Ideas and discoveries developed by our researchers have been taken up by pharmaceutical and agrochemical industries. Here are three examples:
- Our crystallographers have been working with the agrochemicals company Syngenta for over 20 years to develop a successor to glyphosate, the leading herbicide world wide which is faced by problems of resistance. The research focuses on IGPD, an enzyme involved in histidine biosynthesis: the imageshows an intermediate bound to the enzyme active site.
- A collaboration between Molecular Biology Biotechnology and Sheffield Medical School led to the setting up of the company Asterion, which developed new technology for longer lasting drugs. The products are directed against growth disorders and have been licensed by the companies Genzyme and Ipsen.
- The most widely used drugs to treat osteoporosis are bisphosphonates. Until recently, it was not known how these worked, but research from Molecular Biology Biotechnology, collaborating with Chemistry and Medicine and supported by the Medical Research Council and Proctor & Gamble, revealed the mechanism and directly led to a saving of £50m per year to the National Health Service in drug costs.