IN THE FACTOR-VIII GENE. THROMBOSIS AND HAEMOSTASIS, Vol. 73(6) (pp 1221-1221) RIS download Bibtex download
  • Peake IR (1995) The molecular biology of haemophilia. HEREDITARY DISEASES AND BLOOD TRANSFUSION, Vol. 30 (pp 3-9) RIS download Bibtex download
  • Higins KS, Goodeve AC, Yeo WW, Morice AH & Peake IR (1992) Improved detection of the insertion/deletion polymorphism of the ACE gene and relationship to serum ACE activity in a normotensive U.K. population. British Journal of Clinical Pharmacology, Vol. 34(2) RIS download Bibtex download

Posters

  • Federici AB, Peyvandi F, Budde U, Castaman G, Eikenboom J, Eshghi P, Goodeve A, Goodemand J, Hoorfar H, Karimi M , Peake IR et al (2015) New insights into type 3 von Willebrand disease: the type 3 von Willebrand disease international registries and inhibitor prospective study (3WINTERS-IPS) project update. RIS download Bibtex download
Teaching interests

I teach at the postgraduate level.

Professional activities

I was a partner of the Health and Care Professions Council (HCPC) as a Clinical Scientist, I was also Registration Assessor for HCPC and for the Association of Clinical Scientists.

I am a past President of the International Society on Thrombosis and Haemostasis (ISTH Congress Birmingham 2003) and Chair of the ISTH Council (2006-2008). I am a past Council member of the British Society for Haemostasis and Thrombosis and the European Association for Haemophilia and Allied Disorders. I was also a member of the Education Committee of the European Haematology Association until 2012.