MCB/Insigneo mechanobiology seminar: Crowding, compression and cancer

MCB/Insigneo mechanobiology seminar: Crowding, compression and cancer Dr Liam Holt, New York University  Friday 3 February, 12:00 - 13:00

Event details

Friday 3 February 2023
Alfred Denny Building, Alfred Denny Building, The University of Sheffield, Western Bank, Sheffield, S10 2TN


We are pleased to announce that our next mechanobiology seminar is being hosted jointly with the MCB group.  Dr Liam Holt from the Institute for Systems Genetics at New York University will give a talk on 'Crowding, compression and cancer' on Friday 3 February, 12:00 - 13:00.


Cells within tumors are under compressive stress. We find that compression drives nuclear ruptures and mitotic errors. Long-term growth under compression leads to specific genome alterations and mechanoadaptation. We propose that this evolution is crucial for cancer progression and may present opportunities to design new therapeutic approaches. 

Short Bio:

Liam Holt completed his Ph. D. at UCSF, was a Bowes Fellow at UC Berkeley, and is currently Associate Professor at New York University. His lab studies how mechanical compression affects cells, and how the physical properties of the cell interior affect biochemistry in both normal biology and disease. He cofounded Science Sketches (, an online dictionary of science videos now partnered with the Explorer’s Guide to Biology and MBoC Journal; and Inspire Science, a symposium about maintaining happiness in a challenging career.

The University of Sheffield and Insigneo logo

Contact us


Telephone: +44 114 222 0158

Events at the University

Browse upcoming public lectures, exhibitions, family events, concerts, shows and festivals across the University.