Research into trigeminal nerve damage and repair began at the University of Sheffield in the 1990s. Since then we’ve advanced the the treatment for trigeminal nerve repair to ensure the best outcomes for patients.
When research into trigeminal nerve repair began at Sheffield it was known that the trigeminal nerve could be repaired but outcomes were very variable. By using our pre-clinical models that have been developed to mimic the conditions we treat in our patients, we’ve now developed an effective method for trigeminal nerve repair.
Evaluations of our work have shown excellent outcomes, with patients seeing substantial improvements after repair. Before treatment sensation in the affected area, usually the tongue or lip and chin area, is tested using a light touch stimuli test. A fine filament is used to apply pressure to the area and assess the patient's sensation. Often patients have little or no sensation in the affected area. However, after treatment patients show an increased response.
We’re now doing research in a number of different areas.
Sometimes the nerve doesn’t regenerate as well or as quickly as it could. We’re identifying compounds which can be injected into the affected area and enhance nerve regeneration while reducing scarring and inflammation.
Improved methods of repair
In some patients, the area of damaged nerve is too large to be removed and the remaining nerve endings stitched together. We’re working closely with the Department of Material Science and Engineering and the Department of Biomedical Science to develop biocompatible materials that can be used to fill the gap between nerve endings when the gap’s too large.
Not all patients experience pain, but for those who do it can be incredibly uncomfortable and distressing. We’re looking into the nerves themselves to find out why this might be and identifying specific molecules which might be relevant in influencing the amount of pain patients are experiencing.
- A prospective quantitative study on the clinical outcome of lingual nerve repair.
- Current management of damage to the inferior alveolar and lingual nerves as a result of removal of third molars.
- Scarring impedes regeneration at sites of peripheral nerve repair.
- Characteristics of patients referred to the UK trigeminal nerve injury service.
- A comparison between the effects of three potential scar-reducing agents applied at a site of sciatic nerve repair.
- Correlation of Nav 1.8 and Nav 1.9 sodium channel expression with neuropathic pain in human subjects with lingual nerve neuromas.
- Nerve guides manufactured from photocurable polymers to aid peripheral nerve repair.
- Book chapters: Outcomes of trigeminal nerve repair.
- Correlation of miRNA expression with intensity of neuropathic pain in man.
- Additive manufactured biodegradable poly(glycerol sebacate methacrylate) nerve guidance conduits.
- A Novel Role for Lymphotactin (XCL1) Signaling in the Nervous System: XCL1 Acts via its Receptor XCR1 to Increase Trigeminal Neuronal Excitability.
- Mannose-6-phosphate facilitates early peripheral nerve regeneration in thy-1-YFP-H mice.
- TRPA1 expression in human lingual nerve neuromas in patients with and without symptoms of dysaesthesia.
- A prospective, quantitative study on the clinical outcome of inferior alveolar nerve decompression and neurolysis.
- Interleukin-10 reduces scarring and enhances regeneration at a site of sciatic nerve repair.
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