Dr Henry H. Roehl

Department of Biomedical Science

Senior Lecturer

Level 2 Tutor

h.roehl@sheffield.ac.uk
+44 114 222 2351

Full contact details

Dr Henry H. Roehl
Department of Biomedical Science
C21
Firth Court
Western Bank
Sheffield
S10 2TN
Profile
  • 2004-present: MRC Centre for Developmental and Biomedical Genetics, University of Sheffield
  • 2011-present: Senior Lecturer, University of Sheffield
  • 2002-present: Lecturer, University of Sheffield
  • 1997-2002: Postdoctoral Fellow, Max-Planck-Institut, Tuebingen. Research advisor: Dr. Nuesslein-Volhard
  • 1994-1997: Ph.D. Genetics University of Wisconsin-Madison. Research advisor: Dr. Judith Kimble
  • 1990-1994: Masters Genetics University of Wisconsin-Madison. Research advisor: Dr. Judith Kimble
  • 1983-1988: B.S. Biology, Antioch College
Research interests

The Roehl Laboratory uses zebrafish as a model organism to study musculoskeletal development and disease.

Modelling skeletal disease in zebrafish

How do developmental signalling pathways regulate osteoblast differentiation during development and skeletal repair?

Osteoblasts in zebrafish follow the same differentiation pathway as in mammals: The runx2 genes are expressed in early skeletal precursors, followed by osterix and then finally by genes encoding bone proteins such as Osteonectin and Collagen1.

We have analysed how different signalling pathways regulate these steps during osteoblastogenesis using heatshock induction of signalling pathway components and pharmaceuticals that target individual pathways.

Our work has shed light on how stem cells differentiate in vivo and may help to develop regenerative therapies for skeletal diseases such as osteoarthritis and osteoporosis. We have also found a link between osteoblast and adipocyte differentiation in vivo that may help us to unravel the genetic origins of diseases such as diabetes and obesity.

Publications

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Journal articles

All publications

Journal articles

Conference proceedings papers

  • Misra J, Misra J, Mohanty ST, Madan S, Fernandes JA, Ebetino FH, Roehl H, Russell RG & Bellantuono I (2013) Can Bisphosphonates extend Life Span? Effects on Stem Cell survival, DNA Repair and Tissue Regeneration. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 28 RIS download Bibtex download
  • Felber K, Elks P, Croucher P & Roehl H (2009) FGF signalling is regulating bone development in zebrafish. MECHANISMS OF DEVELOPMENT, Vol. 126 (pp S209-S209) RIS download Bibtex download
  • Knight RD, Mebus K & Roehl HH (2008) Mandibular arch muscle identity is regulated by a conserved molecular process during vertebrate development. JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION, Vol. 310B(4) (pp 355-369) RIS download Bibtex download
  • Elks PM, Li N, Roehl HH & Croucher PI (2007) WNT signalling upregulates osteoblast differentiation in zebrafish: A novel model for studies in osteoblastogenesis. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 22(7) (pp 1115-1115) RIS download Bibtex download
Research group

Roehl lab members

PhD studentship opportunities

We advertise PhD opportunities (Funded or Self-Funded) on FindAPhD.com

Grants
  • Cancer Research UK
  • Medical Research Council
  • HEFC
Teaching activities

Undergraduate

  • BMS109-106 Pathobiology
  • BMS109 Cell & Molecular
  • BMS242/243 Cell & Molecular
  • Level 3 Practical and Dissertation Modules