radio-chromatography

Development of the next generation of on-line radio-chromatography detectors

A Knowledge Transfer Partnership between the Faulty of Science and Lablogic.

The Challenge

Radio-chromatography (RC) equipment is used in pharmaceutical studies to investigate the uptake of drugs into the bloodstream.

The on-going collaboration with the University of Sheffield, which was forged via the KTP, has brought a number of advantages to our business. Through the KTP, we have established our R&D capability in a more formal sense and, in addition, the company now has access to knowledge, expertise and resources that would normally be out of reach.

Richard Brown, Managing Director, LabLogic Systems Ltd.

Pharmaceutical and biotech companies are coming under increasing pressure to accelerate the drug development process and bring more compounds to market faster, thus cutting costs. Currently, commercially available on-line detectors are pushed to their operational limits, making sensitivity and resolution improvements to existing RC instruments essential.

The Collaboration

LabLogic is a worldwide market leader in the supply of RC equipment to the pharmaceutical industry. Dr Lee Thompson has years of experience in particle physics and, in particular, in photosensor technology as used in RC instruments. Funding was secured for a Knowledge Transfer Partnership (KTP) between LabLogic and Dr Thompson.

The Result

The KTP Associate, Dr Tom Deakin, and Dr Thompson helped Lablogic to increase the sensitivity of their equipment. Sample mixing, flow cell shape, scintillator liquid properties and the number and physics of photosensors were all investigated.

Future generations of LabLogic’s on-line RC detector will now lead the way in terms of resolution and reproducibility and the company now has detailed insight into the fundamental scientific processes that underpin this technology.

Further projects between LabLogic and the University of Sheffield are underway. Dr Deakin is now employed by Lablogic and continues to work closely with Dr Thompson and the Department of Physics and Astronomy.

Dr Thompson has a greater awareness of the commercially viable applications of experimental particle detection techniques beyond fundamental physics. He relishes the challenges and opportunities of working with a large multinational company.

You can also download the Thompson Lablogic case study.

For more information about the Department of Physics and astronomy or Lablogic please see www.sheffield.ac.uk/physics and www.lablogic.com.

This project was jointly funded through a Knowledge Transfer Partnership from the Technology Strategy Board/STFC and Lablogic.