Professor Mark Dickman

Dr Mark Dickman

Director of Research

Chair of Research Committtee


Profile

I obtained a First Class Honours Degree in Biochemistry/Chemistry at the University of Sheffield. I continued at the Krebs Institute, where I obtained my PhD. Following my PhD I joined a biotechnology company, Transgenomic LTD where I worked as a research scientist developing analytical techniques including DNA/RNA Chromatography. I joined the Dept of Chemical and Biological Engineering in 2003.

I am member of number of research centres/institutes at the University of Sheffield including the Krebs InstituteAdvanced Biomanufacturing Centre (ABC) and Sheffield Institute for Nucleic Acids (SInFoNiA).  I am currently the Director of Student Recruitment in the Department of Chemical and Biological Engineering.


Research

My research focuses on the development and application analytical techniques to study biological systems. In particular, biological mass spectrometry in conjunction with bioseparations have been utilised to study a wide variety of biological systems. Using these analytical approaches we are interested in identifying and characterising protein complexes, protein-RNA/DNA complexes, protein post translational modifications and RNA post transcriptional modifications.

Research interests

• Biological mass spectrometry
• Bioseparations
• Post-translational and post-transcriptional modifications
• Proteomics
• CRISPR systems


Industrial partners

We work closely with a number of industrial partners including SyngentaGlaxoSmithKline, and ThermoFisher.


Publications

Journal articles
Chapters
  • Dickman MJ, Nicholson JM, Reynolds CD, Wood CM & Baldwin JP (2008) Chromatin: The Biophysical Approach to Elucidating Structure and Function In Leroy NH & Fournier NT (Ed.), Cell cycle control (pp. 411-428). New York: Nova Biomedical.  
Conference proceedings papers
  • Njom VS, Buttle DJ, Winks T, Dickman MJ & Duce I (2015) Defining the molecular targets for plant cysteine proteinases on parasitic nematode extracellular matrix. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 96(2) (pp A9-A10)  
  • Tamulaitis G, Kazlauskiene M, Manakova E, Venclovas C, Nwokeoji AO, Dickman MJ, Horvath P & Siksnys V (2014) Characterization of Streptococcus thermophilus Csm complex mediated CRISPR interference in vitro. FEBS JOURNAL, Vol. 281 (pp 678-678)  
  • Cowling L, Varley C, Minshull T, Dickman M, Catto J & Southgate J (2014) 411: Epigenetic mechanisms of cadmium urothelial carcinogenesisEuropean Journal of Cancer, Vol. 50 (pp S98-S98)  
  • Al-Mashhadi SA, Simpson JE, Heath PR, Dickman MJ, Ince PG & Wharton SB (2014) Oxidative stress and DNA damage in cerebral white matter lesions of the ageing human brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 40 (pp 33-34)  
  • Al-Mashhadi SA, Simpson JE, Heath PR, Dickman MJ, Ince PG & Wharton SB (2013) Oxidative stress and DNA damage in cerebral white matter lesions of the ageing human brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 39 (pp 36-37)  
  • Dickman M, Rose JP, Marino MA & Hornby DP (2002) Analysis of the RNA component of human telomerase and its associated activity.. AMERICAN JOURNAL OF HUMAN GENETICS, Vol. 71(4) (pp 333-333)