What happens in ageing?

Our research advances knowledge of the common biological pathways driving age-related diseases.

Amyloid beta peptide alzheimers

The institute aims to achieve a step-change in understanding of the biological and social underpinnings of the common processes that lead to age-related diseases.

Our research advances knowledge on the common biological pathways driving ageing and underpinning cancer, cardiovascular, musculoskeletal and neurodegenerative diseases. These include known pathways related to DNA damage repair, cell senescence and inflammation, and new pathways driving ageing and disease. These discoveries provide targets for monitoring public health interventions and inform the development of new drugs to prevent multimorbidity

We also work to use statistical and machine learning approaches to identify the socio-economic and environmental determinants and predictors of multimorbidity. We push the boundaries of current research by integrating biological, social science and other disciplinary perspectives, investigating how factors such as living in a polluted or deprived neighbourhood can affect health and underlying biology.

We have expertise in information governance and management of large national datasets to address multimorbidity questions and a wealth of experience in clinical and preclinical studies of the most common age-related diseases and underlying ageing mechanisms.

Flagship institutes

The University’s four flagship institutes bring together our key strengths to tackle global issues, turning interdisciplinary and translational research into real-world solutions.