Biochemistry BSc

Core modules:

Experimental Skills for Bioscientists

This core module is designed to give you the essential practical skills you'll need for a successful career in scientific research. Throughout this module, you'll build a strong foundation in laboratory techniques, data handling, and scientific methodology.

In Semester 1 you'll learn fundamental lab skills, such as pipetting, microscopy, and performing basic mathematical calculations. You'll also learn to use analytical software to collect and process data.

In Semester 2 you'll work with your coursemates on group projects that allow you to develop your own hypotheses, design and conduct experiments, collect and analyse data, and present your findings in the form of clear and concise lab reports.

This module will train you in the core competencies you'll need to perform experiments and communicate scientific research effectively.

20 credits

Professional Skills for Bioscientists

This module is built around a team-based project focussing on identifying and communicating a real-world bioscience problem.

Your team will pick one issue from the UN's Sustainable Development Goals to focus on. You'll research this issue using articles, reports, and data to better understand it, before creating a digital project showing why the issue matters and needs action. Depending on your interests, you could choose to focus on environmental issues, health disparities, or agricultural challenges.

You'll then identify key populations that are affected, outlining the underlying causes that have led to such problems, and consider the career pathways that bioscientists could take to address this challenge.

20 credits

Building Blocks of Life

This core module will introduce you to the essential components that constitute all living organisms.

To understand the complexity of any biological system, we must understand it across scales from molecules through to cells, tissues, organisms, populations and ecosystems.

This module explores the key principles of molecular cell biology that form the foundation of life. You'll learn about the structure and function of cellular components, how genetic information is stored and transmitted, and how cells communicate through signalling pathways in microbes, fungi, animal and plant kingdoms. You'll then explore how single cells develop into multicellular organisms.

We'll also discuss the fundamentals of the immune system of animals, how other organisms such as plants respond to and clear infection, and how this knowledge can be exploited to develop therapeutics including vaccines.

20 credits

Genetics and Evolution

This core module explores the genetic and evolutionary mechanisms and processes that underpin all life on Earth which are the central unifying themes of modern biology. You'll examine sources and mechanisms of variation from genes to populations, and investigate evolutionary processes of selection, adaptation, and the origin of species.

We'll also introduce you to the approaches used to study genetics and evolution including classical population and quantitative genetics, phylogenetic trees, and the fossil record.

At the end of this module, you'll be able to recognise real-world applications of genetics and evolution spanning disciplines from medicine to conservation.

10 credits

Origins and Diversity of Life

This core module will introduce you to the staggering diversity of life on Earth, from extremophiles in hydrothermal vents, and the first plants on land, to animals exploiting niches on land, sea, and air.

You'll start by looking at the origins of life and examine the evidence for major transitions in Earth history, such as the colonisation of land and extinction events that have shaped life over geologic time.

We'll take an in-depth look into the great evolutionary success story of the microbial world. You'll learn about the physiological features and adaptations of microbes that have enabled them to colonise every available niche on the planet and extend this knowledge to give you an understanding of their importance for human health.

10 credits

Introduction to Biochemistry

This module will teach you how a cell works at the molecular level, giving you a solid foundation of knowledge to build on throughout your course.

Your lectures will describe molecular structures, interactions within and between molecules, factors affecting reaction rates, and the specific measurements needed to understand these processes. You'll also learn about the fundamental signalling mechanisms that enable cells to sense their environment, trigger appropriate responses, and regulate metabolic pathways. We'll describe key metabolic reactions like the Krebs Cycle and electron transport chain, which generate the energy necessary for cellular function.

During laboratory sessions, you'll measure biochemical reactions and develop your experimental design and data analysis skills.

20 credits

Optional modules:

A student will take 20 credits from this group.

Introduction to Physiology

This module will give you an understanding of the fundamental physiological processes that enable the human body to function.

You'll learn about the major cell types, tissues and organ systems that make up the human anatomy, and be able to explain examples of how diseases and drugs affect them. We'll also introduce you to the experimental methods and techniques used to study physiology.

By the end of the module, you'll have a thorough knowledge of how the human body functions, from cellular level to whole-body systems.

20 credits

Introduction to Neuroscience

During this module, you'll explore the rapidly expanding field of neuroscience, gaining insights into the experimental methods and techniques that are used here.

You'll learn about the fundamental physiological principles that enable the nervous system to function, before exploring the anatomy and physiology of the sensory and motor systems. Alongside understanding the mechanisms of sensation and movement, you'll begin to explore the brain's role in behaviour, cognition, and memory.

By the end of this module, you'll have a solid foundation in neuroscience, preparing you for further study in this exciting field.

20 credits

Form and Function of Living Organisms

This module will introduce you to the scientific study of whole organisms.

You'll explore the physiology, reproduction, and development of animals and plants. You'll learn how both genetic and environmental factors determine animal behaviour, and how those same factors contribute to form, function and diversity across life. You'll also investigate how animals and plants acquire and process energy, nutrients, and water, before examining asexual and sexual reproduction in a range of contexts.

20 credits

Core modules:

Biostructures, Energetics and Synthesis

This module aims to refresh students' understanding of the structures and functions of proteins and how free energy is made available (transduced) from reduced organic carbon compounds (catabolism) to generate ATP and NADPH for biosynthetic metabolism (anabolism). We begin by taking another look at key catabolic pathways in the cell including glycolysis, the Krebs cycle and mitochondrial electron transfer; before considering fatty acid β-oxidation and the pentose phosphate pathway.  We then explore how amino acids and nucleotides, the building blocks of life, are synthesised. This leads on to a study of the nature of biological membranes and the main functions of membranes in cells, including the transduction of energy, nerve transmission and signalling. We then focus on the structure and function of membrane proteins, highlighting their key role in transport of proteins, small molecules and ions across biological membranes. Finally, we come full circle highlighting how solar energy entering the biosphere is harvested by chlorophyll pigments and transferred to specialised reaction centres to initiate photosynthetic electron transfer. We show how photosynthesis converts solar energy into ATP and NADPH, utilising the same redox chemistry and chemiosmotic principles that underlie respiration, and then uses these metabolites to power the fixation of CO2 into reduced organic carbon compounds.

20 credits

Biochemistry 2

This module provides an advanced treatment of the biochemical topics introduced in earlier modules, to provide a deep understanding of the underlying chemical principles and molecular interactions governing life in cells. The module begins with a review of the chemical transformations and molecular interactions governing enzyme function. We then study a number of enzyme examples to illustrate common themes arising in enzyme specificity, types of reaction mechanisms and the relationship between protein structure and function. This leads on to study practical methods to experimentally measure enzyme activity. We then take a detailed look at the fundamentals of enzyme and ligand binding kinetics underlying unimolecular and bimolecular irreversible and reversible reactions. We then turn our focus to small molecule drug development, showing how the principles learned earlier in the module can be applied to develop protein or enzyme inhibitors for therapeutic use. The final part of the module develops an understanding of the ways in which kinetic parameters can be used to study reaction mechanisms and how inhibitors and mutants can modulate the activity of enzymes. We also study aspects of protein and enzyme function in practical classes. Overall, the module aims to give students the knowledge required to analyse and interpret biochemical data, plan appropriate experimental assays and to make pre

20 credits

Skills in Molecular Biology II

This module develops students' appreciation of and aptitude in the scientific method, practical research skills, experimental design, information technology, data visualisation and analysis, critical evaluation, writing and presentation skills, and how science underpins innovative solutions to societal or commercial challenges. The module builds on skills developed in L1. In the autumn semester students will perform a small research project and have the opportunity to further develop their research skills in the spring semester. Students will develop skills in data visualisation and statistics with additional training and through reports on research projects. Students will develop their academic writing skills by preparing essays and lab reports and develop additional scientific communication, such as oral presentation and poster writing skills. This module develops employability skills via interview training, LinkedIn profile writing (or equivalent), and reflection on career choice and skill development.

30 credits

Optional modules:

A student will take a minimum of 20 and a maximum of 40 credits from this group.

Genes, genomes and chromosomes

This module directly builds on material delivered in BIS121 and aims to provide a clear understanding of how genomes are organised within cells and how the expression of specific genes can be regulated. The topics covered in the module include experimental approaches to address the function of specific genes, mechanisms of regulated gene expression, DNA repair and recombination pathways, chromosome structure, genome sequencing technologies and the analysis of sequence data to study protein/DNA interactions, chromosome interactions and DNa methylation patterns .

20 credits

Microbiology 2

This module introduces key concepts in bacterial physiology, genetics, virulence and therapeutics, building on the microbiology topics covered in earlier modules. Topics to be covered in the first half of the module will include aspects of bacterial growth and gene regulation, microbial biodiversity and cellular differentiation, and biotechnology. The module will then move on in the second half to consider both sides of the bacterium-host interaction and the consequences for human health. Using a selection of important human pathogens as examples, the bacterial strategies and virulence factors that contribute to disease will be introduced. The human immune response and the potential of vaccination to protect against disease will then be examined. The targets, mode of action and potential resistance mechanisms of a range of current and potential antimicrobial agents will then be considered. The module will provide opportunities throughout to develop the ability to analyse and interpret microbiological data.

20 credits

Genetics 2

This module builds upon the introduction to genetics provided by Genetics 1.  A range of eukaryotic genetic systems will be considered, including humans and a number of model organisms, ranging from yeasts to Drosophila melanogaster, Caenorhabditis elegans,

Arabidopsis thaliana and Mus musculus. Topics to be covered include methods for isolating and genetically analysing mutants with specific phenotypes, genetic mapping, extranuclear inheritance, human diseases associated with chromosome abnormalities, ethical  considerations associated with genome editing, developmental genetics and genome integrity. Interactive teaching sessions give students opportunities to apply concepts introduced in the lectures to numerical and ethical problems.

20 credits

A student may take up to 30 credits from any available Level 2 Modules from the School of Biosciences. Students can also select 10 credits from Languages for All modules.

Core modules:

Biochemistry Data Handling

The module aims to develop problem solving, interpretative and numerical skills by the study of deductive questions drawn from the broad area of biochemistry. Students will gain experience in the handling, analysis, interpretation and evaluation of published biochemical data of different types.

10 credits

Literature Review

In this module students will consolidate the skills and knowledge they have gained in earlier levels of study.  They will work individually, guided by a member of staff, to identify a key biological question and will address this through a comprehensive literature review.  Students will synthesise information to explore the current state of knowledge, critically evaluate areas of uncertainty and debate, and suggest ways that the field may progress in the future.  They will present their findings in the format of a review paper.

20 credits

Research Project

In this module students will consolidate the skills and knowledge they have gained in earlier levels of study and apply these during a capstone research experience. A range of project types will be available, including laboratory-based, field-based, bioinformatics, computer modelling, education, and science communication. Students will work in groups, guided by a member of staff, to plan a research project, assess health, safety and ethical considerations, undertake the research, and analyse the data. Students will then work individually on interpreting, evaluating and communicating their findings  via a formal report written in the style of a research publication.

30 credits

Optional modules:

A student will take a minimum of 40 and a maximum of 60 credits from this group.

The world of RNA

This module will analyse the vital roles that RNA plays in the life of a cell and how RNA is increasingly used as a tool to understand biology. The module will cover the following 'cutting edge' research topics: RNA interference, CRISPR Genome Editing, non-coding RNAs, together with the latest work on well known RNA based activities. These include transcription, RNA splicing, RNA stability, RNA export and translation and how all these processes are coupled in the cell to ensure efficient, quality-controlled gene expression. The module aims to present the latest innovations and discoveries in the RNA world and their application.

10 credits

Human genomics, proteomics and genome biology

A top-down approach to biology, simultaneously investigating the structure and function of the entire genome and its products, both contrasts with and complements the traditional gene-by-gene approach, allowing us a birds-eye view. In this module, we cover genome-wide approaches to studying the genetic causes and diagnosis of complex and polygenetic human disease. We then discuss how methods such as RNA-seq, ChIP-seq and 4C can be used to investigate the genome-wide transcriptional profile, the chromatin landscape and the three-dimensional structure of the genome. Finally we describe the use of technologies such as mass spectrometry to investigate the complete proteome of a cell. The module builds on the material from the level 2 module Genes, Genomes and Chromosomes, to illustrate how cutting-edge genomic and proteomic methods can be used to address fundamental biological questions.

10 credits

Membrane Protein Structure and Function

The aim of this module is to impart a thorough understanding of the structure and function of membrane proteins. A major theme is the structural basis of energy transduction in membranes. Membrane protein complexes mediate the transfer of excitation energy, electrons and protons upon which all life depends. They also control the entry and exit of proteins, ions, nutrients, drugs and antibiotics from cells and the transfer of signals across membranes. We will examine membrane proteins involved in energy harvesting such as respiration and photosynthesis. The principles underlying the efficiency of energy transduction and redox chemistry taking place in these complexes will be covered. We will look at how harvested energy is coupled to movement of molecules ions and signals across membranes. The role of structure in determining specificity and directionality in vital transport process and signalling will be emphasised.

10 credits

Molecular Immunology

This module explores the mechanisms that higher organisms use to defend themselves against infectious disease. The course considers the relationship between innate immunity (the first line of defence) and adaptive immunity, which can evolve throughout a lifetime to specifically recognise and remember different pathogens. The functions of the various cells and molecules that constitute the immune system are discussed and the genetic mechanisms that contribute to immunological diversity and specificity are examined. Topics include the roles of cytokines, T cell subsets and the structure/function relationship of the different antibody classes. The module also includes an overview of current techniques that exploit or manipulate the immune response for the prevention and treatment of disease e.g. through the development of therapeutic antibodies and the design of new vaccines.

10 credits

Plant Biotechnology

This module considers the application of biotechnology to plants, for both agricultural and research uses. It covers the production of transgenic plants and how this technology has resulted in genetically engineered crop plants that show novel traits or produce novel products. It also covers traditional methods of plant breeding for the development of novel crops without the use of genetic engineering. The release of genetically engineered crops has and is having a major impact on society, raising issues of ethical, economic and ecological importance. An appreciation of these issues will be developed.

10 credits

Protein Folding and Misfolding in Disease

This module examines the mechanisms employed by proteins to adopt unique functional folds and explores the causes and consequences of mis-folding, with a particular reference to neurodegenerative disease, including Alzheimer's and prion diseases.

Students will have an opportunity to acquire knowledge and understanding of the following: methods used to study the assembly of protein complexes; folding of molecules: background thermodynamics; folding pathways; investigating intermediates; kinetic labelling; mutagenesis; modules of folding; the role of disulphide bonds. Protein mis-assembly: off-pathway species, aggregation, amyloids. Control of protein folding and mis-folding in vivo: the concept of proteostasis, the UPR or unfolded protein response, the role of chaperones and disaggregases and the mechanisms for recognition of unfolded protein. Therapeutic development in neurodegeneration: the amyloid cascade hypothesis and the targeting of amyloid formation.

10 credits

Genome Stability and Genetic Change

The module examines in detail the mechanisms that maintain genome integrity and generate genetic variation, both of which are essential to eukaryotic life. The lectures illustrate how the prevention and creation of changes in DNA make use of the same biochemical machinery. The main emphasis is on eukaryotes; reference is made to prokaryotes mainly as an aid to understanding the importance of conserved processes. Mechanisms studied in detail include single-strand break repair, protein-linked DNA break repair, homologous and non-homologous recombination, avoidance of replication errors, mismatch repair, excision repair and mutagenesis. Throughout the module experimental detail is included to illustrate how conclusions on gene function and interactions have been determined.

10 credits

Bacterial Pathogenicity

Infectious diseases account for the majority of deaths worldwide. This will continue to be the case until we have a greater understanding of the mechanisms of microbial pathogenesis. This course builds on the principles introduced in level 2 microbiology and begins by showing how molecular genetic approaches are being used to unravel the complexities of microbial virulence. Following an introduction to the regulation of virulence genes, the pathogenic mechanisms of selected bacterial pathogens are explored in detail, demonstrating the involvement of multiple virulence determinants and their genetic regulation in the disease process. Mechanisms by which toxins deregulate or kill host cells will be explored. Virulence mechanisms that represent common themes in bacterial pathogenesis will be highlighted. The appearance of antibiotic resistant strains and strategies adopted to tackle this problem will also be considered.

10 credits

Topics in Environmental Microbiology

This module aims to provide the opportunity for students to develop (i) their knowledge of current leading-edge research areas in environmental microbiology and (ii) their skills in accessing, interpreting, and synthesising the primary scientific literature in this field. This will be achieved by examining three areas of current research activity in environmental microbiology though detailed analysis of the questions, methods and interpretations in groups of recent publications.

10 credits

A student may take up to 20 credits from any available Level 3 Modules from the School of Biosciences.