Dr Lynne Bingle
BSc (Hons), PhD
School of Clinical Dentistry
Reader in Oral Science
Director of Postgraduate Taught Programmes
Chair of Athena SWAN
+44 114 215 9344
Full contact details
School of Clinical Dentistry
19 Claremont Crescent
Currently I am a Reader in the Academic Unit of Oral and Maxillofacial Pathology having joined the School of Clinical Dentistry as a Lecturer in 2005. Prior to this I spent 7 years as a Research Assistant and then Research Fellow in the Medical School here in Sheffield.
Whilst carrying out my PhD in London, under the supervision of Professors Terry Tetley, Bernard Fox and Abe Guz I developed the first 3D in vitro model of a human pulmonary alveolus; this has shaped much of my research interests. My first post-doctoral position was at Washington University, St Louis Missouri where I spent two years in Robert Senior’s Department working with Erika Crouch on the role of surfactant protein D in lung immunity. I returned to the UK and a post-doctoral position with Professor Tetley isolating novel proteinase inhibitors fro human and sheep lung (a good model of acute respiratory distress).
I have a long-standing collaboration with, and am a visiting Professor at, the Dental School, University of Campinas, Piracicaba in Brazil. Through this collaboration I have also established further links with academic research groups in Sao Paulo, Belo Horizonte and Porto Alegre.
- Research interests
My long-standing research interests have been focused on the role and regulation of epithelial secretory proteins. This work has principally involved the study of the airway epithelium, through the use of 3D in vitro model systems, but more recently has expanded to include the oral and nasal mucosa and the epithelium of the middle ear. My specific interests have focused on the fields of innate immunity, host defence and tumour biology.
I have also recently started to investigate the potential of using my tissue culture expertise to develop in vitro models of human salivary glands from fresh human tissue. We are now routinely isolating cells from human sublingual glands and are currently characterising cell phenotype under different culture conditions. The mid-term aim is to use these models to begin to elucidate the initial stages of salivary gland diseases such as Sjogren’s syndrome and salivary gland tumours.
- SPLUNC1 comes of age? Predicting acute exacerbations in cystic fibrosis. European Respiratory Journal, 58(5), 2101569-2101569.
- IN SITU DETECTION OF CRTC-MAML2 TRANSLOCATION EXPRESSION IN MUCOEPIDERMOID CARCINOMA. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 132(1), e6-e7.
- The transcriptional landscape of the cultured murine middle ear epithelium in vitro. Biology Open, 10(4). View this article in WRRO
- Directed transport of CRP across in vitro models of the blood-saliva barrier strengthens the feasibility of salivary CRP as biomarker for neonatal sepsis. Pharmaceutics, 13(2).
- TrkB-targeted therapy for mucoepidermoid carcinoma. Biomedicines, 8(12). View this article in WRRO
- An In Vitro Barrier Model of the Human Submandibular Salivary Gland Epithelium Based on a Single Cell Clone of Cell Line HTB-41: Establishment and Application for Biomarker Transport Studies. Biomedicines, 8(9).
- EVALUATION OF HE4 AND SLPI EXPRESSION IN INTRAORAL MUCOEPIDERMOID CARCINOMAS. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 129(1), e152-e152.
- Salivary BPIFA proteins are altered in patients undergoing hematopoietic cell transplantation. Oral Diseases.
Conference proceedings papers
- Using mouse tracheal epithelial cells (mTECs) to uncover an antiviral role for BPIFB1. Airway cell biology and immunopathology
- PIERCEing ciliogenesis: defining a role for PIERCE1 and its’ paralog C15ORF65 in multiciliogenesis. Airway cell biology and immunopathology
- Mouse tracheal epithelial cells (mTECs) for the study of influenza A infectio>. Molecular pathology and funct. genomics
- Expression and function of murine WFDC2 in the respiratory tract. Cystic fibrosis
- Comparative transcriptional analysis of differentiation in murine mucociliary epithelia. Molecular pathology and funct. genomics
- Air liquid interface (ALI)-grown immortalized human cell lines: a promising tractable model for human airway. Airway cell biology and immunopathology
- Research group
- Zulaiha Rahman (PhD student; The Development of In Vitro Models of Human Salivary Glands)
- Hannah Armes (PhD student; Expression and Functional Characterisation of WFDC2 in Oral Cancer)
- Esra Amour (PhD student; The role of the MECT-MAML fusion protein in mucopeidermoid tumours)
- Chloe Marshall (PhD student: lead Prof Colin Bingle; Interactions of airway glycoproteins with Staphylococcus aureus in the respiratory epithelium)
- Renata Caikauskaite (PhD student: lead Prof Colin Bingle)
- Priyanka Anujan (PhD student: lead Prof Colin Bingle; Generation of Primary Ciliary Dyskinesia (PCD) phenotype in vitro and assessment of impaired ciliary function on pathogen infection)
- Debora Pereira (PhD student: lead Prof Pablo Vargas; Correlation between the expression of PLUNC/BPIF proteins and the MECT1-MAML2 fusion protein in salivary mucoepidermoid carcinoma cells)
- Ana Carolina Amorim Pellicioli (PhD student: lead Prof Pablo Vargas; Analysis of the expression of Dendritic, Langerhans and T cells in potentially malignant lesions and oral squamous cell carcinoma)
- Teaching activities
I teach on both 1st year BDS modules (Den 103 and 104) and to 2nd year students on the Den 203 module. I also teach first year medical students. I am Deputy Programme Director for the MMedSci in Diagnostic Oral Pathology course; I lead and teach one of the modules (ORP 607) on this course and teach on yet another (ORP 609).
- Professional activities
I am Director of Postgraduate Taught course for the School and in this role sit on the Faculty PGT committee, School Executive committee, Senior Management Committee and Teaching committee.
I am also Deputy Director of Student Affairs with overall responsibility for the pastoral care of our first and second year BDS students.
I am Chair of our Athena SWAN self-assessment team and member of the Faculty Excellence Through Inclusion Committee. I have been a Member of the steering group for Women@TUOS Net since it’s initiation, acted as Chair in the academic year 2015-16 and remain on the steering group in an advisory role.
Outside of Sheffield University I am a visiting Professor at the Faculdade de Odontologia de Piracicaba, University of Campinas, Brazil and external examiner for the iPhD programme, Faculty of medicine, University of Southampton