Dr Gordon Cooper
Senior University Teacher and Examinations Officer
Room: B2 222a Alfred Denny building
Brief career history
Transport of gases and urea by membrane proteins. Function of renal potassium channels.
Epithelial Transport and the movement of small solutes across biological membranes
The underlying theme to my research has been the transport of small solutes and ions across biological membranes, in particular within the kidney and other epithelia. The regulated transport of small solutes such as urea and carbon dioxide plays a critical role in whole body homeostasis.
In classifying my current research I would split it into two major themes. Firstly is the transport of water and gases across biological membranes via Aquaporins. This theme incorporates collaborations with Walter Boron (Case Western) and Gordon Cramb (St Andrews). The second theme focuses on the handling of urea by the kidney, a process critical in the ability of the body to concentrate urine. This process of renal urea handling also has implications in the regulation of blood pressure. This theme involves collaborations with Craig Smith (Manchester) and Gavin Stewart (Dublin).
Over the last few years I have been actively involved in the redevelopment of the delivery of Physiology practical classes within the University. As part of a Physiological Society funded project I have co-ordinated the production of an online teaching resource that has facilitated the delivery of undergraduate practical sessions.
Undergraduate and postgraduate taught modules
- Functional and developmental expression of a zebrafish Kir1.1 (ROMK) potassium channel homologue Kcnj1.. J Physiol, 589(Pt 6), 1489-1503.
- Evidence that aquaporin 1 is a major pathway for CO
2transport across the human erythrocyte membrane. FASEB Journal, 20(12), 1974-1981.
- Effect of PCMBS on CO2permeability of Xenopus oocytes expressing aquaporin 1 or its C189S mutant. American Journal of Physiology-Cell Physiology, 275(6), C1481-C1486.