Dr Ali Khurram

BDS, MSc., PhD., MFDS RCS (Edinburgh), CiLT, FHEA, FRC Path.

School of Clinical Dentistry

Senior Clinical Lecturer

Honorary Consultant Pathologist

s.a.khurram@sheffield.ac.uk
+44 114 215 9378

19 Claremont Crescent

Full contact details

Dr Ali Khurram
School of Clinical Dentistry
19 Claremont Crescent
Sheffield
S10 2TA

Profile: I was appointed as a Senior Clinical Lecturer/Honorary Consultant in Oral and Maxillofacial Pathology in September 2016. Prior to that, I worked as a NIHR Academic Clinical Lecturer/ Honorary Specialist Registrar (Oral and Maxillofacial Pathology) at the University of Sheffield from August 2011 to 2015. I undertook my PhD at Sheffield Dental School as well successfully completing it in March 2008. I worked as a Senior House Officer in Oral Medicine/Pathology at Cardiff Dental Hospital (2008) and Charles Clifford Dental Hospital, Sheffield (2008-09) in addition to two years with the Oral and Maxillofacial Surgery Department in Sheffield (2009-11). Being a clinical academic, I have a strong interest in research and teaching (undergraduate, postgraduate, clinical) as well as diagnostic oral and head and neck pathology.

Research interests

One of my main interests is the application of Artificial Intelligence and Deep Learning to Pathology with numerous recent publications. At present, I am involved in a number of national and international collaborative projects exploring ‘novel digital biomarkers’ in cancers and pre-cancers. I am the PI on a Project Grant (WORTH £405k) by Cancer Research UK which aims to use AI for prognosis prediction in oral pre-cancer. Recently, I have been awarded £247K as part of an International Collaborative Research Grant from The British Council. This project involves working alongside collaborators in Khyber Medical University, Pakistan with matched local funding to explore genetic markers of diagnosis and prognosis in oral cancers.

My main clinical research interest is studying metastasis and extracapsular spread in oral cancer or oral squamous cell carcinoma (OSCC) as it reduces the 5-year patient survival by 80-85%. In particular, I am interested in the role of tumour microenvironment (TME), stroma and epithelial mesenchymal transition in cancer progression, bone invasion, metastasis and extranodal extension. I am also interested in Salivary Gland tumour diagnosis and pathobiology and identification/testing of biomarkers useful in diagnosis and prognosis prediction.

Another research interest of mine is in the interaction of chemokine receptors and their ligands in inflammatory and neoplastic disease. Our previous work showed expression of the XCR1 receptor outside the immune system for the first time where it facilitated cancer cell signalling, migration, invasion, proliferation in addition to stimulating adhesion to ECM components and release of Matrix Metalloproteinases.

Publications

Journal articles

Arboleda LPA, Rodrigues-Fernandes CI, Mariz BALA, de Andrade BAB, Abrahão AC, Agostini M, Romañach MJ, Pontes HAR, Fonseca FP, Robinson L , van Heerden WFP et al (2021) Burkitt lymphoma of the head and neck: An international collaborative study.. J Oral Pathol Med.
Argyris PP, Ho D, Islam MN, Khurram SA, Courville EL, Morgan S, Sundick B, Soliman M, Janakiram M, Gopalakrishnan R & Koutlas IG (2021) Self-regressing Oral CD30-Positive, EBV-Negative, T-cell Lymphoproliferative lesions. A poorly understood process highlighted by ominous clinicopathologic features and indolent behavior. Oral Surgery Oral Medicine Oral Pathology and Oral Radiology.
Bishop JA, Sajed DP, Weinreb I, Dickson BC, Bilodeau EA, Agaimy A, Franchi A, Khurram SA, Da Forno P, Robledo J , Kalmar JR et al (2021) Microsecretory Adenocarcinoma of Salivary Glands: An Expanded Series of 24 Cases.. Head Neck Pathol.
Dos Santos ES, Rodrigues-Fernandes CI, Speight PM, Khurram SA, Alsanie I, Costa Normando AG, Prado-Ribeiro AC, Brandão TB, Kowalski LP, Silva Guerra EN , Lopes MA et al (2021) Impact of tumor site on the prognosis of salivary gland neoplasms: a systematic review and meta-analysis.. Crit Rev Oncol Hematol, 103352.
Mahmood H, Shaban M, Rajpoot N & Khurram SA (2021) Artificial Intelligence-based methods in head and neck cancer diagnosis: an overview.. Br J Cancer.
Walsh H, Robinson I, Mann A, Kumar A & Khurram SA (2021) An unusual finding in a pleomorphic adenoma - A case report. Advances in Oral and Maxillofacial Surgery, 2, 100068-100068.
Camalan S, Mahmood H, Binol H, Araújo ALD, Santos-Silva AR, Vargas PA, Lopes MA, Khurram SA & Gurcan MN (2021) Convolutional neural network-based clinical predictors of oral dysplasia: class activation map analysis of deep learning results. Cancers, 13(6).
Araújo ALD, do Amaral-Silva GK, Pérez-de-Oliveira ME, Gallagher KPD, López de Cáceres CVB, Roza ALOC, Leite AA, Mariz BALA, Rodrigues-Fernandes CI, Fonseca FP , Lopes MA et al (2021) Fully digital pathology laboratory routine and remote reporting of oral and maxillofacial diagnosis during the COVID-19 pandemic: a validation study.. Virchows Arch.
Hankinson PM, Mohammed-Ali RI, Smith AT & Khurram SA (2021) Malignant transformation in a cohort of patients with oral epithelial dysplasia. British Journal of Oral and Maxillofacial Surgery.
Koohbanani NA, Unnikrishnan B, Khurram SA, Krishnaswamy P & Rajpoot N (2021) Self-Path: self-supervision for classification of pathology images with limited annotations. IEEE Transactions on Medical Imaging. View this article in WRRO
Shaban M, Raza SEA, Hassan M, Jamshed A, Mushtaq S, Loya A, Batis N, Brooks J, Nankivell P, Sharma N , Robinson M et al (2021) A digital score of tumour-associated stroma infiltrating lymphocytes predicts survival in head and neck squamous cell carcinoma.. CoRR, abs/2104.12862.
SOLUK TEKKESİN M & Ali KHURRAM S () A New Dawn: The impact of digital technologies in oral and maxillofacial pathology. Journal of Experimental and Clinical Medicine, 38(SI-2), 81-85.
Idrees M, Farah CS, Ali Khurram S, Firth N, Soluk‐Tekkesin M & Kujan O () Observer agreement in the diagnosis of oral lichen planus using the proposed criteria of the American Academy of Oral and Maxillofacial Pathology. Journal of Oral Pathology & Medicine.
Saik W-N, Da Forno P, Thway K & Khurram SA () NUT Carcinoma Arising from the Parotid Gland: A Case Report and Review of the Literature. Head and Neck Pathology.

Chapters

Ali S, Farooq I & Khurram SA (2021) Tooth Development (pp. 1-13). Wiley
Saher F, Khurshid Z, Zafar MS, Mohammed F & Khurram SA (2021) Salivary Glands (pp. 147-166). Wiley
Gilani S, Farooq I, Ali S & Khurram SA (2021) Periodontal Ligament (pp. 81-98). Wiley
Farooq I, Ali S, Khurram SA & Anderson P (2021) Dentin (pp. 35-53). Wiley
Shabbir J, Farooq I, Ali S, Mohammed F, Bugshan A, Khurram SA & Khan E (2021) Dental Pulp (pp. 69-79). Wiley
Ali S, Farooq I, Bugshan A, Khan E & Khurram SA (2021) Cementum (pp. 55-67). Wiley
Ullah R, Husain S, Mohammed F & Khurram SA (2021) Alveolar Bone (pp. 99-121). Wiley

Research group

Head and Founder of NEOPATH Research Group

CURRENT GROUP MEMBERS

Hanya Mahmood (NIHR funded Doctoral Training Fellow)
Ibrahim Alsanie (PhD student- funded by King Saud University, Saudi Arabia)
Neda Azarmehr (Postdoctoral Research Fellow- funded by CR UK)
Paul Hankinson (NIHR Academic Clinical Fellow in Oral and Maxillofacial Pathology)
Mariem Elsharief and Fatima Elalawy (co-supervisor)
Finished PhD students (Areeg Elmusrati, Alice Pilborough, Amir Zaki Abdullah Zubir)

Teaching activities: Module Lead (MMedSci) - ORP611- Advanced Oral Histopathology

Professional activities

Honorary Secretary and Webmaster- British Society for Oral and Maxillofacial Pathology (BSOMP)
Webmaster and Digital Advisor- Pathological Society of Great Britain and Ireland (PathSoc)
Webmaster and Member Organising Committee- International Association of Oral & Maxillofacial Pathologists (IAOP), 2021 Meeting
Member of Educational Committee- European Society of Integrated and Digital Pathology (ESDIP)
Member- British Association of Head and Neck Oncologists (BAHNO)
Member- European Society of Pathology (ESP)

Clinical

I am the Clinical Lead for the diagnostic Oral and Maxillofacial Pathology Service provided by the Unit. This includes macroscopic description and reporting of routine biopsies and major head and neck cancer resection cases alongside other colleagues. My role as the lead involves working closely with the histopathology lab team, maintaining and updating SOPs, undertaking and evaluation relevant clinical audits and quality improvement activities as well as risk assessment and reporting. The department works closely with the Maxillofacial Surgery department and cases are discussed at weekly Regional Multidisciplinary Head and Neck cancer Meetings. I am also involved in training of Dental Core Trainees (DCTs) and Specialist Registrars (StRs). Clinical Lead- Diagnostic Oral and Maxillofacial Pathology Service, Sheffield.

I am passionate about engaging and involving patients in research as well raising awareness about Head and Neck Cancers and am a Patron for The Swallows Head and Neck Cancer Charity. Recently I organised and ran a 12 hour online Virtuathon for Mouth Cancer Awareness in collaboration with the Oral Health Foundation to raise awareness and funds for Mouth Cancer Action Month.