Drug Discovery Science MSc

The module covers techniques and analytical methods commonly used by most researchers in molecular biology and drug discovery sciences. Students learn the importance of experimental design and application of statistical methods for power and significance calculations for different types of experiment. In practical laboratory classes, students are shown how to perform a series of techniques that are frequently used in biology and chemistry and analyse their data statistically and present results in a formal laboratory notebook.

This module will provide an in-depth discussion of relevant disease mechanisms and strategies that can be used to optimise the pharmacodynamic, pharmacokinetic properties of drugs; and how drugs/analogues can be designed using computer-aided drug design (CADD) software.

This module  aims to prepare students to become professional scientific researchers ready to conduct a research project.  Students will be taught how to retrieve and critically assess the existing literature on a particular research topic and to communicate this as a scientific review. They will learn about the attributes of an ethical researcher, scientific method and how to undertake research safely and responsibly and how to manage data. In addition, students will acquire professional skills relevant to their future employability and learn how to present scientific information. Students will undertake a training needs analysis supported by an experienced researcher so that they can take charge of their own development. This will allow them to tailor their subsequent training to the project they are about to undertake and to their wider individual professional and researcher development. On completion of the module students will have produced a portfolio of work that will form the  foundations of their training as a professional researcher.

This module will provide an overview of how medicinal chemistry emerged, how biological mechanisms of disease are identified, how chemistry is used to target these mechanisms, and how drugs are synthesised.

For this module, students complete an extended and independent research project working as a member of a team to solve a problem at the cutting edge of drug discovery. They receive specialist training to help them develop the advanced practical skills they need for their project, and have access to state-of-the-art equipment and facilities. They also put their previous research training and transferable skills into practice through literature searches, communicating their work and presenting their findings

This lecture module will be taught by professionals from a wide range of companies in the drug industry and from the business services team here at the University of Sheffield. The course will teach students the major steps in the drug discovery process including; screening, development, testing, small molecule manufacture, venture capital funding, patent law, the growing field of contract research and the roles each company has within this industry. Students will learn directly from specialists within these fields. From the Sheffield business team, the students will learn how new ventures are started from University and the process of generating new spin out companies.

The module will teach students the basis of small molecule and functional genetic screens, focusing on human disease.  Students will learn about the theory and practice of automated small molecule and genetic screens. Examples of screening methods that will be covered include traditional small molecule screens, modern functional genomics and high throughput phenotypic screens. The emphasis will be to appreciate every step that is involved in this process, from automation to analysis. The student will learn how the biotech, academic and pharmaceutical industry use these techniques to identify new candidates for potential therapies.

The unit will provide a description of the nature of genomic complexity as revealed using next generation sequencing technology. It will explore cancer genotypes and phenotypes in the context of 8 essential characteristics that are common to all cancers, and which collectively dictate malignant growth. These characteristics are : self-sufficiency in growth signals, insensitivity to growth-inhibitory signals, evasion of programmed cell death, limitless replicative potential, sustained angiogenesis, tissue invasion/metastasis, avoidance of immune destruction, and de-regulated cellular energetics. It will discuss how genome instability arises, and together with tumour-promoting inflammation, how these enable the emergence of all other cancer characteristics. It will utilize this conceptual framework to discuss recent and future developments in cancer therapeutics. A brief review of fundamental principles in genetics and molecular cell biology will be given. Nevertheless, students should have a basic understanding of genetics, molecular biology and cell biology.

The ability to synthesise biomolecules has led to many of  the most significant developments in molecular and chemical biology and to the development of biopharmaceuticals. This module looks at how biomolecules are created, from both biological and chemical perspectives. Student's knowledge will build up from understanding the central dogma and basic chemistry of life, to exploring important chemical biology techniques such as DNA sequencing, polymerase chain reaction, protein overproduction and site directed mutagenesis. Topics also include the production of novel biomolecules for bioconjugation, rational design, directed evolution, antibody production, and the new discoveries that synthetic biology might open the door to.