Professor Paul G Overton

BA, PhD

Department of Psychology

Professor of Neuroscience

P.G.Overton@sheffield.ac.uk
+44 114 222 6624

+44 114 276 6515 (fax)

Cathedral Court

Full contact details

Professor Paul G Overton
Department of Psychology
Cathedral Court
1 Vicar Lane
Sheffield
S1 2LT

Qualifications: BA, PhD (Sheffield)

Research interests

My research interests largely revolve around the Basal Ganglia (and related structures): a group of nuclei implicated in a wide range of normal brain processes and neurological/psychiatric disorders. At present, there are four main strands to my work:

Regulation of dopaminergic neurons by sensory afferents.

Work is currently underway to determine the source of sensory information reaching Dopaminergic Neurons, using a combination of in vivo extracellular electrophysiology, neuroanatomical tract tracing, electrochemistry and behavioural analysis.

This work will help to determine the function of the dopaminergic `message´ transmitted to other brain areas – which is currently hotly debated.

Neuroadaptations which underlie the effects of drugs of abuse.

The present neuroadaptations work focuses upon the effects of cocaine and d-amphetamine on sensory processing (using electrophysiology and neuroimaging).

In particular, we are studying the possibility that an interaction between drugs like amphetamine and sensory processing may underlie the generation of cue-induced craving in Drug Addiction and the therapeutic effects in Attention Deficit Hyperactivity Disorder.

Basal ganglia structure and function.

We are currently deriving parameter values from neurons in the main input nucleus of the basal ganglia – the neostriatum – using whole cell patch clamping.

These will be incorporated into developing Computational Models of these cells and larger scale models of the microcircuitry of the neostriatum.

These studies will move us closer to a functional understanding of the the basal ganglia, and inform ongoing work aimed at developing robotic agents embodying basal ganglia circuitry.

Basal ganglia and emotional processing

As well as subserving a motor function, the basal ganglia also subserve a cognitive and an emotional function, and basal ganglia damage in Parkinson's disease can lead to specific problems with the processing of Disgust-related information.

In order to understand the role of the basal ganglia in emotional processing more fully, I have recently initiated an initial set of investigations into disgust reactions in normal humans. Future studies will compare these data with data from clinical populations.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Riley T & Overton P (2019) Enhancing the efficacy of 5-HT uptake inhibitors in the treatment of attention deficit hyperactivity disorder. Medical Hypotheses, 133. View this article in WRRO
Tsatali M, Overton P & Vivas A (2019) Self-reported and experimentally induced self-disgust is heightened in Parkinson’s disease : contribution of behavioural symptoms.. PLoS ONE, 14(10). View this article in WRRO
Pautrat A, Rolland M, Barthelemy M, Baunez C, Sinniger V, Piallat B, Savaster M, Overton PG & David O (2018) Revealing a novel nociceptive network that links the subthalamic nucleus to pain processing. eLife, 7. View this article in WRRO
Turner A, Kraev I, Stewart M, Stramek A, Overton PG & Dommett E (2018) Chronic amphetamine enhances visual input to and suppresses visual output from the superior colliculus in withdrawal. Neuropharmacology, 138, 118-129. View this article in WRRO
Turner AC, Stramek A, Kraev I, Stewart MG, Overton PG & Dommett EJ (2018) Repeated intermittent oral amphetamine administration results in locomotor tolerance not sensitization. Journal of Psychopharmacology. View this article in WRRO
Panagiotidi M, Overton PG & Stafford T (2017) Multisensory integration and ADHD-like traits: Evidence for an abnormal temporal integration window in ADHD. Acta Psychologica, 181, 10-17. View this article in WRRO
Overton PG, panagiotidi M & stafford T (2017) Co-occurrence of ASD and ADHD traits in an adult population. Journal of Attention Disorders. View this article in WRRO
Veltri T, Taroyan N & Overton PG (2017) Nicotine enhances an auditory Event-Related Potential component which is inversely related to habituation. Journal of Psychopharmacology, 31(7), 861-872. View this article in WRRO
Garlovsky JK, Simpson J, Grunewald RA & Overton PG (2016) Impulse control disorders in Parkinson’s disease: Predominant role of psychological determinants. Psychology & Health, 31(12), 1391-1414. View this article in WRRO
Brace LR, Kraev I, Rostron CL, Stewart MG, Overton PG & Dommett EJ (2015) Altered visual processing in a rodent model of Attention-Deficit Hyperactivity Disorder. Neuroscience, 303, 364-377.
Powell PA, Simpson J & Overton PG (2015) Self-affirming trait kindness regulates disgust toward one's physical appearance. Body Image, 12, 98-107.
Overton PG, Vautrelle N & Redgrave P (2014) Sensory regulation of dopaminergic cell activity: Phenomenology, circuitry and function. Neuroscience, 282, 1-12. View this article in WRRO
Clements KM, Devonshire IM, Reynolds JNJ & Overton PG (2014) Enhanced visual responses in the superior colliculus in an animal model of attention-deficit hyperactivity disorder and their suppression by d-amphetamine. Neuroscience, 274, 289-298.
Bertram C, Dahan L, Boorman LW, Harris S, Vautrelle N, Leriche M, Redgrave P & Overton PG (2014) Cortical regulation of dopaminergic neurons: role of the midbrain superior colliculus.. J Neurophysiol, 111(4), 755-767.
Rolland M, Carcenac C, Overton PG, Savasta M & Coizet V (2013) ENHANCED VISUAL RESPONSES IN THE SUPERIOR COLLICULUS AND SUBTHALAMIC NUCLEUS IN AN ANIMAL MODEL OF PARKINSON'S DISEASE. NEUROSCIENCE, 252, 277-288.
Harris S, Bruyns-Haylett M, Kennerley A, Boorman L, Overton PG, Ma H, Zhao M, Schwartz TH & Berwick J (2013) The effects of focal epileptic activity on regional sensory-evoked neurovascular coupling and postictal modulation of bilateral sensory processing.. J Cereb Blood Flow Metab, 33(10), 1595-1604. View this article in WRRO
Powell PA, Simpson J & Overton PG (2013) When disgust leads to dysphoria: a three-wave longitudinal study assessing the temporal relationship between self-disgust and depressive symptoms.. Cogn Emot, 27(5), 900-913.
Delaney M, Leroi I, Simpson J & Overton PG (2012) Impulse Control Disorders in Parkinson's Disease: A Psychosocial Perspective. Journal of Clinical Psychology in Medical Settings, 1-9.
Clements KM, Smith LM, Reynolds JNJ, Overton PG, Thomas JD & Napper RM (2012) Early Postnatal Ethanol Exposure: Glutamatergic Excitotoxic Cell Death During Acute Withdrawal. Neurophysiology, 1-11.
Comoli E, Das Neves Favaro P, Vautrelle N, Leriche M, Overton PG & Redgrave P (2012) Segregated anatomical input to sub-regions of the rodent superior colliculus associated with approach and defense.. Front Neuroanat, 6, 9. View this article in WRRO
Devonshire IM, Papadakis NG, Port M, Berwick J, Kennerley AJ, Mayhew JEW & Overton PG (2012) Neurovascular coupling is brain region-dependent.. Neuroimage, 59(3), 1997-2006.
Lepora NF, Overton PG & Gurney K (2012) Efficient fitting of conductance-based model neurons from somatic current clamp.. J Comput Neurosci, 32(1), 1-24.
Lepora NF, Blomeley CP, Hoyland D, Bracci E, Overton PG & Gurney K (2011) A simple method for characterizing passive and active neuronal properties: application to striatal neurons.. Eur J Neurosci, 34(9), 1390-1405.
Coizet V, Dommett EJ, Klop EM, Redgrave P & Overton PG (2010) The parabrachial nucleus is a critical link in the transmission of short latency nociceptive information to midbrain dopaminergic neurons.. Neuroscience, 168(1), 263-272.
Dommett EJ, Overton PG & Greenfield SA (2009) DRUG THERAPIES FOR ATTENTIONAL DISORDERS ALTER THE SIGNAL-TO-NOISE RATIO IN THE SUPERIOR COLLICULUS. NEUROSCIENCE, 164(3), 1369-1376.
Coizet V, Graham JH, Moss J, Bolam JP, Savasta M, McHaffie JG, Redgrave P & Overton PG (2009) Short-latency visual input to the subthalamic nucleus is provided by the midbrain superior colliculus.. J Neurosci, 29(17), 5701-5709.
Overton PG, Markland FE, Taggart HS, Bagshaw GL & Simpson J (2008) Self-disgust mediates the relationship between dysfunctional cognitions and depressive symptomatology.. Emotion, 8(3), 379-385.
Gowan JD, Coizet V, Devonshire IM & Overton PG (2008) D-amphetamine depresses visual responses in the rat superior colliculus: a possible mechanism for amphetamine-induced decreases in distractibility.. J Neural Transm (Vienna), 115(3), 377-387.
Devonshire IM, Mayhew JEW & Overton PG (2007) Cocaine preferentially enhances sensory processing in the upper layers of the primary sensory cortex.. Neuroscience, 146(2), 841-851.
Dommett E, Coizet V, Blaha CD, Martindale J, Lefebvre V, Walton N, Mayhew JEW, Overton PG & Redgrave P (2005) How visual stimuli activate dopaminergic neurons at short latency.. Science, 307(5714), 1476-1479.
Aked J, Coizet V, Clark D & Overton PG (2005) Local injection of a glutamate uptake inhibitor into the ventral tegmental area produces sensitization to the behavioural effects of d-amphetamine.. Neuroscience, 134(2), 361-367.
Devonshire IM, Berwick J, Jones M, Martindale J, Johnston D, Overton PG & Mayhew JEW (2004) Haemodynamic responses to sensory stimulation are enhanced following acute cocaine administration.. Neuroimage, 22(4), 1744-1753.
Comoli E, Coizet V, Boyes J, Bolam JP, Canteras NS, Quirk RH, Overton PG & Redgrave P (2003) A direct projection from superior colliculus to substantia nigra for detecting salient visual events.. Nat Neurosci, 6(9), 974-980.
Lokwan SJ, Overton PG, Berry MS & Clark D (2000) The medial prefrontal cortex plays an important role in the excitation of A10 dopaminergic neurons following intravenous muscimol administration.. Neuroscience, 95(3), 647-656.

All publications

Edited books

Powell PA, Overton PG & Simpson J (Eds.) (2014) The Revolting Self: Perspectives on the Psychological, Social, and Clinical Implications of Self-Directed Disgust. Karnac Books.

Journal articles

Overton P & Coizet V (2020) The neuropathological basis of anxiety in Parkinson’s disease. Medical Hypotheses. View this article in WRRO
Panagiotidi M & Overton P (2020) Attention deficit hyperactivity symptoms predict problematic mobile phone use. Current Psychology. View this article in WRRO
Taroyan N, Butnicu B, Ypsilanti A & Overton P (2020) Individual differences in performance speed are associated with a positivity/negativity bias. An ERP and behavioural study. Frontiers in Behavioral Neuroscience, 14. View this article in WRRO
Ypsilanti A, Robson A, Lazuras L, Powell P & Overton P (2020) Self-disgust, loneliness and mental health outcomes in older adults: An eye-tracking study. Journal of Affective Disorders. View this article in WRRO
Azlan H, Overton P, Simpson J & Powell P (2019) Disgust propensity has a causal link to the stigmatization of people with cancer. Journal of Behavioral Medicine. View this article in WRRO
Riley T & Overton P (2019) Enhancing the efficacy of 5-HT uptake inhibitors in the treatment of attention deficit hyperactivity disorder. Medical Hypotheses, 133. View this article in WRRO
Tsatali M, Overton P & Vivas A (2019) Self-reported and experimentally induced self-disgust is heightened in Parkinson’s disease : contribution of behavioural symptoms.. PLoS ONE, 14(10). View this article in WRRO
Stafford T, Overton P & Hampsey E (2019) Can microsaccade rate predict drug response?. Journal of Eye Movement Research, 12(6). View this article in WRRO
Janmohammadi S, Haghgoo HA, Overton PG, Farahbod M & Pishyareh E (2019) Effect of a visual tracking intervention on attention and behavior of children with attention deficit hyperactivity disorder. Journal of Eye Movement Research, 12(8). View this article in WRRO
Burden N, Simpson J, Murray C, Overton PG & Powell P (2018) Prosthesis use is associated with reduced physical self-disgust in limb amputees. Body Image, 27, 109-117. View this article in WRRO
Panagiotidi M & Overton PG (2018) The relationship between internet addiction, attention deficit hyperactivity symptoms and online activities in adults. Comprehensive Psychiatry, 87, 7-11. View this article in WRRO
Ypsilanti A, Lazuras L, Powell P & Overton PG (2018) Self-disgust as a potential mechanism explaining the association between loneliness and depression. Journal of Affective Disorders, 243, 108-115. View this article in WRRO
Pautrat A, Rolland M, Barthelemy M, Baunez C, Sinniger V, Piallat B, Savaster M, Overton PG & David O (2018) Revealing a novel nociceptive network that links the subthalamic nucleus to pain processing. eLife, 7. View this article in WRRO
Lazuras L, Ypsilianti A, Powell P & Overton PG (2018) The roles of impulsivity, self-regulation, and emotion regulation in the experience of self-disgust. Motivation and Emotion. View this article in WRRO
Turner A, Kraev I, Stewart M, Stramek A, Overton PG & Dommett E (2018) Chronic amphetamine enhances visual input to and suppresses visual output from the superior colliculus in withdrawal. Neuropharmacology, 138, 118-129. View this article in WRRO
Turner AC, Stramek A, Kraev I, Stewart MG, Overton PG & Dommett EJ (2018) Chronic amphetamine treatment affects collicular-dependent behaviour. Behavioural Brain Research, 343, 1-7. View this article in WRRO
Turner AC, Stramek A, Kraev I, Stewart MG, Overton PG & Dommett EJ (2018) Repeated intermittent oral amphetamine administration results in locomotor tolerance not sensitization. Journal of Psychopharmacology. View this article in WRRO
Panagiotidi M, Overton PG & Stafford T (2018) The relationship between ADHD traits and sensory sensitivity in the general population. Comprehensive Psychiatry, 80, 179-185. View this article in WRRO
Azlan HA, Overton PG, Simpson J & Powell PA (2017) Effect of Partners' Disgust Responses on Psychological Wellbeing in Cancer Patients.. Journal of Clinical Psychology in Medical Settings, 23(3-4), 355-364. View this article in WRRO
Panagiotidi M, Overton PG & Stafford T (2017) Multisensory integration and ADHD-like traits: Evidence for an abnormal temporal integration window in ADHD. Acta Psychologica, 181, 10-17. View this article in WRRO
Hetherington L, Riley T, Haensel J, Dommett E, Turner A & Overton PG (2017) Effect of methylphenidate on visual responses in the superior colliculus in the anaesthetised rat: Role of cortical activation. Journal of Psychopharmacology, 31(10), 1347-1361. View this article in WRRO
Overton PG, panagiotidi M & stafford T (2017) Co-occurrence of ASD and ADHD traits in an adult population. Journal of Attention Disorders. View this article in WRRO
buxton D, Bracci E, gurney K & overton P (2017) Striatal neuropeptides enhance selection and rejection of sequential actions. Frontiers in Computational Neuroscience. View this article in WRRO
Veltri T, Taroyan N & Overton PG (2017) Nicotine enhances an auditory Event-Related Potential component which is inversely related to habituation. Journal of Psychopharmacology, 31(7), 861-872. View this article in WRRO
Panagiotidi M, Overton P & Stafford T (2017) Increased microsaccade rate in individuals with ADHD traits. Journal of Eye Movement Research, 10(1). View this article in WRRO
Panagiotidi M, Overton PG & Stafford T (2016) Attention Deficit Hyperactivity Disorder-like traits and distractibility in the visual periphery. Perception. View this article in WRRO
Azlan HA, Overton PG, Simpson J & Powell PA (2016) Differential disgust responding in people with cancer and implications for psychological wellbeing. Psychology and Health, 32(1), 19-37. View this article in WRRO
Garlovsky JK, Overton PG & Simpson J (2016) Psychological Predictors of Anxiety and Depression in Parkinson's Disease: A Systematic Review. Journal of Clinical Psychology, 72(10), 979-998. View this article in WRRO
Garlovsky JK, Simpson J, Grunewald RA & Overton PG (2016) Impulse control disorders in Parkinson’s disease: Predominant role of psychological determinants. Psychology & Health, 31(12), 1391-1414. View this article in WRRO
Powell PA, Azlan HA, Simpson J & Overton PG (2016) The effect of disgust-related side-effects on symptoms of depression and anxiety in people treated for cancer: a moderated mediation model. Journal of Behavioral Medicine, 39(4), 560-573. View this article in WRRO
Brace LR, Kraev I, Rostron CL, Stewart MG, Overton PG & Dommett EJ (2015) Auditory responses in a rodent model of Attention Deficit Hyperactivity Disorder. Brain Research, 1629, 10-25.
Brace LR, Kraev I, Rostron CL, Stewart MG, Overton PG & Dommett EJ (2015) Altered visual processing in a rodent model of Attention-Deficit Hyperactivity Disorder. Neuroscience, 303, 364-377.
Powell PA, Simpson J & Overton PG (2015) Self-affirming trait kindness regulates disgust toward one's physical appearance. Body Image, 12, 98-107.
Overton PG, Vautrelle N & Redgrave P (2014) Sensory regulation of dopaminergic cell activity: Phenomenology, circuitry and function. Neuroscience, 282, 1-12. View this article in WRRO
Harris S, Boorman L, Bruyns-Haylett M, Kennerley A, Ma H, Zhao M, Overton PG, Schwartz TH & Berwick J (2014) Contralateral dissociation between neural activity and cerebral blood volume during recurrent acute focal neocortical seizures. Epilepsia, 55(9), 1423-1430. View this article in WRRO
Clements KM, Devonshire IM, Reynolds JNJ & Overton PG (2014) Enhanced visual responses in the superior colliculus in an animal model of attention-deficit hyperactivity disorder and their suppression by d-amphetamine. Neuroscience, 274, 289-298.
Harris S, Ma H, Zhao M, Boorman L, Zheng Y, Kennerley A, Bruyns-Haylett M, Overton PG, Berwick J & Schwartz TH (2014) Coupling between gamma-band power and cerebral blood volume during recurrent acute neocortical seizures. NeuroImage, 97, 62-70. View this article in WRRO
Bertram C, Dahan L, Boorman LW, Harris S, Vautrelle N, Leriche M, Redgrave P & Overton PG (2014) Cortical regulation of dopaminergic neurons: role of the midbrain superior colliculus.. J Neurophysiol, 111(4), 755-767.
Rolland M, Carcenac C, Overton PG, Savasta M & Coizet V (2013) ENHANCED VISUAL RESPONSES IN THE SUPERIOR COLLICULUS AND SUBTHALAMIC NUCLEUS IN AN ANIMAL MODEL OF PARKINSON'S DISEASE. NEUROSCIENCE, 252, 277-288.
Harris S, Bruyns-Haylett M, Kennerley A, Boorman L, Overton PG, Ma H, Zhao M, Schwartz TH & Berwick J (2013) The effects of focal epileptic activity on regional sensory-evoked neurovascular coupling and postictal modulation of bilateral sensory processing.. J Cereb Blood Flow Metab, 33(10), 1595-1604. View this article in WRRO
Powell PA, Simpson J & Overton PG (2013) When disgust leads to dysphoria: a three-wave longitudinal study assessing the temporal relationship between self-disgust and depressive symptoms.. Cogn Emot, 27(5), 900-913.
Powell PA, Overton PG & Simpson J (2013) The Revolting Self: An Interpretative Phenomenological Analysis of the Experience of Self-Disgust in Females With Depressive Symptoms. Journal of Clinical Psychology.
Fadda R, Siegal M & Overton PG (2012) Explicit and implicit contamination sensitivity in children with autistic spectrum disorders: an eye tracking study. PERCEPTION, 41, 105-106.
Delaney M, Leroi I, Simpson J & Overton PG (2012) Impulse Control Disorders in Parkinson's Disease: A Psychosocial Perspective. Journal of Clinical Psychology in Medical Settings, 1-9.
Clements KM, Smith LM, Reynolds JNJ, Overton PG, Thomas JD & Napper RM (2012) Early Postnatal Ethanol Exposure: Glutamatergic Excitotoxic Cell Death During Acute Withdrawal. Neurophysiology, 1-11.
Comoli E, Das Neves Favaro P, Vautrelle N, Leriche M, Overton PG & Redgrave P (2012) Segregated anatomical input to sub-regions of the rodent superior colliculus associated with approach and defense.. Front Neuroanat, 6, 9. View this article in WRRO
Devonshire IM, Papadakis NG, Port M, Berwick J, Kennerley AJ, Mayhew JEW & Overton PG (2012) Neurovascular coupling is brain region-dependent.. Neuroimage, 59(3), 1997-2006.
Lepora NF, Overton PG & Gurney K (2012) Efficient fitting of conductance-based model neurons from somatic current clamp.. J Comput Neurosci, 32(1), 1-24.
Siegal M, Fadda R & Overton PG (2011) Contamination sensitivity and the development of disease-avoidant behaviour.. Philos Trans R Soc Lond B Biol Sci, 366(1583), 3427-3432.
Lepora NF, Blomeley CP, Hoyland D, Bracci E, Overton PG & Gurney K (2011) A simple method for characterizing passive and active neuronal properties: application to striatal neurons.. Eur J Neurosci, 34(9), 1390-1405.
Simpson J, Hillman R, Crawford T & Overton PG (2010) Self-esteem and self-disgust both mediate the relationship between dysfunctional cognitions and depressive symptoms. MOTIV EMOTION, 34(4), 399-406.
Coizet V, Dommett EJ, Klop EM, Redgrave P & Overton PG (2010) The parabrachial nucleus is a critical link in the transmission of short latency nociceptive information to midbrain dopaminergic neurons.. Neuroscience, 168(1), 263-272.
Simpson J, Hillman R, Crawford T & Overton PG (2010) Self-esteem and self-disgust both mediate the relationship between dysfunctional cognitions and depressive symptoms. Motivation and Emotion, 1-8.
Redgrave P, Coizet V, Comoli E, McHaffie JG, Leriche M, Vautrelle N, Hayes LM & Overton P (2010) Interactions between the Midbrain Superior Colliculus and the Basal Ganglia.. Front Neuroanat, 4.
Dommett EJ, Overton PG & Greenfield SA (2009) DRUG THERAPIES FOR ATTENTIONAL DISORDERS ALTER THE SIGNAL-TO-NOISE RATIO IN THE SUPERIOR COLLICULUS. NEUROSCIENCE, 164(3), 1369-1376.
Coizet V, Graham JH, Moss J, Bolam JP, Savasta M, McHaffie JG, Redgrave P & Overton PG (2009) Short-latency visual input to the subthalamic nucleus is provided by the midbrain superior colliculus.. J Neurosci, 29(17), 5701-5709.
Overton PG, Markland FE, Taggart HS, Bagshaw GL & Simpson J (2008) Self-disgust mediates the relationship between dysfunctional cognitions and depressive symptomatology.. Emotion, 8(3), 379-385.
Overton PG & Devonshire IM (2008) Cocaine facilitates craving via an action on sensory processing. Bioscience Hypotheses, 1(2), 70-77.
Overton PG (2008) Collicular dysfunction in attention deficit hyperactivity disorder.. Med Hypotheses, 70(6), 1121-1127.
Gowan JD, Coizet V, Devonshire IM & Overton PG (2008) D-amphetamine depresses visual responses in the rat superior colliculus: a possible mechanism for amphetamine-induced decreases in distractibility.. J Neural Transm (Vienna), 115(3), 377-387.
Devonshire IM, Mayhew JEW & Overton PG (2007) Cocaine preferentially enhances sensory processing in the upper layers of the primary sensory cortex.. Neuroscience, 146(2), 841-851.
Simpson J, Anthony SH, Schmeer S & Overton PG (2007) Food-related contextual factors substantially modify the disgust response. FOOD QUAL PREFER, 18(2), 183-189.
Coizet V, Overton PG & Redgrave P (2007) Collateralization of the tectonigral projection with other major output pathways of superior colliculus in the rat.. J Comp Neurol, 500(6), 1034-1049.
Dommett EJ, Simpson J, Clark D & Overton PG (2007) Identification of an excitatory amino acid-mediated component of the ventral tegmental area local field potential response to medial prefrontal cortex stimulation: effect of acute d-amphetamine.. J Neural Transm (Vienna), 114(2), 161-172.
Simpson J, Carter S, Anthony SH & Overton PG (2006) Is disgust a homogeneous emotion?. MOTIV EMOTION, 30(1), 31-41.
McHaffie JG, Jiang H, May PJ, Coizet V, Overton PG, Stein BE & Redgrave P (2006) A direct projection from superior colliculus to substantia nigra pars compacta in the cat.. Neuroscience, 138(1), 221-234.
Coizet V, Dommett EJ, Redgrave P & Overton PG (2006) Nociceptive responses of midbrain dopaminergic neurones are modulated by the superior colliculus in the rat.. Neuroscience, 139(4), 1479-1493.
Dommett E, Coizet V, Blaha CD, Martindale J, Lefebvre V, Walton N, Mayhew JEW, Overton PG & Redgrave P (2005) How visual stimuli activate dopaminergic neurons at short latency.. Science, 307(5714), 1476-1479.
Berwick J, Devonshire IM, Martindale AJ, Johnston D, Zheng Y, Kennerley AJ, Overton PG & Mayhew JEW (2005) Cocaine administration produces a protracted decoupling of neural and haemodynamic responses to intense sensory stimuli.. Neuroscience, 132(2), 361-374.
Aked J, Coizet V, Clark D & Overton PG (2005) Local injection of a glutamate uptake inhibitor into the ventral tegmental area produces sensitization to the behavioural effects of d-amphetamine.. Neuroscience, 134(2), 361-367.
Devonshire IM, Berwick J, Jones M, Martindale J, Johnston D, Overton PG & Mayhew JEW (2004) Haemodynamic responses to sensory stimulation are enhanced following acute cocaine administration.. Neuroimage, 22(4), 1744-1753.
Gurney KN & Overton PG (2004) A model of short and long range selective processing in neostriatum. NEUROCOMPUTING, 58-60, 555-562.
Comoli E, Coizet V, Boyes J, Bolam JP, Canteras NS, Quirk RH, Overton PG & Redgrave P (2003) A direct projection from superior colliculus to substantia nigra for detecting salient visual events.. Nat Neurosci, 6(9), 974-980.
Overton PG, Marrow LP, Brain PF & Clark D (2000) Certain clinically-utilized antibiotics enhance the behavioural effects of cocaine.. Addict Biol, 5(3), 283-288.
Overton PG, Lokwan SJ, Berry MS & Clark D (2000) D-Amphetamine potentiates muscimol-induced disinhibition of A10 dopaminergic neurons in the rat.. J Neural Transm (Vienna), 107(12), 1381-1391.
Lokwan SJ, Overton PG, Berry MS & Clark D (2000) The medial prefrontal cortex plays an important role in the excitation of A10 dopaminergic neurons following intravenous muscimol administration.. Neuroscience, 95(3), 647-656.
Marrow LP, Overton PG, Brain PF & Clark D (1999) Encounters with aggressive conspecifics enhance the locomotor-activating effects of cocaine in the rat.. Addict Biol, 4(4), 437-441.
Overton PG, Richards CD, Berry MS & Clark D (1999) Long-term potentiation at excitatory amino acid synapses on midbrain dopamine neurons.. Neuroreport, 10(2), 221-226.
Marrow LP, Overton PG & Brain PF (1999) A re-evaluation of social defeat as an animal model of depression. Journal of Psychopharmacology, 13, 115-121.
Marrow L, Statham A, Overton PG, Brain PF & Clark D (1999) The corticosteroid synthesis inhibitor metyrapone markedly enhances the behavioural effects of d-amphetamine.. Addict Biol, 4(1), 89-92.
Lokwan SJ, Overton PG, Berry MS & Clark D (1999) Stimulation of the pedunculopontine tegmental nucleus in the rat produces burst firing in A9 dopaminergic neurons.. Neuroscience, 92(1), 245-254.
Clark D & Overton PG (1998) Alterations in excitatory amino acid-mediated regulation of midbrain dopaminergic neurones induced by chronic psychostimulant administration and stress: relevance to behavioural sensitization and drug addiction. ADDICT BIOL, 3(2), 109-135.
Tong ZY, Overton PG, Martinez-Cué C & Clark D (1998) Do non-dopaminergic neurons in the ventral tegmental area play a role in the responses elicited in A10 dopaminergic neurons by electrical stimulation of the prefrontal cortex?. Exp Brain Res, 118(4), 466-476.
Overton PG & Clark D (1997) Burst firing in midbrain dopaminergic neurons.. Brain Res Brain Res Rev, 25(3), 312-334.
Overton PG, Tong ZY, Brain PF & Clark D (1996) Preferential occupation of mineralocorticoid receptors by corticosterone enhances glutamate-induced burst firing in rat midbrain dopaminergic neurons.. Brain Res, 737(1-2), 146-154.
Tong ZY, Overton PG & Clark D (1996) Stimulation of the prefrontal cortex in the rat induces patterns of activity in midbrain dopaminergic neurons which resemble natural burst events.. Synapse, 22(3), 195-208.
Tong ZY, Overton PG & Clark D (1996) Antagonism of NMDA receptors but not AMPA/kainate receptors blocks bursting in dopaminergic neurons induced by electrical stimulation of the prefrontal cortex.. J Neural Transm (Vienna), 103(8-9), 889-904.
Overton PG, Tong ZY & Clark D (1996) A pharmacological analysis of the burst events induced in midbrain dopaminergic neurons by electrical stimulation of the prefrontal cortex in the rat.. J Neural Transm (Vienna), 103(5), 523-540.
Tong ZY, Overton PG & Clark D (1995) Chronic administration of (+)-amphetamine alters the reactivity of midbrain dopaminergic neurons to prefrontal cortex stimulation in the rat.. Brain Res, 674(1), 63-74.
Overton PG & Greenfield SA (1995) Determinants of neuronal firing pattern in the guinea-pig subthalamic nucleus: An in vivo and in vitro comparison.. Journal of Neural Transmission, 10, 41-54.
Overton PG, O'Callaghan JF & Greenfield SA (1995) Possible intermixing of neurons from the subthalamic nucleus and substantia nigra pars compacta in the guinea-pig.. Exp Brain Res, 107(2), 151-165.
Marrow L, Overton P & Clark D (1993) Disruption of conditioned reaction time performance by dopamine receptor antagonists in the rat.. Behav Pharmacol, 4(1), 15-28.
Overton P, Elliott PJ, Hagan RM & Clark D (1992) Neurokinin agonists differentially affect A9 and A10 dopamine cells in the rat.. Eur J Pharmacol, 213(1), 165-166.
MARROW L, OVERTON P & CLARK D (1992) AMELIORATION OF SOME NEUROLEPTIC-INDUCED DEFICITS BY THE NMDA ANTAGONIST MK-801 IN A CONDITIONED REACTION-TIME-TASK. BEHAV PHARMACOL, 3(1), 57-64.
Overton P & Clark D (1992) Iontophoretically administered drugs acting at the N-methyl-D-aspartate receptor modulate burst firing in A9 dopamine neurons in the rat.. Synapse, 10(2), 131-140.
Overton P & Clark D (1992) Electrophysiological evidence that intrastriatally administered N-methyl-D-aspartate augments striatal dopamine tone in the rat.. J Neural Transm Park Dis Dement Sect, 4(1), 1-14.
Redgrave P, Simkins M, overton P & Dean P (1992) Anticonvulsant role of nigrotectal projection in the maximal electroshock model of epilepsy--I. Mapping of dorsal midbrain with bicuculline.. Neuroscience, 46(2), 379-390.
Overton P & Clark D (1991) N-methyl-D-aspartate increases the excitability of nigrostriatal dopamine terminals.. Eur J Pharmacol, 201(1), 117-120.
Overton P & Dean P (1988) Detection of visual stimuli after lesions of the superior colliculus in the rat; deficit not confined to the far periphery.. Behav Brain Res, 31(1), 1-15.
Overton P, Dean P & Redgrave P (1985) Detection of visual stimuli in far periphery by rats: possible role of superior colliculus.. Exp Brain Res, 59(3), 559-569.

Datasets

Overton P, Vivas A & Tsatali M Data for: Self-reported and experimentally induced self-disgust is heightened in Parkinson’s disease: Contribution of behavioural symptoms [to be published in PLoS One].

Grants

Overton, P.G. [PI], Gluing behaviours together - 'chunking' in the normal brain and its disruption in Parkinson's disease. Rosetrees Trust (£5450; 2018-2019)
Overton, P.G., Billington, T. [PI] Attention and behaviour: Transforming achievement and social inclusion following primary-secondary school transition. ESRC Collaborative studentship (£65.983; 2016-2020).
Overton, P.G,., Dommett, E.J. [PI], Singer, B., Byrom, N. Investigating the effects of cardio and non-cardio exercise on adults with Attention Deficit Hyperactivity Disorder. Rosetrees Trust (£59,282; 2019-2020).

Teaching activities: I am module organiser for PSY6306 (Fundamentals of Neuroscience).