Biochemistry and Genetics BSc
Biosciences at Sheffield
You are viewing this course for 2021-22 entry.
Key details
- A Levels AAB
Other entry requirements - UCAS code CC74
- 3 years / Full-time
- Accredited
- Find out the course fee
- Industry placement
Course description
Study two of the fundamentals of biotechnology and medicine. You’ll learn about proteins, enzymes, hormones and receptors, the structure and expression of genes, inheritance and mutations. We’ll also show you the various ways that biochemistry and genetics can be applied to major challenges affecting humanity today, from understanding and treating a range of diseases to feeding a global population sustainably.
From your first year, you’ll study modules that span the molecular biosciences covering biochemistry, genetics, microbiology and molecular biology. Alongside these modules, you’ll have the freedom to explore complementary topics across the breadth of bioscience, such as biomedicine, plant science, evolution and conservation, so you’ll have the option to study biochemistry and genetics in greater depth, keep your interests broad or even switch to another degree programme within the biosciences.
No matter what modules you choose to study, you’ll gain experience that make our graduates attractive to employers, including project management, problem solving, communication skills and data analysis.
We’ll give you plenty of opportunities to apply your new skills and knowledge too. You’ll be in the lab completing in-depth practicals across molecular genetics, DNA manipulation and protein structure analysis and you’ll get the chance to use cutting-edge equipment to run your own in-depth research projects in an area such as clinical diagnostics or brewing biotechnology.
Whether you choose to focus solely on biochemistry and genetics or study a range of topics across the molecular biosciences and beyond, your personal tutor will assist you in tailoring your degree to your interests and career goals.
This course is accredited by the Royal Society of Biology which shows employers that you've developed the practical skills and scientific knowledge that they're looking for.
Modules
The modules listed below are examples from the last academic year. There may be some changes before you start your course. For the very latest module information, check with the department directly.
Choose a year to see modules for a level of study:
UCAS code: CC74
Years: 2021
In your first year, you'll spend six hours in the lab each week learning the practical skills and knowledge that every bioscientist needs, including how to establish bacterial cultures, assess bioenergetics and perform gene cloning. Analysis classes will equip you with the skills you'll use outside the lab, from interacting with your data to interpreting your findings. Your lectures will give you a broad understanding of the molecular biosciences, allowing you to explore what you're most interested in.
Core modules:
- Biochemistry 1
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This module provides a broad introduction to Biochemistry and examines the molecules that carry out and control all the chemical reactions in biological cells. The basic chemical concepts underlying the structures, functions and mechanisms of action of biomolecules.
20 credits - Molecular & Cell Biology
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This module considers the fundamental processes at the heart of all life on this planet. Students will learn about the basic molecular processes that enable cells to store and use genetic information to make proteins, as well as the mechanisms that allow cell growth, division, and ultimately cell death. Learning materials will be delivered through a combination of lectures, videos, practical classes and independent study.
20 credits - Microbiology 1
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This course is an introduction to the field of microbiology. Students will explore the diversity of microorganisms including Bacteria, Archaea, unicellular Eukaryotes and viruses. They will examine the diversity of the structure and the function of these microorganisms, emphasising the fundamental role that they play in our everyday lives by using examples in medicine and biotechnology.
20 credits - Genetics 1
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This course is an introduction to the principles of genetics. Students will explore the genetics of pro- and eukaryotes by studying the mechanisms of gene transmission, genetic exchange, mutations and gene mapping. Additional topics are the genetic basis of diseases, prenatal diagnosis, genetic counselling, gene therapy and genetic basis of antibiotic resistance in bacteria. Students will learn through lectures and videos and independent study.
10 credits - Skills in Molecular Bioscience
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The Skills for Biology module introduces students to the fundamentals of scientific practice: lab practical skills, experimental design, information technology, data visualisation and analysis, writing and presentation skills, skills reflection, professionalism and career development.
30 credits
Optional modules:
A student will select approved modules from the School of Biosciences to the value of 20 credits.
In your second year, you'll begin learning more advanced scientific techniques, both in the lab and in lectures, with topics including experimental design, genome editing using CRISPR/Cas9 and protein purification. You'll continue to take analysis classes to develop your data handling skills further and you can choose to study modules that allow you to work in teams to come up with pioneering science enterprise ideas to launch a virtual business.
Core modules:
- Practical Molecular Bioscience 2
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This module provides detailed knowledge in key areas of practical molecular bioscience, emphasising the integration of the disciplines of biochemistry, microbiology and genetics. An important aim of the module is to provide experience in the preparation of written laboratory reports, and in the correct interpretation and representation of biological data. Laboratory, computer and data analysis sessions build on the skills gained during first year and allow students to develop a high level of technical competence and theoretical understanding. Tutorial-based support is also provided for the enhancement of transferable skills, such as the preparation and delivery of oral and written presentations.
30 credits - Biochemistry 2
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This module provides an advanced treatment of the biochemical topics introduced in earlier modules, to provide a deep understanding of the underlying chemical principles and molecular interactions governing life in cells. Topics covered include reaction and ligand binding kinetics, enzyme catalysis and chemical mechanism, protein structure and function, small molecule drug development and methods in which these processes are studied experimentally.
20 credits - Biostructures, Energetics and Synthesis
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This module aims to furnish students with a working knowledge of the structures and functions of proteins and nucleic acids, in order that they gain an appreciation of the crucial relationship between structure and function. Both cytosolic globular and membrane proteins will be considered, as well as an introduction to nucleic acid structure. The module also explains the basic principles of how energy is made available (transduced) for essential biological functions, such as ATP synthesis and solute and protein transport. To achieve this understanding, the nature of biological membranes and the energy transducing proteins associated with those membranes are considered, and the principles of chemiosmosis, light absorption and biological redox reactions are discussed. Finally the module provides an understanding of the general principles underlying the biosynthesis of complex biomolecules from simpler precursors, and the control of these processes, with particular relevance to biotechnology.
20 credits - Genes, Genomes and Chromosomes
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This module aims to provide the student with a clear understanding of how genomes are organised within cells and how the expression of specific genes can be regulated. One part of the module addresses experimental approaches to address the function of specific genes and how genetic information is expressed in a regulated manner. Both classical and molecular genetics techniques to study gene function will be described. DNA repair and recombination mechanisms will be addressed, along with the use of reporter gene fusions. The regulation of gene expression at the molecular level will be explored through the consideration of (post-) transcriptional control mechanisms and intercellular signalling pathways. The other part of the module discusses the structural features of chromosomes and how they contribute to the maintenance and evolution of the genome; the development of sequencing techniques and their application to genome sequencing projects; the use of scoring systems to determine related DNA sequences and the application of sequencing technologies to measure gene expression, identify protein binding sites within DNA, analyse long range nucleic acid interactions within genomes and study DNA methylation patterns.
20 credits - Genetics 2
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This module builds upon the introduction to genetics provided by MBB162 Genetics. A range of eukaryotic genetic systems will be considered, including humans and a number of model organisms, ranging from yeasts to Drosophila melanogaster, Caenorhabditis elegans, Arabidopsis thaliana and Mus musculus. Topics to be covered include methods for isolating and genetically analysing mutants with specific phenotypes, extranuclear inheritance, developmental genetics, quantitative inheritance, population genetics and evolutionary genetics. A collaborative group work exercise will give students opportunities to apply concepts introduced in the module to the analysis of genetic data, planning of experiments and the creation of a joint report.
20 credits
In your third year, you'll complete an extended research project alongside your chosen specialist modules. This will reflect an area of molecular bioscience that interests you. Depending on your interests and career goals, you can choose a project from: experimental science, clinical diagnostics, industrial biotechnology, molecular systems and computing, science communication or education and outreach.
Core modules:
- Project
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This module is a research project in the molecular biosciences that allows students to apply their core subject knowledge to develop key skills in an area related to their career aspirations. Students have the opportunity to design, plan, and undertake an investigation, either within the Department or externally. Projects choices include laboratory-based research; biotechnology; computational biology and bioinformatics; science communication; science teaching in a local school; and clinical diagnostics. All projects are undertaken under the supervision of a member of academic staff; most placements are within the Department, but a small proportion of students undertake projects in other locations, such as the Medical School. Students will develop skills in the collation, interpretation, presentation, and communication of data and ideas. Students will submit their work in the form of a formal written report and present their research to the department during a showcase poster event.
30 credits - Literature Review
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In this module students are required to write a literature review on a topic chosen from a wide range suggested by members of staff. Students will develop a range of transferrable key skills associated with searching for, analysing and critically evaluating information from the literature, together with presentation skills in writing and presenting their review.
20 credits
Optional modules:
- Biochemical Basis of Human Disease
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The aim of this module is to provide students with an insight into how a fundamental biochemical analysis of the mechanisms of human disease plays a crucial role in understanding the causes of disease and points the way to novel therapeutic interventions. The module aims to show how the combined efforts of biochemists and clinicians are needed to arrive at a complete characterisation of a given disease and to identify possible targets for intervention. During the module we will consider some of the most common major diseases in the population, including inflammation, obesity, amyloid-related diseases, cancer, atherosclerosis and renal scarring, and consider how diseases and their treatments interact.
10 credits - Biochemical Signalling
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This module provides students with an understanding of the mechanisms by which eukaryotic cells communicate via signal transduction pathways. We will discuss how mammalian cells transfer, and receive, information via pathways involving hormones and growth factors, cell surface or intracellular receptors, second messengers, G-proteins, reversible phosphorylation mechanisms, and transcriptional controls. We explore how biochemical characteristics define the activity and specificity of signalling components, and the consequences of defective signalling pathways, for example, how oncogene derived proteins lead to cancers. Examples considered in detail may include: the regulation of cell proliferation by epidermal growth factors, and in plants by auxin; stimulation of muscle contraction or relaxation by a range of signals; control of multiple pathways by adrenaline and cyclic AMP signalling during the fight-or-flight response; the role of membrane derived inositol phosphates in triggering in calcium signals and cell survival; and design of anticancer drugs.
10 credits - Biochemistry Data Handling
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The module aims to develop problem solving, interpretative and numerical skills by the study of deductive questions drawn from the broad area of biochemistry. Students will gain experience in the handling, analysis, interpretation and evaluation of published biochemical data of different types. The module also contains an element that develops the skills required by the students to write on a broad topic drawn from across all their areas of study.
10 credits - Genetic pathways from zygote to organism
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Multicellular organisms develop from a single zygote and in the case of humans, culminates in a mature human body consisting of over a trillion cells and around 200 different cell types. This module will examine the developmental mechanisms and genes that regulate pattern formation and cell identity in multicellular eukaryotes. We will focus on the role of key genes in the regulation of different developmental processes and the mechanisms that determine the correct temporal and spatial expression of these genes. We will illustrate these principles using examples from model organisms such as Mus Musculus, Caenorhabditis elegans, Drosophila melanogaster and Arabidopsis thaliana. These systems have significantly informed our understanding of human disease but also demonstrate the different mechanisms through which cell fate and complexity are controlled.
10 credits - Genetics Data Handling
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The module aims to develop interpretative skills by the study of deductive questions drawn from the broad area of molecular genetics and cell biology. Students will gain experience in the analysis, interpretation and evaluation of published data of different types through a directed programme of reading, discussion and question answering. The module also contains an element that develops the skills required by the students to write on a broad topic drawn from across all their areas of study.
10 credits - Genome Stability and Genetic Change
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The module examines in detail the mechanisms that maintain genome integrity and generate genetic variation, both of which are essential to eukaryotic life. The lectures illustrate how preventing and creating changes in DNA make use of the same biochemical machinery. The main emphasis is on eukaryotes, reference is made to prokaryotes mainly as an aid to understanding the importance of conserved processes. Mechanisms studied in detail include single-strand break repair, protein-linked DNA break repair, homologous and non-homologous recombination, avoidance of replication errors, mismatch repair, excision repair and mutagenesis. Throughout the module experimental detail is included to illustrate how conclusions on gene function and interactions have been determined.
10 credits - Genomic Science
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A top-down approach to biology, simultaneously investigating the structure and function of the entire genome and its products, both contrasts with and complements the traditional gene-by-gene approach, allowing us a birds-eye view. In this module, we cover how genome sequencing can be used to understand the structure of human populations, profile microbial diversity and to trace the origins of disease outbreaks. We then discuss how methods such as RNA-seq, ChIP-seq and 4C can be used to investigate the genome-wide transcriptional profile, the chromatin landscape and the three-dimensional structure of the genome. Finally we describe the use of technologies such as mass spectrometry to investigate the complete proteome of a cell. The module builds on the material from the level 2 module Genes, Genomes and Chromosomes, to illustrate how cutting-edge genomic and proteomic methods can be used address fundamental biological questions.
10 credits - Human Evolutionary Genetics
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This module will provide students with an understanding of how genomics has shaped our understanding of the evolution of modern humans. This will be achieved through lectures, independent reading and a computational biology practical. Topics covered will include: the evolution of modern humans; the history of how humans colonised the world; how the Neanderthal genome has revealed hybridisation between Homo sapiens and Neanderthal man; how human genomes can tell us about the history and causes of modern genetic disorders; how our genomes reveal past episodes of selection; and how life history theory is used to study natural selection and evolution in pre-industrial humans.
10 credits - Human Reproduction and Fertility
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This module will address some of the processes underlying human fertility: that is, hormonal regulation of the reproductive systems, gametogenesis and fertilisation. The module will then consider methods of contraception, reasons for infertility, and issues relating to the assisted reproductive technologies. Finally, the importance of genetic imprinting will be discussed, together with a consideration of the impact of failures in imprinting.
10 credits - Membrane Protein Structure and Function
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The aim of this module is to impart a thorough understanding of the structure and function of membrane proteins. A major theme is the structural basis of energy transduction in membranes. Membrane protein complexes mediate the transfer of excitation energy, electrons and protons upon which all life depends. They also control the entry and exit of proteins, ions, nutrients, drugs and antibiotics from cells and the transfer of signals across membranes. We will examine membrane proteins involved in energy harvesting such as respiration and photosynthesis. The principles underlying the efficiency of energy transduction and redox chemistry taking place in these complexes will be covered. We will look at how harvested energy is coupled to movement of molecules ions and signals across membranes. The role of structure in determining specificity and directionality in vital transport process and signalling will be emphasised.
10 credits - Molecular Immunology
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This module explores the mechanisms that higher organisms use to defend themselves against infectious disease. The course considers the relationship between innate immunity (the first line of defence) and adaptive immunity, which can evolve throughout a lifetime to specifically recognise and remember different pathogens. The functions of the various cells and molecules that constitute the immune system are discussed and the genetic mechanisms that contribute to immunological diversity and specificity are examined. Topics include the roles of cytokines, T cell subsets and the structure/function relationship of the different antibody classes. The module also includes an overview of current techniques that exploit or manipulate the immune response for the prevention and treatment of disease e.g. through the development of therapeutic antibodies and the design of new vaccines.
10 credits - Plant Biotechnology
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This module considers the application of biotechnology to plants, for both agricultural and research uses. It covers the production of transgenic plants and how this technology has resulted in genetically engineered crop plants that show novel traits or produce novel products. It also covers traditional methods of plant breeding for the development of novel crops without the use of genetic engineering. The release of genetically engineered crops has and is having a major impact on society, raising issues of ethical, economic and ecological importance. An appreciation of these issues will be developed.
10 credits - Protein Folding and Misfolding in Disease
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This module examines the mechanisms employed by proteins to adopt unique functional folds and explores the causes and consequences of mis-folding, with a particular reference to neurodegenerative disease, including Alzheimer’s, Parkinson’s and prion diseases. Students will have an opportunity to acquire knowledge and understanding of the following: methods used to study the assembly of protein complexes; folding of molecules: background thermodynamics; folding pathways; investigating intermediates; kinetic labelling; mutagenesis; modules of folding; the role of disulphide bonds; accessory proteins; isomerases; rotamases; chaperones. Protein mis-assembly: off-pathway species, aggregation, amyloids, accessory proteins, chaperones and disaggregases. Control of protein folding and mis-folding in vivo: recognition of unfolded protein, the UPR or unfolded protein response, proteostasis, and the role of the ubiquitin-proteasome system.
10 credits - The Genetics of Human Disease
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This module will address the ways in which genetic factors influence our lifetime health. The module will focus on the methodology used to identify genetic factors involved in human genetic disease; that is, next generation sequencing, diagnostic PCR, karyotype analysis, fluorescence in-situ hybridisation (FISH) and microarray, and how genetic abnormalities result in disease. The rapid advance in the understanding genetic basis of disease has led to the importance of genetic diagnostic testing in healthcare. The scientific tests used in this industry and the real-life patient cases will be addressed in this module.
10 credits - The world of RNA
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This module will analyse the vital roles that RNA plays in the life of a cell and how RNA is increasingly used as a tool to understand biology. The module will cover the following 'cutting edge' research topics: RNA interference, CRISPR Genome Editing, non-coding RNAs, together with the latest work on well known RNA based activities. These include transcription, RNA splicing, RNA stability, RNA export and translation and how all these processes are coupled in the cell to ensure efficient, quality-controlled gene expression. The module aims to present the latest innovations and discoveries in the RNA world and their application.
10 credits
The content of our courses is reviewed annually to make sure it's up-to-date and relevant. Individual modules are occasionally updated or withdrawn. This is in response to discoveries through our world-leading research; funding changes; professional accreditation requirements; student or employer feedback; outcomes of reviews; and variations in staff or student numbers. In the event of any change we'll consult and inform students in good time and take reasonable steps to minimise disruption. We are no longer offering unrestricted module choice. If your course included unrestricted modules, your department will provide a list of modules from their own and other subject areas that you can choose from.
Learning and assessment
Learning
To support your learning, you’ll have access to a virtual learning environment with interactive course materials. You'll also have a personal tutor throughout your course, to give you advice and guidance on both academic and pastoral issues.
Assessment
Throughout the course you will be assessed through a variety of methods, including exams, tests, presentations, coursework and practical work.
Programme specification
This tells you the aims and learning outcomes of this course and how these will be achieved and assessed.
Entry requirements
With Access Sheffield, you could qualify for additional consideration or an alternative offer - find out if you're eligible
The A Level entry requirements for this course are:
AAB
including Chemistry and another science
The A Level entry requirements for this course are:
ABB
including Chemistry & a second Science subject
A Levels + additional qualifications | ABB, including Chemistry and another science + B in a relevant EPQ; ABB, including Chemistry and another science + A in Core Maths ABB, including Chemistry and another science + B in a relevant EPQ; ABB, including Chemistry and another science + A in Core Maths
International Baccalaureate | 34, with 6,5 in Higher Level Chemistry and another science 33 including 6,5 in Higher Level Chemistry and a second Science subject
BTEC | Interim-Reformed: DD in Applied Science + A Level grade A in a science subject (Biology, Chemistry, Human Biology, Physics, Psychology, Maths and Further Maths) + interview. Reformed: DDD in Applied Science, including modules in Applications of Inorganic Chemistry, Applications of Organic Chemistry and Practical Chemical Analysis and no more than one of the following: Forensic Evidence Collection and Analysis, Forensic Fire Investigation or Forensic Traffic Collision Investigation + interview BTEC Dip + A Level: DD Applied Science + B in A Level Science
Scottish Highers + 2 Advanced Highers | AAABB + AB, including Chemistry and another science AABBB + AB, including Chemistry and another science subject
Welsh Baccalaureate + 2 A Levels | B + AA, including Chemistry and another science B + AB, including Chemistry and another science subject
Access to HE Diploma | 60 credits overall in a relevant subject with Distinctions in 36 Level 3 credits, including Chemistry and Biology units, plus Merits in 9 Level 3 credits. Applicants are also interviewed. 60 credits overall in a relevant subject with Distinctions in 30 Level 3 credits, including Chemistry and Biology units, plus Merits in 15 Level 3 credits. Applicants are also interviewed.
Mature students - explore other routes for mature students
You must demonstrate that your English is good enough for you to successfully complete your course. For this course we require: GCSE English Language at grade 4/C; IELTS grade of 6.5 with a minimum of 6.0 in each component; or an alternative acceptable English language qualification
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Acceptable science subjects are Chemistry, Biology/Human Biology, Physics, Psychology Maths and Further Maths
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GCSE Maths grade 6 or grade B
We also accept a range of other UK qualifications and other EU/international qualifications.
If you have any questions about entry requirements, please contact the department.
Biosciences at Sheffield
Biosciences at Sheffield is home to over 120 lecturers who are actively involved in research at the cutting edge of their field. You'll learn from scientists who are helping to solve some of the biggest global challenges, from global food shortages and antibiotic resistance in MRSA to degenerative illnesses such as Alzheimer's and combating infectious diseases like Covid-19.
We're a close-knit community where every student gets the support and encouragement needed to achieve their best work. Whether it’s joining one of our student-led societies and taking part in nights out, trips abroad and quizzes with lecturers, or volunteering, fundraising and organising your own events, there are lots of opportunities to get involved.
Biosciences students are based across Firth Court, the Alfred Denny, Florey and Addison buildings. We are at the heart of the University campus, adjacent to the Students' Union and just a 15-minute walk from the city centre.
Facilities
Our students have access to world-class laboratory and computing resources for biological research and are trained in specialist teaching laboratories, supported by teaching assistants and our technician team.
Biosciences at Sheffield is home to state-of-the-art facilities, including super resolution light, cryo-electron and atomic force microscopy, NMR and X-ray facilities, a Biological Mass Spectrometry facility and the NERC Biomolecular Analysis Facility, which provides molecular genetics facilities and training to the UK science community.
We also have controlled environment facilities that can simulate any past, present and future climate, leading equipment for DNA analysis, and facilities for cell culture used in studying immunology, medically important microbes and biotechnology on campus.
Biosciences at SheffieldWhy choose Sheffield?
The University of Sheffield
A Top 100 university 2021
QS World University Rankings
Top 10% of all UK universities
Research Excellence Framework 2014
No 1 Students' Union in the UK
Whatuni Student Choice Awards 2019, 2018, 2017
Biosciences at Sheffield
The Times and Sunday Times Good University Guide 2021
National Student Survey 2020
National Student Survey 2020
Research Excellence Framework 2014
High Fliers Research 2020
Graduate careers
Biosciences at Sheffield
Our courses equip students for a wide range of careers, from scientific roles to graduate schemes with top employers. Whether you want to pursue a career in science, apply your skills in industry, or continue your studies, bioscience graduates are highly sought after due to their specialist laboratory skills, ability to solve problems, handle and analyse data, and effectively communicate complex ideas to a range of audiences.
As well as progressing onto a masters programme or PhD, our students secure roles in biotechnology and pharmaceutical companies like GSK, Pfizer, AstraZeneca and Redx, the NHS Scientist Training Programme (STP) and government bodies like Public Health England.
Transferable skills are embedded and developed throughout our degrees, which means year on year our graduates join high-profile organisations like Microsoft, HSBC, KPMG, United Kingdom Civil Service, Unilever and Wellcome. You can also apply your degree to other varied careers including brewing, bioinformatics, marketing, medical writing, genetic counselling, agrochemicals, teaching and science policy.
Work experience
Each year undergraduate students can apply to join the Sheffield Undergraduate Research Experience (SURE) scheme. This gives you the chance to spend around six weeks working in one of our research groups over the summer. It's a unique opportunity to pursue research in an area that you’re excited about and can help inform your future career aspirations.
You can choose to do a full year of work experience as a recognised part of your degree and we have a dedicated BSc Biochemistry and Genetics with a Year in Industry programme. You can test out a career path that you're considering between your second and third year – whether that's in the lab or in industry – and earn a salary while you're doing it.
Our students have completed their year in industry at organisations including Pfizer, GSK and Unilever.
Fees and funding
Fees
Additional costs
The annual fee for your course includes a number of items in addition to your tuition. If an item or activity is classed as a compulsory element for your course, it will normally be included in your tuition fee. There are also other costs which you may need to consider.
Funding your study
Depending on your circumstances, you may qualify for a bursary, scholarship or loan to help fund your study and enhance your learning experience.
Use our Student Funding Calculator to work out what you’re eligible for.
Visit us
University open days
There are four open days every year, usually in June, July, September and October. You can talk to staff and students, tour the campus and see inside the accommodation.
Taster days
At various times in the year we run online taster sessions to help Year 12 students experience what it is like to study at the University of Sheffield.
Applicant days
If you've received an offer to study with us, we'll invite you to one of our applicant open days, which take place between November and April. These open days give you the chance to really explore student life here, even if you've visited us before.
Campus tours
Campus tours run regularly throughout the year, at 1pm every Monday, Wednesday and Friday.
Apply for this course
Make sure you've done everything you need to do before you apply.
How to apply When you're ready to apply, see the UCAS website:
www.ucas.com
The awarding body for this course is the University of Sheffield.
Recognition of professional qualifications: from 1 January 2021, in order to have any UK professional qualifications recognised for work in an EU country across a number of regulated and other professions you need to apply to the host country for recognition. Read information from the UK government and the EU Regulated Professions Database.