‘Measuring 129Xe transfer across the blood brain barrier using magnetic resonance spectroscopy’ selected as MRM Editor’s top pick for June 2021

‘Measuring 129Xe transfer across the blood brain barrier using magnetic resonance spectroscopy’ paper selected as MRM Editor’s top pick for June 2021.

Figure: Illustration of BBB, cerebral blood volume for gray matter, gray matter volume, arterial blood volume and transfer of xenon across the barrier
Figure: Illustration of BBB, cerebral blood volume for gray matter, gray matter volume, arterial blood volume and transfer of xenon across the barrier

Congratulations to Insigneo Member Madhwesha Rao and colleagues from the Polaris research group at the University of Sheffield’s Department for Infection, Immunity & Cardiovascular Disease whose paper ‘Measuring 129Xe transfer across the blood brain barrier using magnetic resonance spectroscopy’ has been selected as Magnetic Resonance in Medicine (MRM) Editor’s top pick for June 2021: https://onlinelibrary.wiley.com/page/journal/15222594/homepage/editor_s_picks.htm

In this study the researchers developed a tracer kinetic model for time‐resolved NMR spectra of HP 129Xe in the human brain to estimate the transfer rate of HP 129Xe from cerebral blood to gray matter that depends on a tracer transfer constant for a known mean transit time and cerebral blood volume for gray matter.

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