Professor Michael Wells BSc(Hons) MD FRCPath FRCOG

Michael Wells

Professor of Gynaecological Pathology, University of Sheffield Medical School; Honorary Consultant Histopathologist, Sheffield Teaching Hospitals NHS Foundation Trust.
Director of Studies Phase 3A MBChB, University of Sheffield School of Medicine and Biomedical Sciences


Address:
Academic Unit of Pathology
School of Medicine & Biomedical Sciences
University of Sheffield
Beech Hill Road
Sheffield
S10 2RX
Tel: (+44) (0)114 271 2397
Email: m.wells@sheffield.ac.uk

Clinical Secretary: Miss Laura Medley
Tel: 0114 2712524
Email: laura.medley@sth.nhs.uk

Career Résumé

Michael Wells graduated in 1976 from Manchester Medical School and, following junior posts in Bristol, he moved to the University of Leeds in 1980 as Lecturer in Pathology where he began to take a special interest in gynaecological pathology. He was appointed Senior Lecturer in 1988 and to the Chair of Gynaecological Pathology at St James´s University Hospital, Leeds in 1993. He was invited to move to a similar post in the University of Sheffield in 1997. He is a former President of the British Gynaecological Cancer Society, member of Council of the Royal College of Pathologists, Honorary Secretary of the British Division of the International Academy of Pathology and Meetings Secretary and General Secretary of the Pathological Society of Great Britain and Ireland. He has published more than 200 original papers, book chapters and review articles and has received numerous invitations to lecture around the world. He has a substantial consultation practice. In 2004 he was elected a Fellow of the Royal College of Obstetricians and Gynaecologists (ad eundem) in recognition of the major contributions he has made to the specialty and the well being of women.

Associations and Societies – recent and current posts

Member, Executive Committee, European Society of Pathology 2003-

Gynaecological Visiting Society of Great Britain and Ireland (2005-

President, International Society of Gynecological Pathologists (2003-2005)

Editorial Activities

Co-Editor, Haines & Taylor, Obstetrical and Gynaecological Pathology, Fifth Edition, Churchill Livingstone, 2003

WHO Classification of Tumours: Pathology and Genetics of Tumours of the Breast and Female Genital Organs
Editorial and consensus meeting, WHO/UICC, Lyon, March 2002

Editor of Histopathology (2003- )

Associate Editor (Europe), International Journal of Gynecological Pathology (1998-2003), Member of the Editorial Board (1993-)

Member of the Editorial Board of Virchows Archiv (2002- )

Member of the Editorial Board, Gynecologic Oncology (2005- )

Major Recent Invited Postgraduate Lectures and Seminars

  • Controversies in endometrial pathology (Johannesburg, Capetown, Durban),
    Gynaecological pathology slide seminar (Bloemfontein, Capetown, Stellenbosch [Tygerberg], Durban),
    Histopathological challenges in assessing microinvasive carcinoma of the cervix and vulva (Stellenbosch [Tygerberg]),
    Universities of the Witwatersrand, Orange Free State, Capetown, Stellenbosch, Kwazulu Natal
    Recent advances in glandular neoplasia of the cervix (Education day),
    Recent advances in the pathology and molecular pathology of epithelial ovarian tumours
    Gestational trophoblastic disease – a survival guide.
    47th Annual Congress of the Federation of South African Societies of Pathology, Bela Bela, South Africa, July 2007 (Goodwill Ambassador of the British Division of the International Academy of Pathology)

  • The enigma of trophoblast – a 24 year perspective
    The British Division of the International Academy of Pathology’s 2nd George Cunningham Lecture, Fourth Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, Glasgow, July 2007

  • Recent advances in glandular neoplasia of the cervix
    Gynecologic pathology slide seminar – participant
    Gestational trophoblastic disease
    5th Asia Pacific IAP Congress, Singapore, May 2007

  • Gestational trophoblastic disease
    Plenary lecture, 1st Hellenic-Jordanian Congress of Pathology, Crete, April 2007

  • Recent advances in the pathology of adenocarcinoma of the cervix
    British Society for Colposcopy and Cervical Pathology, Annual Meeting, Sheffield, April 2007

  • Trophoblastic diseases: survival guide
    Chairman of session
    Gynaecological Pathology: Update and Controversies. Joint Meeting of the Royal College of Pathologists and the Pathological Society of Great Britain and Ireland, Royal College of Pathologists, London, February 2007

  • Synchronous and metachronous tumours of the female genital tract
    Current guidelines in the diagnosis and management of endometrial hyperplasia
    Debate: role of peritoneal cytology in gynaecological carcinoma
    Clinicopathological symposium: case presentations
    International Pathology Update, Indraprastha Apollo Hospital, New Delhi, India, February 2007 (sponsored by WASPaLM & BDIAP)

  • Histopathological challenges in assessing microinvasive squamous cell carcinoma of the cervix and vulva
    Diagnostic issues in assessment of glandular neoplasia of the cervix
    Endometrial intraepithelial neoplasia – fact or fiction
    Morphological attributes of difficult epithelial ovarian tumours with current views on borderline ovarian tumours and peritoneal implants
    Challenges in the diagnosis of gestational trophoblastic disease
    Slide seminar
    Workshop - Controversies in Gynaecological Pathology, Ipoh, Malaysia, November 2006

  • Recent advances in the pathology and molecular pathology of epithelial ovarian tumours
    The endometrial effects of hormone replacement therapy
    Synchronous and metachronous tumours of the female genital tract
    Rare tumours of the uterine corpus
    Microinvasive and invasive carcinoma of the vulva
    Recent advances in the pathology of gestational trophoblastic disease
    Gynecologic Pathology Course, Cukurova University, Adana, Turkey, November 2006

  • Chairman, Endometrial carcinoma: pathology & genetics
    Satellite symposium on gynaecological tumour pathology honouring Professor Harold Fox
    Controversies in the grading system of carcinoma of the endometrium
    Meet the Professor session
    11th Biennial Meeting of the International Gynecologic Cancer Society, Santa Monica, California, USA, October 2006

  • Overview (and symposium moderator)
    Symposium – Endometrial carcinoma: pathology & genetics
    Diagnostic pitfalls of molar lesions
    Symposium – Gestational Trophoblastic Disease
    XXVI International Congress, International Academy of Pathology, Montreal, Canada, September 2006

  • Ovarian epithelial neoplasia: H&E meets molecular pathology
    Gynaecology pathology slide seminar
    Glandular lesions of the cervix
    Jordanian Society of Pathology & Laboratory medicine, 2nd International Conference, Amman, Jordan, August, 2006

  • Meet the experts - Gynaecological Pathology
    Chairman – poster session
    Centenary meeting, Pathological Society of Great Britain & Ireland, Manchester, July 2006

  • Recent advances in the pathology and molecular pathology of epithelial ovarian tumours
    Recent advances in the pathology and molecular pathology of endometriosis
    Recent advances in glandular pathology of the cervix
    Microinvasive ad invasive carcinoma of the vulva
    Recent advances in the pathology of gestational trophoblastic diseases
    Gynecologic Pathology Course, 10th National Gynecologic Oncology Congress, Antalya, Turkey, April 2006

  • Potential pitfalls in cervical biopsy diagnosis
    Recent advances in cervical pathology: cytological and histological aspects. Medical Solutions in co-operation with Emirates Medical Association Pathology Society, Dubai, January 2006

Recent Publications (from 2002)

BOOKS

Fox H, Wells M (2003) Haines and Taylor, Obstetrical and Gynaecological Pathology, Fifth Edition (in two volumes) 1626 pages, Churchill Livingstone.

PARTS OF BOOKS

Ferreux E, Lewis CE, Perrett CP, Wells M. (2002) The regulation of angiogenesis in ovarian cancer; role of p53, vascular endothelial growth factor and hypoxia. In: Ovarian Cancer Edited by Jacobs I J et al, Oxford University Press in collaboration with the Helene Harris Memorial Trust, 131-136.

Herrington CS, Wells M. (2003) Premalignant and malignant squamous lesions of the cervix. Haines & Taylor, Obstetrical and Gynaecological Pathology, Fifth Edition, Editors H Fox & M Wells, Churchill Livingstone, 297-338.

Brown LJR, Wells M. (2003) Premalignant and malignant glandular lesions of the cervix. Haines & Taylor, Obstetrical and Gynaecological Pathology, Editors H Fox & M Wells, Fifth Edition, Churchill Livingstone, 339-367.

Fox H, Wells M. (2003) Ovarian tumours: classification,histogenesis and aetiology. Haines & Taylor, Obstetrical and Gynaecological Pathology, Fifth Edition, Editors H Fox & M Wells, Churchill Livingstone, 693-712.

Fox H, Wells M. (2003) Surface epithelial-stromal tumours of the ovary. Haines & Taylor, Obstetrical and Gynaecological Pathology, Fifth Edition, Editors H Fox & M Wells, Churchill Livingstone, 713-743.

Hustin J, Wells M. (2003) Pathology of the pregnant uterus. Haines & Taylor, Obstetrical and Gynaecological Pathology, Fifth Edition, Editors H Fox & M Wells, Churchill Livingstone, 1327-1357.

Cheung A, Fox H, Wells M. (2003) Investigative techniques. Haines & Taylor, Obstetrical and Gynaecological Pathology, Fifth Edition, Editors H Fox & M Wells, Churchill Livingstone, 1595-1626.

Wells M. (2003) Pathology and its prognostic importance. In: Key advances in the clinical mangement of Ovarian Cancer. Edited by S Ghaem-Maghami, K Orton & O Soutter. RSM press, 27-32.

Wells M, Ostor AG, Crum CP, Franceschi S, Tommasino M, Nesland JM, Goodman AK, Sankaranarayanan R, Hanselaar AG, Albores-Saavedra J. (2003) Epithelial tumours In: Tumours of the uterine cervix. World Health Organisation: Tumours of the breast and female genital organs, Pathology & Genetics, 262-279.

Burton JL, Wells M. (2003) The histopathology and quantitative pathology of carcinoma of the endometrium. In:Endometrial Cancer (European Practice in Gynaecology and Obstetrics), Elsevier, Editor P Bosze, Elsevier, 29-39.

Wells M. Hyperplasias of the endometrium. (2004) In Cancers of the Uterine Corpus. In: Gynecologic Cancer: Controversies in Management. Edited by Gershenson DM, Gore M, McGuire WP, Quinn M, Thomas G, Elsevier: Churchill Livingstone, 249-157.

FULL PAPERS IN REFEREED JOURNALS (ABSTRACTS, LETTERS AND BOOK REVIEWS ARE NOT INCLUDED)

Burke B, Tang N, Corke KP, Tazzyman D, Ameri K, Wells M, Lewis CE. Expression of HIF-1 alpha by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy. Journal of Pathology 196, 204-212 (2002)

Petersen VC, Underwood JCE, Wells M, Shepherd NA. Primary endometrioid adenocarcinoma of the large intestine arising in colorectal endometriosis. Histopathology 40, 171-176 (2002).

Wells M, Sturdee DW, Barlow DH, Ulrich LG, O´Brien K, Campbell MJ, Vessey MP, Bragg AJ for the UK Continuous Combined HRT Study Investigators. Effect on endometrium of long term treatment with continuous combined oestrogen-progestogen replacement therapy: follow up study. British Medical Journal 325, 239-242,(2002).
For full text (see also Editorial: Archer DF Continuous combined hormone replacement therapy and endometrial hyperplasia. British Medical Journal 325, 231-232,2002).

Bahathiq AO, Stewart RL, Wells M, Moore HD, Pacey AA, Ledger WL Production of activins by the human endosalpinx. Journal of Clinical Endocrinology and Metabolism 87, 5283-5289 (2002)

Crisp H, Burton JL, Smith O, Stewart R, Wells M. Refining the diagnosis of hydatidiform mole: image ploidy analysis and p57KIP2 immunohistochemistry. Histopathology 43, 363-373 (2003).

Burke B, Giannoudis A, Corke KP, Gill D, Wells M, Ziegler-Heitbrock L, Lewis CE. Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy. American Journal of Pathology 163, 1233-1243 (2003).

Duffy S, Jackson TL, Lansdown M, Philips K, Wells M, Pollard S, Clack G, Cuzik J, Coibion M, Bianco AR. The ATAC adjuvant breast cancer trial in postmenopausal women: basal endometrial subprotocol data. British Journal of Obstetrics and Gynaecology 110, 1099-2106 (2003).

Mohindra A, Bolderson E, Stone J, Wells M, Helleday T, Meuth M. A tumour-derived mutant allele of XRCC2 preferentially suppresses homologous recombination at DNA replication forks. Human Molecular Genetics 13, 203-212 (2004).

Tuckerman E, Laird SM, Stewart R, Wells M, Li TC. Markers of endometrial function in women with unexplained recurrent pregnancy loss: a comparison between morphologically normal and retarded endometrium. Human Reproduction 19, 196-205 (2004).

Refaat BA, Bahathiq AO, Sockanathan S, Stewart RL, Wells M, Ledger WL. Production and localization of activins and activin type IIA and IIB receptors by the human endosalpinx. Reproduction 128, 249-255 (2004).

Duffy S, Jackson TL, Lansdown M, Philips K, Wells M, Pollard S, Clack G, Coiboin M, Bianco AR; ATAC Trialists´ Group. The ATAC (`Arimidex´, Tamoxifen, alone or in combination) adjuvant breast cancer trial: baseline endometrial sub-protocol data on the effectiveness of transvaginal ultrasonography and diagnostic hysteroscopy. Human Reproduction 20, 294-301 (2005).

Bahathiq AO, Stewart RL, Baxter L, Wells M, Moore HD, Ledger WL. Tissue expression and messenger ribonucleic acid localization of inhibin/activin subunit in human epididymis. Fertility and Sterility 83, 78-85 (2005).

Hassadia A, Gillespie A, Tidy J, Everard Rgn J, Wells M, Coleman R, Hancock B. Placental site trophoblastic tumour: Clinical features and management. Gynecologic Oncology 99, 603-607 (2005).

Duffy S, Jackson TL, Lansdown M, Philips K, Wells M, Pollard S, Clack G, Coibion M, Bianco AR. The ATAC (`Arimidex´, Tamoxifen, Alone or in Combination) adjuvant breast cancer trial: first results of the endometrial sub-protocol following 2 years of treatment. Human Reproduction 21, 545-553 (2006).

Ibrahim EM, Stewart RL, Corke K, Blackett AD, Tidy JA, Wells M. Upregulation of CD44 expression by interleukins 1, 4, and 13, transforming growth factor-beta1, estrogen, and progestogen in human cervical adenocarcinoma cell lines. International Journal of Gynecological Cancer 16, 1631-1642 (2006).

Prakash A, Li TC, Tuckerman E, Laird S, Wells M, Ledger WL. A study of luteal phase expression of inhibin, activin and follistatin subunits in the endometrium of women with recurrent miscarriage. Fertility and Sterility 2006 Epub ahead of print.

Hancock BW, Martin K, Evans CA, Everard JE, Wells M. Twin mole and viable fetus: the case for misdiagnosis. Journal of Reproductive Medicine 51: 825-828 (2006).

McCLuggage WG, Sumathi VP, Nucci MR, Hirsch M, Cin, PD, Wells M, Flanagan AM, Fisher C. Ewing family of tumours involving the vulva and vagina. Journal of Clinical Pathology 60, 674-680 (2007).

OTHER SIGNIFICANT CONTRIBUTIONS TO JOURNALS

Burton JL, Wells M. The effect of phytoestrogens on the female genital tract. Journal of Clinical Pathology, 55, 401-407, (2002).

Wells M, Brown LJR. Symposium Part IV: Investigative approaches to endocervical pathology. International Journal of Gynecological Pathology, 21: 360-367, (2002).

Fox H, Wells M Recent advances in the pathology of the vulva. Histopathology, 42: 209-216, (2003).

Wells M. Recent advances in endometriosis with emphasis on pathogenesis, molecular pathology, and neoplastic transformation. International Journal of Gynecological Pathology, 23, 316-320, (2004).

Wells M. The pathology of gestational trophoblastic disease: recent advances. Pathology, 39: 88-96, (2007).