Our work in the Faculty of Science Mass Spectrometry Centre has contributed to the following high impact research publications.


Sec22b is a critical and nonredundant regulator of plasma cell maintenance.
Bonaud A, Gargowitsch L, Gilbert SM, Rajan E, Canales-Herrerias P, Stockholm D, Rahman NF, Collins MO, Taskiran H, Hill DL, Alloatti A, Alouche N, Balor S, Soldan V, Gillet D, Barbier J, Bachelerie F, Smith KGC, Jellusova J, Bruhns P, Amigorena S, Balabanian K, Linterman MA, Peden AA, Espéli M.
Proc Natl Acad Sci U S A. 2023 Jan 10;120(2):e2213056120. doi: 10.1073/pnas.2213056120.
PMID: 36595686

A single amino acid transporter controls the uptake of priming-inducing beta-amino acids and the associated tradeoff between induced resistance and plant growth.
Tao CN, Buswell W, Zhang P, Walker H, Johnson I, Field K, Schwarzenbacher R, Ton J.
Plant Cell. 2022 Nov 29;34(12):4840-4856. doi: 10.1093/plcell/koac271.
PMID: 36040205

Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.
Moll T, Odon V, Harvey C, Collins MO, Peden A, Franklin J, Graves E, Marshall JN, Dos Santos Souza C, Zhang S, Castelli L, Hautbergue G, Azzouz M, Gordon D, Krogan N, Ferraiuolo L, Snyder MP, Shaw PJ, Rehwinkel J, Cooper-Knock J.
Life Sci Alliance. 2022 Oct 14;6(1):e202201449. doi: 10.26508/lsa.202201449.
PMID: 36241425 

A mechanism for oxidative damage repair at gene regulatory elements.
Ray S, Abugable AA, Parker J, Liversidge K, Palminha NM, Liao C, Acosta-Martin AE, Souza CDS, Jurga M, Sudbery I, El-Khamisy SF.
Nature. 2022 Sep;609(7929):1038-1047. doi: 10.1038/s41586-022-05217-8.
PMID: 36171374

Developmental disruption to the cortical transcriptome and synaptosome in a model of SETD1A loss-of-function.
Clifton NE, Bosworth ML, Haan N, Rees E, Holmans PA, Wilkinson LS, Isles AR, Collins MO, Hall J.
Hum Mol Genet. 2022 Sep 10;31(18):3095-3106. doi: 10.1093/hmg/ddac105.
PMID: 35531971 

The EGFR/ErbB inhibitor neratinib modifies the neutrophil phosphoproteome and promotes apoptosis and clearance by airway macrophages.
Herman KD, Wright CG, Marriott HM, McCaughran SC, Bowden KA, Collins MO, Renshaw SA, Prince LR.
Front Immunol. 2022 Jul 28;13:956991. doi: 10.3389/fimmu.2022.956991.
PMID: 35967296 

Altered subgenomic RNA abundance provides unique insight into SARS-CoV-2 B.1.1.7/Alpha variant infections.
Parker MD, Stewart H, Shehata OM, Lindsey BB, Shah DR, Hsu S, Keeley AJ, Partridge DG, Leary S, Cope A, State A, Johnson K, Ali N, Raghei R, Heffer J, Smith N, Zhang P, Gallis M, Louka SF, Hornsby HR, Alamri H, Whiteley M, Foulkes BH, Christou S, Wolverson P, Pohare M, Hansford SE, Green LR, Evans C, Raza M, Wang D, Firth AE, Edgar JR, Gaudieri S, Mallal S; COVID-19 Genomics UK (COG-UK) consortium; Collins MO, Peden AA, de Silva TI.
Commun Biol. 2022 Jul 5;5(1):666. doi: 10.1038/s42003-022-03565-9.
PMID: 35790808 

Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants.
Sanders B, D'Andrea D, Collins MO, Rees E, Steward TGJ, Zhu Y, Chapman G, Legge SE, Pardiñas AF, Harwood AJ, Gray WP, O'Donovan MC, Owen MJ, Errington AC, Blake DJ, Whitcomb DJ, Pocklington AJ, Shin E.
Nat Commun. 2022 Jan 14;13(1):27. doi: 10.1038/s41467-021-27601-0.
PMID: 35031607

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.
Barnes CE, English DM, Broderick M, Collins MO, Cowley SM.
Mol Omics. 2022 Jan 17;18(1):31-44. doi: 10.1039/d1mo00236h.
PMID: 34709266 

PGFinder, a novel analysis pipeline for the consistent, reproducible, and high-resolution structural analysis of bacterial peptidoglycans.
Patel AV, Turner RD, Rifflet A, Acosta-Martin AE, Nichols A, Awad MM, Lyras D, Gomperts Boneca I, Bern M, Collins MO, Mesnage S.
Elife. 2021 Sep 28;10:e70597. doi: 10.7554/eLife.70597.
PMID: 34579805

Proteomic Approaches to Study Cysteine Oxidation: Applications in Neurodegenerative Diseases.
Pham TK, Buczek WA, Mead RJ, Shaw PJ, Collins MO.
Front Mol Neurosci. 2021 Jun 9;14:678837. doi: 10.3389/fnmol.2021.678837. eCollection 2021.
PMID: 34177463

Metabolite imaging by mass spectrometry: A new discovery tool.
Walker, H. J.
Advances in Botanical Research 2020, Academic Press, ISSN 0065-2296. doi:10.1016/bs.abr.2020.09.022

Metabolic signature of articular cartilage following mechanical injury: An integrated transcriptomics and metabolomics analysis. 
Southan, J., McHugh E., Walker H.J. and Ismail H.
Front. Mol. Biosci. 2020. doi: 10.3389/fmolb.2020.592905.

Could breath analysis by MS could be a solution to rapid, non-invasive testing for COVID-19?
Walker HJ, Burrell MM
Bioanalysis. 2020. doi: 10.4155/bio-2020-0125.
PMID: 32734782

The use of catechins in Chinese hamster ovary cell media for the improvement of monoclonal antibody yields and a reduction of acidic species.
Toronjo-Urquiza L, Acosta-Martin AE, James DC, Nagy T, Falconer RJ.
Biotechnol Prog. 2020 Feb 17:e2980. doi: 10.1002/btpr.2980.
PMID: 32067358

Comparison of Independent Evolutionary Origins Reveals Both Convergence and Divergence in the Metabolic Mechanisms of Symbiosis.
Sørensen M.E.S., Wood A.J., Minter E.J.A., Lowe C.D., Cameron D.D., Brockhurst M.A.
Current Biology, 2020, Jan 20; 30 (2) Pages 328-334.e4. doi: 10.1016/j.cub.2019.11.053
PMID: 31902722

Rapid compensatory evolution can rescue low fitness symbioses following partner-switching
Sørensen M.E.S., Wood A.J., Cameron D.D., Brockhurst M.A.
doi: 10.1101/2020.11.06.371401 

The Regulation of Plant Secondary Metabolism in Response to Abiotic Stress: Interactions Between Heat Shock and Elevated CO2.
Austen N, Walker HJ, Lake JA, Phoenix GK, Cameron DD. 
Front Plant Sci. 2019;10:1463. doi:10.3389/fpls.2019.01463.
PMID: 31803207

Resveratrol addition to Chinese hamster ovary cell culture media: The effect on cell growth, monoclonal antibody synthesis, and its chemical modification.
Toronjo-Urquiza L, Acosta-Martin AE, James DC, Nagy T, Falconer RJ.
Biotechnol Prog. 2019 Nov 19:e2940. doi: 10.1002/btpr.2940.
PMID: 31742929

Metabolic regulation of the maize rhizobiome by benzoxazinoids. 
Cotton, T.E.A., Pétriacq, P., Cameron, D.D, Meselmani M.A., Schwarzenbacher R., Rolfe S. A., Ton J. 
ISME J 13, 1647–1658 (2019). doi : 10.1038/s41396-019-0375-2.

Functional complementarity of ancient plant–fungal mutualisms: contrasting nitrogen, phosphorus and carbon exchanges between Mucoromycotina and Glomeromycotina fungal symbionts of liverworts. 
Field, K.J., Bidartondo, M.I., Rimington, W.R., Hoysted, G.A., Beerling, D., Cameron, D.D., Duckett, J.G., Leake, J.R. and Pressel, S. 
New Phytol, 2019, 223: 908-921. doi:10.1111/nph.15819.

Peptidoglycan Production by an Insect-BacterialMosaic.
Bublitz DC, Chadwick GL, Magyar JS, Sandoz KM, Brooks DM, Mesnage S, Ladinsky MS, Garber AI, Bjorkman PJ, Orphan VJ, McCutcheon JP.
Cell. 179(3), 703-712, Oct 17, 2019. doi: 10.1016/j.cell.2019.08.054.

S-acylated Golga7b stabilises DHHC5 at the plasma membrane to regulate cell adhesion.
Woodley KT, Collins MO.
EMBO Rep. 2019 Aug 12:e47472. doi: 10.15252/embr.201847472.
PMID: 31402609

Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95.
Sharma S, Carmona A, Skowronek A, Yu F, Collins MO, Naik S, Murzeau CM, Tseng PL, Erdmann KS.
Nat Commun. 2019 Jul 15;10(1):3105. doi: 10.1038/s41467-019-11025-y.
PMID: 31308371

Proteomic Profiling, Transcription Factor Modeling, and Genomics of Evolved Tolerant Strains Elucidate Mechanisms of Vanillin Toxicity in Escherichia coli.
Pattrick CA, Webb JP, Green J, Chaudhuri RR, Collins MO, Kelly DJ.
mSystems. 2019 Jun 11;4(4). pii: e00163-19. doi: 10.1128/mSystems.00163-19.
PMID: 31186336

Systems Analyses Reveal the Resilience of Escherichia coli Physiology during Accumulation and Export of the Nonnative Organic Acid Citramalate.
Webb J, Springthorpe V, Rossoni L, Minde DP, Langer S, Walker H, Alstrom-Moore A, Larson T, Lilley K, Eastham G, Stephens G, Thomas GH, Kelly DJ, Green J.
mSystems. 2019 Jun 11;4(4). pii: e00187-19. doi: 10.1128/mSystems.00187-19.
PMID: 31186337

Detection of Unknown Chemical Adduct Modifications on Proteins: From Wet to Dry Laboratory.
Antinori P, Michelot T, Lescuyer P, Müller M, Acosta-Martin AE.
Methods Mol Biol. 2019;1977:99-113. doi: 10.1007/978-1-4939-9232-4_8.
PMID: 30980325

Metabolic Profiling of Phloem Exudates as a Tool to Improve Bread-Wheat Cultivars.
S. Marisol L. Basile, Mike M. Burrell, Heather J. Walker, Jorge A. Cardozo, Chloe Steels, Felix Kallenberg, Jorge A. Tognetti, Horacio R. DallaValle and W. John Rogers
Agronomy 2018, 8(4), 45. doi:10.3390/agronomy8040045

S-acylation regulates the trafficking and stability of the unconventional Q-SNARE STX19.
Khamal K. Ampah, Jennifer Greaves, Amber S. M. Shun-Shion, Asral W. B. A. Asnawi, Jessica A. Lidster, Luke H. Chamberlain, Mark O. Collins, Andrew A. Peden.
J Cell Sci. 2018 Sep 25. pii: jcs.212498. doi: 10.1242/jcs.212498.
PMID: 30254024

More to NAD+ than meets the eye: A regulator of metabolic pools and gene expression in Arabidopsis.
Gakière B, Fernie AR, Pétriacq P.
Free Radic Biol Med. 2018 Jul;122:86-95. doi: 10.1016/j.freeradbiomed.2018.01.003. Epub 2018 Jan 5.
PMID: 29309893

The chemical signatures underlying host plant discrimination by aphids.
Hopkins, D.P., Cameron, D.D. & Butlin, R.K. 
Sci Rep 7, 8498 (2017). doi: 10.1038/s41598-017-07729-0

Site Specific Modification of Adeno-Associated Virus Enables Both Fluorescent Imaging of Viral Particles and Characterization of the Capsid Interactome.
Chandran JS, Sharp PS, Karyka E, Aves-Cruzeiro JMDC, Coldicott I, Castelli L, Hautbergue G, Collins MO, Azzouz M.
Sci Rep. 2017 Nov 7;7(1):14766. doi: 10.1038/s41598-017-15255-2.

Photoperiod Affects the Phenotype of Mitochondrial Complex I Mutants.
Pétriacq P, de Bont L, Genestout L, Hao J, Laureau C, Florez-Sarasa I, Rzigui T, Queval G, Gilard F, Mauve C, Guérard F, Lamothe-Sibold M, Marion J, Fresneau C, Brown S, Danon A, Krieger-Liszkay A, Berthomé R, Ribas-Carbo M, Tcherkez G, Cornic G, Pineau B, Gakière B, De Paepe R.
Plant Physiol. 2017 Jan;173(1):434-455. doi: 10.1104/pp.16.01484.

Long-lasting β-aminobutyric acid-induced resistance protects tomato fruit against Botrytis cinerea.
Wilkinson W, Pastor P, Paplauskas S, Pétriacq P, Luna-Diez E
Plant Pathology 2017 May (DOI: 10.1111/ppa.12725)

A metabolite profiling method for diagnosis of pre-cancerous cervical lesions and HPV persistence.
Walker H, Burrell M, Flatley J & Powers H
Bioanalysis. 2017 Apr;9(8):601-608. doi: 10.4155/bio-2017-0012. Epub 2017 May 16.

A novel root-to-shoot stomatal response to very high CO2 levels in the soil: electrical, hydraulic and biochemical signalling.
Lake JA, Walker HJ, Cameron DD & Lomax BH (2016) Physiologia Plantarum 159(4): DOI:10.1111/ppl.12525 433-44

Pyridine nucleotides induce changes in cytosolic pools of calcium in Arabidopsis.
Pétriacq P, Tcherkez G, Gakière B.
Plant Signal Behav. 2016 Oct 21:0.

Morphine delays the onset of action of prasugrel in patients with prior history of ST-elevation myocardial infarction.
Thomas MR, Morton AC, Hossain R, Chen B, Luo L, Shahari NN, Hua P, Beniston RG, Judge HM, Storey RF.
Thromb Haemost. 2016 Jul 4;116(1):96-102. doi: 10.1160/TH16-02-0102.

Metabolic activity in dormant conidia of Aspergillus niger and developmental changes during conidial outgrowth.
Novodvorska M, Stratford M, Blythe MJ, Wilson R, Beniston RG, Archer DB.
Fungal Genet Biol. 2016 Sep;94:23-31. doi: 10.1016/j.fgb.2016.07.002.

MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response.
Staples CJ, Barone G, Myers KN, Ganesh A, Gibbs-Seymour I, Patil AA, Beveridge RD, Daye C, Beniston R, Maslen S, Ahel I, Skehel JM, Collis SJ.
Cell Rep. 2016 Sep 6;16(10):2565-75. doi: 10.1016/j.celrep.2016.07.087.

NAD acts as an integral regulator of multiple defense layers.
Pétriacq P, Ton J, Patrit O, Tcherkez GG, Gakiere B.
Plant Physiol. 2016 Sep 12. [Epub ahead of print]

Towards an automated analysis of bacterial peptidoglycan structure.
Bern M, Beniston R, Mesnage S.
Anal Bioanal Chem. 2016 Aug 13. [Epub ahead of print]
PMID: 27520322

Understanding metabolism of arginine in biological systems via MALDI imaging.
Walker HJ, Steels C, Bendell L, Clench MR, Read DJ, Cameron DD, Burrell MM.
Proteomics. 2016 Jun;16(11-12):1690-4.

DUF3380 domain from a Salmonella phage endolysin shows potent N-acetylmuramidase activity.
Rodríguez-Rubio L, Gerstmans H, Thorpe S, Mesnage S, Lavigne R, Briers Y.
Appl Environ Microbiol. 2016 Jun 10. pii: AEM.00446-16.

The Polycystin-1, Lipoxygenase, and a-Toxin Domain Regulates Polycystin-1 Trafficking.
Xu Y, Streets AJ, Hounslow AM, Tran U, Jean-Alphonse F, Needham AJ, Vilardaga JP, Wessely O, Williamson MP, Ong AC
J Am Soc Nephrol. 2016 Apr;27(4):1159-73.

Spore density determines infection strategy by the plant-pathogenic fungus Plectosphaerella cucumerina.
Pétriacq P, Stassen JHM, Ton J.
Plant Physiol. 2016 Apr;170(4):2325-39.

Imposing control on self-assembly: rational design and synthesis of a mixed-metal, mixed-ligand coordination cage containing four types of component.
Metherell AJ, Ward MD.
Chem Sci. 2016 Feb 1;7(2):910-915. doi: 10.1039/c5sc03526k. Epub 2015 Oct 14.

Phosphorylation Regulates the Endocytic Function of the Yeast Dynamin-Related Protein Vps1.
Smaczynska-de Rooij II, Marklew CJ, Allwood EG, Palmer SE, Booth WI, Mishra R, Goldberg MW, Ayscough KR.
Mol Cell Biol. 2015 Dec 28;36(5):742-55. doi: 10.1128/MCB.00833-15.

Elevated CO2-Induced Responses in Stomata Require ABA and ABA Signaling.
Chater C, Peng K, Movahedi M, Dunn JA, Walker HJ, Liang YK, McLachlan DH, Casson S, Isner JC, Wilson I, Neill SJ, Hedrich R, Gray JE, Hetherington AM.
Curr Biol. 2015 Oct 19;25(20):2709-16

The Genus Sartidia (Poaceae: Aristidoideae) in Madagascar
Maria S. Vorontsova, Thomas Haevermans, Agathe Haevermans, Jacqueline Razanatsoa, Marjorie R. Lundgren, and Guillaume Besnard
Systematic Botany 40(2):448-453. 2015
DOI 10.1600/036364415X688367

A Cytostatic Ruthenium(II)-Platinum(II) Bis(terpyridyl) Anticancer Complex That Blocks Entry into S Phase by Up-regulating p27KIP1.
Ramu V, Gill MR, Jarman PJ, Turton D, Thomas JA, Das A, Smythe C.
Chemistry. 2015 Jun 15;21(25):9185-97.
PMID: 25950156

An interconverting family of coordination cages and a meso-helicate; effects of temperature, concentration, and solvent on the product distribution of a self-assembly process.
Cullen W, Hunter CA, Ward MD.
Inorg Chem. 2015 Mar 16;54(6):2626-37. doi: 10.1021/ic502780b. Epub 2015 Feb 20.
PMID: 25700155

The role of carbon starvation in the induction of enzymes that degrade plant-derived carbohydrates in Aspergillus niger.
van Munster JM, Daly P, Delmas S, Pullan ST, Blythe MJ, Malla S, Kokolski M, Noltorp EC, Wennberg K, Fetherston R, Beniston R, Yu X12, Dupree P, Archer DB.
Fungal Genet Biol. 2014 Nov;72:34-47.
PMID: 24792495

Plant perception of β-aminobutyric acid is mediated by an aspartyl-tRNA synthetase.
Luna E, van Hulten M, Zhang Y, Berkowitz O, López A, Pétriacq P, Sellwood MA, Chen B, Burrell M, van de Meene A, Pieterse CM, Flors V, Ton J.
Nat Chem Biol. 2014 Jun;10(6):450-6.
PMID: 2477693